EA200300306A1 - SPYROPYRIMIDIN-2,4,6-TRIONE METALPROTEINASE INHIBITORS - Google Patents

SPYROPYRIMIDIN-2,4,6-TRIONE METALPROTEINASE INHIBITORS

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Publication number
EA200300306A1
EA200300306A1 EA200300306A EA200300306A EA200300306A1 EA 200300306 A1 EA200300306 A1 EA 200300306A1 EA 200300306 A EA200300306 A EA 200300306A EA 200300306 A EA200300306 A EA 200300306A EA 200300306 A1 EA200300306 A1 EA 200300306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trione
spyropyrimidin
metalproteinase
inhibitors
spiropirimidine
Prior art date
Application number
EA200300306A
Other languages
Russian (ru)
Other versions
EA005762B1 (en
Inventor
Брайан Скотт Бронк
Марк Карл Ноу
Мартин Джеймс Уайтс
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200300306A1 publication Critical patent/EA200300306A1/en
Publication of EA005762B1 publication Critical patent/EA005762B1/en

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Настоящее изобретение относится к 5-спиропиримидин-2,4,6-трионовым ингибиторам металлопротеиназы формулы, где указанное "А" представляет собой 5-7-членное гетероциклическое кольцо, как определено в описании, и к фармацевтическим композициям и способам лечения воспаления, рака и других расстройств.Отчет о международном поиске был опубликован 2002.08.15.The present invention relates to a 5-spiropirimidine-2,4,6-trione metalloproteinase inhibitor of the formula, where said “A” is a 5-7-membered heterocyclic ring, as defined herein, and to pharmaceutical compositions and methods for treating inflammation, cancer and other disorders. The international search report was published 2002.08.15.

EA200300306A 2000-10-26 2001-10-23 Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors EA005762B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24338900P 2000-10-26 2000-10-26
PCT/IB2001/001986 WO2002034753A2 (en) 2000-10-26 2001-10-23 Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

Publications (2)

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EA200300306A1 true EA200300306A1 (en) 2003-08-28
EA005762B1 EA005762B1 (en) 2005-06-30

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EA200300306A EA005762B1 (en) 2000-10-26 2001-10-23 Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

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JP (1) JP2004518635A (en)
KR (1) KR20040004412A (en)
CN (1) CN1501937A (en)
AP (1) AP2001002318A0 (en)
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AU (1) AU2002210813A1 (en)
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Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
CA2433772C (en) 2001-02-14 2008-10-07 Warner-Lambert Company Llc Pyrimidine matrix metalloproteinase inhibitors
DOP2002000333A (en) 2001-02-14 2002-09-30 Warner Lambert Co DERIVATIVES OF ISOFTALIC ACID AS INHIBITORS OF METALOPROTEINASES OF THE MATRIX
ATE280164T1 (en) 2001-02-14 2004-11-15 Warner Lambert Co BENZOTHIADIAZINE AS MATRIX METALPROTEINASE INHIBITORS
PA8539501A1 (en) 2001-02-14 2002-09-30 Warner Lambert Co TRIAZOLO COMPOUNDS AS MMP INHIBITORS
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
BR0213233A (en) 2001-10-12 2005-01-04 Warner Lambert Co Matrix metalloproteinase inhibitor alkynes
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
AU2003228701A1 (en) * 2002-04-25 2003-11-10 Bristol-Myers Squibb Company Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
ES2247527T3 (en) * 2002-04-26 2006-03-01 Pfizer Prod Inc METALOPROTEINASE TRIARIL-OXI-ARIL-ESPIRO-PYRIMIDINE-2,4,6-TRIONA INHIBITORS.
CA2480092A1 (en) * 2002-04-26 2003-11-06 Pfizer Products Inc. N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
AU2003250466A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
AU2003253150A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Chromone derivatives as matrix metalloproteinase inhibitors
AU2003253186A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
EP1537098A1 (en) 2002-08-13 2005-06-08 Warner-Lambert Company LLC Monocyclic derivatives as matrix metalloproteinase inhibitors
WO2004014375A2 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused bicyclic metalloproteinase inhibitors
JP2006500351A (en) 2002-08-13 2006-01-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Pyrimidine-2,4-dione derivatives as matrix metalloproteinase-13 inhibitors
PA8578101A1 (en) 2002-08-13 2004-05-07 Warner Lambert Co HETEROBIARILO DERIVATIVES AS METALOPROTEINASE IN MATRIX INHIBITORS
AU2003250470A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
AU2003249477A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
BR0313724A (en) 2002-08-13 2005-06-28 Warner Lambert Co Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
FR2858232B1 (en) * 2003-07-29 2006-03-03 Pierre Potier USE OF A BIGUANIDE DERIVATIVE TO PROTECT THE SKIN FROM UVB RADIATION
US20070225253A1 (en) * 2004-04-01 2007-09-27 Didier Cataldo Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
DOP2006000268A (en) 2005-12-22 2007-07-31 Pfizer Prod Inc ANTIBACTERIAL AGENTS
US8153166B2 (en) * 2006-06-08 2012-04-10 Chih-Hsiung Lin Composition for prophylaxis or treatment of urinary system infection and method thereof
CN102285934B (en) * 2009-01-08 2013-08-14 四川大学 Spirocycle dienone derivates as well as preparation method and application thereof
PE20151295A1 (en) * 2012-12-10 2015-10-10 Chugai Pharmaceutical Co Ltd HYDANTOIN DERIVATIVE
KR101594506B1 (en) * 2014-03-20 2016-02-17 한국화학연구원 A Composition for Treating Bone-Related Diseases
CN106572994B (en) 2014-06-09 2020-09-18 中外制药株式会社 Pharmaceutical composition containing hydantoin derivatives
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
CN110092790B (en) * 2019-06-11 2020-07-24 东北农业大学 Alkaloid compound and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714093A (en) * 1970-05-19 1973-01-30 American Home Prod Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones
CA2294259A1 (en) * 1997-06-21 1998-12-30 Roche Diagnostics Gmbh Barbituric acid derivatives with antimetastatic and antitumor activity
US6265578B1 (en) * 1999-02-12 2001-07-24 Hoffmann-La Roche Inc. Pyrimidine-2,4,6-triones
PA8498701A1 (en) * 1999-08-12 2002-08-26 Pfizer Prod Inc PYRIMIDINE-2,4,6-METALOPROTEINASE INHIBITING TRIONES

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