EA200301309A1 - Усовершенствованный фармакокинетический профиль гидрофобных веществ - Google Patents

Усовершенствованный фармакокинетический профиль гидрофобных веществ

Info

Publication number
EA200301309A1
EA200301309A1 EA200301309A EA200301309A EA200301309A1 EA 200301309 A1 EA200301309 A1 EA 200301309A1 EA 200301309 A EA200301309 A EA 200301309A EA 200301309 A EA200301309 A EA 200301309A EA 200301309 A1 EA200301309 A1 EA 200301309A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmacokinetic profile
improved pharmacokinetic
hydrophobic substances
hydrophobic substance
administration
Prior art date
Application number
EA200301309A
Other languages
English (en)
Other versions
EA006961B1 (ru
Inventor
Томас К. Пинкертон
Original Assignee
Фармация Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Корпорейшн filed Critical Фармация Корпорейшн
Publication of EA200301309A1 publication Critical patent/EA200301309A1/ru
Publication of EA006961B1 publication Critical patent/EA006961B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • C01G23/04—Oxides; Hydroxides
    • C01G23/047—Titanium dioxide
    • C01G23/053—Producing by wet processes, e.g. hydrolysing titanium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/46—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on titanium oxides or titanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ceramic Engineering (AREA)
  • Nanotechnology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Environmental & Geological Engineering (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Раскрыт способ системного введения гидрофобного вещества млекопитающему. Способ включает доставку упомянутого гидрофобного вещества в дерму млекопитающего, благодаря чему получают улучшенное системное всасывание по сравнению со всасыванием, получаемым при подкожной доставке посредством введения ударной дозы.
EA200301309A 2001-06-29 2002-06-24 Усовершенствованный фармакокинетический профиль гидрофобных веществ EA006961B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/897,801 US20030073609A1 (en) 2001-06-29 2001-06-29 Enhanced pharmacokinetic profile of intradermally delivered substances
PCT/US2002/020080 WO2003002094A2 (en) 2001-06-29 2002-06-24 Enhanced pharmacokinetic profile of hydrophobic substances

Publications (2)

Publication Number Publication Date
EA200301309A1 true EA200301309A1 (ru) 2004-12-30
EA006961B1 EA006961B1 (ru) 2006-06-30

Family

ID=25408438

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200301307A EA006922B1 (ru) 2001-06-29 2001-12-26 Усиленное системное всасывание веществ, введённых интрадермальным путём
EA200301308A EA006578B1 (ru) 2001-06-29 2002-06-24 Гидрофобные агонисты допамина, введенные в дерму
EA200301309A EA006961B1 (ru) 2001-06-29 2002-06-24 Усовершенствованный фармакокинетический профиль гидрофобных веществ

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA200301307A EA006922B1 (ru) 2001-06-29 2001-12-26 Усиленное системное всасывание веществ, введённых интрадермальным путём
EA200301308A EA006578B1 (ru) 2001-06-29 2002-06-24 Гидрофобные агонисты допамина, введенные в дерму

Country Status (17)

Country Link
US (4) US20030073609A1 (ru)
EP (3) EP1399205A2 (ru)
JP (3) JP2004537540A (ru)
KR (3) KR20040022438A (ru)
CN (3) CN1610567A (ru)
AU (1) AU2002345813B2 (ru)
BR (2) BR0210665A (ru)
CA (3) CA2450354A1 (ru)
CO (2) CO5540369A2 (ru)
CZ (3) CZ20033059A3 (ru)
EA (3) EA006922B1 (ru)
IL (3) IL158651A0 (ru)
MX (3) MXPA03011931A (ru)
NO (3) NO20035580D0 (ru)
PL (3) PL365667A1 (ru)
WO (3) WO2003002175A2 (ru)
ZA (3) ZA200308385B (ru)

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Also Published As

Publication number Publication date
JP2005503359A (ja) 2005-02-03
WO2003002103A3 (en) 2003-04-10
CA2452393A1 (en) 2003-01-09
EP1399205A2 (en) 2004-03-24
CZ20033059A3 (cs) 2004-04-14
MXPA03011710A (es) 2004-12-06
IL158651A0 (en) 2004-05-12
PL366370A1 (en) 2005-01-24
WO2003002175A8 (en) 2003-07-10
US20030073609A1 (en) 2003-04-17
CZ20033363A3 (cs) 2004-09-15
EA006961B1 (ru) 2006-06-30
NO20035580D0 (no) 2003-12-15
ZA200308385B (en) 2004-10-28
KR20040019024A (ko) 2004-03-04
JP2004537540A (ja) 2004-12-16
AU2002345813B2 (en) 2006-10-26
WO2003002094A8 (en) 2005-10-20
WO2003002175A2 (en) 2003-01-09
MXPA03011794A (es) 2005-03-07
EP1399206A2 (en) 2004-03-24
IL159024A0 (en) 2004-05-12
PL365667A1 (en) 2005-01-10
US20040175401A1 (en) 2004-09-09
CA2452321A1 (en) 2003-01-09
IL159025A0 (en) 2004-05-12
NO20035782L (no) 2004-02-24
ZA200309125B (en) 2004-11-24
ZA200309151B (en) 2004-11-25
NO20035731L (no) 2004-02-27
CO5540369A2 (es) 2005-07-29
BR0210665A (pt) 2004-10-05
EA200301307A1 (ru) 2004-06-24
EA006922B1 (ru) 2006-04-28
JP2005502613A (ja) 2005-01-27
KR20040029327A (ko) 2004-04-06
US20040028707A1 (en) 2004-02-12
CA2450354A1 (en) 2003-01-09
EA200301308A1 (ru) 2004-08-26
CN1610567A (zh) 2005-04-27
BR0210688A (pt) 2004-09-21
CN1723052A (zh) 2006-01-18
WO2003002103A2 (en) 2003-01-09
KR20040022438A (ko) 2004-03-12
EA006578B1 (ru) 2006-02-24
NO20035731D0 (no) 2003-12-19
MXPA03011931A (es) 2005-03-07
WO2003002094A2 (en) 2003-01-09
WO2003002175A3 (en) 2003-03-20
PL366635A1 (en) 2005-02-07
EP1416915A1 (en) 2004-05-12
US20040170654A1 (en) 2004-09-02
CZ20033364A3 (cs) 2004-08-18
CN1522139A (zh) 2004-08-18
CO5640074A2 (es) 2006-05-31

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