EA200601227A1 - Применение ротиготина для лечения или предотвращения гибели дофаминергических нейронов - Google Patents

Применение ротиготина для лечения или предотвращения гибели дофаминергических нейронов

Info

Publication number
EA200601227A1
EA200601227A1 EA200601227A EA200601227A EA200601227A1 EA 200601227 A1 EA200601227 A1 EA 200601227A1 EA 200601227 A EA200601227 A EA 200601227A EA 200601227 A EA200601227 A EA 200601227A EA 200601227 A1 EA200601227 A1 EA 200601227A1
Authority
EA
Eurasian Patent Office
Prior art keywords
rotigotine
treatment
prevention
death
dopaminergic neurons
Prior art date
Application number
EA200601227A
Other languages
English (en)
Other versions
EA014418B1 (ru
Inventor
Дитер Шеллер
Франк Дрессен
Original Assignee
Шварц Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34706587&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601227(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Шварц Фарма Аг filed Critical Шварц Фарма Аг
Publication of EA200601227A1 publication Critical patent/EA200601227A1/ru
Publication of EA014418B1 publication Critical patent/EA014418B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Данное изобретение относится к применению ротиготина или его солей и пролекарств для изготовления лекарства для лечения или предотвращения деструкции дофаминергических клеток при заболеваниях, которые связаны с повышенной деструкцией дофаминергических клеток. Изобретение также относится к применению ротиготина в качестве лекарства для превентивного лечения болезни Паркинсона.
EA200601227A 2003-12-24 2004-12-23 Применение ротиготина для лечения или предотвращения гибели дофаминергических нейронов EA014418B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361259A DE10361259A1 (de) 2003-12-24 2003-12-24 Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
PCT/EP2004/014655 WO2005063237A1 (de) 2003-12-24 2004-12-23 Verwendung von rotigotin zur behandlung oder zur prävention des dopaminergen neuronenverlustes

Publications (2)

Publication Number Publication Date
EA200601227A1 true EA200601227A1 (ru) 2006-12-29
EA014418B1 EA014418B1 (ru) 2010-12-30

Family

ID=34706587

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601227A EA014418B1 (ru) 2003-12-24 2004-12-23 Применение ротиготина для лечения или предотвращения гибели дофаминергических нейронов

Country Status (20)

Country Link
EP (1) EP1696904B1 (ru)
JP (1) JP5032125B2 (ru)
KR (1) KR101296561B1 (ru)
CN (1) CN1897935B (ru)
AT (1) ATE533484T1 (ru)
AU (1) AU2004308648B2 (ru)
BR (1) BRPI0418195A (ru)
CA (1) CA2547645C (ru)
DE (1) DE10361259A1 (ru)
DK (1) DK1696904T3 (ru)
EA (1) EA014418B1 (ru)
ES (1) ES2376881T3 (ru)
HK (1) HK1094538A1 (ru)
IL (1) IL175891A0 (ru)
IS (1) IS8493A (ru)
NO (1) NO20063276L (ru)
NZ (1) NZ547841A (ru)
PL (1) PL1696904T3 (ru)
UA (1) UA85858C2 (ru)
WO (1) WO2005063237A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2717542C1 (ru) * 2016-07-21 2020-03-24 Шаньдун Луе Фармасьютикал Ко., Лтд. Ротиготина бегенат, его способ получения и применение

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
DE102004014841B4 (de) * 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
CN103149368B (zh) * 2005-10-21 2015-06-10 株式会社芳珂 特应性皮炎标记物及其利用技术
CN101147739B (zh) 2007-07-06 2010-12-08 北京康倍得医药技术开发有限公司 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂
SG10201610626PA (en) 2007-11-28 2017-01-27 Ucb Pharma Gmbh Polymorphic form of rotigotine
EP2201941A1 (de) 2008-12-29 2010-06-30 UCB Pharma GmbH Pflaster-Herstellungstechnologie
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
EP3257504A1 (en) 2009-12-22 2017-12-20 UCB Biopharma SPRL Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
WO2011095539A2 (en) 2010-02-05 2011-08-11 Ucb Pharma Gmbh Novel process for the preparation of nitrogen substituted aminotetralins derivatives
MX2012013818A (es) 2010-06-25 2013-01-24 Ucb Pharma Gmbh Procesos para la resolucion de derivados de (s)-5-alcoxi-2-amino-t etralina sustituida con nitrogeno.
CN102379873B (zh) * 2010-09-06 2013-10-30 四川大学华西医院 一种急性全身性猴帕金森病模型及其药物筛选方法
EP2559435A1 (en) 2011-08-19 2013-02-20 UCB Pharma GmbH Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
WO2013075823A1 (en) 2011-11-22 2013-05-30 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system comprising rotigotine and crystallization inhibitor
DE102012013439A1 (de) 2012-07-03 2014-01-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor
DE102012013421A1 (de) 2012-07-03 2014-01-09 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales therapeutisches System (TTS) mit Rotigotin
CA2873093A1 (en) 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
JP2015519333A (ja) 2012-05-07 2015-07-09 セリックスビオ プライヴェート リミテッド 神経疾患の治療のための組成物および方法
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
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US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
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US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
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BR112015032929B1 (pt) 2013-07-03 2022-08-23 Lts Lohmann Therapie-Systeme Ag Sistema terapêutico transdérmico com componente eletrônico e métodos de produção de um sistema terapêutico transdérmico
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CN106456566B (zh) * 2014-05-20 2020-06-16 Lts勒曼治疗***股份公司 含罗替戈汀的经皮递送***
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US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
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US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
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PT3854388T (pt) 2020-01-24 2023-12-11 Luye Pharma Switzerland Ag Sistema terapêutico transdérmico com o princípio ativo rotigotina e pelo menos um adesivo de silicone não resistente a aminas
CN112014193B (zh) * 2020-07-24 2021-06-15 武汉大学中南医院 一种新的fj染色方法和装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564628A (en) * 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
CO5111024A1 (es) * 1998-12-29 2001-12-26 Kimberly Clark Co Composiciones de recubrimientos de polimero disparado por ion sobre peliculas de polimero sensibles al agua
SE9904723D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
WO2002031499A1 (en) * 2000-10-09 2002-04-18 Unisearch Limited Detection of neurodegenerative disorders
PT1256340E (pt) * 2001-05-08 2003-12-31 Sanol Arznei Schwarz Gmbh Sistema terapeutico transdermico aperfeicoado para o tratamento da doenca de parkinson
DE60100994T2 (de) * 2001-05-08 2004-07-22 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System für die Erzielung hoher Plasmaspiegel von Rotigotin in der Therapie von Morbus Parkinson
FR2828212B1 (fr) * 2001-08-03 2003-10-31 Aventis Pharma Sa Methodes de diagnostic et de pronostic de la maladie de parkinson
EP1386605A1 (en) * 2002-07-30 2004-02-04 Schwarz Pharma Ag Improved transdermal delivery system for the administration of rotigotine
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
DE102004014841B4 (de) * 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2717542C1 (ru) * 2016-07-21 2020-03-24 Шаньдун Луе Фармасьютикал Ко., Лтд. Ротиготина бегенат, его способ получения и применение
RU2717542C9 (ru) * 2016-07-21 2020-08-12 Шаньдун Луе Фармасьютикал Ко., Лтд. Ротиготина бегенат, его способ получения и применение

Also Published As

Publication number Publication date
DK1696904T3 (da) 2012-02-13
HK1094538A1 (en) 2007-04-04
KR20060109952A (ko) 2006-10-23
CA2547645C (en) 2013-07-16
AU2004308648A1 (en) 2005-07-14
CN1897935A (zh) 2007-01-17
IS8493A (is) 2006-05-31
JP5032125B2 (ja) 2012-09-26
CA2547645A1 (en) 2005-07-14
AU2004308648B2 (en) 2010-12-16
ES2376881T3 (es) 2012-03-20
BRPI0418195A (pt) 2007-06-19
EP1696904A1 (de) 2006-09-06
UA85858C2 (ru) 2009-03-10
EP1696904B1 (de) 2011-11-16
JP2007516996A (ja) 2007-06-28
NZ547841A (en) 2011-02-25
PL1696904T3 (pl) 2012-04-30
IL175891A0 (en) 2006-10-05
KR101296561B1 (ko) 2013-08-13
CN1897935B (zh) 2010-05-26
NO20063276L (no) 2006-08-30
WO2005063237A1 (de) 2005-07-14
EA014418B1 (ru) 2010-12-30
ATE533484T1 (de) 2011-12-15
DE10361259A1 (de) 2005-07-28

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