DK3286183T3 - Isoxazolylsubstituerede benzimidazoler - Google Patents

Isoxazolylsubstituerede benzimidazoler Download PDF

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Publication number
DK3286183T3
DK3286183T3 DK16718863.0T DK16718863T DK3286183T3 DK 3286183 T3 DK3286183 T3 DK 3286183T3 DK 16718863 T DK16718863 T DK 16718863T DK 3286183 T3 DK3286183 T3 DK 3286183T3
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Prior art keywords
isoxazolyl
substituted benzimidazoles
benzimidazoles
substituted
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DK16718863.0T
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English (en)
Inventor
Neil Anthony Pegg
David Michel Adrien Taddei
Stuart Thomas Onions
Eric Sing Yuen Tse
Richard James Brown
David Kenneth Mycock
David Cousin
Anil Patel
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Cellcentric Ltd
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Publication of DK3286183T3 publication Critical patent/DK3286183T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16718863.0T 2015-04-20 2016-04-20 Isoxazolylsubstituerede benzimidazoler DK3286183T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1506658.2A GB201506658D0 (en) 2015-04-20 2015-04-20 Pharmaceutical compounds
PCT/GB2016/051088 WO2016170324A1 (en) 2015-04-20 2016-04-20 Isoxazolyl substituted benzimidazoles

Publications (1)

Publication Number Publication Date
DK3286183T3 true DK3286183T3 (da) 2021-09-20

Family

ID=53298840

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16718863.0T DK3286183T3 (da) 2015-04-20 2016-04-20 Isoxazolylsubstituerede benzimidazoler

Country Status (9)

Country Link
US (1) US10118920B2 (da)
EP (1) EP3286183B1 (da)
JP (1) JP6871864B2 (da)
CN (1) CN107750249A (da)
DK (1) DK3286183T3 (da)
ES (1) ES2888473T3 (da)
GB (1) GB201506658D0 (da)
HU (1) HUE056334T2 (da)
WO (1) WO2016170324A1 (da)

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AU2019245403A1 (en) 2018-03-29 2020-10-22 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
GB201806320D0 (en) * 2018-04-18 2018-05-30 Cellcentric Ltd Process
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CN112574189B (zh) * 2019-09-27 2024-05-31 海创药业股份有限公司 一种ep300/cbp抑制剂
CN112574191B (zh) * 2019-09-29 2024-01-23 南京圣和药业股份有限公司 异噁唑杂环类化合物及其应用
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US20230233558A1 (en) 2020-06-25 2023-07-27 Tolremo Therapeutics Ag Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
CN112250672B (zh) * 2020-10-21 2022-06-21 清华大学深圳国际研究生院 一种核苷碱基衍生物及其制备方法和应用
CN116670129A (zh) * 2020-12-31 2023-08-29 南京明德新药研发有限公司 苯并咪唑类化合物及其应用

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EP3286183B1 (en) 2021-08-25
US20180127402A1 (en) 2018-05-10
ES2888473T3 (es) 2022-01-04
CN107750249A (zh) 2018-03-02
US10118920B2 (en) 2018-11-06
GB201506658D0 (en) 2015-06-03
HUE056334T2 (hu) 2022-02-28
EP3286183A1 (en) 2018-02-28

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