EA200301282A1 - Гранулярные препараты габоксадола - Google Patents

Гранулярные препараты габоксадола

Info

Publication number
EA200301282A1
EA200301282A1 EA200301282A EA200301282A EA200301282A1 EA 200301282 A1 EA200301282 A1 EA 200301282A1 EA 200301282 A EA200301282 A EA 200301282A EA 200301282 A EA200301282 A EA 200301282A EA 200301282 A1 EA200301282 A1 EA 200301282A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hoboxadol
granular preparations
gaboxadola
granular
melting
Prior art date
Application number
EA200301282A
Other languages
English (en)
Other versions
EA009731B1 (ru
Inventor
Михиль Онне Элема
Лене Андресен
Пер Хольм
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200301282A1 publication Critical patent/EA200301282A1/ru
Publication of EA009731B1 publication Critical patent/EA009731B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Настоящее изобретение относится к гранулированному продукту, содержащему габоксадол в виде аддитивной соли кислоты, к способу гранулирования путем расплавления для его получения и к твердым фармацевтическим стандартным дозированным формам, получаемым из указанного гранулярного препарата габоксадола.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301282A 2001-05-21 2002-05-17 Гранулярные препараты габоксадола EA009731B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100817 2001-05-21
PCT/DK2002/000332 WO2002094225A1 (en) 2001-05-21 2002-05-17 Granular preparations of gaboxadol

Publications (2)

Publication Number Publication Date
EA200301282A1 true EA200301282A1 (ru) 2004-04-29
EA009731B1 EA009731B1 (ru) 2008-02-28

Family

ID=8160520

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200700703A EA200700703A1 (ru) 2001-05-21 2002-05-17 Гранулярные препараты габоксадола
EA200301282A EA009731B1 (ru) 2001-05-21 2002-05-17 Гранулярные препараты габоксадола

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200700703A EA200700703A1 (ru) 2001-05-21 2002-05-17 Гранулярные препараты габоксадола

Country Status (26)

Country Link
US (1) US20040157876A1 (ru)
EP (1) EP1389091A1 (ru)
JP (1) JP2004530695A (ru)
KR (1) KR20030097890A (ru)
CN (1) CN1511026A (ru)
AR (1) AR033896A1 (ru)
AU (1) AU2002338855B2 (ru)
BG (1) BG108441A (ru)
BR (1) BR0209834A (ru)
CA (1) CA2447603A1 (ru)
CZ (1) CZ20033269A3 (ru)
EA (2) EA200700703A1 (ru)
HR (1) HRP20030950A2 (ru)
HU (1) HUP0400051A2 (ru)
IL (1) IL158733A0 (ru)
IS (1) IS7020A (ru)
ME (1) MEP6308A (ru)
MX (1) MXPA03010596A (ru)
NO (1) NO20035146D0 (ru)
NZ (1) NZ547636A (ru)
PL (1) PL366541A1 (ru)
SK (1) SK15542003A3 (ru)
UA (1) UA80092C2 (ru)
WO (1) WO2002094225A1 (ru)
YU (1) YU92103A (ru)
ZA (1) ZA200308594B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385749A1 (en) * 1999-09-28 2001-04-05 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
PL1641456T3 (pl) 2003-06-25 2010-08-31 H Lundbeck As Gaboksadol do leczenia depresji i innych zaburzeń afektywnych
TW200528098A (en) * 2003-12-18 2005-09-01 Lundbeck & Co As H Treatment of insomnia in human patients
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
EP2292222A1 (en) 2005-01-28 2011-03-09 H. Lundbeck A/S Polymorphic Forms of a GABAA Agonist
EP1906953A4 (en) * 2005-04-29 2009-05-20 Lundbeck & Co As H FORMS OF ACID SALTS AND BASIC SALTS OF GABOXADOL
JP5792061B2 (ja) * 2008-05-30 2015-10-07 サイコジェニックス・インコーポレーテッドＰｓｙｃｈｏｇｅｎｉｃｓ Ｉｎｃ． 神経及び精神障害の治療法
CA2732636A1 (en) * 2008-09-01 2009-05-07 H. Lundbeck A/S Pharmaceutical composition comprising gaboxadol and an inhibitor of pat1 or oat
WO2013090452A1 (en) 2011-12-12 2013-06-20 Orbis Biosciences, Inc. Sustained release particle formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315934A (en) * 1979-09-24 1982-02-16 Sandoz Ltd. Organic compounds
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
US6649186B1 (en) * 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
CA2385749A1 (en) * 1999-09-28 2001-04-05 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
US6375982B1 (en) * 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same

Also Published As

Publication number Publication date
WO2002094225A1 (en) 2002-11-28
NZ547636A (en) 2008-03-28
AR033896A1 (es) 2004-01-07
IL158733A0 (en) 2004-05-12
CA2447603A1 (en) 2002-11-28
BG108441A (en) 2005-02-28
AU2002338855B2 (en) 2007-08-16
UA80092C2 (en) 2007-08-27
PL366541A1 (en) 2005-02-07
NO20035146L (no) 2003-11-19
SK15542003A3 (sk) 2004-05-04
HUP0400051A2 (hu) 2004-04-28
CZ20033269A3 (en) 2004-03-17
US20040157876A1 (en) 2004-08-12
KR20030097890A (ko) 2003-12-31
EA009731B1 (ru) 2008-02-28
JP2004530695A (ja) 2004-10-07
CN1511026A (zh) 2004-07-07
HRP20030950A2 (en) 2005-08-31
BR0209834A (pt) 2004-06-15
EP1389091A1 (en) 2004-02-18
EA200700703A1 (ru) 2007-08-31
MEP6308A (xx) 2010-02-10
IS7020A (is) 2003-11-10
MXPA03010596A (es) 2004-03-09
ZA200308594B (en) 2004-11-04
NO20035146D0 (no) 2003-11-19
YU92103A (sh) 2006-05-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM