EA200401398A1 - Замещённые фенилацетамиды и их применение в качестве активаторов глюкокиназы - Google Patents
Замещённые фенилацетамиды и их применение в качестве активаторов глюкокиназыInfo
- Publication number
- EA200401398A1 EA200401398A1 EA200401398A EA200401398A EA200401398A1 EA 200401398 A1 EA200401398 A1 EA 200401398A1 EA 200401398 A EA200401398 A EA 200401398A EA 200401398 A EA200401398 A EA 200401398A EA 200401398 A1 EA200401398 A1 EA 200401398A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- activators
- application
- glukokinase
- group
- substituted phenylacetamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/50—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Abstract
В заявке описаны соединения формулы I, где формула II означает замещенную группу, оксациклоалкильную группу или тиациклоалкильную группу. Соединения являются активаторами глюкокиназы и используются для лечения диабета типа II.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37616102P | 2002-04-26 | 2002-04-26 | |
PCT/EP2003/003844 WO2003095438A1 (en) | 2002-04-26 | 2003-04-14 | Substituted phenylacetamides and their use as glucokinase activators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200401398A1 true EA200401398A1 (ru) | 2005-06-30 |
EA011297B1 EA011297B1 (ru) | 2009-02-27 |
Family
ID=29420328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200401398A EA011297B1 (ru) | 2002-04-26 | 2003-04-14 | Замещённые фенилацетамиды и их применение в качестве активаторов глюкокиназы |
Country Status (35)
Country | Link |
---|---|
US (2) | US7105671B2 (ru) |
EP (1) | EP1501815B1 (ru) |
JP (1) | JP4091600B2 (ru) |
KR (1) | KR100669587B1 (ru) |
CN (1) | CN1329386C (ru) |
AR (1) | AR039665A1 (ru) |
AT (1) | ATE346056T1 (ru) |
AU (1) | AU2003232204B8 (ru) |
BR (1) | BR0309546A (ru) |
CA (1) | CA2482346C (ru) |
DE (1) | DE60309856T2 (ru) |
DK (1) | DK1501815T3 (ru) |
EA (1) | EA011297B1 (ru) |
EC (1) | ECSP045382A (ru) |
ES (1) | ES2276097T3 (ru) |
GT (1) | GT200300096A (ru) |
HK (1) | HK1078088A1 (ru) |
HR (1) | HRP20040953A2 (ru) |
IL (1) | IL164780A (ru) |
MA (1) | MA27113A1 (ru) |
MX (1) | MXPA04010605A (ru) |
MY (1) | MY135222A (ru) |
NO (1) | NO20044534L (ru) |
NZ (1) | NZ535706A (ru) |
PA (1) | PA8572301A1 (ru) |
PE (1) | PE20040451A1 (ru) |
PL (1) | PL373701A1 (ru) |
PT (1) | PT1501815E (ru) |
RS (1) | RS93604A (ru) |
TN (1) | TNSN04211A1 (ru) |
TW (1) | TWI281917B (ru) |
UA (1) | UA80427C2 (ru) |
UY (1) | UY27787A1 (ru) |
WO (1) | WO2003095438A1 (ru) |
ZA (1) | ZA200407986B (ru) |
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JPH04115996U (ja) * | 1991-03-28 | 1992-10-15 | 東洋運搬機株式会社 | ボートリフタ |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
EP1549626A1 (en) | 2002-10-03 | 2005-07-06 | Novartis AG | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
DE602005013491D1 (de) | 2004-02-18 | 2009-05-07 | Astrazeneca Ab | Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel |
JP2007530631A (ja) | 2004-04-02 | 2007-11-01 | ノバルティス アクチエンゲゼルシャフト | チアゾロピリジン誘導体、それを含む医薬組成物およびグルコキナーゼ介在性状態の処置法 |
ATE524479T1 (de) | 2004-04-02 | 2011-09-15 | Novartis Ag | Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren |
NZ550567A (en) * | 2004-04-21 | 2010-07-30 | Prosidion Ltd | Tri(cyclo) substituted amide compounds |
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
MX2007001650A (es) * | 2004-08-12 | 2007-07-13 | Prosidion Ltd | Fenilacetamidas substituidas y su uso como activadores de glucocinasa. |
GB0418058D0 (en) * | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
GB0418046D0 (en) * | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
CA2614746C (en) | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
RU2420525C2 (ru) | 2005-07-11 | 2011-06-10 | Мицубиси Танабе Фарма Корпорейшн | Производные оксимов и их получение |
RU2008112184A (ru) | 2005-08-31 | 2009-10-10 | Астеллас Фарма Инк. (Jp) | Производное тиазола |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
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EP1943238A1 (en) | 2005-10-24 | 2008-07-16 | F.Hoffmann-La Roche Ag | Preparation of cyclic, ketalized ketones by favorskii rearrangement and the use thereof for the preparation of glucokinase activator 70 |
US20080293741A1 (en) * | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
EP2001875A2 (en) | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Glucokinase activators |
WO2007115968A2 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Process for the preparation of a glucokinase activator |
WO2007115967A1 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Crystalline isopropanol solvate of glucokinase activator |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
JP5386350B2 (ja) | 2006-05-31 | 2014-01-15 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体 |
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US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
WO2008012227A2 (en) | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
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US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
WO2008074694A1 (en) * | 2006-12-20 | 2008-06-26 | F. Hoffmann-La Roche Ag | Crystallization of glucokinase activators |
TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
WO2008080824A1 (en) * | 2006-12-29 | 2008-07-10 | F. Hoffmann-La Roche Ag | Aromatic sulfonated ketals |
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CN101827832B (zh) * | 2007-10-08 | 2014-05-07 | 阿德维纳斯治疗私人有限公司 | 作为葡糖激酶活化剂的乙酰胺衍生物、其制备方法及医药应用 |
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US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
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MY163114A (en) * | 2008-04-28 | 2017-08-15 | Kyorin Seiyaku Kk | Cyclopentylacrylamide derivative |
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GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
BR112020004441B1 (pt) | 2017-09-18 | 2024-01-16 | Basf Se | Compostos da fórmula i, composição agroquímica, semente revestida, uso de compostos e método não-terapêutico de combate de fungos |
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2003
- 2003-04-14 RS YUP-936/04A patent/RS93604A/sr unknown
- 2003-04-14 PL PL03373701A patent/PL373701A1/xx not_active Application Discontinuation
- 2003-04-14 CA CA002482346A patent/CA2482346C/en not_active Expired - Fee Related
- 2003-04-14 UA UA20041109723A patent/UA80427C2/uk unknown
- 2003-04-14 AU AU2003232204A patent/AU2003232204B8/en not_active Ceased
- 2003-04-14 AT AT03749855T patent/ATE346056T1/de active
- 2003-04-14 BR BR0309546-0A patent/BR0309546A/pt not_active IP Right Cessation
- 2003-04-14 NZ NZ535706A patent/NZ535706A/en unknown
- 2003-04-14 EP EP03749855A patent/EP1501815B1/en not_active Expired - Lifetime
- 2003-04-14 PT PT03749855T patent/PT1501815E/pt unknown
- 2003-04-14 JP JP2004503454A patent/JP4091600B2/ja not_active Expired - Fee Related
- 2003-04-14 CN CNB038093839A patent/CN1329386C/zh not_active Expired - Fee Related
- 2003-04-14 MX MXPA04010605A patent/MXPA04010605A/es active IP Right Grant
- 2003-04-14 DE DE60309856T patent/DE60309856T2/de not_active Expired - Lifetime
- 2003-04-14 WO PCT/EP2003/003844 patent/WO2003095438A1/en active IP Right Grant
- 2003-04-14 ES ES03749855T patent/ES2276097T3/es not_active Expired - Lifetime
- 2003-04-14 EA EA200401398A patent/EA011297B1/ru not_active IP Right Cessation
- 2003-04-14 DK DK03749855T patent/DK1501815T3/da active
- 2003-04-14 KR KR1020047017204A patent/KR100669587B1/ko not_active IP Right Cessation
- 2003-04-23 TW TWSUBSTITUTA patent/TWI281917B/zh active
- 2003-04-23 US US10/421,109 patent/US7105671B2/en not_active Expired - Fee Related
- 2003-04-24 PA PA20038572301A patent/PA8572301A1/es unknown
- 2003-04-24 MY MYPI20031564A patent/MY135222A/en unknown
- 2003-04-24 AR ARP030101426A patent/AR039665A1/es active IP Right Grant
- 2003-04-24 PE PE2003000409A patent/PE20040451A1/es not_active Application Discontinuation
- 2003-04-24 GT GT200300096A patent/GT200300096A/es unknown
- 2003-04-28 UY UY27787A patent/UY27787A1/es not_active Application Discontinuation
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2004
- 2004-10-04 ZA ZA200407986A patent/ZA200407986B/xx unknown
- 2004-10-12 HR HR20040953A patent/HRP20040953A2/hr not_active Application Discontinuation
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- 2004-10-22 EC EC2004005382A patent/ECSP045382A/es unknown
- 2004-10-26 MA MA27915A patent/MA27113A1/fr unknown
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