GR1000608B - Μεθοδος για την παρασκευη ανταγωνιστων bombesin. - Google Patents

Μεθοδος για την παρασκευη ανταγωνιστων bombesin.

Info

Publication number
GR1000608B
GR1000608B GR890100414A GR890100414A GR1000608B GR 1000608 B GR1000608 B GR 1000608B GR 890100414 A GR890100414 A GR 890100414A GR 890100414 A GR890100414 A GR 890100414A GR 1000608 B GR1000608 B GR 1000608B
Authority
GR
Greece
Prior art keywords
leu
gly
phe
ala
arg
Prior art date
Application number
GR890100414A
Other languages
English (en)
Other versions
GR890100414A (en
Inventor
Marina Ciomei
Fabio Corradi
Castiglione Roberto De
Mauro Galantino
Luigia Gozzini
Isabella Molinari
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888817379A external-priority patent/GB8817379D0/en
Priority claimed from GB898906900A external-priority patent/GB8906900D0/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of GR890100414A publication Critical patent/GR890100414A/el
Publication of GR1000608B publication Critical patent/GR1000608B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Παρέχεται μαι μέθοδος για την παρασκευή πεπτιδίων του τύπου A-B-C-D-GLN-TRP-ALA-VAL-X-Y-T-W (είτε A=H, Boc, AC ένα από Β και C= pMEL, mMEL το άλλο των Β και C είναι δεσμός σθένους, GLY, LEU-GLY, E- LEU-GLY,GLN-E-LEU-GLY, E, E-GLY με E=ARG (A), arg(A), LYS (A), lys (A), ORN (A), orn (A) ή A=H, B=GLP-ARG-LEU-GLY, C-pMEL ή mMEL και D= δεσμός σθένους, ASN, THR X= GLY, ala: Y= δεσμός σθένους HIS(R1), his(R1), PHE, phe, SER, ser, ALA, ala T= δεσμός σθένους, LEU, leu, PHE, Phe W= OH, NH2, NH(CH2)4CH3, NH(CH2)2C6H5, MET-R2, LEU-R2, ILE- R2,NLE-R2 R1= H, Tos, Dnp, BzI R2=NH2, OH, OCH3, NHNH2) και των φαρμακευτικά αποδεκτών αλατιών τους η οποία μέθοδος πραγματοποιείται με την μέθοδο κλασσικού διαλύματος. Τα πεπτίδια της παρούσας εφεύρεσης είναι ανταγωνιστές BOMBESIN. Περιγραφεται επίσης η παρασκευή των φαρμακευτικών συνθέσεων που τα περιέχουν. ω
GR890100414A 1988-07-21 1989-06-21 Μεθοδος για την παρασκευη ανταγωνιστων bombesin. GR1000608B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888817379A GB8817379D0 (en) 1988-07-21 1988-07-21 Irreversible peptide ligands for bombesin receptors
GB898906900A GB8906900D0 (en) 1989-03-28 1989-03-28 Irreversible peptide ligands for bombesin receptors

Publications (2)

Publication Number Publication Date
GR890100414A GR890100414A (en) 1990-06-27
GR1000608B true GR1000608B (el) 1992-08-31

Family

ID=26294185

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100414A GR1000608B (el) 1988-07-21 1989-06-21 Μεθοδος για την παρασκευη ανταγωνιστων bombesin.

Country Status (16)

Country Link
US (1) US5100873A (el)
EP (1) EP0380623B1 (el)
JP (1) JPH03500414A (el)
KR (1) KR900701829A (el)
AU (1) AU619573B2 (el)
CA (1) CA1331074C (el)
DE (1) DE68909584T2 (el)
DK (1) DK71990A (el)
ES (1) ES2017028A6 (el)
FI (1) FI901369A0 (el)
GR (1) GR1000608B (el)
HU (1) HU205771B (el)
IL (1) IL90997A0 (el)
NZ (1) NZ229957A (el)
PT (1) PT91215B (el)
WO (1) WO1990001037A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902790A (en) * 1995-10-03 1999-05-11 Cytran, Inc. Pharmaceutical angiostatic dipeptide compositions and method of use thereof
IE903958A1 (en) * 1989-11-06 1991-05-08 Erba Carlo Spa Reduced irreversible bombesin antagonists
US5767236A (en) * 1990-05-09 1998-06-16 Biomeasure, Inc. Linear therapeutic peptides
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
US5620959A (en) * 1990-07-31 1997-04-15 Glaxo Wellcome Inc. Bombesin antagonists
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
DK0585397T3 (da) * 1991-05-23 1997-08-25 Merrell Pharma Inc Bombesinanaloger
JPH07505865A (ja) * 1992-02-07 1995-06-29 メレルダウファーマスーティカルズ　インコーポレイテッド ボンベシンのフェニルアラニン類似体類
CN1777439A (zh) 2003-04-22 2006-05-24 研究及应用科学协会股份有限公司 生长抑素的载体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3792032A (en) * 1970-07-31 1974-02-12 Farmaceutical Soc Polypeptides related to the c-terminal heptapeptide of bombesin and alytesin
US4207311A (en) * 1977-07-18 1980-06-10 The Salk Institute For Biological Studies Peptides having analgesic and thermoregulative properties
IT1134503B (it) * 1980-11-28 1986-08-13 Proter Spa Composti della diclorodietilaminofenilalanina ad azione antitumorale
US4314999A (en) * 1978-07-31 1982-02-09 Proter S.P.A. N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
US4540683A (en) * 1978-07-31 1985-09-10 Proter S.P.A. In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound
US4331661A (en) * 1980-10-03 1982-05-25 The Salk Institute For Biological Studies Bombesin analogs

Also Published As

Publication number Publication date
WO1990001037A1 (en) 1990-02-08
PT91215A (pt) 1990-02-08
DE68909584D1 (de) 1993-11-04
GR890100414A (en) 1990-06-27
ES2017028A6 (es) 1990-12-16
DE68909584T2 (de) 1994-03-10
HUT54711A (en) 1991-03-28
US5100873A (en) 1992-03-31
EP0380623A1 (en) 1990-08-08
CA1331074C (en) 1994-07-26
JPH03500414A (ja) 1991-01-31
PT91215B (pt) 1995-03-01
NZ229957A (en) 1991-03-26
HU205771B (en) 1992-06-29
HU894456D0 (en) 1990-12-28
AU619573B2 (en) 1992-01-30
FI901369A0 (fi) 1990-03-19
AU3878889A (en) 1990-02-19
EP0380623B1 (en) 1993-09-29
KR900701829A (ko) 1990-12-04
DK71990A (da) 1990-05-21
DK71990D0 (da) 1990-03-20
IL90997A0 (en) 1990-02-09

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