DZ2514A1 - Dérivés substitués en c-4'de9-désoxo-9a-aza-9a-homoérythromycine a. - Google Patents

Dérivés substitués en c-4'de9-désoxo-9a-aza-9a-homoérythromycine a.

Info

Publication number
DZ2514A1
DZ2514A1 DZ980124A DZ980124A DZ2514A1 DZ 2514 A1 DZ2514 A1 DZ 2514A1 DZ 980124 A DZ980124 A DZ 980124A DZ 980124 A DZ980124 A DZ 980124A DZ 2514 A1 DZ2514 A1 DZ 2514A1
Authority
DZ
Algeria
Prior art keywords
homoerythromycin
deoxo
aza
substituted derivatives
derivatives
Prior art date
Application number
DZ980124A
Other languages
English (en)
Inventor
Brian Scott Bronk
Michael Anthony Letavic
Takushi Kaneko
Bingweivera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DZ2514(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DZ2514A1 publication Critical patent/DZ2514A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DZ980124A 1997-06-11 1998-06-10 Dérivés substitués en c-4'de9-désoxo-9a-aza-9a-homoérythromycine a. DZ2514A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
DZ2514A1 true DZ2514A1 (fr) 2003-02-01

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ980124A DZ2514A1 (fr) 1997-06-11 1998-06-10 Dérivés substitués en c-4'de9-désoxo-9a-aza-9a-homoérythromycine a.

Country Status (50)

