DK73080A - METHOD FOR MANUFACTURING MONACOLIN K. - Google Patents

METHOD FOR MANUFACTURING MONACOLIN K.

Info

Publication number
DK73080A
DK73080A DK73080A DK73080A DK73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A
Authority
DK
Denmark
Prior art keywords
monacolin
manufacturing
manufacturing monacolin
Prior art date
Application number
DK73080A
Other languages
Danish (da)
Other versions
DK149095C (en
DK149095B (en
Inventor
A Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK73080A publication Critical patent/DK73080A/en
Priority to DK47085A priority Critical patent/DK165990C/en
Publication of DK149095B publication Critical patent/DK149095B/en
Application granted granted Critical
Publication of DK149095C publication Critical patent/DK149095C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
DK73080A 1979-02-20 1980-02-20 PROCEDURE FOR PREPARING A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND called MONACOLIN K DK149095C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK47085A DK165990C (en) 1979-02-20 1985-02-01 PROCEDURE FOR PREPARING THE CARBOXYLIC ACID OF A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND CALLED MONACOLIN K OR SALTS THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (en) 1979-02-20 1979-02-20 New physiologically active substance monacolin K and its production method
JP1785679 1979-02-20

Publications (3)

Publication Number Publication Date
DK73080A true DK73080A (en) 1980-08-21
DK149095B DK149095B (en) 1986-01-20
DK149095C DK149095C (en) 1986-06-16

Family

ID=11955290

Family Applications (2)

Application Number Title Priority Date Filing Date
DK73080A DK149095C (en) 1979-02-20 1980-02-20 PROCEDURE FOR PREPARING A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND called MONACOLIN K
DK021889A DK21889D0 (en) 1979-02-20 1989-01-18 APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK021889A DK21889D0 (en) 1979-02-20 1989-01-18 APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA

Country Status (27)

Country Link
JP (1) JPS5925599B2 (en)
KR (1) KR830002801B1 (en)
AT (1) AT373915B (en)
AU (1) AU532626B2 (en)
BE (1) BE881825A (en)
CA (1) CA1129794A (en)
CH (1) CH645890A5 (en)
DD (1) DD154494A5 (en)
DE (2) DE3051175C2 (en)
DK (2) DK149095C (en)
ES (1) ES488796A0 (en)
FI (1) FI66427C (en)
FR (1) FR2449685B1 (en)
GB (1) GB2046737B (en)
HU (1) HU182069B (en)
IE (1) IE49743B1 (en)
IT (1) IT1175260B (en)
MX (1) MX6314E (en)
NL (1) NL191540C (en)
NO (1) NO153974C (en)
NZ (1) NZ192919A (en)
PH (1) PH15145A (en)
PL (1) PL124304B1 (en)
SE (1) SE453301B (en)
SG (1) SG6784G (en)
SU (2) SU1158048A3 (en)
ZA (1) ZA80962B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (en) * 1980-03-31 1994-11-16 三共株式会社 MB-530A derivative
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (en) * 1980-06-06 1987-04-10 Sankyo Co A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
JPS5835144A (en) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb-530b derivative and its preparation
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
JPH07504568A (en) * 1992-03-04 1995-05-25 藤沢薬品工業株式会社 Tetralin derivatives as HMG-CoA reductase inhibitors
ZA933359B (en) 1992-05-15 1993-12-08 Sankyo Co Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
UA73074C2 (en) 1998-03-20 2005-06-15 Method of controlled fermentation for production of lovastatin as hydroxy-acid
CZ20022779A3 (en) 2000-02-24 2003-02-12 Biogal Gyogyszergyar Rt. Purification process of fermentation broth
WO2001066538A1 (en) 2000-03-03 2001-09-13 Biogal Gyogyszergyar Rt. A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
KR20010095780A (en) * 2000-04-12 2001-11-07 나가오카 마사시 Embryo monascus
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
ATE356554T1 (en) * 2001-02-09 2007-04-15 Unilever Nv FOODS CONTAINING SOY PROTEIN AND STATIN
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (en) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 Preventive and Dietary Supplement for adult chronic disease
KR100710500B1 (en) 2005-05-18 2007-04-24 고려대학교 산학협력단 Method for producing Monacolin K using Monascus sp
SI2373609T1 (en) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (en) 2012-10-12 2013-09-30 Ion Gigel Fulga Composition for the treatment or prevention of dyslipidemias
CN110331151A (en) * 2019-04-11 2019-10-15 北京工商大学 The construction method of purple Monascus mokH gene overexpression bacterial strain
CN111297938A (en) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 Method for detecting lovastatin in composition for assisting in reducing blood fat

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPS5925599B2 (en) 1984-06-19
PH15145A (en) 1982-08-24
AU5567380A (en) 1980-08-28
KR830002801B1 (en) 1983-12-16
ATA92980A (en) 1983-07-15
PL222120A1 (en) 1980-10-20
IE49743B1 (en) 1985-12-11
NO153974C (en) 1986-06-25
SE8001339L (en) 1980-08-21
FI800506A (en) 1980-08-21
SE453301B (en) 1988-01-25
ZA80962B (en) 1981-03-25
DE3006216A1 (en) 1980-09-04
IT8067262A0 (en) 1980-02-20
ES8103171A1 (en) 1981-02-16
PL124304B1 (en) 1983-01-31
GB2046737A (en) 1980-11-19
SG6784G (en) 1985-02-08
CH645890A5 (en) 1984-10-31
IT1175260B (en) 1987-07-01
NL8001041A (en) 1980-08-22
FR2449685B1 (en) 1985-06-28
NO800451L (en) 1980-08-21
NL191540B (en) 1995-05-01
AT373915B (en) 1984-03-12
DK21889A (en) 1989-01-18
GB2046737B (en) 1983-01-12
NO153974B (en) 1986-03-17
DK149095C (en) 1986-06-16
DK21889D0 (en) 1989-01-18
ES488796A0 (en) 1981-02-16
CA1129794A (en) 1982-08-17
DK149095B (en) 1986-01-20
IE800321L (en) 1980-08-20
KR830002030A (en) 1983-05-21
JPS55111790A (en) 1980-08-28
FI66427C (en) 1984-10-10
FR2449685A1 (en) 1980-09-19
DE3006216C2 (en) 1985-10-31
BE881825A (en) 1980-08-20
SU1158048A3 (en) 1985-05-23
MX6314E (en) 1985-04-01
NZ192919A (en) 1984-07-06
DE3051175C2 (en) 1989-12-21
SU969702A1 (en) 1982-10-30
HU182069B (en) 1983-12-28
FI66427B (en) 1984-06-29
DD154494A5 (en) 1982-03-24
AU532626B2 (en) 1983-10-06
NL191540C (en) 1995-09-04

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Legal Events

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PUP Patent expired