DK3088384T3 - Aryloazol-2-yl-cyanoethylamino-forbindelser, fremgangsmåde til fremstilling og fremgangsmåde til anvendelse deraf - Google Patents
Aryloazol-2-yl-cyanoethylamino-forbindelser, fremgangsmåde til fremstilling og fremgangsmåde til anvendelse deraf Download PDFInfo
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Claims (20)
1. Parasiticid sammensætning i form afen injicerbarformulering, hvilken sammensætning omfatter en aryloazol-2-yl-cyanoethylaminforbindelse med formlen (I):
hvor: P er C-Ri eller N; Q er C-R2 eller N; V er C-Rs eller N; W er C-R9 eller N; X er C-R10 eller N; Y er C-R11 eller N; Ri; R2, Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, amino, amido, cyano, nitro, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, hydroxyalkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, phenoxy, alkoxyalkoxy, cycloalkyloxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, alkylamin, di(alkyl)amino, alkylcarbonylamino, alkylaminoalkoxy, dialkylaminoalkoxy, alkylaminoalkyl, dialkylaminoalkyl, aminoalkyl, formyl, HO2C-, alkyl-CkC-, usubstitueret eller substitueret aryl eller usubstitueret eller substitueret phenoxy, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl; R3, R4 og R5 hver, uafhængigt af hinanden, er hydrogen, halogen, alkyl, hydroxyalkyl, alkylthioalkyl, haloalkyl, alkyloxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkylsulfonyloxyalkyl; usubstitueret eller substitueret
cycloalkyl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af halogen og alkyl; usubstitueret eller substitueret phenyl, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylamin, di(alkyl)amino; eller FU og FU sammen med det carbonatom til hvilket de er bundet danner en cycloalkylring; R6 er hydrogen, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl eller usubstitueret eller substitueret benzyl, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylamin, di(alkyl)amino; R7 er hydrogen, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl eller usubstitueret eller substitueret phenyl hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, phenyl, phenoxy, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl alkylamin, di(alkyl)amino; usubstitueret eller substitueret hetaryl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, alkylamin, di(alkyl)amino; eller usubstitueret eller substitueret naphthyl eller quinolyl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, arylthio, alkoxy, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, alkylamin, di(alkyl)amino; Z er en direkte binding, C(0), C(S) eller S(0)P; a er 1, 2 eller 3; p er O, 1 eller 2; og salte deraf.
2. Parasiticid sammensætning ifølge krav 1, hvor P er C-Ri eller N; Q er C-R2 eller N; V er C-Rs eller N; W er C-R9 eller N; X er C-R10 eller N; Y er C-R11 eller N; Ri; R2, Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, amino, amido, cyano, nitro, halogen, Ci-Ce-alkyl, Ci-Ce-alkenyl, Ci-Ce-alkynyl, C3-C7-cycloalkyl, hydroxyl-Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-Ce-alkylthio arylthio, Ci-Cs-alkoxy, phenoxy, Ci-Ce-alkoxy-Ci-Ce-alkoxy, C3-C7-cycloalkyloxy, halo-Ci-Ce-alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-C6-alkylsulfinyl, halo-Ci-C6-alkylsulfinyl, -Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino, Ci-C6-alkylcarboxylamino, Ci-C6-alkylamino-Ci-C6-alkoxy, di-Ci-Ce-alkylamino-Ci-Ce-alkoxy, Ci-Ce-alkylamino-Ci-Ce-alkyl, di-Ci-Ce-alkylamino-Ci-C6-alkyl, amino-Ci-C6-alkyl, formyl, HO2C-, Ci-C6-alkyl-O2C-, usubstitueret eller substitueret aryl eller usubstitueret eller substitueret phenoxy, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, -halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, C1-C6-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsuIfnyl, halo-Ci-Ce-alkylsulfinyl, Ci-C6-alkylsulfonyl, halo-Ci-C6-alkylsulfonyl; R3, R4 og R5 hver, uafhængigt af hinanden, er hydrogen, halogen, Ci-C6-alkyl, hydroxy-Ci-Ce-alkyl, Ci-Ce-alkylthio-Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkoxy-Ci-Ce-alkyl, Ci-Ce-alkylsulfinyl-Ci-Ce-alkyl, Ci-Ce-alkylsulfonyl-Ci-Ce-alkyl, Ci-Ce-alkylsulfonyloxy-Ci-C6-alkyl; usubstitueret eller substitueret C3-C7-cycloalkyl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af halogen og Ci-C6-alkyl; usubstitueret eller substitueret phenyl, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, C1-C6-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-Ce-alkylsulfinyl, Ci-C6-alkylsulfonyl, halo-Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; eller FU og FU sammen med det carbonatom til hvilket de er bundet danner en cycloalkylring; FU er hydrogen, Ci-Ce-alkyl, Ci-Ce-alkoxy-Ci-Ce-alkyl, Ci-Ce-alkyloarbonyl, Ci-C6-alkylthiocarbonyl eller usubstitueret eller substitueret benzyl, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, C1-C6-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulflnyl, halo-Ci-Ce-alkylsulfinyl, Ci-C6-alkylsulfonyl, halo-Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; FU er hydrogen, Ci-Ce-alkyl, Ci-Ce-alkoxy-Ci-Ce-alkyl, Ci-Ce-alkylcarbonyl, Ci-Ce alkylthiocarbonyl eller usubstitueret eller substitueret phenyl hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, phenyl, phenoxy, Ci-Ce-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, C1-C6-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-Ce-alkylsulfinyl, Ci-C6-alkylsulfonyl, halo-Ci-C6-alkylsulfonyl Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; usubstitueret eller substitueret hetaryl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-Ce-alkoxy, halo-Ci-Ce-alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce alkylcarbonyl, Ci-C6-alkylsulfinyl, halo-Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; eller usubstitueret eller substitueret naphthyl eller quinolyl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, Ci-Ce-alkylcarbonyl, haloCi-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; Z er en direkte binding, C(O), C(S) eller S(O)P; a er 1, 2 eller 3; p er 0, 1 eller 2; og salte deraf.
3. Parasiticid sammensætning ifølge krav 2, hvor P og Q hver er N; V er C-Rs; W er C-R9; X er C-Rio; Y er C-Ru; Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, amino, amido, cyano, nitro, halogen, Ci-Ce-alkyl, C2-Ce-alkenyl, C2-Ce-alkynyl, C3-C7-cycloalkyl, hydroxy-Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkylthio, halo-Ci-C6-alkylthio arylthio, Ci-C6-alkoxy, phenoxy, Ci-C6-alkoxy-Ci-C6-alkoxy, C3-C7-cycloalkyloxy, halo-Ci-Ce-alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino, Ci-C6-alkylcarboxylamino, Ci-C6-alkylamino-Ci-C6-alkoxy, di-Ci-C6-alkylamino-Ci-C6-alkoxy, Ci-C6-alkylamino-Ci-C6-alkyl, di-Ci-C6-alkylamino-Ci-Ce-alkyl, amino-Ci-Cs-alkyl, formyl, HO2C-, Ci-Ce-alkyl-CkC-, usubstitueret eller substitueret aryl eller usubstitueret eller substitueret phenoxy, hvorved substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-Ce-alkylthio, arylthio, Ci-Ce-alkoxy, halo-Ci-Ce-alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-Ce-alkylsulfinyl, Ci-C6-alkylsulfonyl, halo-Ci-C6-alkylsulfonyl; R3, R4 og Re er H; Rs er methyl; R7 er usubstitueret eller substitueret phenyl hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkylthio, halo-Ci-C6-alkylthio, arylthio, Ci-Ce-alkoxy, halo-Ci-Ce -alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-C6-alkylsulfinyl, halo-Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; usubstitueret eller substitueret heteroaryl, hvor substituenterne hver kan være uafhængige af hinanden og er valgt fra gruppen bestående af cyano, nitro, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkylthio, halo-Ci-C6-alkylthlo, arylthio, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, Ci-Ce-alkylcarbonyl, halo-Ci-Ce-alkylcarbonyl, Ci-Ce-alkylsulfinyl, halo-Ci-Ce- alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-alkylamino, di(Ci-C6-alkyl)amino; Z er C(0); og a er 1; og salte deraf.
4. Parasiticid sammensætning ifølge krav 1, hvor P og Q hver er N; V er C-Rs; W er C-Rg; X er C-Rio; Y er C-Ru; R3, R4 og Re er hydrogen; Rs er hydrogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, hydroxy-Ci-Ce-alkyl, Ci-Ce-alkylthio-Ci-Ce-alkyl, Ci-Ce-alkyloxy-Ci-Ce-alkyl, eller Ci-Ce-alkylsulfonyloxy-Ci-Ce-alkyl; R7 er usubstitueret phenyl eller phenyl substitueret med én eller flere substituenter valgt fra gruppen bestående af Ci-C6-alkyl, halo-Ci-C6-alkyl, phenyl, phenyloxy, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, Ci-C6-alkylthlo, halo-Ci-C6-alkylthio, halo-Ci-C6-alkylsulfinyl og halo-Ci-C6-alkylsulfonyl; Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, halogen, C1-C6-alkyl, halo-Ci-Ce-alkyl,cyano, Ci-Ce-alkoxy, halo-Ci-Ce-alkoxy, Ci-Ce-alkenyl, Ci-C6-alkylamino, hydroxy-Ci-C6-alkyl, formyl, Ci-C6-alkylamino-Ci-C6-alkyl, HO2C-, Ci-C6-alkyl-O2C- eller usubstitueret eller substitueret phenyl hvor substituenterne er Ci-Ce-alkyl eller halo-Ci-Ce-alkyl; Z er C(O); a er 1; og salte deraf.
5. Parasiticid sammensætning ifølge krav 1, hvor P og Q hver er N; V er C-Rs; W er C-Rg; X er C-R10; Y er C-Ru; R3, R4 og Re er hydrogen; Rs er methyl, ethyl, butyl, CH2OH, CH2OCH3, CH2SCH3, eller CH2OSO2CH3; R7 er phenyl substitueret med butyl, CF3, phenyl, phenoxy, OCF3, SCF3, SOCF3, eller SO2CF3; Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, methyl, CH2NH2, CH2N(CH3)2, vinyl, CH2OH, CH(OH)CH2OH, CO2H, CO2CH3, Ph-CF3, F, Cl, Br, CF3, OCF3 eller CN; Z er C(O); a er 1; og salte deraf.
6. Parasiticid sammensætning ifølge krav 1, hvor P er N; Q er C-R2; V er C-Rs; W er C-Rg; X er C-R10; Y er C-Ru; R2 er hydrogen, Cl, methyl, methoxy, ethoxy, propoxy, butoxy, O(CH2)2OCH3, eller O(CH2)2N(CH3)2; R3, R4 og Re er hydrogen; Rs er methyl; R7 er phenyl substitueret med OCF3, phenoxy, eller SCF3; Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, Cl, Br, Ci-C6-alkyl; CF3, nitro, amino, amido, CO2CH3, eller NHCOCH3; Z er C(O); a er 1; og salte deraf.
7. Parasiticid sammensætning ifølge krav 1, hvor P er N; Q er C-R2 eller N; V er N; W er C-Rg; X er C-R10; Y er C-Ru; Fb er hydrogen, Cl, Br, eller methoxy; Fb, R4 og Re er hydrogen; Rs er methyl; R7 er phenyl substitueret med OCF3 eller SCF3; R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, Cl, Br eller methyl; Z er C(O); og a er 1; og salte deraf.
8. Parasiticid sammensætning ifølge krav 1, hvor: P er N; Q er C-R2; V er C-Rs; W er C-Rg; X er C-R10; Y er C-Ru; R2 er hydrogen, halogen, Ci-Ce-alkyl, halo-Ci-Ce-alkyl, Ci-Ce-alkoxy, halo-Ci-C6-alkoxy, Ci-C6-alkoxy-Ci-C6-alkoxy, eller Ci-C6-alkylamino-Ci-C6-alkoxy; R3, R4 og Re er hydrogen; Rs er hydrogen, Ci-Ce-alkyl, eller halo-Ci-Ce-alkyl; R7 er usubstitueret phenyl eller phenyl substitueret med én eller flere substituenter valgt fra gruppen bestående af Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, Ci-C6-alkylthio, halo-Ci-C6-alkylthio, halo-Ci-C6-alkylsulfinyl og halo-Ci-C6-alkylsulfonyl; Rs, R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, halogen, Ci-Ce-alkyl, halo-Ci-C6-alkyl, nitro, amino, amido, Ci-Ce-alkyl-CkC- eller Ci-C6-alkylcarbonylamino; Z er C(0); og a er 1.
9. Parasiticid sammensætning ifølge krav 1, hvor: P er N; Q er C-R2 eller N; V er N; W er C-Rg; X er C-Rio; Y er C-Ru; R2 er hydrogen, halogen, Ci-Ce-alkyl, Ci-Ce-alkoxy, eller halo-Ci-Ce-alkoxy; R3, R4 og Re er hydrogen; Rs er hydrogen, Ci-Ce-alkyl, eller halo-Ci-Ce-alkyl; R7 er usubstitueret phenyl eller phenyl substitueret med én eller flere substituenter valgt fra gruppen bestående af Ci-C6-alkyl, halo-Ci-C6-alkyl, Ci-C6-alkoxy, halo-Ci-C6-alkoxy, Ci-C6-alkylthio, halo-Ci-C6-alkylthio, halo-Ci-C6-alkylsulfinyl og halo-Ci-C6-alkylsulfonyl; R9, Rio og Ru hver, uafhængigt af hinanden, er hydrogen, halogen, C1-C6-alkyl, eller halo-Ci-Ce-alkyl; Z er C(O); og a er 1.
10. Parasiticid sammensætning ifølge krav 1, hvor: P er N; Q er C-R2 eller N; V er C-Rs eller N; W er C-Rg; X er C-R10; Y er C-Ru; R2 er hydrogen, Cl, Br, methyl eller methoxy; R3, R4 og Re er H; Rs er methyl; R7 er phenyl eventuelt substitueret med OCF3, SCF3 eller CHFCF3; Rs, R9, Rio og Ru, hver, uafhængigt af hinanden er H, Cl, Br, methyl, CF3 eller CN; Z er C(O); og a er 1.
11. Parasiticid sammensætning ifølge krav 1 hvor aryloazol-2-yl- cyanoethylaminforbindelsen er valgt fra: N-[2-(6-chlor-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.001) N-[2-(6-chlor-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethylthiobenzamid (forbindelse nr. 3.002) N-[2-(6-brom-7-methyl-2H-[l,2,3]triazolo[4,5-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.003) N-[2-(6-brom-7-methyl-2H-[l,2,3]triazolo[4,5-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethylthiobenzamid (forbindelse nr. 3.004) N-[2-(6-chlor-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.005) N-[2-(6-chlor-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethylthiobenzamid (forbindelse nr. 3.006) N-[2-(6-brom-3-methoxy-7-methyl-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.007) N-[2-(6-chlor-3-methoxy-7-methyl-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.008) N-[2-(6-brom-7-methyl-2H-pyrazolo[4,3-b]-pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.009) N-[2-(6-chlor-7-methyl-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.01-0) N-[2-(6-brom-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxy-benzamid (forbindelse nr. 3.011) N-[2-(6-brom-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4trifluormethylthiobenzamid (forbindelse nr. 3.012). N-[2-(6-brom-7-methyl-2H-pyrazolo[4,3-b]pyrid-in-2-yl)-l-cyano-l-methylethyl]-4 trifluormethylthiobenzamid (forbindelse nr. 3.023) N-[l-cyano-2-(3,-6-dichlor-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.017) N-[2-(3-brom-6-chlor-2H-pyrazolo[4,3-b]pyridin-2-yl)-l-cyano-l-methylethyl]-4-trifluormethoxybenzamid (forbindelse nr. 3.019).
12. Parasiticid sammensætning ifølge et hvilket som helst af de foregående krav der endvidere omfatter en yderligere aktiv bestanddel.
13. Parasiticid sammensætning ifølge et hvilket som helst af de foregående krav der er i form af en steril injicerbar vandig eller olieholdig suspension.
14. Parasiticid sammensætning ifølge et hvilket som helst af kravene 1 til 12 der er i form af en steril injicerbar opløsning.
15. Parasiticid sammensætning ifølge et hvilket som helst af de foregående krav til anvendelse i behandling af endoparasitisk infektion hos et pattedyr.
16. Parasiticid sammensætning til anvendelse ifølge krav 15, hvor endoparasitinfektionen er med en helminth valgt fra gruppen bestående af Anaplocephala (Anoplocephala), Ancylostoma, Anecator, Ascaris, Brugia, Bunostomum, Capillaria, Chabertia, Cooperia, Cyathostomum, Cylicocyclus, Cylicodontophorus, Cylicostephanus, Craterostomum, Dictyocaulus, Dipetalonema, Dipylidium, Dirofilaria, Dracunculus, Echinococcus, Enterobius, Fasciola, Filaroides, Habronema, Haemonchus, Metastrongylus, Moniezia, Necator, Nematodirus, Nippostrongylus, Oesophagostumum, Onchocerca, Ostertagia, Oxyuris, Paracaris, Schistosoma, Strongylus, Taenia, Toxocara, Strongyloides, Toxascaris, Trichinella, Trichuris, Trichostrongylus, Triodontophorous, Uncinaria, Wuchereria, og kombinationer deraf.
17. Parasiticid sammensætning til anvendelse ifølge krav 15, hvor helminthen er Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Nematodirus battus og kombinationer deraf.
18. Parasiticid sammensætning ifølge et hvilket som helst af kravene 1 til 14 til anvendelse i behandling afen ectoparasitisk infektion hos et pattedyr.
19. Parasiticid sammensætning til anvendelse ifølge krav 18, hvor ectoparasitinfektionen er med en ectoparasit valgt fra gruppen bestående af lopper, tæger, mider, moskitoer, fluer, lus, spyfluer og kombinationer deraf.
20. Parasiticid sammensætning til anvendelse ifølge krav 18, hvor ectoparasitinfektionen er med lopper.
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DK08769452.7T DK2155699T5 (da) | 2007-05-15 | 2008-05-12 | Arylazol-2-yl-cyanoethylamino-forbindelser, fremgangsmåde til fremstilling og fremgangsmåde til anvendelse deraf |
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