DK2844637T5 - Substituerede 3-haloallylamin-inhibitorer af ssao samt anvendelser deraf - Google Patents

Substituerede 3-haloallylamin-inhibitorer af ssao samt anvendelser deraf Download PDF

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DK2844637T5
DK2844637T5 DK13784562.4T DK13784562T DK2844637T5 DK 2844637 T5 DK2844637 T5 DK 2844637T5 DK 13784562 T DK13784562 T DK 13784562T DK 2844637 T5 DK2844637 T5 DK 2844637T5
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compound
pharmaceutically acceptable
disease
acceptable salt
compounds
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DK2844637T3 (da
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Mandar Deodhar
Alison Dorothy Findlay
Jonathan Stuart Foot
Wolfgang Jarolimek
Ian Alexander Mcdonald
Alan Robertson
Craig Ivan Turner
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Boehringer Ingelheim Int
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Claims (18)

1
1. Forbindelse med formel II:
Formel II eller et farmaceutisk acceptabelt salt, solvat eller polymorf form deraf; hvor: 5 R5 er en usubstitueret phenylengruppe eller en phenylengruppe substitueret med én eller flere grupper uafhængigt valgt blandt alkyl, halogen, alkoxy og halogenalkyl; R5 er valgt fra
R7 og R8 er uafhængigt valgt fra gruppen bestående af hydrogen, eventuelt substitute) eret Ci ealkyl og eventuelt substitueret C3-7cycloalkyl; og X er oxygen; hvor udtrykket "alkyl" henviser til monovalente ligekædede eller forgrenede mættede carbonhydridradikaler med fra 1 til 6 carbonatomer, og hvor udtrykket "halo" henviser til fluor, chlor, brom og iod og 15 hvor udtrykket "alkoxy" henviser til ligekædede eller forgrenede alkyloxygrupper, hvor alkyl er som defineret ovenfor, og hvor udtrykket "eventuelt substitueret" betyder den gruppe, som dette udtryk angår, kan være usubstitueret eller kan være substitueret med én eller flere grupper uafhængigt valgt blandt halogen, Ci-C5alkyl, C2-C5alkenyl, Ci-C6halogenalkyl, Ci-C6alkoxy, 20 hydroxy(Ci-5)alkyl, C3-C5cycloalkyl, C(0)H, C(0)0H, NHC(0)H, NHC(0)Ci-C4alkyl, C(0)Ci-C4alkyl, NH2, NHCi-C4alkyl , N(Ci-C4alkyl)2, N02, OH og CN.
2. Forbindelse ifølge krav 1, hvor R5 er en usubstitueret phenylengruppe eller en phenylengruppe substitueret med én eller flere grupper uafhængigt valgt blandt methyl, fluor, chlor, brom, OCH3 og CF3.
3. Forbindelse ifølge et hvilket som helst af kravene 1 eller 2, hvor R7 og R8 begge er hydrogen, R7 og R8 begge er Ci-5alkyl, eller R7 er hydrogen, og R8 er Ci-5alkyl.
4. Forbindelse ifølge et hvilket som helst af kravene 1 til 3, hvor R5 er
hvori R7 og R8 er defineret i krav 1 eller 3.
5. Forbindelse ifølge et hvilket som helst af kravene 1 til 3, hvor R6 er
hvori R7 og R8 er defineret i krav 1 eller 3.
6. Forbindelse ifølge krav 1, hvor forbindelsen er valgt fra gruppen bestående af:
eller et farmaceutisk acceptabelt salt eller solvat deraf.
7. Forbindelse ifølge krav 1, hvor forbindelsen er (E)-4-(2-(aminomethyl)-3-fluorallyloxy)-/V-tert-butylbenzamid, eller et farmaceutisk acceptabelt salt eller solvat deraf.
8. Farmaceutisk acceptabelt salt af en forbindelse ifølge et hvilket som helst af kravene 1 til 7.
9. Farmaceutisk acceptabelt salt ifølge krav 8, kendetegnet ved, at det er et syreadditionssalt.
10. Farmaceutisk acceptabelt salt ifølge krav 9, kendetegnet ved, at syreadditionssaltet er valgt fra gruppen bestående af hydrochlorider, hydrobromider, sulfater, formater, acetater, lactater, malater, tartrater, citrater, ascorbater, succinater, maleater, butyrater, valerater og fumarater.
11. Farmaceutisk acceptabelt salt ifølge krav 10, kendetegnet ved, at syreadditionssaltet er et hydrochloridsalt.
12. Farmaceutisk acceptabelt salt ifølge krav 11, hvor det farmaceutisk acceptable salt er (E)-4-(2-(aminomethyl)-3-fluorallyloxy)-/V-tert'-butylbenzamidhydrochlorid.
13. Sammensætning omfattende en forbindelse ifølge et hvilket som helst af kravene 1 til 7 eller et farmaceutisk acceptabelt salt ifølge et hvilket som helst af kravene 8 til 12 eller et solvat deraf og mindst et farmaceutisk acceptabelt excipiens, bærer eller fortyndingsmiddel.
14. Forbindelse ifølge et hvilket som helst af kravene 1 til 7 eller et farmaceutisk acceptabelt salt ifølge et hvilket som helst af kravene 8 til 12 eller et solvat deraf til anvendelse i en fremgangsmåde til behandling af en sygdom forbundet med eller moduleret af SSAO/VAP-l-protein, omfattende indgivelse til et individ med behov derfor af en terapeutisk virkningsfuld mængde af forbindelsen eller det farmaceutisk acceptable salt eller solvat deraf, hvor sygdommen er inflammation, fibrose, en diabetesfremkaldt sygdom, en neuro-inflammatorisk sygdom eller en cancer.
15. Forbindelse eller farmaceutisk acceptabelt salt eller solvat til anvendelse ifølge krav 14, hvor inflammationen er forbundet med leversygdom, respiratorisk sygdom, cystisk fibrose, astma eller kronisk obstruktiv lungesygdom eller okulær sygdom.
16. Forbindelse eller farmaceutisk acceptabelt salt eller solvat til anvendelse ifølge krav 14, hvor sygdommen er en diabetesfremkaldt sygdom udvalgt fra gruppen bestående af diabetisk nefropati, glomerulosclerose, diabetisk retinopati, ikke-alkoholisk fedtleversygdom og choroidal neovaskularisering.
17. Forbindelse eller farmaceutisk acceptabelt salt eller solvat til anvendelse ifølge krav 14, hvor sygdommen er valgt fra gruppen bestående af cystisk fibrose, leverfibrose, levercirrhose, nyrefibrose, sclerodermi, idiopatisk lungefibrose og strålingsinduceret fibrose.
18. Forbindelse eller farmaceutisk acceptabelt salt eller solvat til anvendelse ifølge krav 17, kendetegnet ved, at sygdommen er en ikke-alkoholisk fedtleversygdom, ikke-alkoholisk steatohepatitis (NASFI) eller alkoholinduceret fibrose, der fører til levercirrhose.
DK13784562.4T 2012-05-02 2013-04-05 Substituerede 3-haloallylamin-inhibitorer af ssao samt anvendelser deraf DK2844637T5 (da)

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RS57086B1 (sr) * 2012-05-02 2018-06-29 Boehringer Ingelheim Int Supstituisani 3-haloalilamin inhibitori ssao i njihova primena
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
JP2018076236A (ja) * 2015-06-05 2018-05-17 株式会社アールテック・ウエノ がんを処置するための医薬組成物
JP2019502672A (ja) 2015-12-07 2019-01-31 ベネボレンタイ ケンブリッジ リミティド 疼痛の治療のためのｖａｐ−１阻害剤
JP6843888B2 (ja) * 2016-02-12 2021-03-17 ファーマクシス リミテッド リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用
WO2018027892A1 (en) * 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
MX2019004549A (es) * 2016-10-19 2019-06-12 Boehringer Ingelheim Int Combinaciones que comprenden un inhibidor ssao/vap-1 y un inhibidor sglt2 y usos de los mismos.
CN108341752B (zh) * 2017-01-21 2022-12-23 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2018148856A1 (en) * 2017-02-14 2018-08-23 Eli Lilly And Company Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors
NZ755847A (en) * 2017-03-01 2021-12-24 Boehringer Ingelheim Int Transition metal-catalyzed protodecarboxylation of α-halo-acrylic acid derivatives
US20200069648A1 (en) * 2017-03-02 2020-03-05 Pharmaxis Ltd. Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof
WO2018196677A1 (zh) * 2017-04-28 2018-11-01 四川科伦博泰生物医药股份有限公司 氟代烯丙胺衍生物及其用途
CN110662534A (zh) 2017-05-31 2020-01-07 勃林格殷格翰国际有限公司 包含(e)-4-(2-(氨基甲基)-3-氟烯丙基氧基)-n-叔丁基苯甲酰胺的药物组合物和药物剂型，其制备方法、治疗方法及用途
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
WO2018233633A1 (zh) 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂
CN109251166B (zh) * 2017-07-13 2021-11-05 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
CN110914234B (zh) * 2017-08-04 2023-06-23 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
CN109810041B (zh) * 2017-11-21 2023-08-15 药捷安康(南京)科技股份有限公司 卤代烯丙基胺类ssao/vap-1抑制剂及其应用
CN109988109B (zh) * 2017-12-29 2020-12-29 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其用途
CN109988106B (zh) * 2017-12-29 2023-03-31 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
MX2020009843A (es) 2018-03-22 2020-12-11 Viking Therapeutics Inc Formas cristalinas y metodos de produccion de formas cristalinas de un compuesto.
WO2020006177A1 (en) * 2018-06-29 2020-01-02 Blade Therapeutics, Inc. Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof
KR20200004036A (ko) 2018-07-03 2020-01-13 주식회사유한양행 (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법
KR20210045984A (ko) * 2018-08-03 2021-04-27 파맥시스 엘티디 라이실 옥시다제의 할로알릴아민 설폰 유도체 저해제 및 이의 용도
CN110938059A (zh) * 2018-09-25 2020-03-31 上海轶诺药业有限公司 胺基脲敏感性胺氧化酶抑制剂制备及其应用
WO2020063854A1 (zh) * 2018-09-27 2020-04-02 南京明德新药研发有限公司 作为vap-1抑制剂的喹啉类衍生物
CN113164489A (zh) * 2018-09-28 2021-07-23 奥克塞拉有限公司 Vap-1的抑制剂
CA3114208A1 (en) * 2018-09-28 2020-04-02 Acucela Inc. Inhibitors of vap-1
EP3870162A4 (en) * 2018-10-24 2022-08-24 Metacrine, Inc. SSAO INHIBITORS AND USES THEREOF
RS64963B1 (sr) 2018-10-29 2024-01-31 Boehringer Ingelheim Int Piridinil sulfonamidni derivati, farmaceutske kompozicije i njihova upotreba
CN112955214B (zh) * 2018-10-29 2024-05-07 勃林格殷格翰国际有限公司 吡啶基磺酰胺衍生物、药物组合物及其用途
KR20210099612A (ko) * 2018-12-05 2021-08-12 바이킹 테라퓨틱스 인코포레이티드 간 장애의 치료를 위한 조성물 및 방법
TW202039486A (zh) * 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 ***并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
TWI835945B (zh) 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
US20220024880A1 (en) 2018-12-20 2022-01-27 Shandong Danhong Pharmaceutical Co., Ltd. Process route of compound of formula (iv), crystal form and preparation method therefor
CN111434662B (zh) 2019-01-11 2023-01-10 药捷安康(南京)科技股份有限公司 卤代烯丙基胺类化合物及其应用
US20220315536A1 (en) * 2019-05-20 2022-10-06 Sunshine Lake Pharma Co., Ltd. Isoquinolinone compound for inhibiting ssao/vap-1, and use thereof
JP2022544031A (ja) * 2019-07-25 2022-10-17 ファーマクシス リミテッド リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用
IL292416A (en) * 2019-10-29 2022-06-01 Eccogene Shanghai Co Ltd ssao inhibitors and their use
WO2021102774A1 (zh) * 2019-11-28 2021-06-03 广东东阳光药业有限公司 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途
US20230127498A1 (en) * 2020-03-25 2023-04-27 Terns, Inc. Treatment of respiratory disorders
CN111654920B (zh) * 2020-06-02 2022-03-11 重庆邮电大学 一种分布式能效子载波功率分配方法
WO2021258159A1 (en) * 2020-06-26 2021-12-30 Pharmaxis Ltd. Haloallylamine dual amine oxidase inhibitors
CA3193057A1 (en) 2020-08-25 2022-03-03 Eli Lilly And Company Polymorphs of an ssao inhibitor
CN114621190B (zh) * 2020-12-14 2023-12-05 上海拓界生物医药科技有限公司 一种烯丙基胺类衍生物及其用途
CN114621243B (zh) * 2020-12-14 2024-03-01 上海拓界生物医药科技有限公司 一种磺酰胺类衍生物及其用途
CN114621189B (zh) * 2020-12-14 2024-01-02 上海拓界生物医药科技有限公司 一种内酰胺类衍生物及其用途
WO2024044813A1 (en) * 2022-08-29 2024-03-07 Pharmaxis Ltd. Novel selective inhibitors of lysyl oxidases

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4454158A (en) 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ZA855101B (en) * 1984-07-13 1986-05-28 Merrell Dow Pharma Fluoroallylaine derivatives
US4699928A (en) 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US4650907A (en) 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US6010715A (en) 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
US6024975A (en) 1992-04-08 2000-02-15 Americare International Diagnostics, Inc. Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5759542A (en) 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5983134A (en) 1995-04-23 1999-11-09 Electromagnetic Bracing Systems Inc. Electrophoretic cuff apparatus drug delivery system
US6316652B1 (en) 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
US6039975A (en) 1995-10-17 2000-03-21 Hoffman-La Roche Inc. Colon targeted delivery system
TW345603B (en) 1996-05-29 1998-11-21 Gmundner Fertigteile Gmbh A noise control device for tracks
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
JP2000508339A (ja) 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
KR100719273B1 (ko) 1997-10-28 2007-05-18 반도 카가쿠 가부시키가이샤 피부 패치 시트 및 그것을 위한 베이스 시트의 제조 방법
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
AU2003259965A1 (en) 2002-08-20 2004-03-11 Neurogenetics, Inc. Methods and compositions for modulating amyloid beta
AU2005216955A1 (en) 2004-02-25 2005-09-09 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
CN1921841A (zh) * 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
WO2007005737A2 (en) 2005-07-01 2007-01-11 Case Western Reserve University Amine oxidase inhibitors
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
CA2658096A1 (en) 2006-07-19 2008-01-24 Osurf (Ohio State University Research Foundation) Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
CN103120690A (zh) 2007-10-19 2013-05-29 株式会社·R-技术上野 用于治疗白内障的药物组合物
US20090170770A1 (en) 2007-11-06 2009-07-02 Ali Hafezi-Moghadam Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor
JP2011504485A (ja) * 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
UA112154C2 (uk) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
RS57086B1 (sr) * 2012-05-02 2018-06-29 Boehringer Ingelheim Int Supstituisani 3-haloalilamin inhibitori ssao i njihova primena

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