DK2804858T3 - Metalloenzym-inhibitorforbindelser - Google Patents
Metalloenzym-inhibitorforbindelser Download PDFInfo
- Publication number
- DK2804858T3 DK2804858T3 DK13738427.7T DK13738427T DK2804858T3 DK 2804858 T3 DK2804858 T3 DK 2804858T3 DK 13738427 T DK13738427 T DK 13738427T DK 2804858 T3 DK2804858 T3 DK 2804858T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor compounds
- metalloenzyme inhibitor
- metalloenzyme
- compounds
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261589076P | 2012-01-20 | 2012-01-20 | |
PCT/US2013/022313 WO2013109998A1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2804858T3 true DK2804858T3 (da) | 2020-03-16 |
Family
ID=48799718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13738427.7T DK2804858T3 (da) | 2012-01-20 | 2013-01-18 | Metalloenzym-inhibitorforbindelser |
Country Status (14)
Country | Link |
---|---|
US (3) | US10221160B2 (da) |
EP (1) | EP2804858B1 (da) |
JP (1) | JP6189865B2 (da) |
KR (1) | KR102061137B1 (da) |
CN (1) | CN104136427B (da) |
AU (2) | AU2013209516A1 (da) |
BR (1) | BR112014017751B1 (da) |
CA (1) | CA2861339C (da) |
DK (1) | DK2804858T3 (da) |
EA (1) | EA026209B1 (da) |
ES (1) | ES2774267T3 (da) |
IN (1) | IN2014DN06792A (da) |
PL (1) | PL2804858T3 (da) |
WO (1) | WO2013109998A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103764646A (zh) | 2011-06-19 | 2014-04-30 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
AU2013209516A1 (en) * | 2012-01-20 | 2014-08-28 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
WO2015143192A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
AU2015231234B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
WO2015143162A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
HUE052446T2 (hu) * | 2014-03-19 | 2021-04-28 | Mycovia Pharmaceuticals Inc | Eljárás gombaellenes vegyület elõállítása céljából |
JP2017512777A (ja) * | 2014-03-19 | 2017-05-25 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 抗真菌化合物の調製方法 |
CA2942979A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
EA201691648A1 (ru) * | 2014-03-19 | 2017-01-30 | Ваймет Фармасьютикалс, Инк. | Способ получения противогрибковых соединений |
CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
WO2015143142A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
EA037556B1 (ru) | 2015-03-19 | 2021-04-14 | Майковиа Фармасьютикалс, Инк. | Полиморфные формы противогрибковых соединений и способы их получения |
JP6887993B2 (ja) | 2015-09-18 | 2021-06-16 | エヌキューピー 1598,リミテッド | 抗真菌化合物調製方法 |
JP6803923B2 (ja) * | 2015-12-30 | 2020-12-23 | エヌキューピー 1598,リミテッド | 金属酵素阻害化合物 |
TWI818902B (zh) | 2016-12-22 | 2023-10-21 | 美商卡利泰拉生物科技公司 | 用於抑制精胺酸酶活性的組合物及方法 |
CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
CN109810049B (zh) * | 2018-11-30 | 2021-01-15 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
TW202140445A (zh) * | 2020-01-17 | 2021-11-01 | 大陸商上海森輝醫藥有限公司 | 四氮唑類化合物的可藥用鹽及其結晶形式、製備方法和用途 |
Family Cites Families (54)
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GB8304282D0 (en) * | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
GB8305377D0 (en) * | 1983-02-25 | 1983-03-30 | Pfizer Ltd | Antifungal agents |
US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
AU4327585A (en) | 1984-06-21 | 1986-01-02 | Imperial Chemical Industries Plc | Antifungal azole compounds |
GB8415889D0 (en) * | 1984-06-21 | 1984-07-25 | Ici Plc | Antifungal azole compounds |
US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
ATE107176T1 (de) | 1989-12-04 | 1994-07-15 | Searle & Co | System zur transdermalen albuterol applikation. |
US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
GB9121456D0 (en) * | 1991-10-10 | 1991-11-27 | Pfizer Ltd | Triazole antifungal agents |
US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
WO1993011938A1 (en) | 1991-12-18 | 1993-06-24 | Minnesota Mining And Manufacturing Company | Multilayered barrier structures |
EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
US5358939A (en) | 1992-06-25 | 1994-10-25 | Rohm And Haas Company | Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles |
IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
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GB9512961D0 (en) | 1995-06-26 | 1995-08-30 | Pfizer Ltd | Antifungal agents |
GB9602080D0 (en) * | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
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CN101563045B (zh) | 2006-10-18 | 2012-07-04 | 白李生物科技有限公司 | 用于根管充填的牙髓仪器和适于它的加热探头 |
AU2007323614B2 (en) | 2006-11-21 | 2012-09-20 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
US8221057B2 (en) | 2008-06-25 | 2012-07-17 | General Electric Company | Method, system and controller for establishing a wheel space temperature alarm in a turbomachine |
WO2010025832A1 (en) | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Use of fungicidal compound compositions for controlling certain rust fungi |
WO2011082245A2 (en) * | 2009-12-31 | 2011-07-07 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
DK2563771T3 (da) * | 2010-04-24 | 2016-02-29 | Viamet Pharmaceuticals Inc | Metalloenzyminhibitorforbindelser |
AU2011320565A1 (en) * | 2010-10-28 | 2013-05-23 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
JP5828343B2 (ja) * | 2010-11-13 | 2015-12-02 | イノクリン ファーマシューティカルズ,インコーポレイテッド | 金属酵素阻害化合物 |
CA2820718A1 (en) * | 2010-12-13 | 2012-06-21 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
EA025406B1 (ru) * | 2011-06-19 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
CN103764646A (zh) * | 2011-06-19 | 2014-04-30 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
IN2014DN00286A (da) * | 2011-06-23 | 2015-06-05 | Viamet Pharmaceuticals Inc | |
JP2014525442A (ja) * | 2011-08-30 | 2014-09-29 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 金属酵素阻害化合物 |
EA025437B1 (ru) * | 2011-12-11 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
AU2013209516A1 (en) * | 2012-01-20 | 2014-08-28 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
BR112014017799A8 (pt) * | 2012-01-20 | 2017-07-11 | Viamet Pharmaceuticals Inc | Compostos inibidores de metaloenzima |
JP2016508487A (ja) * | 2013-01-28 | 2016-03-22 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 金属酵素阻害剤化合物 |
AU2014278172B2 (en) * | 2013-06-12 | 2018-08-09 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
KR20160144410A (ko) * | 2014-04-15 | 2016-12-16 | 다우 아그로사이언시즈 엘엘씨 | 살진균제로서의 금속효소 억제제 화합물 |
KR20160145640A (ko) * | 2014-04-15 | 2016-12-20 | 다우 아그로사이언시즈 엘엘씨 | 살진균제로서의 금속효소 억제제 화합물 |
AU2017387033B2 (en) * | 2016-12-29 | 2024-02-01 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
-
2013
- 2013-01-18 AU AU2013209516A patent/AU2013209516A1/en not_active Abandoned
- 2013-01-18 WO PCT/US2013/022313 patent/WO2013109998A1/en active Application Filing
- 2013-01-18 BR BR112014017751-1A patent/BR112014017751B1/pt active IP Right Grant
- 2013-01-18 ES ES13738427T patent/ES2774267T3/es active Active
- 2013-01-18 KR KR1020147023020A patent/KR102061137B1/ko active IP Right Grant
- 2013-01-18 CA CA2861339A patent/CA2861339C/en active Active
- 2013-01-18 DK DK13738427.7T patent/DK2804858T3/da active
- 2013-01-18 IN IN6792DEN2014 patent/IN2014DN06792A/en unknown
- 2013-01-18 JP JP2014553491A patent/JP6189865B2/ja active Active
- 2013-01-18 PL PL13738427T patent/PL2804858T3/pl unknown
- 2013-01-18 US US14/373,314 patent/US10221160B2/en active Active
- 2013-01-18 CN CN201380010231.4A patent/CN104136427B/zh active Active
- 2013-01-18 EA EA201491385A patent/EA026209B1/ru unknown
- 2013-01-18 EP EP13738427.7A patent/EP2804858B1/en active Active
-
2017
- 2017-09-20 AU AU2017232080A patent/AU2017232080B2/en active Active
-
2019
- 2019-01-28 US US16/259,096 patent/US10526312B2/en active Active
-
2020
- 2020-01-06 US US16/735,094 patent/US11247981B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP6189865B2 (ja) | 2017-08-30 |
US20200247779A1 (en) | 2020-08-06 |
ES2774267T3 (es) | 2020-07-20 |
US20190169159A1 (en) | 2019-06-06 |
IN2014DN06792A (da) | 2015-05-22 |
EP2804858B1 (en) | 2019-12-25 |
US11247981B2 (en) | 2022-02-15 |
CN104136427A (zh) | 2014-11-05 |
AU2013209516A1 (en) | 2014-08-28 |
CN104136427B (zh) | 2017-03-01 |
AU2017232080A1 (en) | 2017-10-12 |
WO2013109998A1 (en) | 2013-07-25 |
EP2804858A1 (en) | 2014-11-26 |
US20150004666A1 (en) | 2015-01-01 |
US10221160B2 (en) | 2019-03-05 |
KR20140116939A (ko) | 2014-10-06 |
CA2861339C (en) | 2020-08-25 |
BR112014017751A8 (pt) | 2021-03-09 |
KR102061137B1 (ko) | 2019-12-31 |
JP2015504095A (ja) | 2015-02-05 |
BR112014017751B1 (pt) | 2021-12-07 |
EA201491385A1 (ru) | 2015-02-27 |
AU2017232080B2 (en) | 2019-02-14 |
EP2804858A4 (en) | 2015-07-29 |
PL2804858T3 (pl) | 2020-06-29 |
US10526312B2 (en) | 2020-01-07 |
CA2861339A1 (en) | 2013-07-25 |
EA026209B1 (ru) | 2017-03-31 |
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