DK596385D0 - Peptidaldehyder og farmaceutiske praeparater indeholdende saadanne forbindelser - Google Patents

Peptidaldehyder og farmaceutiske praeparater indeholdende saadanne forbindelser

Info

Publication number
DK596385D0
DK596385D0 DK596385A DK596385A DK596385D0 DK 596385 D0 DK596385 D0 DK 596385D0 DK 596385 A DK596385 A DK 596385A DK 596385 A DK596385 A DK 596385A DK 596385 D0 DK596385 D0 DK 596385D0
Authority
DK
Denmark
Prior art keywords
peptidal
deads
compounds
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK596385A
Other languages
English (en)
Other versions
DK596385A (da
DK171403B1 (da
Inventor
Sandor Bajusz
Erzsebet Szell
Daniel Bagdy
Eva Barabas
Mariann Dioszegi
Zsuzsa Fittler
Ferencz Jozsa
Gyula Horvath
Eva Tomori
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK596385D0 publication Critical patent/DK596385D0/da
Publication of DK596385A publication Critical patent/DK596385A/da
Application granted granted Critical
Publication of DK171403B1 publication Critical patent/DK171403B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK596385A 1984-12-21 1985-12-20 Peptidaldehyder og farmaceutiske præparater indeholdende sådanne forbindelser, samt fremgangsmåder til fremstilling heraf DK171403B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU844763A HU192646B (en) 1984-12-21 1984-12-21 Process for preparing new n-alkyl-peptide aldehydes
HU476384 1984-12-21

Publications (3)

Publication Number Publication Date
DK596385D0 true DK596385D0 (da) 1985-12-20
DK596385A DK596385A (da) 1986-06-22
DK171403B1 DK171403B1 (da) 1996-10-14

Family

ID=10968854

Family Applications (1)

Application Number Title Priority Date Filing Date
DK596385A DK171403B1 (da) 1984-12-21 1985-12-20 Peptidaldehyder og farmaceutiske præparater indeholdende sådanne forbindelser, samt fremgangsmåder til fremstilling heraf

Country Status (18)

Country Link
US (1) US4703036A (da)
EP (1) EP0185390B1 (da)
JP (1) JPH0680078B2 (da)
CN (1) CN1025738C (da)
AR (1) AR241710A1 (da)
AT (1) ATE68002T1 (da)
AU (1) AU585561B2 (da)
CA (1) CA1261547A (da)
DE (1) DE3584281D1 (da)
DK (1) DK171403B1 (da)
ES (1) ES8708237A1 (da)
FI (1) FI85980C (da)
GR (1) GR853121B (da)
HU (1) HU192646B (da)
IL (1) IL77416A (da)
PT (1) PT81746B (da)
SU (1) SU1384203A3 (da)
ZA (1) ZA859756B (da)

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CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
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US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
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ES2184763T3 (es) * 1993-04-30 2003-04-16 Merck & Co Inc Inhibidores de trombina.
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US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
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US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
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US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
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CA2192697A1 (en) * 1994-06-17 1995-12-28 Thomas R. Webb Methods of synthesis of peptidyl argininals
US5514777A (en) * 1994-06-17 1996-05-07 Corvas International, Inc. Methods of synthesis of peptidyl argininals
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
US6025472A (en) * 1994-12-21 2000-02-15 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
US5696231A (en) * 1994-12-21 1997-12-09 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
AR005245A1 (es) * 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
DE19605039A1 (de) 1996-02-12 1997-08-14 Hoechst Ag Verfahren zur Herstellung von Oligopeptid-Aldehyden
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
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HU224315B1 (hu) * 1996-06-05 2005-07-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
CN1113088C (zh) * 1996-09-24 2003-07-02 普罗格特-甘布尔公司 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂
US6165966A (en) * 1996-09-24 2000-12-26 The Procter & Gamble Company Liquid detergents containing proteolytic enzyme and protease inhibitors
CN1238003A (zh) 1996-09-24 1999-12-08 普罗格特-甘布尔公司 含有蛋白酶和蛋白酶抑制剂的液体洗衣洗涤剂组合物
US5798377A (en) * 1996-10-21 1998-08-25 Merck & Co., Inc. Thrombin inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
AU751111B2 (en) 1998-01-26 2002-08-08 Basf Aktiengesellschaft Thrombin inhibitors
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
CN1170842C (zh) 1999-01-13 2004-10-13 阿斯特拉曾尼卡有限公司 新的脒基苄基胺衍生物及其作为凝血酶抑制剂的用途
WO2000055188A1 (fr) * 1999-03-16 2000-09-21 C & C Research Laboratories Derives de proline substitues et compositions medicinales les contenant
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
US6528503B2 (en) 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
CA2431588A1 (en) 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
CA2436176A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
JP4230908B2 (ja) * 2001-08-21 2009-02-25 イヴァックス インスティテュート フォー ドラッグ リサーチ，リミテッド ペプチド・アルギナル類および播種性血管内血液凝固の治療方法
US7084134B2 (en) * 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
EP2224949B1 (en) 2007-11-30 2012-10-17 University of Debrecen Use of urokinase type plasminogen activator inhibitors for the treatment of corneal disorders
ES2539504T3 (es) 2011-07-01 2015-07-01 Novozymes A/S Composición de subtilisina estabilizada
CN106471110A (zh) 2014-07-03 2017-03-01 诺维信公司 改进的非蛋白酶类酶稳定化
CN107469379B (zh) * 2016-06-07 2020-03-06 中国科学院大连化学物理研究所 一种样品中残留水溶性有机溶剂的去除方法
BR112021023457A2 (pt) 2019-07-01 2022-01-25 Basf Se Composto, uso do composto, composição, e, métodos para preparar a composição e um composto

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HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
US4434096A (en) * 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
US4448717A (en) * 1982-11-12 1984-05-15 Eli Lilly And Company Pharmacologically active peptides
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes

Also Published As

Publication number Publication date
EP0185390A2 (de) 1986-06-25
CA1261547A (en) 1989-09-26
GR853121B (da) 1986-04-22
FI85980B (fi) 1992-03-13
ES550296A0 (es) 1987-10-01
CN85109736A (zh) 1987-03-18
AU585561B2 (en) 1989-06-22
JPH0680078B2 (ja) 1994-10-12
FI855118A (fi) 1986-06-22
US4703036A (en) 1987-10-27
IL77416A (en) 1990-04-29
AU5155385A (en) 1986-06-26
HUT38954A (en) 1986-07-28
DK596385A (da) 1986-06-22
ATE68002T1 (de) 1991-10-15
EP0185390A3 (en) 1988-09-07
HU192646B (en) 1987-06-29
FI855118A0 (fi) 1985-12-20
SU1384203A3 (ru) 1988-03-23
ZA859756B (en) 1986-09-24
PT81746B (pt) 1987-11-11
DK171403B1 (da) 1996-10-14
FI85980C (fi) 1992-06-25
AR241710A1 (es) 1992-11-30
PT81746A (en) 1986-01-01
ES8708237A1 (es) 1987-10-01
CN1025738C (zh) 1994-08-24
DE3584281D1 (de) 1991-11-07
EP0185390B1 (de) 1991-10-02
JPS61152699A (ja) 1986-07-11

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B1 Patent granted (law 1993)
PBP Patent lapsed

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