DK2975030T3 - Dihydropyridazin-3,5-dion-derivat - Google Patents

Dihydropyridazin-3,5-dion-derivat Download PDF

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Publication number
DK2975030T3
DK2975030T3 DK14765619.3T DK14765619T DK2975030T3 DK 2975030 T3 DK2975030 T3 DK 2975030T3 DK 14765619 T DK14765619 T DK 14765619T DK 2975030 T3 DK2975030 T3 DK 2975030T3
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DK
Denmark
Prior art keywords
dihydropyridazine
dion
derivative
Prior art date
Application number
DK14765619.3T
Other languages
English (en)
Inventor
Yoshihito Ohtake
Naoki Okamoto
Yoshiyuki Ono
Hirotaka Kashiwagi
Atsushi Kimbara
Takeo Harada
Nobuyuki Hori
Yoshihisa Murata
Kazutaka Tachibana
Shota Tanaka
Kenichi Nomura
Mitsuaki Ide
Eisaku Mizuguchi
Yasuhiro Ichida
Shuichi Ohtomo
Naoshi Horiba
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
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Publication of DK2975030T3 publication Critical patent/DK2975030T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/504Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18Bridged systems
DK14765619.3T 2013-03-13 2014-03-13 Dihydropyridazin-3,5-dion-derivat DK2975030T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013051082 2013-03-13
JP2013132889 2013-06-25
PCT/JP2014/056778 WO2014142273A1 (ja) 2013-03-13 2014-03-13 ジヒドロピリダジン-3,5-ジオン誘導体

Publications (1)

Publication Number Publication Date
DK2975030T3 true DK2975030T3 (da) 2020-08-31

Family

ID=51536921

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14765619.3T DK2975030T3 (da) 2013-03-13 2014-03-13 Dihydropyridazin-3,5-dion-derivat

Country Status (30)

Country Link
EP (2) EP2975030B1 (da)
JP (2) JP5814488B2 (da)
KR (2) KR102072268B1 (da)
CN (1) CN105073715B (da)
AU (1) AU2014230552B2 (da)
BR (1) BR112015022092B1 (da)
CA (1) CA2901868C (da)
CL (1) CL2015002543A1 (da)
CR (1) CR20150505A (da)
DK (1) DK2975030T3 (da)
ES (1) ES2811126T3 (da)
HK (1) HK1212700A1 (da)
HR (1) HRP20201211T1 (da)
HU (1) HUE050577T2 (da)
IL (1) IL240825B (da)
LT (1) LT2975030T (da)
MX (1) MX2015012537A (da)
MY (1) MY174269A (da)
NZ (1) NZ711182A (da)
PE (1) PE20151535A1 (da)
PH (1) PH12015501940A1 (da)
PL (1) PL2975030T3 (da)
PT (1) PT2975030T (da)
RS (1) RS60911B1 (da)
RU (1) RU2662832C2 (da)
SG (1) SG11201507345RA (da)
SI (1) SI2975030T1 (da)
TW (2) TWI683811B (da)
UA (1) UA118755C2 (da)
WO (1) WO2014142273A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2975030T3 (da) * 2013-03-13 2020-08-31 Chugai Pharmaceutical Co Ltd Dihydropyridazin-3,5-dion-derivat
MY182634A (en) * 2014-09-12 2021-01-27 Chugai Pharmaceutical Co Ltd Pharmaceutical containing sodium-dependent phosphate transporter inhibitor
WO2018019755A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
WO2018019721A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
CN110885290A (zh) * 2019-12-16 2020-03-17 阿里生物新材料(常州)有限公司 一种3-氟-2-甲基-4-三氟甲基苯胺盐酸盐的合成方法
AU2021296100A1 (en) 2020-06-26 2023-02-16 Nihon Nohyaku Co., Ltd. Aryltetrahydropyridazine derivative or salt thereof, insecticidal agent containing the compound, and method of use thereof
WO2022221182A1 (en) * 2021-04-12 2022-10-20 Jnana Therapeutics Inc. Small molecule inhibitors of mammalian slc34a1 function
AU2022288895A1 (en) 2021-06-08 2024-01-18 Chugai Seiyaku Kabushiki Kaisha Formulation containing dihydropyridazine-3,5-dione derivative
AR126060A1 (es) 2021-06-08 2023-09-06 Chugai Pharmaceutical Co Ltd Método para producir derivado de dihidropiridazin-3,5-diona
WO2023219127A1 (ja) * 2022-05-11 2023-11-16 中外製薬株式会社 嚢胞性疾患を治療または予防するための医薬組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2292337C2 (ru) * 2002-02-19 2007-01-27 Оно Фармасьютикал Ко., Лтд. Конденсированные производные пиридазина и лекарственные препараты, содержащие данные соединения в качестве активного ингредиента
CN1662529A (zh) * 2002-06-19 2005-08-31 默克专利有限公司 作为磷酸二酯酶iv抑制剂的噻唑衍生物
UA93678C2 (ru) * 2005-05-18 2011-03-10 Астразенека Аб Гетероциклические ингибиторы mek и их применение
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
UA97498C2 (ru) * 2006-11-03 2012-02-27 Басф Се Способ получения дифторметилпиразолилкарбоксилатов
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
WO2010022240A1 (en) 2008-08-20 2010-02-25 Fibrogen, Inc. Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
WO2011048611A1 (en) * 2009-10-07 2011-04-28 Torrent Pharmaceuticals Limited Novel fused pyridazine derivatives
CA2793856C (en) * 2010-04-28 2018-07-17 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
WO2012006474A2 (en) * 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2591354B1 (en) 2010-07-07 2016-09-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN103906741B (zh) 2011-10-27 2016-01-20 安斯泰来制药株式会社 氨烷基取代的n-噻吩基苯甲酰胺衍生物
DK2975030T3 (da) * 2013-03-13 2020-08-31 Chugai Pharmaceutical Co Ltd Dihydropyridazin-3,5-dion-derivat

Also Published As

Publication number Publication date
TW201446756A (zh) 2014-12-16
CR20150505A (es) 2015-10-26
MX2015012537A (es) 2016-02-10
SI2975030T1 (sl) 2020-10-30
BR112015022092A8 (pt) 2018-01-23
PH12015501940B1 (en) 2016-01-11
BR112015022092B1 (pt) 2023-04-11
HRP20201211T1 (hr) 2020-11-13
KR20160119282A (ko) 2016-10-12
PL2975030T3 (pl) 2021-01-11
ES2811126T3 (es) 2021-03-10
EP2975030A4 (en) 2016-08-03
IL240825B (en) 2020-07-30
KR20150127721A (ko) 2015-11-17
NZ711182A (en) 2020-05-29
CA2901868C (en) 2022-05-03
TWI596095B (zh) 2017-08-21
MY174269A (en) 2020-04-01
JP5814488B2 (ja) 2015-11-17
WO2014142273A1 (ja) 2014-09-18
CN105073715A (zh) 2015-11-18
RU2015143507A (ru) 2017-04-19
CA2901868A1 (en) 2014-09-18
CN105073715B (zh) 2017-12-01
KR102072268B1 (ko) 2020-01-31
EP2975030B1 (en) 2020-07-15
PH12015501940A1 (en) 2016-01-11
KR101664460B1 (ko) 2016-10-10
EP2975030A1 (en) 2016-01-20
HK1212700A1 (zh) 2016-06-17
LT2975030T (lt) 2020-09-25
RU2662832C2 (ru) 2018-07-31
JP2016040262A (ja) 2016-03-24
JP6420738B2 (ja) 2018-11-07
BR112015022092A2 (pt) 2017-07-18
SG11201507345RA (en) 2015-10-29
HUE050577T2 (hu) 2020-12-28
AU2014230552B2 (en) 2017-11-16
JPWO2014142273A1 (ja) 2017-02-16
TWI683811B (zh) 2020-02-01
UA118755C2 (uk) 2019-03-11
CL2015002543A1 (es) 2016-02-26
AU2014230552A1 (en) 2015-08-13
PT2975030T (pt) 2020-09-28
TW201741304A (zh) 2017-12-01
EP3757093A1 (en) 2020-12-30
IL240825A0 (en) 2015-10-29
PE20151535A1 (es) 2015-10-28
RS60911B1 (sr) 2020-11-30

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