EA200200728A1 - Способ получения циталопрама - Google Patents

Способ получения циталопрама

Info

Publication number
EA200200728A1
EA200200728A1 EA200200728A EA200200728A EA200200728A1 EA 200200728 A1 EA200200728 A1 EA 200200728A1 EA 200200728 A EA200200728 A EA 200200728A EA 200200728 A EA200200728 A EA 200200728A EA 200200728 A1 EA200200728 A1 EA 200200728A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cytaloprama
obtaining
cyanophthalide
producing
preparation
Prior art date
Application number
EA200200728A
Other languages
English (en)
Other versions
EA004055B1 (ru
Inventor
Ханс Петерсен
Майкл Хэролд Рок
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200200728A1 publication Critical patent/EA200200728A1/ru
Publication of EA004055B1 publication Critical patent/EA004055B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/74—Iron group metals
    • B01J23/755—Nickel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Настоящее изобретение предлагает новый и улучшенный способ получения 5-цианофталида, который является основным промежуточным соединением при получении антидепрессантного соединения циталопрама.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200728A 1999-12-30 1999-12-30 Способ получения циталопрама EA004055B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000740 WO2001049672A1 (en) 1999-12-30 1999-12-30 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
EA200200728A1 true EA200200728A1 (ru) 2002-12-26
EA004055B1 EA004055B1 (ru) 2003-12-25

Family

ID=8157174

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200728A EA004055B1 (ru) 1999-12-30 1999-12-30 Способ получения циталопрама

Country Status (28)

Country Link
US (2) US20020198391A1 (ru)
EP (1) EP1246813B1 (ru)
JP (1) JP2003519218A (ru)
KR (1) KR100653141B1 (ru)
CN (1) CN1211377C (ru)
AT (1) ATE253568T1 (ru)
AU (1) AU1858400A (ru)
BR (1) BR9917604A (ru)
CA (1) CA2395733C (ru)
CZ (1) CZ20022627A3 (ru)
DE (1) DE69912652T2 (ru)
DK (1) DK1246813T3 (ru)
EA (1) EA004055B1 (ru)
ES (1) ES2207312T3 (ru)
HK (1) HK1052512B (ru)
HR (1) HRP20020633A2 (ru)
HU (1) HUP0203840A3 (ru)
IL (2) IL150367A0 (ru)
IS (1) IS2167B (ru)
MX (1) MXPA02006504A (ru)
NO (1) NO328359B1 (ru)
PL (1) PL198803B1 (ru)
PT (1) PT1246813E (ru)
SI (1) SI1246813T1 (ru)
SK (1) SK11052002A3 (ru)
TR (1) TR200201688T2 (ru)
UA (1) UA73336C2 (ru)
WO (1) WO2001049672A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
SI1254129T1 (en) 2000-01-14 2004-02-29 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
NZ521204A (en) 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
WO2001068630A1 (en) 2000-03-14 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US6339182B1 (en) * 2000-06-20 2002-01-15 Chevron U.S.A. Inc. Separation of olefins from paraffins using ionic liquid solutions
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100457747C (zh) * 2006-11-21 2009-02-04 浙江大学 抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
CN103127815B (zh) * 2013-02-19 2015-10-28 浙江大学 一种利用卤硫作用提高二氧化硫捕集性能的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (ru) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4665181A (en) * 1984-05-17 1987-05-12 Pennwalt Corporation Anti-inflammatory phthalazinones
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
JPH0881456A (ja) * 1994-09-14 1996-03-26 Sumitomo Chem Co Ltd １，１，３，３−テトラクロロ−１，３−ジヒドロイソベンゾフラン誘導体の製造法
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1129592C (zh) 1998-10-20 2003-12-03 H·隆德贝克有限公司 制备西酞普兰的方法
SI1140886T1 (en) 1998-12-23 2003-08-31 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
SI1254129T1 (en) 2000-01-14 2004-02-29 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
SG167655A1 (en) 2000-12-22 2011-01-28 Lundbeck & Co As H Method for the preparation of pure citalopram
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法

Also Published As

Publication number Publication date
NO328359B1 (no) 2010-02-01
HUP0203840A3 (en) 2005-02-28
CN1211377C (zh) 2005-07-20
CA2395733A1 (en) 2001-07-12
PT1246813E (pt) 2004-02-27
KR20020073495A (ko) 2002-09-26
CN1391566A (zh) 2003-01-15
EP1246813A1 (en) 2002-10-09
HRP20020633A2 (en) 2004-12-31
AU1858400A (en) 2001-07-16
KR100653141B1 (ko) 2006-12-01
IL150367A (en) 2010-06-16
IS6433A (is) 2002-06-19
UA73336C2 (en) 2005-07-15
SK11052002A3 (sk) 2003-01-09
SI1246813T1 (en) 2004-08-31
PL198803B1 (pl) 2008-07-31
DE69912652D1 (de) 2003-12-11
NO20023150L (no) 2002-06-28
EP1246813B1 (en) 2003-11-05
BR9917604A (pt) 2002-12-31
ATE253568T1 (de) 2003-11-15
WO2001049672A1 (en) 2001-07-12
NO20023150D0 (no) 2002-06-28
HK1052512B (zh) 2006-03-03
PL355531A1 (en) 2004-05-04
CZ20022627A3 (cs) 2002-10-16
IL150367A0 (en) 2002-12-01
EA004055B1 (ru) 2003-12-25
MXPA02006504A (es) 2002-12-09
DE69912652T2 (de) 2004-06-09
US7271273B2 (en) 2007-09-18
TR200201688T2 (tr) 2002-11-21
ES2207312T3 (es) 2004-05-16
JP2003519218A (ja) 2003-06-17
CA2395733C (en) 2007-03-20
HUP0203840A2 (en) 2003-05-28
IS2167B (is) 2006-11-15
US20020198391A1 (en) 2002-12-26
HK1052512A1 (en) 2003-09-19
DK1246813T3 (da) 2004-03-01
US20060079700A1 (en) 2006-04-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU