DK2813512T3 - Fremgangsmåde til cyklisering af en peptidforbindelse - Google Patents
Fremgangsmåde til cyklisering af en peptidforbindelse Download PDFInfo
- Publication number
- DK2813512T3 DK2813512T3 DK12861199.3T DK12861199T DK2813512T3 DK 2813512 T3 DK2813512 T3 DK 2813512T3 DK 12861199 T DK12861199 T DK 12861199T DK 2813512 T3 DK2813512 T3 DK 2813512T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclizing
- procedure
- peptide connection
- peptide
- connection
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011288865 | 2011-12-28 | ||
| JP2012156943 | 2012-07-12 | ||
| PCT/JP2012/084103 WO2013100132A1 (ja) | 2011-12-28 | 2012-12-28 | ペプチド化合物の環化方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2813512T3 true DK2813512T3 (da) | 2021-04-26 |
Family
ID=48697609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12861199.3T DK2813512T3 (da) | 2011-12-28 | 2012-12-28 | Fremgangsmåde til cyklisering af en peptidforbindelse |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9409952B2 (da) |
| EP (2) | EP3974563A1 (da) |
| JP (5) | JP6294080B2 (da) |
| DK (1) | DK2813512T3 (da) |
| HU (1) | HUE054006T2 (da) |
| TW (5) | TWI787670B (da) |
| WO (1) | WO2013100132A1 (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3974563A1 (en) * | 2011-12-28 | 2022-03-30 | Chugai Seiyaku Kabushiki Kaisha | Cyclic peptides |
| EP4166664A1 (en) | 2015-03-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-trna synthetase and use thereof |
| CN107835871B (zh) * | 2015-04-23 | 2021-07-02 | 豪夫迈·罗氏有限公司 | 用于肽环化和蛋白酶处理的方法和组合物 |
| US10011631B2 (en) * | 2015-12-01 | 2018-07-03 | The University Of Hong Kong | Stapled helical peptides and methods of synthesis |
| EP3424941A4 (en) * | 2016-03-03 | 2019-10-23 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF PRODUCTION OF NON-CYCLIC PEPTIDE NUCLEIC ACID COMPLEX WITH AMINO ACID WITH THIOL GROUP, IN ADDITION TO THE AMINO GROUP ON N-TERMINUS, LIBRARY THEREOF, AND CYCLIC PEPTIDE NUCLEIC ACID COMPLEX LIBRARY THEREOF |
| JP6906547B2 (ja) * | 2016-12-09 | 2021-07-21 | 富士フイルム株式会社 | ミックスモードアフィニティクロマトグラフィー用担体 |
| US20190380958A1 (en) | 2016-12-28 | 2019-12-19 | Chugai Seiyaku Kabushiki Kaisha | Self-emulsifying drug formulation for improving membrane permeability of compound |
| JP7187323B2 (ja) * | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| WO2018201050A1 (en) * | 2017-04-28 | 2018-11-01 | Board Of Trustees Of Michigan State University | Tryptathionine biosynthesis by flavin mono-oxygenase 1 (fmo1) |
| US11807664B2 (en) | 2017-05-12 | 2023-11-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic organic compound |
| JP7232758B2 (ja) * | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| EP3636656A4 (en) | 2017-06-09 | 2021-04-14 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR SYNTHESIS OF A PEPTIDE CONTAINING AN N-SUBSTITUTED AMINO ACID |
| ES2907640T3 (es) * | 2017-07-20 | 2022-04-25 | Bristol Myers Squibb Co | Proceso para la preparación de N-((1R,2S,5R)-5-(terc-butilamino)-2-((S)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| US11814621B2 (en) | 2018-06-01 | 2023-11-14 | Northwestern University | Expanding the chemical substrates for genetic code reprogramming |
| EP3805757A4 (en) | 2018-06-04 | 2022-03-23 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR DETECTING A COMPLEX |
| WO2019235581A1 (ja) | 2018-06-06 | 2019-12-12 | 国立大学法人大阪大学 | Ｒｅｇｎａｓｅ－１が関与する疾患の治療および／または予防方法 |
| US11732002B2 (en) | 2018-11-30 | 2023-08-22 | Chugai Seiyaku Kabushiki Kaisha | Deprotection method and resin removal method in solid-phase reaction for peptide compound or amide compound, and method for producing peptide compound |
| EP3896056A4 (en) * | 2018-12-12 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | AMINO ACID HAVING A FUNCTIONAL GROUP CAPABLE OF FORMING AN INTERMOLECULAR HYDROGEN BOND, PEPTIDE COMPOUND CONTAINING IT AND METHOD FOR PRODUCTION |
| EP3904568A4 (en) | 2018-12-26 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | ARNT MUTATED FOR CODON EXPANSION |
| CN109824622B (zh) * | 2019-02-27 | 2022-12-30 | 中国科学技术大学 | 一类细胞内形成纳米结构杀死癌细胞的前体药物及其制法 |
| EP3978018A4 (en) | 2019-05-31 | 2023-07-19 | Osaka University | NEW THERAPEUTIC AGENT AGAINST DIGESTIVE CANCERS, AND ASSOCIATED SCREENING METHOD |
| US20240092836A1 (en) | 2019-10-08 | 2024-03-21 | Genefrontier Corporation | Cyclic peptide having ctla-4 inhibitory activity and use thereof |
| CR20220235A (es) * | 2019-11-07 | 2022-07-02 | Chugai Pharmaceutical Co Ltd | Compuesto de péptidos cíclicos que tiene acción inhibidora de kras |
| WO2021090856A1 (ja) | 2019-11-07 | 2021-05-14 | 中外製薬株式会社 | 立体障害の大きなアミノ酸を含むペプチド化合物の製造方法 |
| CN114787359A (zh) | 2019-12-12 | 2022-07-22 | 中外制药株式会社 | 产生含有非天然氨基酸的肽的方法 |
| US20230108274A1 (en) | 2019-12-26 | 2023-04-06 | Chugai Seiyaku Kabushiki Kaisha | Composition for translation, and method for producing peptide |
| WO2021246471A1 (ja) | 2020-06-03 | 2021-12-09 | 中外製薬株式会社 | 高難度配列の効率的ペプチド縮合法 |
| TW202208623A (zh) | 2020-06-25 | 2022-03-01 | 日商中外製藥股份有限公司 | 具有經改變之遺傳密碼表的轉譯系統 |
| US20230391818A1 (en) | 2020-11-05 | 2023-12-07 | Chugai Seiyaku Kabushiki Kaisha | Peptide synthesis method for suppressing defect caused by diketopiperazine formation |
| TW202235429A (zh) | 2020-12-25 | 2022-09-16 | 日商中外製藥股份有限公司 | 含ｎ－置換－胺基酸殘基之胜肽化合物的製備方法 |
| JPWO2022138892A1 (da) | 2020-12-25 | 2022-06-30 | ||
| WO2022145444A1 (ja) | 2020-12-28 | 2022-07-07 | 中外製薬株式会社 | アミノ酸の固相合成用樹脂への担持方法 |
| WO2022173627A2 (en) * | 2021-02-02 | 2022-08-18 | Northwestern University | Ribosome-mediated polymerization of novel chemistries |
| AU2022270499A1 (en) | 2021-05-07 | 2023-11-23 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical use of cyclic peptide compound |
| TW202309063A (zh) | 2021-05-07 | 2023-03-01 | 日商中外製藥股份有限公司 | 具有相對於ｈｒａｓ與ｎｒａｓ選擇性ｋｒａｓ抑制作用的環狀化合物 |
| AR125800A1 (es) * | 2021-05-07 | 2023-08-16 | Chugai Pharmaceutical Co Ltd | Métodos para producir compuestos cíclicos que comprendan residuos de aminoácidos sustituidos con n |
| CA3219090A1 (en) | 2021-05-07 | 2022-11-10 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing cyclic peptide compound and method for producing same |
| WO2022234639A1 (ja) | 2021-05-07 | 2022-11-10 | 中外製薬株式会社 | 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子 |
| AU2022269959A1 (en) | 2021-05-07 | 2023-11-16 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| EP4378944A1 (en) | 2021-09-30 | 2024-06-05 | Chugai Seiyaku Kabushiki Kaisha | Compound having photocleavable site, linker, and screening method using same |
| KR20240070705A (ko) | 2021-10-13 | 2024-05-21 | 추가이 세이야쿠 가부시키가이샤 | 펩타이드 화합물 및 계면활성제를 포함하는 조성물 |
| TW202406566A (zh) | 2022-05-02 | 2024-02-16 | 日商中外製藥股份有限公司 | 包含用於與界面活性劑結合使用之胜肽化合物的組合物 |
| CN115286671B (zh) * | 2022-07-13 | 2023-06-23 | 康龙化成(宁波)科技发展有限公司 | 一种寡聚核酸-噻唑烷类化合物、合成方法、应用 |
| WO2024085235A1 (ja) * | 2022-10-20 | 2024-04-25 | 中外製薬株式会社 | 環状ペプチドの結晶の製造方法 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57159747A (en) | 1981-03-27 | 1982-10-01 | Kenji Okawa | Synthesis of amino acid derivative |
| JPS60169451A (ja) | 1984-02-13 | 1985-09-02 | Mitsui Toatsu Chem Inc | Ｌ−フエニルアラニンの分離精製法 |
| FR2583432B1 (fr) | 1985-06-13 | 1988-11-04 | Inst Francais Du Petrole | Procede de production enzymatique de l-a-aminoacides a partir d'a-cetoacides |
| ES8607214A1 (es) | 1985-10-16 | 1986-06-01 | Gema Sa | Procedimiento enzimatico de resolucion de n-fenilacetil-ami-nocompuestos y purificacion de sus isomeros opticamente ac- tivos |
| US4859736A (en) | 1987-03-30 | 1989-08-22 | Ciba-Geigy Corporation | Synthetic polystyrene resin and its use in solid phase peptide synthesis |
| DE3733198A1 (de) | 1987-10-01 | 1989-04-13 | Kernforschungsanlage Juelich | Enzymatisches verfahren zur herstellung von dipeptiden |
| JPH0681759B2 (ja) | 1988-03-31 | 1994-10-19 | 信越化学工業株式会社 | ポリペプチドの製造方法 |
| EP1712623B1 (en) * | 1997-01-21 | 2011-10-19 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| US20020068301A1 (en) | 1997-05-28 | 2002-06-06 | Hung-Sen Lai | Cyclic peptide libraries and methods of use thereof to identify binding motifs |
| JP4502293B2 (ja) | 1999-06-04 | 2010-07-14 | 長瀬産業株式会社 | 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用 |
| DE19942624A1 (de) | 1999-08-28 | 2001-03-08 | Chemotopix Gmbh | Verfahren zur Herstellung von zyklischen Peptidomimetika |
| IL151935A0 (en) | 2000-04-19 | 2003-04-10 | Schering Corp | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties |
| EP1277755A4 (en) | 2000-04-21 | 2006-01-11 | Nagase & Co Ltd | OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT BY AXIAL ASYMMETRY, METHOD FOR THE PRODUCTION THEREOF, AND THEIR APPLICATION IN THE ASYMMETRIC SYNTHESIS OF ALPHA-AMINO-ACID DERIVATIVES |
| JP4061043B2 (ja) | 2000-12-28 | 2008-03-12 | 株式会社ポストゲノム研究所 | ｉｎｖｉｔｒｏ転写／翻訳系によるペプチド等の製造方法 |
| EP1456360B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | Methods and composition for the production of orthoganal trna-aminoacyltrna synthetase pairs |
| EP1424395B1 (en) | 2001-08-01 | 2011-07-27 | Japan Science and Technology Agency | Tyrosyl-trna synthase variants |
| US7288372B2 (en) | 2002-01-17 | 2007-10-30 | Ambergen, Inc. | Methods for the preparation of chemically misaminoacylated tRNA via protective groups |
| US20030235851A1 (en) * | 2002-04-19 | 2003-12-25 | Roberts Richard W. | Methods of using sense and/or nonsense suppression to make nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues |
| JP4490663B2 (ja) | 2003-09-22 | 2010-06-30 | 株式会社東京大学Ｔｌｏ | イソロイシンｔＲＮＡ（ｔＲＮＡＩｌｅ）のライシジン合成酵素（ＴｉｌＳ）としてのｍｅｓＪ遺伝子産物及びその相同性遺伝子（ＣＯＧ００３７） |
| ATE376556T1 (de) | 2003-12-31 | 2007-11-15 | Hoffmann La Roche | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
| US20080221303A1 (en) | 2004-02-18 | 2008-09-11 | Jehoshua Katzhendler | Method for the Preparation of Peptide-Oligonucleotide Conjugates |
| EP1964916B1 (en) | 2005-12-06 | 2012-08-01 | The University of Tokyo | Multi-purpose acylation catalayst and use thereof |
| PL1999259T3 (pl) | 2006-03-03 | 2015-01-30 | California Inst Of Techn | Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek |
| US8754192B2 (en) | 2006-04-11 | 2014-06-17 | Sloan-Kettering Institute For Cancer Research | Compositions comprising homogeneously glycosylated erythropoietin |
| JP2007319064A (ja) | 2006-05-31 | 2007-12-13 | Japan Science & Technology Agency | 修飾化アミノ酸を部位特異的に導入したタンパク質を発現させる方法 |
| JP5200241B2 (ja) | 2006-11-17 | 2013-06-05 | 国立大学法人 東京大学 | Ｎ末端に非天然骨格をもつポリペプチドの翻訳合成とその応用 |
| JP5605602B2 (ja) * | 2007-03-26 | 2014-10-15 | 国立大学法人 東京大学 | 環状ペプチド化合物の合成方法 |
| JP2009096791A (ja) | 2007-09-26 | 2009-05-07 | Kaneka Corp | アミノ酸の製造方法 |
| EP2177533A1 (en) | 2008-10-09 | 2010-04-21 | TU München | Multiple N-methylated cyclic hexapeptides for treatment of neurogenic inflammation |
| TWI468375B (zh) | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之ｌ－丙胺酸衍生物之方法 |
| WO2010053050A1 (ja) | 2008-11-04 | 2010-05-14 | 株式会社カネカ | Ｏ－アルキルセリンおよびｎ－ベンジル－ｏ－アルキルセリンの製造法 |
| WO2010063604A1 (en) | 2008-12-03 | 2010-06-10 | F. Hoffmann-La Roche Ag | Process for preparing therapeutic peptide |
| CN102414220A (zh) | 2009-05-01 | 2012-04-11 | 霍夫曼-拉罗奇有限公司 | 使用固相和液相组合技术的促胰岛素肽合成 |
| JP5174971B2 (ja) | 2009-10-22 | 2013-04-03 | ペプチドリーム株式会社 | ペプチド翻訳合成におけるｒａｐｉｄディスプレイ法 |
| GB0919194D0 (en) | 2009-11-02 | 2009-12-16 | Lytix Biopharma As | Compounds |
| US20110118314A1 (en) | 2009-11-16 | 2011-05-19 | Weiya Yun | Piperidine analogs as glycogen synthase activators |
| JP2011139667A (ja) | 2010-01-07 | 2011-07-21 | Tottori Univ | プロリンおよびβ−アラニンをＮ末端に有するジペプチド、及びその環化ジペプチドの酵素合成法 |
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| JP5725467B2 (ja) | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| JP5818237B2 (ja) * | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| US10195578B2 (en) | 2010-12-03 | 2019-02-05 | The University Of Tokyo | Peptide library production method, peptide library, and screening method |
| ES2586411T3 (es) | 2011-03-04 | 2016-10-14 | New York University | Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras |
| WO2012173762A1 (en) | 2011-06-13 | 2012-12-20 | Trustees Of Boston College | Cyclic lactadherin peptide mimetics and their uses |
| EP3974563A1 (en) * | 2011-12-28 | 2022-03-30 | Chugai Seiyaku Kabushiki Kaisha | Cyclic peptides |
| GB201215538D0 (en) | 2012-08-31 | 2012-10-17 | Stetsenko Dmitry | Method and compositions for removing acid-labile protecting groups |
| WO2014044803A1 (en) | 2012-09-24 | 2014-03-27 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Method for producing a cyclic peptide |
| JP6440055B2 (ja) | 2013-05-10 | 2018-12-19 | 国立大学法人 東京大学 | ペプチドライブラリの製造方法、ペプチドライブラリ、及びスクリーニング方法 |
| JP6357154B2 (ja) | 2013-08-05 | 2018-07-11 | 国立大学法人 東京大学 | 荷電性非タンパク質性アミノ酸含有ペプチドの製造方法 |
| US9981908B2 (en) | 2013-08-05 | 2018-05-29 | Medimmune Limited | Amino acid derivatives |
| US20170022254A1 (en) | 2014-04-08 | 2017-01-26 | Novartis Ag | Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates |
| TW201622746A (zh) | 2014-04-24 | 2016-07-01 | 諾華公司 | 改善或加速髖部骨折術後身體復原之方法 |
| WO2015179434A1 (en) | 2014-05-20 | 2015-11-26 | Ohio State Innovation Foundation | Small molecule ras inhibitors |
| PL3152226T3 (pl) | 2014-06-06 | 2019-10-31 | Univ Muenchen Tech | Modyfikowane cyklopentapeptydy i ich zastosowania |
| US20170369871A1 (en) | 2015-01-12 | 2017-12-28 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| EP4166664A1 (en) | 2015-03-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-trna synthetase and use thereof |
| CN107614689A (zh) | 2015-03-27 | 2018-01-19 | 昆士兰大学 | 用于将非天然氨基酸并入蛋白质中的平台 |
| JP2017043615A (ja) | 2015-08-27 | 2017-03-02 | 塩野義製薬株式会社 | 環状ペプチドの膜透過性および／または代謝安定性を改善するシクロプロパンアミノ酸ユニット |
| EP3411413A4 (en) | 2016-02-04 | 2019-09-18 | The Johns Hopkins University | SYNTHESIS AND COMPOSITION OF RAPAFUCINE LIBRARIES |
| EP3424941A4 (en) | 2016-03-03 | 2019-10-23 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF PRODUCTION OF NON-CYCLIC PEPTIDE NUCLEIC ACID COMPLEX WITH AMINO ACID WITH THIOL GROUP, IN ADDITION TO THE AMINO GROUP ON N-TERMINUS, LIBRARY THEREOF, AND CYCLIC PEPTIDE NUCLEIC ACID COMPLEX LIBRARY THEREOF |
| EP3442991A4 (en) | 2016-04-15 | 2019-11-20 | RA Pharmaceuticals, Inc. | RAS-BINDING PEPTIDES AND METHODS OF USE |
| IT201600122363A1 (it) | 2016-12-02 | 2018-06-02 | Dolores Fregona | Composti di coordinazione, sintesi, nanoformulazione ed uso degli stessi in oncologia |
| JP7187323B2 (ja) | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| EP3636656A4 (en) | 2017-06-09 | 2021-04-14 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR SYNTHESIS OF A PEPTIDE CONTAINING AN N-SUBSTITUTED AMINO ACID |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| EP3878836A4 (en) | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
| US11732002B2 (en) | 2018-11-30 | 2023-08-22 | Chugai Seiyaku Kabushiki Kaisha | Deprotection method and resin removal method in solid-phase reaction for peptide compound or amide compound, and method for producing peptide compound |
| EP3896056A4 (en) | 2018-12-12 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | AMINO ACID HAVING A FUNCTIONAL GROUP CAPABLE OF FORMING AN INTERMOLECULAR HYDROGEN BOND, PEPTIDE COMPOUND CONTAINING IT AND METHOD FOR PRODUCTION |
| EP3904568A4 (en) | 2018-12-26 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | ARNT MUTATED FOR CODON EXPANSION |
| JP7472101B2 (ja) | 2019-03-15 | 2024-04-22 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
-
2012
- 2012-12-28 EP EP21165014.8A patent/EP3974563A1/en active Pending
- 2012-12-28 JP JP2013551857A patent/JP6294080B2/ja active Active
- 2012-12-28 TW TW109139943A patent/TWI787670B/zh active
- 2012-12-28 TW TW106103188A patent/TWI640541B/zh active
- 2012-12-28 TW TW107130626A patent/TWI713889B/zh active
- 2012-12-28 US US14/368,564 patent/US9409952B2/en active Active
- 2012-12-28 TW TW111144798A patent/TW202313654A/zh unknown
- 2012-12-28 WO PCT/JP2012/084103 patent/WO2013100132A1/ja active Application Filing
- 2012-12-28 HU HUE12861199A patent/HUE054006T2/hu unknown
- 2012-12-28 EP EP12861199.3A patent/EP2813512B1/en active Active
- 2012-12-28 TW TW101150926A patent/TWI579296B/zh active
- 2012-12-28 DK DK12861199.3T patent/DK2813512T3/da active
-
2016
- 2016-05-27 US US15/166,550 patent/US20160311858A1/en not_active Abandoned
-
2018
- 2018-02-15 JP JP2018024856A patent/JP2018118968A/ja not_active Ceased
-
2020
- 2020-03-31 JP JP2020062647A patent/JP6961742B2/ja active Active
- 2020-09-03 US US17/011,815 patent/US11891457B2/en active Active
-
2021
- 2021-10-13 JP JP2021167863A patent/JP7297027B2/ja active Active
-
2023
- 2023-06-13 JP JP2023096892A patent/JP2023123570A/ja active Pending
- 2023-09-01 US US18/460,300 patent/US20240166689A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW201333029A (zh) | 2013-08-16 |
| JP2020109120A (ja) | 2020-07-16 |
| JP2022003092A (ja) | 2022-01-11 |
| JP2023123570A (ja) | 2023-09-05 |
| WO2013100132A1 (ja) | 2013-07-04 |
| US9409952B2 (en) | 2016-08-09 |
| JP2018118968A (ja) | 2018-08-02 |
| US11891457B2 (en) | 2024-02-06 |
| TWI713889B (zh) | 2020-12-21 |
| EP3974563A1 (en) | 2022-03-30 |
| JPWO2013100132A1 (ja) | 2015-05-11 |
| TWI579296B (zh) | 2017-04-21 |
| US20150080549A1 (en) | 2015-03-19 |
| EP2813512A4 (en) | 2016-02-10 |
| TW202313654A (zh) | 2023-04-01 |
| EP2813512B1 (en) | 2021-03-31 |
| TWI787670B (zh) | 2022-12-21 |
| TW202112802A (zh) | 2021-04-01 |
| JP7297027B2 (ja) | 2023-06-23 |
| JP6961742B2 (ja) | 2021-11-05 |
| TW201900670A (zh) | 2019-01-01 |
| US20240166689A1 (en) | 2024-05-23 |
| TWI640541B (zh) | 2018-11-11 |
| EP2813512A1 (en) | 2014-12-17 |
| US20160311858A1 (en) | 2016-10-27 |
| TW201720841A (zh) | 2017-06-16 |
| HUE054006T2 (hu) | 2021-08-30 |
| US20210061860A1 (en) | 2021-03-04 |
| JP6294080B2 (ja) | 2018-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2813512T3 (da) | Fremgangsmåde til cyklisering af en peptidforbindelse | |
| DK2788767T3 (da) | Fremgangsmåde til detektering af nukleosomaddukter | |
| DK2766392T3 (da) | Fremgangsmåde til oprensning af antistoffer | |
| DK3829176T3 (da) | Fremgangsmåde til at konstruere fletningsliste | |
| DK2768857T3 (da) | Fremgangsmåder til oprensning af antistoffer | |
| DK3760159T3 (da) | Fremgangsmåde til udformning af en dental indretning | |
| DK2605335T4 (da) | Tilslutningsklemme | |
| DK2467204T3 (da) | Fremgangsmåde til fremstilling af en sorbent | |
| BR112014004902A2 (pt) | peptídeos | |
| DK3351631T3 (da) | Fremgangsmåder til mærkning af dna-kodede biblioteker | |
| DK3104003T3 (da) | Nacellekonstruktion til en vindmølle | |
| BR302012001035S1 (pt) | Configuração aplicada a televisão | |
| DK2649101T3 (da) | Fremgangsmåde til fremstilling af en tværbundet gel | |
| DK2595948T3 (da) | Fremgangsmåde til fremstilling af ingenol-3-angelat | |
| DK2776224T3 (da) | Fremgangsmåde til formaling af poly(aryletherketoner) | |
| DK3985979T3 (da) | Fremgangsmåde til bestemmelse af referenceenhed | |
| DK3396980T3 (da) | Binaural kompressor til opnåelse af retningsanvisninger | |
| DK2671011T3 (da) | Klemring | |
| DK2582283T3 (da) | Fremgangsmåde til estimering af en referencestilling | |
| DK2511892T3 (da) | Fremgangsmåde til detektering af en grænseoverskridelse | |
| DK2751924T3 (da) | Fremgangsmåde til regulering af et generatorsæt | |
| DK2701776T4 (da) | Teknologi til samling af en dispenseringsgrænseflade | |
| ES1168758Y (es) | Un accesorio de vertido | |
| DK2616101T3 (da) | Fremgangsmåde til oprensning af pegyleret erythropoietin | |
| DK2872536T3 (da) | Fremgangsmåde til ekstraktion af biomasse |