DK696988A - Nucleosider og nucleosidanaloge, farmaceutiske praeparater indeholdende disse forbindelser og fremgangsmaade til fremstilling af forbindelserne - Google Patents

Nucleosider og nucleosidanaloge, farmaceutiske praeparater indeholdende disse forbindelser og fremgangsmaade til fremstilling af forbindelserne

Info

Publication number
DK696988A
DK696988A DK696988A DK696988A DK696988A DK 696988 A DK696988 A DK 696988A DK 696988 A DK696988 A DK 696988A DK 696988 A DK696988 A DK 696988A DK 696988 A DK696988 A DK 696988A
Authority
DK
Denmark
Prior art keywords
nucleosides
procedures
compounds
preparation
pharmaceutical preparations
Prior art date
Application number
DK696988A
Other languages
English (en)
Other versions
DK168443B1 (da
DK696988D0 (da
Inventor
Roelf Datema
Zsuzanna Maria Ilona Kovacs
Karl Nils Gunnar Johansson
Bjoern Gunnar Lindborg
Goeran Bertil Stening
Bo Fredrik Oeberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of DK696988D0 publication Critical patent/DK696988D0/da
Publication of DK696988A publication Critical patent/DK696988A/da
Application granted granted Critical
Publication of DK168443B1 publication Critical patent/DK168443B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK696988A 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne DK168443B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE8701605 1987-04-16
SE8701605A SE8701605D0 (sv) 1987-04-16 1987-04-16 Novel medicinal compounds
SE8800169 1988-04-06
PCT/SE1988/000169 WO1988008001A1 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
CA000580141A CA1336088C (en) 1987-04-16 1988-10-14 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil
CA580141 1988-10-14

Publications (3)

Publication Number Publication Date
DK696988D0 DK696988D0 (da) 1988-12-15
DK696988A true DK696988A (da) 1989-01-31
DK168443B1 DK168443B1 (da) 1994-03-28

Family

ID=25672174

Family Applications (3)

Application Number Title Priority Date Filing Date
DK696988A DK168443B1 (da) 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne
DK911084A DK108491D0 (da) 1987-04-16 1991-06-07 Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
DK104994A DK104994A (da) 1987-04-16 1994-09-13 Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK911084A DK108491D0 (da) 1987-04-16 1991-06-07 Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
DK104994A DK104994A (da) 1987-04-16 1994-09-13 Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus

Country Status (9)

Country Link
JP (1) JPH01503069A (da)
AT (1) ATE115958T1 (da)
AU (1) AU614082B2 (da)
CA (1) CA1336088C (da)
DE (1) DE3852531T2 (da)
DK (3) DK168443B1 (da)
HU (1) HU211547A9 (da)
SE (1) SE8701605D0 (da)
WO (1) WO1988008001A1 (da)

Families Citing this family (38)

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GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5212161A (en) * 1988-02-24 1993-05-18 Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) Derivatives of 2'-deoxyuridine substituted in the 5-,3'-or 5'-position by α-aminacyl groups, process for their preparation and drugs in which they are present
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US5198539A (en) * 1988-08-19 1993-03-30 Burroughs Wellcome Co. 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FR2648045B1 (fr) * 1989-06-13 1991-09-27 Centre Nat Rech Scient Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
JP3207852B2 (ja) * 1989-09-15 2001-09-10 サザン リサーチ インスティテュート 抗ウィルス剤及び抗癌剤としての２′―デオキシ―４′―チオリボヌクレオシド
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
US6228860B1 (en) 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
CA2095613C (en) * 1990-11-13 2001-01-02 Bernard Belleau Substituted 1, 3-oxathiolanes and substituted 1, 3-dithiolanes with antiviral properties
WO1993010820A1 (en) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
CA2190862A1 (en) * 1994-05-31 1995-12-07 Bo Oberg Post exposure prevention of hiv
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
DE69636734T2 (de) 1995-06-07 2007-10-18 Emory University Nucleoside mit anti-hepatitis b virus wirksamkeit
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
DK1058686T3 (da) 1998-02-25 2007-03-05 Univ Emory 2'-fluornukleosider
PT1411954E (pt) 2000-10-18 2011-03-16 Pharmasset Inc Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal
ES2358853T3 (es) 2006-10-10 2011-05-16 Medivir Ab Inhibidor nucleosídico de vhc.
JP6270742B2 (ja) * 2013-01-10 2018-01-31 塩野義製薬株式会社 架橋型核酸誘導体の製造方法

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DD75084A (da) *
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) * 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2918260A1 (de) * 1979-05-07 1980-11-27 Robugen Gmbh Anwendung von 5-alkyl-2'-desoxyuridinen
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
DE2930904A1 (de) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
DE3229169A1 (de) * 1982-08-05 1984-02-09 Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika
EP0199451B1 (en) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutic nucleosides
EP0196185B1 (en) * 1985-03-16 1989-07-12 The Wellcome Foundation Limited Antiviral nucleosides
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
JPH07116042B2 (ja) * 1985-05-15 1995-12-13 ザ ウエルカム フアウンデ−シヨン リミテツド ヌクレオシド化合物
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides

Also Published As

Publication number Publication date
AU614082B2 (en) 1991-08-22
ATE115958T1 (de) 1995-01-15
DK168443B1 (da) 1994-03-28
WO1988008001A1 (en) 1988-10-20
DK104994A (da) 1994-09-13
DK108491A (da) 1991-06-07
DE3852531D1 (de) 1995-02-02
SE8701605D0 (sv) 1987-04-16
CA1336088C (en) 1995-06-27
AU1689988A (en) 1988-11-04
DE3852531T2 (de) 1995-08-10
DK696988D0 (da) 1988-12-15
DK108491D0 (da) 1991-06-07
JPH01503069A (ja) 1989-10-19
HU211547A9 (en) 1995-12-28

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed