EA199800357A1 - Фармацевтические ангиостатические дипептидные композиции и способы их применения - Google Patents

Фармацевтические ангиостатические дипептидные композиции и способы их применения

Info

Publication number
EA199800357A1
EA199800357A1 EA199800357A EA199800357A EA199800357A1 EA 199800357 A1 EA199800357 A1 EA 199800357A1 EA 199800357 A EA199800357 A EA 199800357A EA 199800357 A EA199800357 A EA 199800357A EA 199800357 A1 EA199800357 A1 EA 199800357A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
pharmaceutical
methods
angiostatic
dipeptide
Prior art date
Application number
EA199800357A
Other languages
English (en)
Other versions
EA001146B1 (ru
Inventor
Лоуренс Р. Грин
Джон В. Блэсеки
Original Assignee
Цитрэн, Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Цитрэн, Лтд filed Critical Цитрэн, Лтд
Publication of EA199800357A1 publication Critical patent/EA199800357A1/ru
Publication of EA001146B1 publication Critical patent/EA001146B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Abstract

Предложены способы подавления неоваскуляризации путем введения субъекту фармацевтического препарата, содержащего R'-Glu-Trp-R".Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800357A 1995-10-03 1996-10-02 Способ лечения индивидуума, страдающего от заболевания, в патогенезе которого существенную роль играет неоваскуляризация EA001146B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53870195A 1995-10-03 1995-10-03
US08/614,764 US5902790A (en) 1995-10-03 1996-03-13 Pharmaceutical angiostatic dipeptide compositions and method of use thereof
PCT/US1996/015856 WO1997012625A1 (en) 1995-10-03 1996-10-02 Pharmaceutical angiostatic dipeptide compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
EA199800357A1 true EA199800357A1 (ru) 1998-10-29
EA001146B1 EA001146B1 (ru) 2000-10-30

Family

ID=27065900

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800357A EA001146B1 (ru) 1995-10-03 1996-10-02 Способ лечения индивидуума, страдающего от заболевания, в патогенезе которого существенную роль играет неоваскуляризация

Country Status (23)

Country Link
US (4) US5902790A (ru)
EP (1) EP0869808B1 (ru)
JP (2) JP3679129B2 (ru)
KR (1) KR100483779B1 (ru)
CN (1) CN1128636C (ru)
AT (1) ATE332702T1 (ru)
AU (1) AU714846B2 (ru)
BR (1) BR9610838A (ru)
CA (1) CA2233457C (ru)
CZ (1) CZ298345B6 (ru)
DE (1) DE69636343T2 (ru)
DK (1) DK0869808T3 (ru)
EA (1) EA001146B1 (ru)
ES (1) ES2268710T3 (ru)
HU (1) HUP9902105A3 (ru)
IL (1) IL123889A0 (ru)
MX (1) MX9802564A (ru)
NO (1) NO326298B1 (ru)
NZ (1) NZ319907A (ru)
PL (1) PL186123B1 (ru)
SK (1) SK283677B6 (ru)
TR (1) TR199800653T1 (ru)
WO (1) WO1997012625A1 (ru)

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US6060452A (en) * 1996-03-13 2000-05-09 Cytran, Inc. Analogs of L-Glu-L-Trp having pharmacological activity
AU3467099A (en) * 1998-04-03 1999-10-25 Cytran Ltd. Methods for production of therapeutic cytokines
BR0112969A (pt) 2000-08-04 2004-06-22 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composições contendo-as
DE10100052A1 (de) * 2001-01-02 2002-07-11 Inst Medizintechnologie Magdeb Kombinierte Verwendung von Enzyminhibitoren und pharmazeutischen Zubereitungen daraus zur Therapie und Prophylaxe der Atheriosklerose
US7229969B2 (en) * 2001-01-02 2007-06-12 Imtm Gmbh Combinations of enzyme inhibitors and the use thereof
US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
PL2537524T3 (pl) 2003-05-15 2017-01-31 Ampio Pharmaceuticals, Inc. Leczenie chorób mediowanych przez komórki T
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
CA2538864C (en) 2003-09-17 2013-05-07 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
CA2569204A1 (en) 2006-11-28 2008-05-28 Apotex Technologies Inc. Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan
CA2571645A1 (en) * 2006-12-19 2008-06-19 Apotex Technologies Inc. Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
AU2008216799A1 (en) * 2007-02-13 2008-08-21 Sciclone Pharmaceuticals, Inc. Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa
CA2579119C (en) * 2007-02-16 2013-03-05 Apotex Technologies Inc. Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan
US20110189305A1 (en) * 2007-08-23 2011-08-04 Tuthill Cynthia W Treatment of lung cancer
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
DE102008032828A1 (de) * 2008-07-02 2010-01-07 Technische Universität Dresden Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
JP2013537195A (ja) 2010-09-07 2013-09-30 ディエムアイ アクイジション コーポレイション 疾患の治療
ES2795803T3 (es) 2011-10-10 2020-11-24 Ampio Pharmaceuticals Inc Tratamiento de artropatía degenerativa
WO2013055749A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA201490737A1 (ru) 2011-10-28 2014-09-30 Ампио Фармасьютикалз, Инк. Лечение ринита
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
CN102631464B (zh) * 2012-05-18 2013-07-31 崔新明 一种治疗婴幼儿血管瘤的中药膏剂及其制备方法
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
US9956217B2 (en) 2014-08-18 2018-05-01 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
AU2018326835A1 (en) * 2017-08-31 2020-03-26 National University Of Singapore Angio-3 for treatment of retinal angiogenic diseases

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Also Published As

Publication number Publication date
EA001146B1 (ru) 2000-10-30
NO981436L (no) 1998-05-19
CN1198673A (zh) 1998-11-11
WO1997012625A1 (en) 1997-04-10
CA2233457C (en) 2004-08-03
US6096713A (en) 2000-08-01
SK42398A3 (en) 1998-10-07
US5902790A (en) 1999-05-11
CA2233457A1 (en) 1997-04-10
CN1128636C (zh) 2003-11-26
ATE332702T1 (de) 2006-08-15
ES2268710T3 (es) 2007-03-16
JP2005194287A (ja) 2005-07-21
SK283677B6 (sk) 2003-11-04
AU7254096A (en) 1997-04-28
DE69636343T2 (de) 2007-07-19
MX9802564A (es) 1998-11-30
US20060094665A1 (en) 2006-05-04
NO981436D0 (no) 1998-03-30
HUP9902105A2 (hu) 1999-09-28
AU714846B2 (en) 2000-01-13
US6911431B1 (en) 2005-06-28
NZ319907A (en) 2000-09-29
EP0869808A1 (en) 1998-10-14
KR100483779B1 (ko) 2007-03-02
KR19990063958A (ko) 1999-07-26
DK0869808T3 (da) 2006-11-13
NO326298B1 (no) 2008-11-03
HUP9902105A3 (en) 2001-02-28
EP0869808B1 (en) 2006-07-12
JP3679129B2 (ja) 2005-08-03
CZ298345B6 (cs) 2007-09-05
DE69636343D1 (de) 2006-08-24
PL186123B1 (pl) 2003-10-31
PL326149A1 (en) 1998-08-31
TR199800653T1 (xx) 1998-06-22
JPH11504943A (ja) 1999-05-11
BR9610838A (pt) 1999-12-21
CZ91398A3 (cs) 1998-11-11
IL123889A0 (en) 1998-10-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU