DK463887D0 - Gaerleader - Google Patents
GaerleaderInfo
- Publication number
- DK463887D0 DK463887D0 DK463887A DK463887A DK463887D0 DK 463887 D0 DK463887 D0 DK 463887D0 DK 463887 A DK463887 A DK 463887A DK 463887 A DK463887 A DK 463887A DK 463887 D0 DK463887 D0 DK 463887D0
- Authority
- DK
- Denmark
- Prior art keywords
- gaerleader
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK463887A DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Gaerleader |
PCT/DK1988/000147 WO1989002463A1 (en) | 1987-09-07 | 1988-09-06 | Synthetic yeast leader peptides |
AT88908171T ATE98691T1 (de) | 1987-09-07 | 1988-09-06 | Synthetische hefe-signalpeptide. |
EP88908171A EP0378567B1 (de) | 1987-09-07 | 1988-09-06 | Synthetische hefe-signalpeptide |
DE88908171T DE3886408T2 (de) | 1987-09-07 | 1988-09-06 | Synthetische hefe-signalpeptide. |
JP63507561A JP2708518B2 (ja) | 1987-09-07 | 1988-09-06 | 合成酵母リーダーペプチド |
US07/406,392 US5162498A (en) | 1987-09-07 | 1989-09-12 | Synthetic yeast leader peptides |
DK053290A DK164874C (da) | 1987-09-07 | 1990-03-01 | Syntetiske gaer-leader-peptider, dna-sekvens, der indkoder saadanne leader-peptider, vektorer og transformerede gaerstammer samt en fremgangsmaade til fremstilling af proteiner i gaer |
US07/973,483 US5316923A (en) | 1987-09-07 | 1992-11-09 | Synthetic yeast leader peptides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK463887A DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Gaerleader |
Publications (1)
Publication Number | Publication Date |
---|---|
DK463887D0 true DK463887D0 (da) | 1987-09-07 |
Family
ID=8135352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK463887A DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Gaerleader |
Country Status (6)
Country | Link |
---|---|
US (2) | US5162498A (de) |
EP (1) | EP0378567B1 (de) |
JP (1) | JP2708518B2 (de) |
DE (1) | DE3886408T2 (de) |
DK (1) | DK463887D0 (de) |
WO (1) | WO1989002463A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
US5759802A (en) * | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
CA2025180A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting pathogenic candida yeasts |
ATE158816T1 (de) | 1990-11-26 | 1997-10-15 | Genetics Inst | Expression von pace in wirtszellen und verfahren zu dessen verwendung |
DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
DK6893D0 (da) * | 1993-01-21 | 1993-01-21 | Novo Nordisk As | Peptid |
US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
DE4417353A1 (de) * | 1994-05-18 | 1996-01-25 | Bayer Ag | Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz |
CN102080070B (zh) | 1995-03-17 | 2016-01-20 | 诺沃奇梅兹有限公司 | 新的内切葡聚糖酶 |
EP1231218B1 (de) | 1996-03-01 | 2008-05-14 | Novo Nordisk A/S | Peptid zur Appetitzügelung, dessen Zusammensetzungen und Verwendung |
DE19629982A1 (de) | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
AU9363798A (en) | 1997-11-06 | 1999-05-31 | Chiron S.P.A. | Neisserial antigens |
CA2317815A1 (en) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Neisseria meningitidis antigens |
GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
ES2304065T3 (es) | 1998-05-01 | 2008-09-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos y composiciones de neisseria meningitidis. |
US6190883B1 (en) | 1998-09-09 | 2001-02-20 | Novo Nordisk A/S | Method for the production of heterologous polypeptides in transformed yeast cells |
NZ581940A (en) | 1999-04-30 | 2011-07-29 | Novartis Vaccines & Diagnostic | Conserved neisserial antigens |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
EP1200566A2 (de) | 1999-07-09 | 2002-05-02 | Novozymes A/S | Variante der glucoamylase |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
RU2281956C2 (ru) | 1999-10-29 | 2006-08-20 | Чирон С.Р.Л. | Антигенные пептиды neisseria |
CN1415019A (zh) | 1999-12-29 | 2003-04-30 | 诺沃挪第克公司 | 用于生产在酵母中具有改进发酵产量的胰岛素前体和胰岛素前体类似物的方法 |
DK2289545T3 (en) | 2000-01-17 | 2016-09-05 | Glaxosmithkline Biologicals Sa | Supplemented OMV vaccine against meningococcus |
EP2189473A3 (de) | 2000-10-27 | 2010-08-11 | Novartis Vaccines and Diagnostics S.r.l. | Nukleinsäure und Proteine von Gruppen A und B Streptokokken |
AU2002249096B2 (en) | 2001-03-22 | 2007-06-28 | Novo Nordisk Health Care Ag | Coagulation factor VII derivatives |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
US20030082671A1 (en) * | 2001-07-24 | 2003-05-01 | Thomas Hoeg-Jensen | Method for making acylated polypeptides |
US7595172B2 (en) * | 2001-07-24 | 2009-09-29 | Novo Nordisk A/S | Method for making acylated polypeptides |
CA2461003A1 (en) | 2001-09-27 | 2003-04-03 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
JP4413617B2 (ja) | 2001-12-12 | 2010-02-10 | カイロン ソチエタ ア レスポンサビリタ リミタータ | Chlamydiatrachomatisに対する免疫化 |
CA2498017C (en) | 2002-09-13 | 2016-06-14 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
DK2279746T3 (da) | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
ATE547519T1 (de) | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
KR20060126449A (ko) * | 2003-09-23 | 2006-12-07 | 파브릴, 인크. | 자가 유도된 항원을 특이적-결합 세포감소제와 병용하여 b세포 병증을 개선시키는 방법 |
EP1687428A1 (de) | 2003-11-14 | 2006-08-09 | Novo Nordisk A/S | Verfahren zur herstellung von acyliertem insulin |
WO2005054291A1 (en) | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
US8034326B2 (en) | 2005-04-18 | 2011-10-11 | Novo Nordisk A/S | IL-21 variants |
ES2368500T3 (es) | 2005-08-16 | 2011-11-17 | Novo Nordisk A/S | Método para producir polipéptidos de insulina maduros. |
EP2316930A1 (de) | 2005-09-14 | 2011-05-04 | Novo Nordisk Health Care AG | Menschliche Polypeptide des Koagulationfaktors VII |
ATE482977T1 (de) | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
JP5503968B2 (ja) | 2006-09-27 | 2014-05-28 | ノボ・ノルデイスク・エー/エス | 成熟インスリンポリペプチドの作製方法 |
US7795411B2 (en) * | 2006-10-05 | 2010-09-14 | Fred Hutchinson Cancer Research Center | Vectors for expressing in vivo biotinylated recombinant proteins |
WO2009010428A1 (en) | 2007-07-16 | 2009-01-22 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
EP2910571B1 (de) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Proteasestabilisierte, acylierte insulinanaloga |
WO2010103038A1 (en) | 2009-03-11 | 2010-09-16 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
WO2010103546A2 (en) * | 2009-03-12 | 2010-09-16 | Bigtec Private Limited | A polynucleotide and polypeptide sequence and methods thereof |
KR102184713B1 (ko) | 2009-07-17 | 2020-12-01 | 오메로스 코포레이션 | 보체 활성화의 억제제로서의 masp 이소형 |
ES2583259T3 (es) | 2009-12-01 | 2016-09-20 | Novo Nordisk A/S | Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina |
JP6148013B2 (ja) | 2010-03-05 | 2017-06-14 | リグショスピタレト | 補体活性化のキメラ抑制分子 |
DK2812024T3 (en) | 2012-02-09 | 2018-07-23 | Var2 Pharmaceuticals Aps | TARGET ORIENTATION OF CHONDROITIN-SULPHATE GLYCANES |
US20150307865A1 (en) | 2012-10-15 | 2015-10-29 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体 |
JP2016521701A (ja) | 2013-06-07 | 2016-07-25 | ノヴォ ノルディスク アー/エス | 成熟インスリンポリペプチドを作製するための方法 |
EP3268384B1 (de) | 2015-03-10 | 2021-11-03 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung von rekombinantem insulin unter verwendung von mikrofiltration |
CN112789504A (zh) | 2018-07-13 | 2021-05-11 | 瓦克特诊断有限责任公司 | 使用重组疟疾蛋白var2csa分离胎儿来源的循环细胞 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4546082A (en) * | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
US5015575A (en) * | 1983-04-07 | 1991-05-14 | Chiron Corporation | Hybrid DNA synthesis of insulin |
DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
JPS6236183A (ja) * | 1985-06-20 | 1987-02-17 | ザ・サルク・インステイチユ−ト・バイオテクノロジ−/インダストリアル・アソシエイツ・インコ−ポレ−テツド | サツカロミセス・セレビシエからのポリペプチドの発現および分泌 |
DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
-
1987
- 1987-09-07 DK DK463887A patent/DK463887D0/da not_active Application Discontinuation
-
1988
- 1988-09-06 DE DE88908171T patent/DE3886408T2/de not_active Expired - Fee Related
- 1988-09-06 WO PCT/DK1988/000147 patent/WO1989002463A1/en active IP Right Grant
- 1988-09-06 EP EP88908171A patent/EP0378567B1/de not_active Expired - Lifetime
- 1988-09-06 JP JP63507561A patent/JP2708518B2/ja not_active Expired - Fee Related
-
1989
- 1989-09-12 US US07/406,392 patent/US5162498A/en not_active Expired - Fee Related
-
1992
- 1992-11-09 US US07/973,483 patent/US5316923A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5162498A (en) | 1992-11-10 |
WO1989002463A1 (en) | 1989-03-23 |
EP0378567A1 (de) | 1990-07-25 |
EP0378567B1 (de) | 1993-12-15 |
JPH03500171A (ja) | 1991-01-17 |
JP2708518B2 (ja) | 1998-02-04 |
US5316923A (en) | 1994-05-31 |
DE3886408T2 (de) | 1994-05-11 |
DE3886408D1 (en) | 1994-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment |