EA200801033A1 - Применение олигоуронатов для лечения повышенной вязкости слизи - Google Patents
Применение олигоуронатов для лечения повышенной вязкости слизиInfo
- Publication number
- EA200801033A1 EA200801033A1 EA200801033A EA200801033A EA200801033A1 EA 200801033 A1 EA200801033 A1 EA 200801033A1 EA 200801033 A EA200801033 A EA 200801033A EA 200801033 A EA200801033 A EA 200801033A EA 200801033 A1 EA200801033 A1 EA 200801033A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oligouronates
- slim
- treatment
- application
- improved viscosity
- Prior art date
Links
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Dispersion Chemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Согласно изобретению предложен способ лечения человека или субъекта, не являющегося человеком, для борьбы с повышенной вязкостью слизи в дыхательных путях, включающий нанесение на поверхность слизистой оболочки указанных путей у указанного субъекта эффективного количества физиологически приемлемого олигоуроната.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0520375A GB2430881B (en) | 2005-10-06 | 2005-10-06 | Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity |
PCT/GB2006/003720 WO2007039754A1 (en) | 2005-10-06 | 2006-10-06 | Use of oligouronates for treating mucus hyperviscosity |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801033A1 true EA200801033A1 (ru) | 2008-10-30 |
EA015436B1 EA015436B1 (ru) | 2011-08-30 |
Family
ID=35429950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801033A EA015436B1 (ru) | 2005-10-06 | 2006-10-06 | Применение олигоуронатов для лечения повышенной вязкости слизи |
Country Status (15)
Country | Link |
---|---|
US (2) | US8754063B2 (ru) |
EP (4) | EP1942938B1 (ru) |
JP (1) | JP5313677B2 (ru) |
KR (1) | KR101144576B1 (ru) |
CN (1) | CN101325973B (ru) |
AU (1) | AU2006298544B2 (ru) |
BR (1) | BRPI0616982B8 (ru) |
CA (1) | CA2624568C (ru) |
DK (3) | DK2311497T3 (ru) |
EA (1) | EA015436B1 (ru) |
ES (3) | ES2688971T3 (ru) |
GB (1) | GB2430881B (ru) |
HK (1) | HK1125855A1 (ru) |
PL (1) | PL3403657T3 (ru) |
WO (2) | WO2007039760A2 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2430881B (en) | 2005-10-06 | 2010-10-13 | Ntnu Technology Transfer As | Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity |
GB0707096D0 (en) * | 2007-04-12 | 2007-05-23 | Ntnu Technology Transfer As | Method |
DK2268142T3 (en) | 2007-11-27 | 2017-05-22 | Algipharma As | USING ALGINATED OLIGOMERS TO FIGHT BIOFILM |
GB0904942D0 (en) | 2009-03-23 | 2009-05-06 | Ntnu Technology Transfer As | Composition |
GB0904941D0 (en) | 2009-03-23 | 2009-05-06 | Ntnu Technology Transfer As | Composition |
GB0909557D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Anti-microbial alginate oligomers |
PL2437783T3 (pl) | 2009-06-03 | 2014-05-30 | Algipharma As | Leczenie zakażenia Acinetobacter oligomerami alginianu i antybiotykami |
GB0909529D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Alginate oligomers for the inhibition of microbial adherence to surfaces |
GB201116010D0 (en) | 2011-09-15 | 2011-10-26 | Algipharma As | Use of alginate oligomers to enhance the effects of antifungal agents |
US9987235B2 (en) | 2013-08-01 | 2018-06-05 | Nicholas L. Abbott | Methods and compositions for modifying mucous membranes |
GB201322777D0 (en) | 2013-12-20 | 2014-02-05 | Algipharma As | Use of alginate oligomers as blood anticoagulants |
CA2934950A1 (en) * | 2013-12-23 | 2015-07-02 | Norwegian University Of Science And Technology | Uses of oligouronates in cancer treatment |
US20160361342A1 (en) * | 2014-02-28 | 2016-12-15 | Algipharama As | Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective cftr ion channel function |
FR3024358B1 (fr) * | 2014-08-01 | 2017-11-10 | Soc De Courtage Et De Diffusion Codif Int | Compositions cosmetiques et complements alimentaires neuro-protecteurs comprenant de l'oligoalginate ayant un degre de polymerisation de 10 pour lutter contre le vieillissement de la peau. |
GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
GB201504878D0 (en) | 2015-03-23 | 2015-05-06 | Algipharma As | Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion |
GB201517639D0 (en) * | 2015-10-06 | 2015-11-18 | Algipharma As | Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract |
GB201812473D0 (en) | 2018-07-31 | 2018-09-12 | Algipharma As | Method for the qualitative and quantitative detection of alginate oligomers in body fluids |
GB201908639D0 (en) | 2019-06-17 | 2019-07-31 | Algipharma Ipr As | Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure |
CN115005447B (zh) * | 2022-06-16 | 2024-02-06 | 青岛海关技术中心 | 低聚古罗糖醛酸在制备抗疲劳产品中的应用 |
EP4393472A1 (en) * | 2022-12-27 | 2024-07-03 | Abbas Mirshafiey | Mannuronate, guluronate and gulumannuronate tablet, capsule or ampoule formulation and method for its preparation |
WO2024141760A1 (en) | 2022-12-30 | 2024-07-04 | Algipharma As | Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL297511A (ru) | 1956-12-20 | |||
FR7576M (ru) * | 1968-03-27 | 1970-01-05 | ||
HU172831B (hu) * | 1976-03-31 | 1978-12-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija kompleksov oligo- i poligalakturonnyk kislot s ionami zhiznenno vazhnykh metallov |
JPS6176413A (ja) | 1984-09-21 | 1986-04-18 | Junzo Sunamoto | 吸水性高分子によりカプセル化されたリポソ−ムの製造法 |
DD268865A1 (de) * | 1987-01-16 | 1989-06-14 | Adw Ddr | Verfahren zur herstellung eines pharmazeutischen praeparates |
US4898852A (en) * | 1987-06-02 | 1990-02-06 | Walsh William E | Cyclopolgalcturonic acid composition and treatment |
US4855128A (en) * | 1988-01-14 | 1989-08-08 | Warner-Lambert Company | Saccharide inhibition of dental plaque |
JP2641472B2 (ja) | 1988-01-30 | 1997-08-13 | 日本レダリー株式会社 | 感染症治療剤 |
US5459054A (en) * | 1989-12-05 | 1995-10-17 | Neocrin Company | Cells encapsulated in alginate containing a high content of a- l- guluronic acid |
EP0502949A4 (en) | 1989-12-05 | 1993-02-24 | Trancel Corporation | Homologous guluronic acid alginate coating composition for in-vivo application and implantation and method of using same |
AU7221691A (en) | 1990-01-23 | 1991-08-21 | Terje Espevik | Mannuronic acid containing alginate wound healing composition and method |
US5166137A (en) * | 1991-03-27 | 1992-11-24 | Nobipols Forskningsstiftelse | Guluronic acid polymers and use of same for inhibition of cytokine production |
US5952308A (en) * | 1991-07-29 | 1999-09-14 | Pola Chemical Industries Inc. | Mineral absorption promoting agent |
US5460957A (en) | 1992-04-28 | 1995-10-24 | Maruha Corporation | Calcium alginate oligosaccharide and method for producing the same from potassium or sodium alginate |
HU213872B (en) | 1993-09-08 | 1997-11-28 | Mta Koezponti Kemiai Kutato In | Oligo- and polygalacturonate mixed complex, pharmaceutical and food compositions containing them, further process for preparing these compounds |
DE4330773A1 (de) * | 1993-09-10 | 1995-03-16 | Laevosan Gmbh & Co Kg | Blockierung der Anlagerung von Keimen an menschliche Zellen |
JP2828391B2 (ja) | 1993-10-29 | 1998-11-25 | 東燃株式会社 | オリゴ糖を表面に有するリポソーム |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
WO1997014785A2 (en) * | 1995-10-19 | 1997-04-24 | Advanced Reproduction Technologies, Inc. | Methods and compositions to improve germ cell and embryo survival and function |
JP3512553B2 (ja) | 1996-01-30 | 2004-03-29 | ポーラ化成工業株式会社 | 便秘抑制剤及びそれを含有する組成物 |
FR2747045B1 (fr) * | 1996-04-05 | 1998-06-26 | Hooreman Michel | Nouveau medicament optimisant la viscosite des mucus et ameliorant le fonctionnement de l'intestin |
NO305441B1 (no) * | 1996-07-12 | 1999-05-31 | Norsk Hydro As | Anvendelse av G-blokk polysakkarider |
DE69732308T2 (de) | 1996-09-27 | 2005-06-02 | Jagotec Ag | Arzneistoffverabreichungssystem mit hyaluronsäure |
NO305033B1 (no) | 1997-05-09 | 1999-03-22 | Algipharma As | Fremgangsmate for fremstilling av uronsyreblokker fra alginat |
US6339075B1 (en) | 1997-06-30 | 2002-01-15 | The University Of British Columbia | Use of dextran and other polysaccharides to improve mucus clearance |
KR100219918B1 (ko) | 1997-07-03 | 1999-09-01 | 김윤 | 대장선택적 약물전달용 조성물 |
JP3932679B2 (ja) | 1998-07-21 | 2007-06-20 | セイコーエプソン株式会社 | ポリグルロン酸の製造法 |
US6290987B1 (en) | 1998-09-27 | 2001-09-18 | Generex Pharmaceuticals, Inc. | Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids |
US20040224922A1 (en) * | 1999-08-26 | 2004-11-11 | Malcolm King | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
EP1212047A2 (en) * | 1999-08-26 | 2002-06-12 | The Governors Of The University Of Alberta | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US7785625B2 (en) * | 2000-01-14 | 2010-08-31 | Lg Life Sciences, Limited | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
KR100501584B1 (ko) * | 2000-02-03 | 2005-07-18 | (주)케이비피 | 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품 |
DE10006989A1 (de) * | 2000-02-16 | 2001-08-23 | Nutricia Nv | Antiadhäsive Kohlenhydratmischung |
RU2274442C2 (ru) | 2000-03-07 | 2006-04-20 | Раш-Презбитериан-Ст. Лук'С Медикал Сентер | Композиции и способы улавливания и инактивации патогенных микроорганизмов и сперматозоидов |
WO2001072278A2 (en) | 2000-03-30 | 2001-10-04 | Generex Pharmaceuticals Inc. | Method for administering insulin to the buccal region |
DE10019076A1 (de) * | 2000-04-06 | 2001-10-18 | Lang Christine | Verwendung von Polygalakturoniden als Lebensmittelzusatzstoffe |
JP2002338493A (ja) | 2000-10-23 | 2002-11-27 | Genaera Corp | ムチン合成インヒビター |
DE10057976B4 (de) | 2000-11-22 | 2005-02-03 | Südzucker AG Mannheim/Ochsenfurt | Verfahren zur Herstellung von Pektinhydrolyseprodukten |
US6440314B1 (en) * | 2001-01-03 | 2002-08-27 | Vulcan Chemical Technologies, Inc. | Method for destroying chlorite in solution |
ITMI20010347A1 (it) | 2001-02-21 | 2002-08-21 | Grisotech S A | Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale |
US6610331B1 (en) * | 2002-05-30 | 2003-08-26 | Scott M. Sweazy | Fertility kit |
JP2005145885A (ja) | 2003-11-14 | 2005-06-09 | Japan Science & Technology Agency | アルギン酸オリゴマーからなる免疫機構賦活剤 |
PT1740154E (pt) | 2004-03-12 | 2009-09-11 | Biodel Inc | Composições de insulina com absorção melhorada |
JP4764426B2 (ja) | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
JP2006028041A (ja) | 2004-07-13 | 2006-02-02 | Ltt Bio-Pharma Co Ltd | 核酸含有ナノ粒子 |
EP1714660A1 (en) | 2005-04-21 | 2006-10-25 | N.V. Nutricia | Uronic acid and probiotics |
US7621036B2 (en) | 2005-06-21 | 2009-11-24 | Cardiomems, Inc. | Method of manufacturing implantable wireless sensor for in vivo pressure measurement |
EP1745705A1 (en) | 2005-07-20 | 2007-01-24 | N.V. Nutricia | Process for preparing uronic acid oligosaccharides by extrusion |
GB2430881B (en) * | 2005-10-06 | 2010-10-13 | Ntnu Technology Transfer As | Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity |
CN101312736B (zh) | 2005-10-21 | 2013-03-20 | 生命细胞产品有限公司 | 包囊体系 |
GB0707096D0 (en) | 2007-04-12 | 2007-05-23 | Ntnu Technology Transfer As | Method |
US20110130444A1 (en) | 2007-05-04 | 2011-06-02 | Stefan Moisyadi | Methods and compositions for targeted delivery of gene therapeutic vectors |
EP2276727A1 (en) | 2008-05-19 | 2011-01-26 | The University of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
-
2005
- 2005-10-06 GB GB0520375A patent/GB2430881B/en not_active Expired - Fee Related
-
2006
- 2006-10-06 ES ES10189506.8T patent/ES2688971T3/es active Active
- 2006-10-06 EP EP06794671A patent/EP1942938B1/en active Active
- 2006-10-06 ES ES06794671T patent/ES2390974T3/es active Active
- 2006-10-06 PL PL18179968T patent/PL3403657T3/pl unknown
- 2006-10-06 US US12/089,529 patent/US8754063B2/en active Active
- 2006-10-06 WO PCT/GB2006/003732 patent/WO2007039760A2/en active Application Filing
- 2006-10-06 CA CA2624568A patent/CA2624568C/en active Active
- 2006-10-06 ES ES18179968T patent/ES2907875T3/es active Active
- 2006-10-06 AU AU2006298544A patent/AU2006298544B2/en active Active
- 2006-10-06 EA EA200801033A patent/EA015436B1/ru unknown
- 2006-10-06 DK DK10189506.8T patent/DK2311497T3/en active
- 2006-10-06 EP EP10189506.8A patent/EP2311497B1/en active Active
- 2006-10-06 US US12/089,530 patent/US8673878B2/en active Active
- 2006-10-06 EP EP18179968.5A patent/EP3403657B1/en active Active
- 2006-10-06 DK DK18179968.5T patent/DK3403657T3/da active
- 2006-10-06 BR BRPI0616982A patent/BRPI0616982B8/pt not_active IP Right Cessation
- 2006-10-06 CN CN2006800460615A patent/CN101325973B/zh active Active
- 2006-10-06 KR KR1020087010474A patent/KR101144576B1/ko active IP Right Grant
- 2006-10-06 EP EP06794683A patent/EP1954315A2/en not_active Withdrawn
- 2006-10-06 DK DK06794671.5T patent/DK1942938T3/da active
- 2006-10-06 WO PCT/GB2006/003720 patent/WO2007039754A1/en active Application Filing
- 2006-10-06 JP JP2008534075A patent/JP5313677B2/ja active Active
-
2009
- 2009-05-21 HK HK09104636.3A patent/HK1125855A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200801033A1 (ru) | Применение олигоуронатов для лечения повышенной вязкости слизи | |
EA200900177A1 (ru) | Замещенные ациланилиды и способы их применения | |
EA201000914A1 (ru) | Новые терапевтические подходы в лечении смт и связанных с ней расстройств | |
IT1394617B1 (it) | Metodi integrati per la determinazione della corrosivita', dell'invecchiamento, del fingerprint, nonchè la diagnosi, la decontaminazione, la depolarizzazione e la detossificazione di oli | |
MY170728A (en) | Treatment for diabetes in patients inappropriate for metformin therapy | |
NO20074999L (no) | Metode og preparat for behandling av perifere vaskulaere sykdommer | |
EA200900345A1 (ru) | Замещенные ациланилиды и способы их применения | |
WO2007087468A3 (en) | Adiponectin for treatment of various disorders | |
EP1906854A4 (en) | MEDICAL TREATMENT ELECTRODE ARRANGEMENT AND MEDICAL TREATMENT METHOD | |
WO2006078463A3 (en) | Method for treating cardiovascular disease | |
WO2008042231A3 (en) | Compositions and methods for evaluating and treating heart failure | |
EA200701995A1 (ru) | Способы уменьшения кальцификации | |
EA200870088A1 (ru) | Применение бензоконденсированных гетероциклических сульфамидных производных для понижения уровней липидов и глюкозы в крови | |
IL192600A0 (en) | Method of treating or preventing tissue damage caused by increased blood flow | |
WO2008016640A3 (en) | Use of poloxamer for the prevention and/or treatment of heart failure | |
CY2016019I1 (el) | Θεραπευτικη αγωγη της σκληρυνσης κατα πλακας (ms) me campath-1h | |
WO2008155390A3 (en) | Use of inhibitors of sirtuins and/or ampk for the preparation of a medicament for the treatment of polyalanine diseases. | |
GB0805357D0 (en) | Method of treating learning impairment in down's syndrome subjects | |
EA200801296A1 (ru) | Способ лечения метаболического синдрома | |
PL379512A1 (pl) | Nowe metody i ich zastosowanie | |
ATE551067T1 (de) | Tumstatin zur behandlung von erkrankungen die mit der neumodellierung von atemwegsgewebe zusammenhängen | |
EA200901062A1 (ru) | Использование ингибиторов растворимой эпоксидгидролазы для предотвращения и лечения метаболического синдрома и соответствующих расстройств | |
DK1732551T3 (da) | Perhexilin til behandling af kronisk hjertesvigt | |
EA200601853A1 (ru) | Лечение нарушенной дыхательной функции | |
WO2005009361A3 (en) | Method of treating hit patients with argatroban |