Country Link
US (4) US6420536B1 (fr)
EP (1) EP0988310B9 (fr)
JP (2) JP3315704B2 (fr)
KR (1) KR100396168B1 (fr)
CN (4) CN1243766C (fr)
AP (1) AP1231A (fr)
AR (1) AR013086A1 (fr)
AT (1) ATE251173T1 (fr)
AU (1) AU749816B2 (fr)
BG (1) BG64391B1 (fr)
BR (1) BRPI9810519B8 (fr)
CA (1) CA2293823C (fr)
CO (1) CO4950611A1 (fr)
CZ (1) CZ298556B6 (fr)
DE (2) DE122004000018I2 (fr)
DK (1) DK0988310T3 (fr)
DZ (1) DZ2514A1 (fr)
EA (1) EA002441B1 (fr)
EG (1) EG24081A (fr)
ES (1) ES2205487T3 (fr)
FR (1) FR04C0013I2 (fr)
GT (1) GT199800077A (fr)
HK (3) HK1028048A1 (fr)
HN (1) HN1998000086A (fr)
HR (1) HRP980314B1 (fr)
HU (2) HU228005B1 (fr)
ID (1) ID22992A (fr)
IL (1) IL132809A0 (fr)
IS (1) IS1998B (fr)
LU (1) LU91076I9 (fr)
MA (1) MA24564A1 (fr)
ME (1) ME00876B (fr)
MY (1) MY123354A (fr)
NL (1) NL300150I2 (fr)
NO (1) NO316911B1 (fr)
NZ (2) NZ500660A (fr)
OA (1) OA11224A (fr)
PA (1) PA8452201A1 (fr)
PE (1) PE79699A1 (fr)
PL (1) PL191601B1 (fr)
PT (1) PT988310E (fr)
RS (1) RS49675B (fr)
SI (1) SI0988310T1 (fr)
SK (1) SK284171B6 (fr)
TN (1) TNSN98082A1 (fr)
TW (1) TW472060B (fr)
UA (1) UA67744C2 (fr)
UY (1) UY25040A1 (fr)
WO (1) WO1998056802A1 (fr)
ZA (1) ZA985017B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
EP1779853A3 (fr) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides en tant qu'agents anti-microbiens à usage vétérinaire
WO1999012552A1 (fr) * 1997-09-10 1999-03-18 Merck & Co., Inc. 9a-AZALIDES UTILISES COMME AGENTS ANTIMICROBIENS VETERINAIRES
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (fr) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-carbamates des macrolides antibactériens
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (fr) * 1999-01-28 2004-09-28 Pfizer Products Inc. Nouveaux azalides et procede de fabrication
DK1189912T3 (da) * 1999-05-18 2008-06-30 Pfizer Prod Inc Nye krystallinske former af et makrolid antibiotikum
CN1351608A (zh) * 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
BR0009101A (pt) * 1999-08-24 2002-02-05 Abbott Lab 9a-azalidas com atividade antibacteriana
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
DE60003586T2 (de) * 2000-01-27 2004-01-08 Pfizer Products Inc., Groton Antibiotische azalid-zusammensetzungen
BR0110382A (pt) * 2000-04-27 2003-06-24 Pfizer Prod Inc Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
MXPA03009786A (es) * 2001-04-27 2004-01-29 Pfizer Prod Inc Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos.
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
MXPA06005639A (es) * 2003-11-21 2006-08-17 Pfizer Prod Inc Adyuvante antimicrobiano.
CA2557801C (fr) * 2004-03-16 2013-06-25 Boehringer Ingelheim International Gmbh Derives du benzol substitues par un glucopyranosyle,, medicaments renfermant ces composes, leur utilisation et leur procede de production
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
CN101917850B (zh) * 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
ES2565083T3 (es) 2008-10-24 2016-03-31 Cempra Pharmaceuticals, Inc. Biodefensas usando macrólidos que contienen triazol
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2012038372A1 (fr) 2010-09-20 2012-03-29 Novartis Ag Nouveau procédé de préparation de 9-déoxo-9a-aza-9a-homoérythromycine a modifiée dans le c-4'' du cycle cladinose par un groupe époxyde
CA2814333A1 (fr) * 2010-10-10 2012-04-19 Synovo Gmbh Macrolides antiinflammatoires
WO2013004116A1 (fr) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 Dérivé de 9a-aza-9a-érythromycine c-3-substituée et 9-désoxydée
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (fr) 2011-07-27 2013-01-31 Farma Grs, D.O.O. Nouvelles formes cristallines de tulathromycine
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2015014907A1 (fr) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Procédé de préparation de tulathromycine
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (fr) 1991-04-04 1998-08-04 James V. Heck Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
US5226958A (en) * 1991-04-11 1993-07-13 Pacemark, Inc. Sealant for pneumatic inner tubes and tubeless tires
EP0549040A1 (fr) * 1991-12-20 1993-06-30 Merck & Co. Inc. Méthodes pour fabriquer 4" dérivés de 9-désoxo-8a-aza-8a-alkyl-8a-homoérythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
HK1088014A1 (en) 2006-10-27
CN1172947C (zh) 2004-10-27
SK168399A3 (en) 2000-11-07
HU228005B1 (en) 2012-08-28
GT199800077A (es) 1999-12-02
SI0988310T1 (en) 2004-02-29
PL191601B1 (pl) 2006-06-30
YU58699A (fr) 2002-08-12
NL300150I2 (nl) 2004-09-01
NZ514871A (en) 2003-08-29
US20040180842A1 (en) 2004-09-16
PE79699A1 (es) 1999-08-25
NO316911B1 (no) 2004-06-21
BRPI9810519B8 (pt) 2022-11-16
CZ442199A3 (cs) 2000-07-12
US6777393B2 (en) 2004-08-17
BRPI9810519B1 (pt) 2012-02-22
TW472060B (en) 2002-01-11
HUP0002209A2 (hu) 2000-12-28
AR013086A1 (es) 2000-12-13
FR04C0013I2 (fr) 2005-10-21
US20020061858A1 (en) 2002-05-23
KR20010013632A (ko) 2001-02-26
US6420536B1 (en) 2002-07-16
BG103945A (en) 2000-07-31
UY25040A1 (es) 2000-09-29
CN1793155A (zh) 2006-06-28
HUS1200028I1 (hu) 2016-08-29
BRPI9810519A (pt) 2000-09-19
DE69818665D1 (de) 2003-11-06
NZ500660A (en) 2002-03-01
LU91076I2 (fr) 2004-07-05
HRP980314B1 (en) 2004-04-30
HUP0002209A3 (en) 2003-05-28
CN1259136A (zh) 2000-07-05
EG24081A (en) 2008-05-11
CA2293823C (fr) 2004-02-17
ATE251173T1 (de) 2003-10-15
UA67744C2 (uk) 2004-07-15
IS5252A (is) 1999-11-16
HN1998000086A (es) 1999-03-08
ZA985017B (en) 1999-12-17
PL337505A1 (en) 2000-08-28
FR04C0013I1 (fr) 2004-06-11
DE122004000018I2 (de) 2011-01-13
CN1566129A (zh) 2005-01-19
DK0988310T3 (da) 2003-12-15
ID22992A (id) 1999-12-23
KR100396168B1 (ko) 2003-08-27
US6936592B2 (en) 2005-08-30
JP2002316933A (ja) 2002-10-31
IL132809A0 (en) 2001-03-19
IS1998B (is) 2005-03-15
DE122004000018I1 (de) 2004-09-30
AU749816B2 (en) 2002-07-04
CN1243766C (zh) 2006-03-01
CA2293823A1 (fr) 1998-12-17
AP1231A (en) 2003-12-11
EP0988310A1 (fr) 2000-03-29
EP0988310B1 (fr) 2003-10-01
PA8452201A1 (es) 2000-05-24
BG64391B1 (bg) 2004-12-30
US20040023896A1 (en) 2004-02-05
HRP980314A2 (en) 1999-04-30
WO1998056802A1 (fr) 1998-12-17
HK1068893A1 (en) 2005-07-29
EA199901015A1 (ru) 2000-06-26
CN1793155B (zh) 2010-05-12
AP9801255A0 (en) 1998-06-30
MY123354A (en) 2006-05-31
EA002441B1 (ru) 2002-04-25
JP3315704B2 (ja) 2002-08-19
AU7347598A (en) 1998-12-30
HK1028048A1 (en) 2001-02-02
PT988310E (pt) 2003-12-31
NO996106L (no) 2000-02-10
TNSN98082A1 (fr) 2005-03-15
CZ298556B6 (cs) 2007-11-07
MA24564A1 (fr) 1998-12-31
EP0988310B9 (fr) 2006-03-08
RS49675B (sr) 2007-11-15
CO4950611A1 (es) 2000-09-01
LU91076I9 (en) 2018-07-02
ES2205487T3 (es) 2004-05-01
OA11224A (en) 2003-07-16
NL300150I1 (nl) 2004-08-02
JP2000514098A (ja) 2000-10-24
ME00876B (me) 2012-06-20
NO996106D0 (no) 1999-12-10
DE69818665T2 (de) 2004-04-29
CN101691390A (zh) 2010-04-07
SK284171B6 (sk) 2004-10-05

Similar Documents

Publication Publication Date Title
DZ2514A1 (fr) Dérivés substitués en c-4'de9-désoxo-9a-aza-9a-homoérythromycine a.
CY2007024I1 (el) Kαινοφανη παραγωγα 3.3-διαφαινυλοπροπυλινων
DE69832486D1 (de) C-4"-substitutierte macrolid-derivate
DZ2569A1 (fr) Dérivés 1,2,3,4-tétrahydronaphtalène substitués.
FR2690919B1 (fr) Dérivés de l'indole.
FR07C0051I2 (fr) Dérivés de l' Erythropoietine
DZ2495A1 (fr) Formule nouvelle de l'oméprazole-s.
ID20053A (id) Hipolipidemat 1,4-benzotiazepin-1,1-dioksida
DK0966477T3 (da) 3'-N-oxid, 3'-N-dimethylamin, 9-oxim-erythromycin A-derivater
ATE340176T1 (de) Substituierte 6,5-heterobicyclische-derivate
ATE231847T1 (de) Substituierte 1,2,3,4- tetrahydronaphthalinderivate
PT921125E (pt) Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
TR199800988A3 (tr) 5' Deoksi-Sitidin türevleri.
IT1302243B1 (it) Sintesi dell'1,1,1,3,3-pentafluoropropano.
FR2713641B1 (fr) Dérivés de l'épi-épibatidine.
FR2716192B1 (fr) Dérivés de 2-imidazoline-5-ones fongicides.
DZ1985A1 (fr) Dérivés d'indole substitués.
ATE220674T1 (de) 12h-dibenzo(d,g)(1,3)dioxocin derivate
DZ2597A1 (fr) Dérivés d'urée.
ATE243218T1 (de) 2''-deoxyhygromycinderivate
PT796843E (pt) Derivados de 1,25-di-hidroxi-16,22,23-trisde-hidro-colecalciferol
ID16434A (id) Senyawa-senyawa 1,4-dihidropiridin
FR2721022B1 (fr) Dérivés de 5-imino 2-imidazolines fongicides.
BR1100301A (pt) Derivados de 3-azabiciclo (3.2.0) heptano n-substituìdos
BR1100649A (pt) Derivados de 10,11-metano dibenzo suberano