DK165987A - Modificeret fibrinolytisk enzym - Google Patents

Modificeret fibrinolytisk enzym

Info

Publication number
DK165987A
DK165987A DK165987A DK165987A DK165987A DK 165987 A DK165987 A DK 165987A DK 165987 A DK165987 A DK 165987A DK 165987 A DK165987 A DK 165987A DK 165987 A DK165987 A DK 165987A
Authority
DK
Denmark
Prior art keywords
enzym
fibrinolytic
modified
modified fibrinolytic
fibrinolytic enzym
Prior art date
Application number
DK165987A
Other languages
English (en)
Other versions
DK165987D0 (da
Inventor
Michael Joseph Browne
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868608014A external-priority patent/GB8608014D0/en
Priority claimed from GB868629483A external-priority patent/GB8629483D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK165987D0 publication Critical patent/DK165987D0/da
Publication of DK165987A publication Critical patent/DK165987A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK165987A 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym DK165987A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868608014A GB8608014D0 (en) 1986-04-02 1986-04-02 Compounds
GB868629483A GB8629483D0 (en) 1986-12-10 1986-12-10 Compounds

Publications (2)

Publication Number Publication Date
DK165987D0 DK165987D0 (da) 1987-04-01
DK165987A true DK165987A (da) 1987-10-03

Family

ID=26290571

Family Applications (1)

Application Number Title Priority Date Filing Date
DK165987A DK165987A (da) 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym

Country Status (5)

Country Link
EP (1) EP0240334A1 (da)
AU (1) AU7090687A (da)
DK (1) DK165987A (da)
NZ (1) NZ219829A (da)
PT (1) PT84587B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
GB2200640B (en) * 1987-01-30 1991-07-10 American Home Prod Des-epidermal growth factor plasminogen activators
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
CA2025180A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting pathogenic candida yeasts
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (da) * 1982-05-05 1984-10-22 Genentech Inc
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain

Also Published As

Publication number Publication date
EP0240334A1 (en) 1987-10-07
NZ219829A (en) 1990-05-28
PT84587A (en) 1987-04-01
AU7090687A (en) 1987-10-08
PT84587B (pt) 1989-11-30
DK165987D0 (da) 1987-04-01

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
PUP Patent expired