EA200801481A1 - 5-(арилсульфонил)пиразолопиперидины - Google Patents
5-(арилсульфонил)пиразолопиперидиныInfo
- Publication number
- EA200801481A1 EA200801481A1 EA200801481A EA200801481A EA200801481A1 EA 200801481 A1 EA200801481 A1 EA 200801481A1 EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A1 EA200801481 A1 EA 200801481A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- compounds
- pyrazolopiperides
- arosulfonyl
- alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Изобретение относится к N-циклическим сульфонамидным соединениям формулы I в которой A, B, R, R, R, R, Rи Rявляются такими, как описано в описании. Соединения формулы I могут быть использованы в лечении или профилактике когнитивных нарушений, таких как болезнь Альцгеймера. Изобретение также охватывает фармацевтические композиции, включающие соединения формулы I, способы получения соединений формулы I и способы лечения когнитивных нарушений, таких как болезнь Альцгеймера.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74136605P | 2005-12-01 | 2005-12-01 | |
PCT/US2006/046039 WO2007064914A2 (en) | 2005-12-01 | 2006-12-01 | 5-(arylsulfonyl)-pyrazolopiperidines |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801481A1 true EA200801481A1 (ru) | 2009-02-27 |
EA014906B1 EA014906B1 (ru) | 2011-02-28 |
Family
ID=38092841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801481A EA014906B1 (ru) | 2005-12-01 | 2006-12-01 | 5-(арилсульфонил)пиразолопиперидины |
Country Status (18)
Country | Link |
---|---|
US (2) | US7732609B2 (ru) |
EP (1) | EP1957458A2 (ru) |
JP (1) | JP2009518301A (ru) |
KR (1) | KR20080073359A (ru) |
CN (1) | CN101370776A (ru) |
AR (1) | AR057959A1 (ru) |
AU (1) | AU2006320423B2 (ru) |
BR (1) | BRPI0619633A2 (ru) |
CA (1) | CA2632227A1 (ru) |
EA (1) | EA014906B1 (ru) |
EC (1) | ECSP088593A (ru) |
IL (1) | IL190608A0 (ru) |
MA (1) | MA30089B1 (ru) |
MY (1) | MY149422A (ru) |
NZ (1) | NZ568109A (ru) |
PE (1) | PE20071090A1 (ru) |
TW (1) | TW200736255A (ru) |
WO (1) | WO2007064914A2 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200870592A1 (ru) * | 2006-05-31 | 2009-08-28 | Галапагос Н.В. | Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний |
ES2373253T3 (es) * | 2007-05-25 | 2012-02-01 | Elan Pharmaceuticals Inc. | Pirazolopirrolidinos como inhibidores de gamma secretasa. |
US8653100B2 (en) | 2008-04-01 | 2014-02-18 | Abbvie Inc. | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
TW201038569A (en) * | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
WO2010111418A2 (en) * | 2009-03-25 | 2010-09-30 | Elan Pharmaceuticals, Inc. | Process for the production of fused, tricyclic sulfonamides |
US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
WO2013020930A1 (en) | 2011-08-05 | 2013-02-14 | Abbott Gmbh & Co. Kg | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
CA2853254A1 (en) | 2011-11-18 | 2013-05-23 | Abbvie Inc. | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
JP2016533375A (ja) | 2013-10-17 | 2016-10-27 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノテトラリン誘導体およびアミノインダン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用 |
CN105992764A (zh) | 2013-10-17 | 2016-10-05 | 艾伯维德国有限责任两合公司 | 氨基色满、氨基硫代色满及氨基-1,2,3,4-四氢喹啉衍生物,包含其的药物组合物及其在治疗中的用途 |
CN104059063A (zh) * | 2014-04-03 | 2014-09-24 | 丽水绿氟科技有限公司 | 7,7-二氟-4,5,6,7-四氢吡唑并[4,3-c]吡啶及其衍生物的制备方法 |
MX2020009228A (es) | 2018-03-08 | 2021-01-08 | Incyte Corp | Compuestos diolicos de aminopirazina como inhibidores de fosfoinositida 3-cinasas-gamma. |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ292991A (en) * | 1994-10-20 | 1999-02-25 | Pfizer | Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them |
NZ524475A (en) * | 2000-08-10 | 2004-11-26 | Pharmacia Italia S | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
EP1443046B1 (en) * | 2001-10-09 | 2008-12-17 | Kyorin Pharmaceutical Co., Ltd. | Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
AU2003292724A1 (en) * | 2002-12-27 | 2004-07-29 | Japan Tobacco Inc. | Fused n-containing heterocyclic compounds and medicinal use thereof |
US20060035884A1 (en) * | 2004-05-20 | 2006-02-16 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
ATE495742T1 (de) | 2004-10-27 | 2011-02-15 | Janssen Pharmaceutica Nv | Tetrahydro pyridinyl pyrazole cannabinoid modulatoren |
DE102005002500A1 (de) * | 2005-01-19 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen |
TW200716628A (en) * | 2005-03-22 | 2007-05-01 | Astrazeneca Ab | Novel compounds |
DE102005016170A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
BRPI0614944A2 (pt) * | 2005-08-19 | 2011-04-26 | Elan Pharm Inc | inibidores sulfonamido n-bicìclicos ponte de gama-secretase |
-
2006
- 2006-12-01 TW TW095144766A patent/TW200736255A/zh unknown
- 2006-12-01 CN CNA2006800451866A patent/CN101370776A/zh active Pending
- 2006-12-01 BR BRPI0619633-0A patent/BRPI0619633A2/pt not_active Application Discontinuation
- 2006-12-01 CA CA002632227A patent/CA2632227A1/en not_active Abandoned
- 2006-12-01 EP EP06844721A patent/EP1957458A2/en not_active Withdrawn
- 2006-12-01 NZ NZ568109A patent/NZ568109A/en not_active IP Right Cessation
- 2006-12-01 AR ARP060105326A patent/AR057959A1/es not_active Application Discontinuation
- 2006-12-01 PE PE2006001542A patent/PE20071090A1/es not_active Application Discontinuation
- 2006-12-01 KR KR1020087015935A patent/KR20080073359A/ko not_active Application Discontinuation
- 2006-12-01 AU AU2006320423A patent/AU2006320423B2/en not_active Ceased
- 2006-12-01 EA EA200801481A patent/EA014906B1/ru not_active IP Right Cessation
- 2006-12-01 WO PCT/US2006/046039 patent/WO2007064914A2/en active Application Filing
- 2006-12-01 JP JP2008543496A patent/JP2009518301A/ja active Pending
- 2006-12-01 MY MYPI20081060A patent/MY149422A/en unknown
- 2006-12-01 US US11/566,070 patent/US7732609B2/en not_active Expired - Fee Related
-
2008
- 2008-04-03 IL IL190608A patent/IL190608A0/en unknown
- 2008-06-26 MA MA31080A patent/MA30089B1/fr unknown
- 2008-07-01 EC EC2008008593A patent/ECSP088593A/es unknown
-
2010
- 2010-06-08 US US12/796,441 patent/US20100267747A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2009518301A (ja) | 2009-05-07 |
CA2632227A1 (en) | 2007-06-07 |
MA30089B1 (fr) | 2008-12-01 |
PE20071090A1 (es) | 2007-10-24 |
EA014906B1 (ru) | 2011-02-28 |
US20070155753A1 (en) | 2007-07-05 |
AU2006320423A1 (en) | 2007-06-07 |
WO2007064914A3 (en) | 2007-12-27 |
AR057959A1 (es) | 2007-12-26 |
MY149422A (en) | 2013-08-30 |
KR20080073359A (ko) | 2008-08-08 |
IL190608A0 (en) | 2008-11-03 |
WO2007064914A2 (en) | 2007-06-07 |
US20100267747A1 (en) | 2010-10-21 |
NZ568109A (en) | 2011-07-29 |
ECSP088593A (es) | 2008-08-29 |
EP1957458A2 (en) | 2008-08-20 |
US7732609B2 (en) | 2010-06-08 |
BRPI0619633A2 (pt) | 2011-10-04 |
CN101370776A (zh) | 2009-02-18 |
TW200736255A (en) | 2007-10-01 |
AU2006320423B2 (en) | 2012-06-21 |
WO2007064914A8 (en) | 2008-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |