DK2804858T3 - Metalloenzym-inhibitorforbindelser - Google Patents

Metalloenzym-inhibitorforbindelser Download PDF

Info

Publication number
DK2804858T3
DK2804858T3 DK13738427.7T DK13738427T DK2804858T3 DK 2804858 T3 DK2804858 T3 DK 2804858T3 DK 13738427 T DK13738427 T DK 13738427T DK 2804858 T3 DK2804858 T3 DK 2804858T3
Authority
DK
Denmark
Prior art keywords
inhibitor compounds
metalloenzyme inhibitor
metalloenzyme
compounds
inhibitor
Prior art date
Application number
DK13738427.7T
Other languages
English (en)
Inventor
William J Hoekstra
Robert J Schotzinger
Stephen W Rafferty
Original Assignee
Mycovia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mycovia Pharmaceuticals Inc filed Critical Mycovia Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2804858T3 publication Critical patent/DK2804858T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
DK13738427.7T 2012-01-20 2013-01-18 Metalloenzym-inhibitorforbindelser DK2804858T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261589076P 2012-01-20 2012-01-20
PCT/US2013/022313 WO2013109998A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
DK2804858T3 true DK2804858T3 (da) 2020-03-16

Family

ID=48799718

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13738427.7T DK2804858T3 (da) 2012-01-20 2013-01-18 Metalloenzym-inhibitorforbindelser

Country Status (14)

Country Link
US (3) US10221160B2 (da)
EP (1) EP2804858B1 (da)
JP (1) JP6189865B2 (da)
KR (1) KR102061137B1 (da)
CN (1) CN104136427B (da)
AU (2) AU2013209516A1 (da)
BR (1) BR112014017751B1 (da)
CA (1) CA2861339C (da)
DK (1) DK2804858T3 (da)
EA (1) EA026209B1 (da)
ES (1) ES2774267T3 (da)
IN (1) IN2014DN06792A (da)
PL (1) PL2804858T3 (da)
WO (1) WO2013109998A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764646A (zh) 2011-06-19 2014-04-30 威尔金制药有限公司 金属酶抑制剂化合物
AU2013209516A1 (en) * 2012-01-20 2014-08-28 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
AU2015231234B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
WO2015143162A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
HUE052446T2 (hu) * 2014-03-19 2021-04-28 Mycovia Pharmaceuticals Inc Eljárás gombaellenes vegyület elõállítása céljából
JP2017512777A (ja) * 2014-03-19 2017-05-25 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
CA2942979A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
EA201691648A1 (ru) * 2014-03-19 2017-01-30 Ваймет Фармасьютикалс, Инк. Способ получения противогрибковых соединений
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143142A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EA037556B1 (ru) 2015-03-19 2021-04-14 Майковиа Фармасьютикалс, Инк. Полиморфные формы противогрибковых соединений и способы их получения
JP6887993B2 (ja) 2015-09-18 2021-06-16 エヌキューピー 1598,リミテッド 抗真菌化合物調製方法
JP6803923B2 (ja) * 2015-12-30 2020-12-23 エヌキューピー 1598,リミテッド 金属酵素阻害化合物
TWI818902B (zh) 2016-12-22 2023-10-21 美商卡利泰拉生物科技公司 用於抑制精胺酸酶活性的組合物及方法
CN109666019B (zh) * 2017-10-14 2021-04-06 朱允涛 一种氘代的氮唑醇类化合物及其制备方法和用途
CN109810049B (zh) * 2018-11-30 2021-01-15 深圳大学 一种含吡啶的化合物及其提取方法
TW202140445A (zh) * 2020-01-17 2021-11-01 大陸商上海森輝醫藥有限公司 四氮唑類化合物的可藥用鹽及其結晶形式、製備方法和用途

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
AU4327585A (en) 1984-06-21 1986-01-02 Imperial Chemical Industries Plc Antifungal azole compounds
GB8415889D0 (en) * 1984-06-21 1984-07-25 Ici Plc Antifungal azole compounds
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
ATE107176T1 (de) 1989-12-04 1994-07-15 Searle & Co System zur transdermalen albuterol applikation.
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
DE69212850T2 (de) 1991-01-15 1997-03-06 Alcon Lab Inc Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
WO1993011938A1 (en) 1991-12-18 1993-06-24 Minnesota Mining And Manufacturing Company Multilayered barrier structures
EP0553769B1 (de) 1992-01-29 1996-01-03 FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG Ballspielschläger, insbesondere Tennisschläger
US5358939A (en) 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
MY115814A (en) 1995-06-16 2003-09-30 Bayer Ip Gmbh Crop protection compositions
GB9512961D0 (en) 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2000344744A (ja) 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
CN101563045B (zh) 2006-10-18 2012-07-04 白李生物科技有限公司 用于根管充填的牙髓仪器和适于它的加热探头
AU2007323614B2 (en) 2006-11-21 2012-09-20 Viamet Pharmaceuticals, Inc. Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties
US8221057B2 (en) 2008-06-25 2012-07-17 General Electric Company Method, system and controller for establishing a wheel space temperature alarm in a turbomachine
WO2010025832A1 (en) 2008-09-03 2010-03-11 Bayer Cropscience Ag Use of fungicidal compound compositions for controlling certain rust fungi
WO2011082245A2 (en) * 2009-12-31 2011-07-07 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
DK2563771T3 (da) * 2010-04-24 2016-02-29 Viamet Pharmaceuticals Inc Metalloenzyminhibitorforbindelser
AU2011320565A1 (en) * 2010-10-28 2013-05-23 Innocrin Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP5828343B2 (ja) * 2010-11-13 2015-12-02 イノクリン ファーマシューティカルズ,インコーポレイテッド 金属酵素阻害化合物
CA2820718A1 (en) * 2010-12-13 2012-06-21 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
EA025406B1 (ru) * 2011-06-19 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
CN103764646A (zh) * 2011-06-19 2014-04-30 威尔金制药有限公司 金属酶抑制剂化合物
IN2014DN00286A (da) * 2011-06-23 2015-06-05 Viamet Pharmaceuticals Inc
JP2014525442A (ja) * 2011-08-30 2014-09-29 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 金属酵素阻害化合物
EA025437B1 (ru) * 2011-12-11 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
AU2013209516A1 (en) * 2012-01-20 2014-08-28 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
BR112014017799A8 (pt) * 2012-01-20 2017-07-11 Viamet Pharmaceuticals Inc Compostos inibidores de metaloenzima
JP2016508487A (ja) * 2013-01-28 2016-03-22 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 金属酵素阻害剤化合物
AU2014278172B2 (en) * 2013-06-12 2018-08-09 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20160144410A (ko) * 2014-04-15 2016-12-16 다우 아그로사이언시즈 엘엘씨 살진균제로서의 금속효소 억제제 화합물
KR20160145640A (ko) * 2014-04-15 2016-12-20 다우 아그로사이언시즈 엘엘씨 살진균제로서의 금속효소 억제제 화합물
AU2017387033B2 (en) * 2016-12-29 2024-02-01 Ji Xing Pharmaceuticals Hong Kong Limited Metalloenzyme inhibitor compounds

Also Published As

Publication number Publication date
JP6189865B2 (ja) 2017-08-30
US20200247779A1 (en) 2020-08-06
ES2774267T3 (es) 2020-07-20
US20190169159A1 (en) 2019-06-06
IN2014DN06792A (da) 2015-05-22
EP2804858B1 (en) 2019-12-25
US11247981B2 (en) 2022-02-15
CN104136427A (zh) 2014-11-05
AU2013209516A1 (en) 2014-08-28
CN104136427B (zh) 2017-03-01
AU2017232080A1 (en) 2017-10-12
WO2013109998A1 (en) 2013-07-25
EP2804858A1 (en) 2014-11-26
US20150004666A1 (en) 2015-01-01
US10221160B2 (en) 2019-03-05
KR20140116939A (ko) 2014-10-06
CA2861339C (en) 2020-08-25
BR112014017751A8 (pt) 2021-03-09
KR102061137B1 (ko) 2019-12-31
JP2015504095A (ja) 2015-02-05
BR112014017751B1 (pt) 2021-12-07
EA201491385A1 (ru) 2015-02-27
AU2017232080B2 (en) 2019-02-14
EP2804858A4 (en) 2015-07-29
PL2804858T3 (pl) 2020-06-29
US10526312B2 (en) 2020-01-07
CA2861339A1 (en) 2013-07-25
EA026209B1 (ru) 2017-03-31

Similar Documents

Publication Publication Date Title
NL301231I2 (nl) Loncastuximab tesirine
CO6930358A2 (es) Compuestos inhibidores de metaloenzimas
SMT201700094B (it) Composto di pirazina carbossammide
DK2804858T3 (da) Metalloenzym-inhibitorforbindelser
EP2804479A4 (en) METALLOENZYME INHIBITOR COMPOUNDS
HK1211921A1 (en) Inhibitor compounds
SMT201600114B (it) Inibitori di beta-secretasi
EP2948450A4 (en) METALLOENZYMINHIBITORVERBINDUNGEN
CO7071137A2 (es) Compuetos inhibidores de beta-lactamasas
EP2894981A4 (en) METALLO ENZYME INHIBITOR COMPOUNDS
DK3178818T3 (da) Pyrazolylquinoxalinkinasehæmmere
CO6990736A2 (es) Pirrolidina-2-carboxamidas sustituídas
BR112014012016A2 (pt) compostos
BR112014032798A2 (pt) composição
CU24164B1 (es) Inhibidores sustituidos de acetil-coa carboxilasa
SMT201600357B (it) Inibitori di iap
BR112013028029A2 (pt) composto
DK2804611T3 (da) Chitosanafledte forbindelser
BR112014032712A2 (pt) composição
BR112013014484A2 (pt) compostos inibidores de metaloenzimas
DK2888228T3 (da) Inhibitorer af CD40-TRAF6 interaktion
DK2934510T3 (da) Lfa-1-inhibitorformuleringer
BR112014015607A2 (pt) composto
BR112013032866A2 (pt) composto
DK2811828T3 (da) Adjuvanssammensætninger