EA200000741A1 - Новые производные дигидроксигексановой кислоты - Google Patents

Новые производные дигидроксигексановой кислоты

Info

Publication number
EA200000741A1
EA200000741A1 EA200000741A EA200000741A EA200000741A1 EA 200000741 A1 EA200000741 A1 EA 200000741A1 EA 200000741 A EA200000741 A EA 200000741A EA 200000741 A EA200000741 A EA 200000741A EA 200000741 A1 EA200000741 A1 EA 200000741A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acid derivatives
dihydroxygexane
new
inflammation
published
Prior art date
Application number
EA200000741A
Other languages
English (en)
Other versions
EA003137B1 (ru
Inventor
Джон Чарлз Кэт
Мэттью Фрэнк Браун
Кристофер Стэнли Посс
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200000741A1 publication Critical patent/EA200000741A1/ru
Publication of EA003137B1 publication Critical patent/EA003137B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение раскрывает производные дигидроксигексановой кислоты общей формулы (I)которые полезны для лечения воспаления и других иммунных нарушений.Отчет о международном поиске был опубликован 1999.10.21.
EA200000741A 1998-02-05 1999-01-18 Новые производные дигидроксигексановой кислоты EA003137B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7380198P 1998-02-05 1998-02-05
PCT/IB1999/000067 WO1999040061A2 (en) 1998-02-05 1999-01-18 Novel dihydroxyhexanoic acid derivatives

Publications (2)

Publication Number Publication Date
EA200000741A1 true EA200000741A1 (ru) 2001-02-26
EA003137B1 EA003137B1 (ru) 2003-02-27

Family

ID=22115885

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000741A EA003137B1 (ru) 1998-02-05 1999-01-18 Новые производные дигидроксигексановой кислоты

Country Status (37)

Country Link
EP (1) EP1051405B1 (ru)
JP (1) JP3693916B2 (ru)
KR (1) KR100385529B1 (ru)
CN (1) CN1177834C (ru)
AP (1) AP992A (ru)
AR (1) AR016175A1 (ru)
AT (1) ATE337307T1 (ru)
AU (1) AU752407B2 (ru)
BG (1) BG104726A (ru)
BR (1) BR9907655A (ru)
CA (1) CA2320388C (ru)
DE (1) DE69932920T2 (ru)
DZ (1) DZ2717A1 (ru)
EA (1) EA003137B1 (ru)
ES (1) ES2268847T3 (ru)
GT (1) GT199900011A (ru)
HK (1) HK1034969A1 (ru)
HR (1) HRP20000529B1 (ru)
HU (1) HUP0100832A3 (ru)
IL (1) IL137330A0 (ru)
IS (1) IS5562A (ru)
MA (1) MA26603A1 (ru)
MY (1) MY133125A (ru)
NO (1) NO20003965D0 (ru)
NZ (1) NZ505724A (ru)
OA (1) OA11448A (ru)
PA (1) PA8467301A1 (ru)
PE (1) PE20000243A1 (ru)
PL (1) PL342817A1 (ru)
SK (1) SK11262000A3 (ru)
TN (1) TNSN99013A1 (ru)
TR (1) TR200002248T2 (ru)
TW (1) TW470744B (ru)
UA (1) UA57824C2 (ru)
WO (1) WO1999040061A2 (ru)
YU (1) YU47100A (ru)
ZA (1) ZA99873B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2862300A (en) * 1999-01-29 2000-08-18 Millennium Pharmaceuticals, Inc. Methods for preventing graft rejection and ischemia-reperfusion injury
WO2001014339A2 (en) * 1999-08-20 2001-03-01 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives
NZ520075A (en) * 2000-02-04 2004-02-27 Pfizer Prod Inc Heterocyclic amide derivatives
US6740636B2 (en) * 2000-07-31 2004-05-25 Schering Aktiengesellschaft Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
US6746856B2 (en) 2000-08-09 2004-06-08 Pfizer Inc. Microbial conversion of bicyclic heteroaromatic compounds
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
MXPA03010165A (es) 2001-06-22 2004-03-10 Pfizer Prod Inc Composiciones farmaceuticas de adsorbatos de farmaco amorfo.
JP2004534812A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク 薬物および中性ポリマーの分散物の医薬組成物
DE10152351B4 (de) * 2001-10-18 2005-09-22 Schering Ag Feste Arzneimittelformulierung für ein Piperazinharnstoffderivat
CA2474838C (en) 2002-02-01 2009-01-06 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
WO2003095440A1 (en) * 2002-05-14 2003-11-20 Pfizer Products Inc. Dihydroxyhexanoic acid derivatives, their intermediates, and methods of making
BR0309932A (pt) * 2002-05-14 2005-02-09 Pfizer Prod Inc Métodos para a fabricação de derivados de diidro-furan-2-ona
DE60329188D1 (de) 2002-08-12 2009-10-22 Bend Res Inc Arzneizubereitungen bestehend aus arzneimitteln in halb-geordneter form und polymeren
WO2004014875A1 (en) * 2002-08-12 2004-02-19 Pfizer Products Inc. Crystal forms of quinoxaline-2-carboxylic acid [4-carbamoyl-1-(3-fluorobenzyl)-2,7-dihydroxy-7-methyl-octyl]-amide
US20040097554A1 (en) * 2002-10-30 2004-05-20 Pfizer Inc Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
US20040087571A1 (en) * 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
ATE540671T1 (de) 2003-08-04 2012-01-15 Bend Res Inc Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923864A (en) * 1987-12-15 1990-05-08 Pfizer Inc. Certain heterocyclic-hexanamides useful for treating hypertension
EP0708085B1 (en) * 1994-10-19 2002-07-17 Novartis AG Antiviral ethers of aspartate protease substrate isosteres
DE19708106A1 (de) * 1997-02-28 1998-09-03 Bosch Gmbh Robert Einrichtung und Verfahren zur Information über Verkehrsstörungen

Also Published As

Publication number Publication date
HUP0100832A3 (en) 2002-03-28
IS5562A (is) 2000-07-14
AU752407B2 (en) 2002-09-19
MY133125A (en) 2007-10-31
CA2320388A1 (en) 1999-08-12
EP1051405B1 (en) 2006-08-23
DE69932920T2 (de) 2007-02-08
DZ2717A1 (fr) 2003-09-01
KR100385529B1 (ko) 2003-05-27
DE69932920D1 (de) 2006-10-05
JP2002502839A (ja) 2002-01-29
YU47100A (sh) 2002-11-15
BG104726A (en) 2001-04-30
TW470744B (en) 2002-01-01
ATE337307T1 (de) 2006-09-15
TNSN99013A1 (fr) 2005-11-10
CA2320388C (en) 2005-05-03
CN1177834C (zh) 2004-12-01
NO20003965D0 (no) 2000-08-04
EA003137B1 (ru) 2003-02-27
PA8467301A1 (es) 2000-05-24
HK1034969A1 (en) 2001-11-09
AU1778999A (en) 1999-08-23
ZA99873B (en) 2000-08-04
AP9901457A0 (en) 1999-03-31
WO1999040061A2 (en) 1999-08-12
TR200002248T2 (tr) 2000-12-21
MA26603A1 (fr) 2004-12-20
NO20003965L (ru) 2000-10-03
CN1290255A (zh) 2001-04-04
UA57824C2 (ru) 2003-07-15
ES2268847T3 (es) 2007-03-16
WO1999040061A3 (en) 1999-10-21
HRP20000529A2 (en) 2001-08-31
OA11448A (en) 2003-11-18
KR20010040684A (ko) 2001-05-15
HRP20000529B1 (en) 2004-12-31
IL137330A0 (en) 2001-07-24
SK11262000A3 (sk) 2001-01-18
HUP0100832A2 (hu) 2002-02-28
AP992A (en) 2001-08-06
JP3693916B2 (ja) 2005-09-14
BR9907655A (pt) 2000-10-24
AR016175A1 (es) 2001-06-20
PE20000243A1 (es) 2000-04-07
PL342817A1 (en) 2001-07-02
EP1051405A2 (en) 2000-11-15
NZ505724A (en) 2003-02-28
GT199900011A (es) 2000-07-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU