SE8701605D0 - Novel medicinal compounds - Google Patents

Novel medicinal compounds

Info

Publication number
SE8701605D0
SE8701605D0 SE8701605A SE8701605A SE8701605D0 SE 8701605 D0 SE8701605 D0 SE 8701605D0 SE 8701605 A SE8701605 A SE 8701605A SE 8701605 A SE8701605 A SE 8701605A SE 8701605 D0 SE8701605 D0 SE 8701605D0
Authority
SE
Sweden
Prior art keywords
formula
carbon
medicinal compounds
novel medicinal
ch2oh
Prior art date
Application number
SE8701605A
Other languages
English (en)
Inventor
R Datema
Z M I Kovacs
K N G Johansson
B G Lindborg
G B Stening
B F Oberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8701605A priority Critical patent/SE8701605D0/sv
Publication of SE8701605D0 publication Critical patent/SE8701605D0/sv
Priority to EP88903972A priority patent/EP0309560B1/en
Priority to PCT/SE1988/000169 priority patent/WO1988008001A1/en
Priority to AT88903972T priority patent/ATE115958T1/de
Priority to AU16899/88A priority patent/AU614082B2/en
Priority to EP94108798A priority patent/EP0615975A1/en
Priority to DE3852531T priority patent/DE3852531T2/de
Priority to EP19920112530 priority patent/EP0516186A3/en
Priority to JP63503532A priority patent/JPH01503069A/ja
Priority to CA000580141A priority patent/CA1336088C/en
Priority to DK696988A priority patent/DK168443B1/da
Priority to DK108491A priority patent/DK108491A/da
Priority to US07/794,704 priority patent/US5215970A/en
Priority to US08/041,165 priority patent/US5409906A/en
Priority to DK104994A priority patent/DK104994A/da
Priority to HU95P/P00134P priority patent/HU211547A9/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE8701605A 1987-04-16 1987-04-16 Novel medicinal compounds SE8701605D0 (sv)

Priority Applications (16)

Application Number Priority Date Filing Date Title
SE8701605A SE8701605D0 (sv) 1987-04-16 1987-04-16 Novel medicinal compounds
PCT/SE1988/000169 WO1988008001A1 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
DE3852531T DE3852531T2 (de) 1987-04-16 1988-04-06 Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.
JP63503532A JPH01503069A (ja) 1987-04-16 1988-04-06 新規な医薬化合物
AT88903972T ATE115958T1 (de) 1987-04-16 1988-04-06 Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.
AU16899/88A AU614082B2 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
EP94108798A EP0615975A1 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for preparation of the compounds
EP88903972A EP0309560B1 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
EP19920112530 EP0516186A3 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
CA000580141A CA1336088C (en) 1987-04-16 1988-10-14 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil
DK696988A DK168443B1 (da) 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne
DK108491A DK108491A (da) 1987-04-16 1991-06-07 Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
US07/794,704 US5215970A (en) 1987-04-16 1991-11-20 Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US08/041,165 US5409906A (en) 1987-04-16 1993-04-01 α nucleoside compounds and a method for treating HBV using said compounds
DK104994A DK104994A (da) 1987-04-16 1994-09-13 Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus
HU95P/P00134P HU211547A9 (en) 1987-04-16 1995-05-12 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8701605A SE8701605D0 (sv) 1987-04-16 1987-04-16 Novel medicinal compounds
CA000580141A CA1336088C (en) 1987-04-16 1988-10-14 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil

Publications (1)

Publication Number Publication Date
SE8701605D0 true SE8701605D0 (sv) 1987-04-16

Family

ID=25672174

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8701605A SE8701605D0 (sv) 1987-04-16 1987-04-16 Novel medicinal compounds

Country Status (9)

Country Link
JP (1) JPH01503069A (sv)
AT (1) ATE115958T1 (sv)
AU (1) AU614082B2 (sv)
CA (1) CA1336088C (sv)
DE (1) DE3852531T2 (sv)
DK (3) DK168443B1 (sv)
HU (1) HU211547A9 (sv)
SE (1) SE8701605D0 (sv)
WO (1) WO1988008001A1 (sv)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5212161A (en) * 1988-02-24 1993-05-18 Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) Derivatives of 2'-deoxyuridine substituted in the 5-,3'-or 5'-position by α-aminacyl groups, process for their preparation and drugs in which they are present
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5198539A (en) * 1988-08-19 1993-03-30 Burroughs Wellcome Co. 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
FI95384C (sv) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Förfarande för framställning 3'-deoxi-3'-substituerade metylnukleosider och mellanprodukter som används i förfarandet
FR2648045B1 (fr) * 1989-06-13 1991-09-27 Centre Nat Rech Scient Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
ES2253732T3 (es) * 1989-09-15 2006-06-01 Southern Research Institute 2'-deoxi-4'-tioribonucleosidos como agentes antivirales y anticancerosos.
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US6069252A (en) 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US6228860B1 (en) 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
DE69122264T2 (de) * 1990-11-13 1997-02-06 Iaf Biochem Int Substituierte 1,3-oxathiolane mit antiviralen eigenschaften
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
EP1256589A3 (en) * 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
EP0763048A1 (en) * 1994-05-31 1997-03-19 Medivir Aktiebolag Post exposure prevention of hiv
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
EP2390257A1 (en) 1998-02-25 2011-11-30 Emory University 2'-fluoronucleosides
KR101005299B1 (ko) 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
RS51643B (en) 2006-10-10 2011-10-31 Medivir Ab. INHIBITOR HCV NUKLEOZIDA
JP6270742B2 (ja) * 2013-01-10 2018-01-31 塩野義製薬株式会社 架橋型核酸誘導体の製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD75084A (sv) *
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) * 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2918260A1 (de) * 1979-05-07 1980-11-27 Robugen Gmbh Anwendung von 5-alkyl-2'-desoxyuridinen
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
DE2930904A1 (de) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
DE3229169A1 (de) * 1982-08-05 1984-02-09 Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
EP0199451B1 (en) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutic nucleosides
DE3608606A1 (de) * 1985-03-16 1986-09-18 The Wellcome Foundation Ltd., London 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung
DK224286A (da) * 1985-05-15 1986-11-16 Wellcome Found 2',3'-dideoxy-nucleosider
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides

Also Published As

Publication number Publication date
HU211547A9 (en) 1995-12-28
DK168443B1 (da) 1994-03-28
CA1336088C (en) 1995-06-27
WO1988008001A1 (en) 1988-10-20
DK696988D0 (da) 1988-12-15
DK108491D0 (da) 1991-06-07
DE3852531D1 (de) 1995-02-02
JPH01503069A (ja) 1989-10-19
AU1689988A (en) 1988-11-04
AU614082B2 (en) 1991-08-22
DE3852531T2 (de) 1995-08-10
DK696988A (da) 1989-01-31
DK108491A (da) 1991-06-07
ATE115958T1 (de) 1995-01-15
DK104994A (da) 1994-09-13

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