EA199900927A1 - Трициклические соединения - Google Patents

Трициклические соединения

Info

Publication number
EA199900927A1
EA199900927A1 EA199900927A EA199900927A EA199900927A1 EA 199900927 A1 EA199900927 A1 EA 199900927A1 EA 199900927 A EA199900927 A EA 199900927A EA 199900927 A EA199900927 A EA 199900927A EA 199900927 A1 EA199900927 A1 EA 199900927A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
unsubstituted
alkyl
hydrogen
soch
Prior art date
Application number
EA199900927A
Other languages
English (en)
Other versions
EA002322B1 (ru
Inventor
Макото Ёшида
Такаши Сейши
Шигеру Аоно
Харуки Такаи
Коджи Сузуки
Тсуёши Ямагата
Каору Атсуки
Акира Карасава
Тошиаки Кумазава
Original Assignee
Киова Хакко Когио Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киова Хакко Когио Ко., Лтд. filed Critical Киова Хакко Когио Ко., Лтд.
Publication of EA199900927A1 publication Critical patent/EA199900927A1/ru
Publication of EA002322B1 publication Critical patent/EA002322B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Led Devices (AREA)
  • Surgical Instruments (AREA)
  • Eye Examination Apparatus (AREA)
  • Indole Compounds (AREA)

Abstract

В заявке описаны трициклические соединения для применения при лечении поллакиурии и недержания мочи общей формулы (I)[где Rозначает водород, замещенный или незамещенный (низш.)алкил и др., X-X-Xозначает CR=CR-CR=CR(где R, R, Rи R, которые могут быть одинаковыми или различными, каждый означает водород, замещенный или незамещенный (низш.)алкил, гидрокси, замещенный или незамещенный (низш-)алкокси и др.), N(O)=CR-CR=CR(где R, Rи Rимеют значения, указанные выше, a m означает 0 или 1), S-CR=CR(где Rи Rимеют значения, указанные выше) и др., и, если Rозначает водород, замещенный или незамещенный (низш.)алкил, замещенный или незамещенный (низш.)алкокси, замещенную или незамещенную азотсодержащую гетероциклическую группу(где n означает 0 или 1, Rи R, которые могут быть одинаковыми или различными, каждый означает водород, замещенный или незамещенный (низш.)алкил, трифторметил и др., или Rи Rвместе образуют циклический алкил, a Q означает гидрокси, галоген и др.) и др., то Y означает -CHSO-, -SCH-, -SOCH-, -SOCH- и др.] и фармацевтически приемлемые соли указанных соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900927A 1997-04-15 1998-04-15 Трициклические соединения EA002322B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9723397 1997-04-15
PCT/JP1998/001713 WO1998046587A1 (fr) 1997-04-15 1998-04-15 Composes tricycliques

Publications (2)

Publication Number Publication Date
EA199900927A1 true EA199900927A1 (ru) 2000-08-28
EA002322B1 EA002322B1 (ru) 2002-04-25

Family

ID=14186913

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900927A EA002322B1 (ru) 1997-04-15 1998-04-15 Трициклические соединения

Country Status (19)

Country Link
US (1) US6211227B1 (ru)
EP (1) EP0979821B1 (ru)
JP (1) JP3283267B2 (ru)
KR (1) KR100447674B1 (ru)
CN (1) CN1260220C (ru)
AT (1) ATE339409T1 (ru)
AU (1) AU738757B2 (ru)
BR (1) BR9808552A (ru)
CA (1) CA2286723C (ru)
CY (1) CY1105821T1 (ru)
DE (1) DE69835877T2 (ru)
DK (1) DK0979821T3 (ru)
EA (1) EA002322B1 (ru)
ES (1) ES2273413T3 (ru)
HK (1) HK1025572A1 (ru)
HU (1) HUP0002461A3 (ru)
NO (1) NO994960L (ru)
PT (1) PT979821E (ru)
WO (1) WO1998046587A1 (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6329385B1 (en) 1998-01-21 2001-12-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1999037619A1 (en) 1998-01-21 1999-07-29 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
PL352840A1 (en) * 1999-06-03 2003-09-08 Nippon Suisan Kaisha, Ltd. Tricyclic fused heterocycle compounds, process for preparing the same and use thereof
MXPA03008815A (es) * 2001-03-30 2004-02-17 Kyowa Hakko Kogyo Kk Agente terapeutico para sintomas irritantes de vejiga asociados con hiperplasia prostatica benigna.
WO2002078523A2 (en) * 2001-03-30 2002-10-10 Kyowa Hakko Kogyo Co., Ltd. Agent for the treatment of overactive bladder
CA2442463A1 (en) 2001-03-30 2002-10-10 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for overactive bladder
EA007069B1 (ru) * 2001-03-30 2006-06-30 Киова Хакко Когио Ко., Лтд. Терапевтическое средство по поводу повышенной чувствительности мочевого пузыря
EP1372639A4 (en) * 2001-03-30 2006-03-15 Kyowa Hakko Kogyo Kk TREATMENT AGENT FOR BLADDER IRRITATION SYMPTOMS ACCOMPANIED WITH BENIGN PROSTATIC HYPERPLASIA
EP1444980A1 (en) * 2001-11-13 2004-08-11 Kyowa Hakko Kogyo Co., Ltd. Preventive or remedy for pruritus
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US20040132803A1 (en) * 2002-03-29 2004-07-08 Tsuyoshi Yamagata Agent for the treatment of overactive bladder
US20060205756A1 (en) * 2003-03-31 2006-09-14 Kyowa Hakko Kogyo Co., Ltd. Antitussives
AR044870A1 (es) * 2003-06-27 2005-10-05 Kyowa Hakko Kogyo Kk Compuesto azufrado triciclico y su uso como agente terapeutico para la vejiga hiperactiva
JPWO2005007191A1 (ja) * 2003-07-16 2006-08-31 協和醗酵工業株式会社 医薬組成物
WO2005007155A1 (ja) * 2003-07-16 2005-01-27 Kyowa Hakko Kogyo Co., Ltd. 医薬組成物
WO2005007154A1 (ja) * 2003-07-16 2005-01-27 Kyowa Hakko Kogyo Co., Ltd. 疼痛の予防及び／または治療剤
WO2005011674A1 (ja) * 2003-08-05 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. 気管支喘息の予防及び／または治療剤
TW200522943A (en) * 2003-12-11 2005-07-16 Kyowa Hakko Kogyo Kk Fine crystallites and a pharmaceutical composition comprising them
JPWO2006013965A1 (ja) * 2004-08-06 2008-05-01 協和醗酵工業株式会社 三環系スルホンの製造法
TW200827367A (en) 2006-10-26 2008-07-01 Kyowa Hakko Kogyo Kk A therapeutic agent for irritable bowel syndrome
WO2009131200A1 (ja) * 2008-04-25 2009-10-29 協和発酵キリン株式会社 過敏性腸症候群治療剤
WO2009131201A1 (ja) * 2008-04-25 2009-10-29 協和発酵キリン株式会社 間欠性跛行症治療剤
EP2206534A1 (de) * 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
EP2325040B1 (en) 2009-11-23 2018-01-03 Faurecia Automotive Seating, Inc. Controllable comfort shell for vehicle seat
CN107233682B (zh) * 2017-07-04 2019-08-06 李烨 以压缩空气为动力的发射装置
CN110357850A (zh) * 2018-03-26 2019-10-22 广东东阳光药业有限公司 一种含硫杂环化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI258574A (ru) 1973-09-13 1975-03-14 Sandoz Ag
SE8500273D0 (sv) * 1985-01-22 1985-01-22 Leo Ab Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
US4645748A (en) 1985-02-01 1987-02-24 Charles Hurwitz Protein which is characteristic of rheumatoid arthritis
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
GB9214120D0 (en) 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
ES2159047T3 (es) 1995-10-16 2001-09-16 Kyowa Hakko Kogyo Kk Compuestos triciclicos.

Also Published As

Publication number Publication date
DK0979821T3 (da) 2007-01-29
KR20010006390A (ko) 2001-01-26
ATE339409T1 (de) 2006-10-15
HK1025572A1 (en) 2000-11-17
HUP0002461A2 (hu) 2001-06-28
AU738757B2 (en) 2001-09-27
KR100447674B1 (ko) 2004-09-08
CY1105821T1 (el) 2011-02-02
EP0979821A4 (en) 2002-04-24
NO994960D0 (no) 1999-10-12
CN1260220C (zh) 2006-06-21
EP0979821A1 (en) 2000-02-16
PT979821E (pt) 2007-01-31
CA2286723C (en) 2007-01-30
CN1255129A (zh) 2000-05-31
EA002322B1 (ru) 2002-04-25
AU6851598A (en) 1998-11-11
EP0979821B1 (en) 2006-09-13
DE69835877T2 (de) 2007-05-16
HUP0002461A3 (en) 2003-01-28
JP3283267B2 (ja) 2002-05-20
ES2273413T3 (es) 2007-05-01
US6211227B1 (en) 2001-04-03
NO994960L (no) 1999-12-09
DE69835877D1 (de) 2006-10-26
WO1998046587A1 (fr) 1998-10-22
BR9808552A (pt) 2000-05-23
CA2286723A1 (en) 1998-10-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU