EA199900928A1 - Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты - Google Patents
Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простатыInfo
- Publication number
- EA199900928A1 EA199900928A1 EA199900928A EA199900928A EA199900928A1 EA 199900928 A1 EA199900928 A1 EA 199900928A1 EA 199900928 A EA199900928 A EA 199900928A EA 199900928 A EA199900928 A EA 199900928A EA 199900928 A1 EA199900928 A1 EA 199900928A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- piperazines
- hyperplasia
- prostat
- beneficial
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Данное изобретение относится к ряду арилзамещенных пиперазинов формулы (I), к фармацевтическим композициям, содержащим их, и к промежуточным соединениям, использующимся в их производстве. Соединения данного изобретения селективно ингибируют связывание с α-1адренергическим рецептором, рецептором, который участвует в развитии доброкачественной гиперплазии простаты. Как таковые эти соединения являются потенциально полезными при лечении этого и других заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4623697P | 1997-05-12 | 1997-05-12 | |
PCT/US1998/009023 WO1998051298A1 (en) | 1997-05-12 | 1998-05-08 | Arylsubstituted piperazines useful in the treatement of benign prostatic hyperlasia |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900928A1 true EA199900928A1 (ru) | 2000-08-28 |
EA001904B1 EA001904B1 (ru) | 2001-10-22 |
Family
ID=21942353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900928A EA001904B1 (ru) | 1997-05-12 | 1998-05-08 | Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты |
Country Status (28)
Country | Link |
---|---|
US (4) | US6071915A (ru) |
EP (1) | EP0984777B1 (ru) |
JP (1) | JP4189867B2 (ru) |
KR (1) | KR100440755B1 (ru) |
CN (3) | CN1515556A (ru) |
AP (1) | AP1349A (ru) |
AR (1) | AR012686A1 (ru) |
AT (1) | ATE250033T1 (ru) |
AU (1) | AU7366998A (ru) |
BR (1) | BR9809804A (ru) |
CA (1) | CA2289987C (ru) |
CZ (1) | CZ298217B6 (ru) |
DE (1) | DE69818255T2 (ru) |
DK (1) | DK0984777T3 (ru) |
EA (1) | EA001904B1 (ru) |
ES (1) | ES2206928T3 (ru) |
HK (1) | HK1024630A1 (ru) |
HU (1) | HUP0100048A3 (ru) |
IL (1) | IL132836A0 (ru) |
MY (2) | MY127385A (ru) |
NO (1) | NO314144B1 (ru) |
NZ (1) | NZ500992A (ru) |
PL (1) | PL192596B1 (ru) |
PT (1) | PT984777E (ru) |
TR (1) | TR199902971T2 (ru) |
TW (1) | TW512146B (ru) |
WO (1) | WO1998051298A1 (ru) |
ZA (1) | ZA983968B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2768055A1 (fr) * | 1997-09-11 | 1999-03-12 | Synthelabo | Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie |
TW536538B (en) | 1998-02-20 | 2003-06-11 | Ortho Mcneil Pharm Inc | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
ZA991319B (en) * | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
EP1346983A3 (en) * | 1998-02-20 | 2003-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia |
WO2002022582A2 (en) * | 2000-09-14 | 2002-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | Solid salt forms of n-[2-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]ethyl]-2-oxo-1-piperidineacetamide |
MXPA03004850A (es) | 2000-11-30 | 2004-01-26 | Ranbaxy Lab Ltd | Derivados de piperazina 1,4-disustituida utiles como bloqueadores de alfa1 adrenoceptores uro-selectivos. |
WO2005118537A2 (en) * | 2004-05-31 | 2005-12-15 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives as adrenergic receptor antagonists |
WO2006092710A1 (en) * | 2005-03-02 | 2006-09-08 | Ranbaxy Laboratories Limited | Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione |
WO2007029156A2 (en) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Isoindoledione derivatives as adrenergic receptor antagonists |
CN102391169B (zh) * | 2011-10-17 | 2015-10-28 | 上海化学试剂研究所 | N-(5-甲氧基-3-吲哚乙基)-4-取代苯基哌嗪-1-乙酰胺的制备方法 |
CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性***增生中的应用 |
CN103980195A (zh) * | 2014-04-28 | 2014-08-13 | 广州医科大学 | 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性***增生症药物中的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069336A (en) * | 1976-02-25 | 1978-01-17 | Chemisches Laboratorium Fritz-Walter Lange Gmbh & Co Kg | (2-oxo-pyrrolidines)-acetic hydrazides |
JPS5955878A (ja) | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
AU1475583A (en) * | 1983-04-27 | 1984-11-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted picolinic acids, processes for their preparation,their use and medicaments containing them |
JPS62135464A (ja) * | 1985-12-10 | 1987-06-18 | Nippon Kayaku Co Ltd | フエニルピペラジン誘導体 |
GB8703749D0 (en) | 1987-02-18 | 1987-03-25 | Sandoz Ltd | Piperazinecarboxylic acid |
US5254552A (en) * | 1988-05-24 | 1993-10-19 | American Home Products Corporation | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
EP0558245A1 (en) * | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors |
FR2692894B1 (fr) * | 1992-06-24 | 1994-10-14 | Irceba | Aryl-1-(o-alcoxy-phényl-4-pipérazinyl-1)-2, 3- ou 4-alcanols, leur procédé de préparation et leur utilisation pour la préparation de médicaments. |
US5403847A (en) * | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
US5807856A (en) * | 1995-11-15 | 1998-09-15 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonist |
EP0881235A1 (fr) * | 1997-05-26 | 1998-12-02 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles |
TW536538B (en) * | 1998-02-20 | 2003-06-11 | Ortho Mcneil Pharm Inc | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
US6218396B1 (en) * | 1998-02-20 | 2001-04-17 | Orth-Mcneil Pharmaceutical, Inc. | Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia |
US6063785A (en) * | 1999-02-17 | 2000-05-16 | Ortho-Mcneil Pharmaceutical Inc. | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
-
1998
- 1998-05-08 PT PT98920950T patent/PT984777E/pt unknown
- 1998-05-08 EP EP98920950A patent/EP0984777B1/en not_active Expired - Lifetime
- 1998-05-08 KR KR10-1999-7010460A patent/KR100440755B1/ko not_active IP Right Cessation
- 1998-05-08 CN CNA031070485A patent/CN1515556A/zh active Pending
- 1998-05-08 AU AU73669/98A patent/AU7366998A/en not_active Abandoned
- 1998-05-08 HU HU0100048A patent/HUP0100048A3/hu unknown
- 1998-05-08 DE DE69818255T patent/DE69818255T2/de not_active Expired - Fee Related
- 1998-05-08 IL IL13283698A patent/IL132836A0/xx not_active IP Right Cessation
- 1998-05-08 AP APAP/P/1999/001684A patent/AP1349A/en active
- 1998-05-08 CZ CZ0399799A patent/CZ298217B6/cs not_active IP Right Cessation
- 1998-05-08 CA CA002289987A patent/CA2289987C/en not_active Expired - Fee Related
- 1998-05-08 PL PL342518A patent/PL192596B1/pl not_active IP Right Cessation
- 1998-05-08 NZ NZ500992A patent/NZ500992A/xx unknown
- 1998-05-08 WO PCT/US1998/009023 patent/WO1998051298A1/en active IP Right Grant
- 1998-05-08 BR BR9809804-7A patent/BR9809804A/pt active Search and Examination
- 1998-05-08 ES ES98920950T patent/ES2206928T3/es not_active Expired - Lifetime
- 1998-05-08 CN CNB988049112A patent/CN1149081C/zh not_active Expired - Fee Related
- 1998-05-08 EA EA199900928A patent/EA001904B1/ru not_active IP Right Cessation
- 1998-05-08 DK DK98920950T patent/DK0984777T3/da active
- 1998-05-08 TR TR1999/02971T patent/TR199902971T2/xx unknown
- 1998-05-08 US US09/074,789 patent/US6071915A/en not_active Expired - Lifetime
- 1998-05-08 AT AT98920950T patent/ATE250033T1/de not_active IP Right Cessation
- 1998-05-08 JP JP54927698A patent/JP4189867B2/ja not_active Expired - Fee Related
- 1998-05-08 CN CNB2003101029013A patent/CN1269807C/zh not_active Expired - Fee Related
- 1998-05-09 MY MYPI20041438A patent/MY127385A/en unknown
- 1998-05-09 MY MYPI98002108A patent/MY122095A/en unknown
- 1998-05-11 ZA ZA9803968A patent/ZA983968B/xx unknown
- 1998-05-11 AR ARP980102181A patent/AR012686A1/es active IP Right Grant
- 1998-08-12 TW TW087107253A patent/TW512146B/zh not_active IP Right Cessation
-
1999
- 1999-11-11 NO NO19995518A patent/NO314144B1/no not_active IP Right Cessation
-
2000
- 2000-03-15 US US09/526,224 patent/US6890921B1/en not_active Expired - Lifetime
- 2000-06-12 US US09/591,814 patent/US6593474B1/en not_active Expired - Lifetime
- 2000-06-29 HK HK00103972A patent/HK1024630A1/xx not_active IP Right Cessation
-
2003
- 2003-06-02 US US10/452,255 patent/US20030220493A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200100139A1 (ru) | Фармацевтические композиции, содержащие 2-хинолоны | |
EA200100203A1 (ru) | Производные 4,4-биарилпиперидина с активностью в отношении опиоидных рецепторов | |
IL135536A0 (en) | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same | |
EA199900928A1 (ru) | Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты | |
EA199900937A1 (ru) | Фармацевтические композиции, содержащие вориконазол | |
TR199900920T2 (xx) | Nafthiridin t�revleri. | |
EA200200262A1 (ru) | Пиперазиновые производные и их применение в качестве противовоспалительных агентов | |
EA200400815A1 (ru) | Контролируемый синтез зипразидона и его композиции | |
EA200200253A1 (ru) | Ингибиторы клеточной адгезии | |
DE602004001857D1 (de) | Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen | |
TR199901765T2 (xx) | S�lfomid-metalloproteaz inhibit�rleri | |
EA200100516A1 (ru) | Производные 3,3-биарилпиперидина и 2,2-биарилморфолина | |
PT1273572E (pt) | Piperazinas substituidas com tiofeno uteis no tratamento da hiperplasia prostatica benigna | |
EA200101234A1 (ru) | Новые производные аминотиазола, их получение и содержащие их фармацевтические композиции | |
TR200002932T2 (tr) | Azabisayklik 5HT1 Alıcı liganolları | |
AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
NO970340L (no) | Organiske forbindelser | |
PL328225A1 (en) | Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors | |
EA200100140A1 (ru) | Терапевтическая композиция на основе флавоноидов для применения в лечении опухолей цитотоксическими агентами | |
TR200504091T2 (tr) | (7alfa,17alfa)-17-hidroksi-7-metil-19-nor-17-pregn-5(10)-en 20-in-3-on içeren yüksek saflıkta bileşim. | |
EA200100141A1 (ru) | Терапевтическая композиция на основе изофлавоноидов для применения в лечении опухолей цитотоксическими агентами | |
HUP0100781A2 (hu) | A jóindulatú prosztata hiperplázia kezelésére alkalmas szubsztituált piridino aril piperazin-származékok és a vegyületeket tartalmazó gyógyszerkészítmények | |
EA200000522A1 (ru) | 5-htагонисты | |
EA200300400A1 (ru) | 17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ | |
EA200100152A1 (ru) | Замещенные пиперазиноны и их терапевтическое применение |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
NF4A | Restoration of lapsed right to a eurasian patent |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): KZ RU |