DK3554681T3 - Fremgangsmåde til proteincorona-sensorarray til tidlig detektering af sygdomme - Google Patents

Fremgangsmåde til proteincorona-sensorarray til tidlig detektering af sygdomme Download PDF

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Publication number
DK3554681T3
DK3554681T3 DK17881767.2T DK17881767T DK3554681T3 DK 3554681 T3 DK3554681 T3 DK 3554681T3 DK 17881767 T DK17881767 T DK 17881767T DK 3554681 T3 DK3554681 T3 DK 3554681T3
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Prior art keywords
proteincorona
diseases
procedure
early detection
sensor ray
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DK17881767.2T
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English (en)
Inventor
Omid Farokhzad
Morteza Mahmoudi
Claudia Corbo
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Brigham & Womens Hospital Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Data Mining & Analysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
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DK17881767.2T 2016-12-16 2017-12-18 Fremgangsmåde til proteincorona-sensorarray til tidlig detektering af sygdomme DK3554681T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435409P 2016-12-16 2016-12-16
PCT/US2017/067013 WO2018112460A1 (en) 2016-12-16 2017-12-18 System and method for protein corona sensor array for early detection of diseases

Publications (1)

Publication Number Publication Date
DK3554681T3 true DK3554681T3 (da) 2022-03-21

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DK17881767.2T DK3554681T3 (da) 2016-12-16 2017-12-18 Fremgangsmåde til proteincorona-sensorarray til tidlig detektering af sygdomme

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Country Link
US (3) US10866242B2 (da)
EP (2) EP3554681B1 (da)
JP (3) JP7069170B2 (da)
CN (5) CN116908452A (da)
AU (2) AU2017375496B2 (da)
CA (1) CA3046540A1 (da)
DE (4) DE202017007363U1 (da)
DK (1) DK3554681T3 (da)
ES (1) ES2914787T3 (da)
GB (1) GB2561940A (da)
MX (2) MX2019006982A (da)
PL (1) PL3554681T3 (da)
PT (1) PT3554681T (da)
WO (1) WO2018112460A1 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201615128D0 (en) * 2016-09-06 2016-10-19 Univ Manchester Methods
PT3554681T (pt) 2016-12-16 2022-03-21 Brigham & Womens Hospital Inc Método para matriz de sensores de coroa de proteínas para a deteção precoce de doenças
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
CN111565624A (zh) * 2017-11-27 2020-08-21 雷蒂斯派克股份有限公司 用于阿尔茨海默氏病病理的高光谱图像指导的raman眼科成像仪
CN108760700A (zh) * 2018-05-29 2018-11-06 云南健牛生物科技有限公司 一种荧光金纳米簇的制备及用于四环素及铜荧光探针
KR102594366B1 (ko) 2018-11-07 2023-10-27 시어 인코퍼레이티드 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도
CN109212217B (zh) * 2018-11-07 2021-09-10 李玉民 基于amy1a蛋白胃癌检测试剂盒及其使用方法
CN109599177B (zh) * 2018-11-27 2023-04-11 华侨大学 一种基于病历的深度学习预测医疗轨迹的方法
CN109734792B (zh) * 2019-01-17 2022-05-24 武汉明德生物科技股份有限公司 人cntn1抗原、人cntn1抗体检测试剂盒及其制备方法与应用
GB201903054D0 (en) * 2019-03-07 2019-04-24 Univ Bristol Sensor
JP2022527196A (ja) 2019-03-26 2022-05-31 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
CN110385427B (zh) * 2019-07-31 2021-10-19 东南大学 一种水溶性纳米粒子及其制备方法和应用
KR20220078560A (ko) 2019-08-05 2022-06-10 시어 인코퍼레이티드 샘플 제조, 데이터 생성, 및 단백질 코로나 분석을 위한 시스템 및 방법
WO2021057986A1 (zh) * 2019-09-27 2021-04-01 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
WO2021087407A1 (en) * 2019-11-02 2021-05-06 Seer, Inc. Systems for protein corona analysis
CN111292801A (zh) * 2020-01-21 2020-06-16 西湖大学 蛋白质质谱结合深度学习评估甲状腺结节的方法
CA3165068A1 (en) 2020-01-30 2021-08-05 John E. Blume Lung biomarkers and methods of use thereof
DE102020202262A1 (de) 2020-02-21 2021-08-26 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zur Herstellung einer nanoskaligen Kanalstruktur
US20210333222A1 (en) * 2020-04-24 2021-10-28 Nokomis, Inc Rf rapid diagnostics of infection and contamination
US20210350897A1 (en) * 2020-05-06 2021-11-11 Janssen Pharmaceuticals, Inc. Aggregating and analyzing drug administration data
WO2021243285A1 (en) * 2020-05-29 2021-12-02 Seer, Inc. Systems and methods for rapid identification of proteins
GB202008287D0 (en) * 2020-06-02 2020-07-15 Kostarelos Kostas Methods of determining cancer
EP4182474A1 (en) * 2020-07-20 2023-05-24 Seer, Inc. Particles and methods of assaying
GB202012433D0 (en) * 2020-08-10 2020-09-23 Univ Manchester Nanoparticle-enabled analysis of cell-free nucleic acid in complex biological fluids
GB202012434D0 (en) * 2020-08-10 2020-09-23 Univ Manchester Multiomic analysis of nanoparticle-coronas
CN112034182A (zh) * 2020-09-01 2020-12-04 复旦大学附属中山医院 一种结肠癌转移预测方法和***
US11250723B1 (en) * 2020-11-04 2022-02-15 King Abdulaziz University Visuospatial disorders detection in dementia using a computer-generated environment based on voting approach of machine learning algorithms
US20220260559A1 (en) * 2020-11-04 2022-08-18 Seer, Inc. Biomarkers for diagnosing alzheimer's disease
IT202000031139A1 (it) * 2020-12-16 2022-06-16 Univ Degli Studi Roma La Sapienza Test sierologico per coadiuvare la diagnosi e il monitoraggio del glioblastoma multiforme
CN112730692B (zh) * 2021-01-08 2022-11-29 首都医科大学附属北京朝阳医院 用于预测胎膜早破的生物标记物和方法
CA3203535A1 (en) 2021-01-21 2022-07-28 Gregory KAPP Systems and methods for biomolecule preparation
GB202102399D0 (en) * 2021-02-19 2021-04-07 Univ Manchester Methods of determining alzheimer's disease
CN112951321B (zh) * 2021-03-01 2023-10-24 湖南大学 一种基于张量分解的miRNA-疾病关联预测方法及***
EP4056271A1 (en) 2021-03-10 2022-09-14 Cline Scientific AB Quantification of cell migration and metastatic potential of tumor cells
US11735303B2 (en) * 2021-06-22 2023-08-22 David Haase Apparatus and method for determining a composition of a replacement therapy treatment
CN113409335B (zh) * 2021-06-22 2023-04-07 西安邮电大学 基于强弱联合半监督直觉模糊聚类的图像分割方法
CN113470739B (zh) * 2021-07-03 2023-04-18 中国科学院新疆理化技术研究所 一种基于混合隶属度随机块模型的蛋白质相互作用预测方法和***
US12007397B2 (en) 2021-09-13 2024-06-11 PrognomIQ, Inc. Enhanced detection and quantitation of biomolecules
CN114019042B (zh) * 2021-10-29 2023-06-20 浙江工商大学 基于石墨烯的黄颡鱼蛋白酶抑制剂含量测定方法及装置
WO2023141580A2 (en) * 2022-01-20 2023-07-27 Seer, Inc. Particles and methods of assaying
CN117593306B (zh) * 2024-01-19 2024-05-03 数据空间研究院 一种功能磁共振大脑皮层的分区方法及***

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ATE444481T1 (de) 1998-11-16 2009-10-15 California Inst Of Techn Gleichzeitige bestimmung von gleichgewichts- und kinetischen eigenschaften
US6969615B2 (en) 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
US6780602B2 (en) 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
CA2487424C (en) 2002-05-30 2011-01-04 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
CN1832763A (zh) * 2003-06-05 2006-09-13 森特利昂公司 编码纤维母细胞生长因子的质粒用于治疗与高胆固醇血症或糖尿病相关的血管生成缺陷
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
US9002652B1 (en) 2005-01-27 2015-04-07 Institute For Systems Biology Methods for identifying and using organ-specific proteins in blood
CN101484803A (zh) * 2006-01-27 2009-07-15 乔治梅森大学 眼内液标志物
ES2448426T3 (es) 2007-10-12 2014-03-13 Pronota Nv Uso de aptámeros en proteómica
US8021891B2 (en) 2007-11-28 2011-09-20 University Of Massachusetts Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes
KR101039629B1 (ko) * 2008-05-22 2011-06-08 성균관대학교산학협력단 생체물질의 검출방법, 생체물질 검출용 칩의 제조방법 및생물질 검출용 칩
EP2401619A1 (en) * 2009-02-26 2012-01-04 University College Dublin National University Of Ireland, Dublin A method for the selective concentration of a specific low abundance biomolecule
US20120190574A1 (en) 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling
EP2524219A4 (en) 2010-01-14 2013-08-07 Univ Central Florida Res Found METHODS OF DETECTION AND ANALYSIS OF BIOMOLECULES AND BIOMOLECULE COMPLEXES (BMC) AND THEIR USE FOR MEDICAL RESEARCH AND DIAGNOSIS
AU2011215789A1 (en) 2010-02-10 2012-08-30 The Regents Of The University Of California Salivary biomarkers for lung cancer detection
US9329176B2 (en) 2010-11-18 2016-05-03 Academia Sinica Glycopeptide-functionalized nanoparticles arrays for capturing and detecting biomolecules
EP2670863B1 (en) * 2011-01-31 2018-06-27 H. Hoffnabb-La Roche Ag Methods of identifying multiple epitopes in cells
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
BR112013031591A2 (pt) * 2011-06-07 2016-12-13 Caris Life Sciences Luxembourg Holdings S A R L biomarcadores de circulação para câncer
US20130058923A1 (en) * 2011-08-03 2013-03-07 Qun Huo Biomolecular interactions and interaction products as biomarkers for detection, diagnosis, prognosis and predicting therapeutic responses of human diseases
KR20140067001A (ko) * 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
KR20140068087A (ko) * 2011-08-23 2014-06-05 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 펩티드 나노입자 및 이의 용도
US10900975B2 (en) 2015-05-12 2021-01-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods of epitope binning and antibody profiling
US11474102B2 (en) 2015-11-23 2022-10-18 Massachusetts Institute Of Technology Protein corona phase molecular recognition
GB201615128D0 (en) 2016-09-06 2016-10-19 Univ Manchester Methods
PT3554681T (pt) 2016-12-16 2022-03-21 Brigham & Womens Hospital Inc Método para matriz de sensores de coroa de proteínas para a deteção precoce de doenças

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