EA199900663A1 - Новые белки, связывающиеся с рецептором 1 интерферона, кодирующая их днк и способы модуляции клеточного ответа на интерфероны - Google Patents

Новые белки, связывающиеся с рецептором 1 интерферона, кодирующая их днк и способы модуляции клеточного ответа на интерфероны

Info

Publication number
EA199900663A1
EA199900663A1 EA199900663A EA199900663A EA199900663A1 EA 199900663 A1 EA199900663 A1 EA 199900663A1 EA 199900663 A EA199900663 A EA 199900663A EA 199900663 A EA199900663 A EA 199900663A EA 199900663 A1 EA199900663 A1 EA 199900663A1
Authority
EA
Eurasian Patent Office
Prior art keywords
interferon
cellular response
dna
encoding
receptor
Prior art date
Application number
EA199900663A
Other languages
English (en)
Other versions
EA003250B1 (ru
Inventor
Мишель Ревель
Каролина Абрамович
Джудит Е. Чебат
Original Assignee
Йеда Рисерч Энд Дивелопмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Йеда Рисерч Энд Дивелопмент Ко., Лтд. filed Critical Йеда Рисерч Энд Дивелопмент Ко., Лтд.
Publication of EA199900663A1 publication Critical patent/EA199900663A1/ru
Publication of EA003250B1 publication Critical patent/EA003250B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Abstract

Были выделены новые белки IR1B1 и IR1B4, которые связываются с рецептором интерферона типа I IFNAR1 и участвуют в клеточном ответе на интерфероны. ДНК, кодирующую такие белки в смысловой или антисмысловой ориентации, можно вводить для усиления или ингибирования клеточного ответа на интерфероны. Антитела к указанным белкам можно использовать для выделения нового белка или иммунологического анализа.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900663A 1997-01-15 1998-01-15 Новые белки, связывающиеся с рецептором 1 интерферона, кодирующая их днк и способы модуляции клеточного ответа на интерфероны EA003250B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3563697P 1997-01-15 1997-01-15
PCT/US1998/000671 WO1998031796A1 (en) 1997-01-15 1998-01-15 Novel ifn receptor 1 binding proteins, dna encoding them, and methods of modulating cellular response to interferons

Publications (2)

Publication Number Publication Date
EA199900663A1 true EA199900663A1 (ru) 2000-02-28
EA003250B1 EA003250B1 (ru) 2003-02-27

Family

ID=21883894

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900663A EA003250B1 (ru) 1997-01-15 1998-01-15 Новые белки, связывающиеся с рецептором 1 интерферона, кодирующая их днк и способы модуляции клеточного ответа на интерфероны

Country Status (20)

Country Link
US (1) US7264945B2 (ru)
EP (1) EP1019500B1 (ru)
JP (1) JP4614473B2 (ru)
KR (2) KR100799828B1 (ru)
CN (1) CN1212398C (ru)
AT (1) ATE342972T1 (ru)
AU (1) AU731206C (ru)
BG (1) BG64829B1 (ru)
BR (1) BR9806755A (ru)
CA (1) CA2276111A1 (ru)
CZ (1) CZ299096B6 (ru)
DE (1) DE69836226T2 (ru)
DK (1) DK1019500T3 (ru)
EA (1) EA003250B1 (ru)
EE (1) EE04819B1 (ru)
ES (1) ES2275297T3 (ru)
IL (2) IL130960A0 (ru)
NO (1) NO326104B1 (ru)
UA (1) UA75560C2 (ru)
WO (1) WO1998031796A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119129A1 (en) * 1997-01-15 2002-08-29 Yeda Research And Development Co. Ltd. Novel IFN receptor 1 binding proteins, DNA encoding them, and methods of modulating cellular response to interferons
EP1459754A4 (en) * 2001-12-27 2005-08-31 Takeda Pharmaceutical MEANS FOR THE PREVENTION / TREATMENT OF CANCER

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4220759A1 (de) * 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenzen für Oligosaccharid-Transporter, Plasmide, Bakterien und Pflanzen enthaltend einen Transporter sowie Verfahren zur Herstellung und Transformation von Hefestämmen zur Identifikation des Transporteers
IL107378A (en) * 1993-10-24 2005-05-17 Yeda Res & Dev SOLUBLE INTERFERON alpha-RECEPTOR, ITS PREPARATION AND USE
US6242587B1 (en) * 1996-10-02 2001-06-05 The University Of North Carolina At Chapel Hill DNA molecules encoding a calcium-integrin binding protein

Also Published As

Publication number Publication date
KR100799828B1 (ko) 2008-01-31
EE04819B1 (et) 2007-04-16
DE69836226T2 (de) 2007-02-01
EP1019500A4 (en) 2004-04-07
AU5824098A (en) 1998-08-07
AU731206B2 (en) 2001-03-29
KR20000070181A (ko) 2000-11-25
ATE342972T1 (de) 2006-11-15
NO326104B1 (no) 2008-09-22
EP1019500B1 (en) 2006-10-18
CA2276111A1 (en) 1998-07-23
KR20050046779A (ko) 2005-05-18
AU731206C (en) 2002-05-16
EP1019500A2 (en) 2000-07-19
CZ247199A3 (cs) 2000-01-12
ES2275297T3 (es) 2007-06-01
CZ299096B6 (cs) 2008-04-23
NO993412D0 (no) 1999-07-09
EA003250B1 (ru) 2003-02-27
IL130960A (en) 2008-03-20
US20030176678A1 (en) 2003-09-18
BG103627A (en) 2000-04-28
BG64829B1 (bg) 2006-05-31
DK1019500T3 (da) 2007-02-19
JP4614473B2 (ja) 2011-01-19
BR9806755A (pt) 2000-03-14
IL130960A0 (en) 2001-01-28
KR100591988B1 (ko) 2006-06-21
US7264945B2 (en) 2007-09-04
CN1243544A (zh) 2000-02-02
EE9900272A (et) 2000-02-15
NO993412L (no) 1999-07-09
DE69836226D1 (de) 2006-11-30
UA75560C2 (en) 2006-05-15
WO1998031796A8 (en) 1999-05-20
CN1212398C (zh) 2005-07-27
JP2001508306A (ja) 2001-06-26
WO1998031796A1 (en) 1998-07-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU