DK2529619T3 - Behandling af neurologiske sygdomme - Google Patents

Behandling af neurologiske sygdomme Download PDF

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Publication number
DK2529619T3
DK2529619T3 DK12171177.4T DK12171177T DK2529619T3 DK 2529619 T3 DK2529619 T3 DK 2529619T3 DK 12171177 T DK12171177 T DK 12171177T DK 2529619 T3 DK2529619 T3 DK 2529619T3
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DK
Denmark
Prior art keywords
tweak
agent
antibody
use according
receptor
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DK12171177.4T
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English (en)
Inventor
Kyungmin Hahm
Linda C Burkly
Timothy Zheng
Steven Perrin
John Lincecum
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Biogen Ma Inc
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Publication of DK2529619T3 publication Critical patent/DK2529619T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Psychology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)

Claims (12)

1. Anvendelse af et middel, som blokerer for en TWEAK/TWEAK-R-inter-aktion eller -aktivitet til fremstillingen af et medikament til behandling af et menneske, som har eller risikerer at få Parkinsons sygdom, hvor midlet er: i) et antistof eller antigen-bindende fragment deraf, som specifikt binder til TWEAK, ii) et antistof eller antigen-bindende fragment deraf, som specifikt binder til TWEAK-receptor, eller iii) en opløselig form af en TWEAK-receptor, der binder til TWEAK.
2. Middel, som blokerer for en TWEAK/TWEAK-R-interaktion eller -aktivitet til anvendelse ved behandling af et menneske, som har eller risikerer at få Parkinsons sygdom, hvor midlet er: i) et antistof eller antigen-bindende fragment deraf, som specifikt binder til TWEAK, ii) et antistof eller antigen-bindende fragment deraf, som specifikt binder til TWEAK-receptor, eller iii) en opløselig form af en TWEAK-receptor, der binder til TWEAK.
3. Anvendelse ifølge krav 1 eller middel til anvendelse ifølge krav 2, hvor midlet reducerer TWEAK's evne til at binde sig til Fn14.
4. Anvendelse ifølge krav 1 eller middel til anvendelse ifølge krav 2, hvor midlet er et antistof eller et antigen-bindende fragment deraf, der binder til human TWEAK.
5. Anvendelse ifølge krav 4 eller middel til anvendelse ifølge krav 4, hvor antistoffet er et IgG med fuld længde.
6. Anvendelse ifølge krav 4 eller middel til anvendelse ifølge krav 4, hvor det antigenbindende fragment omfatter et enkeltkædet antistof, et Fab-fragment, et F(ab')2-fragment, et Fd-fragment, et Fv-fragment eller et dAb-fragment.
7. Anvendelse ifølge krav 4 eller middel til anvendelse ifølge krav 4, hvor antistoffet er et humant eller humaniseret antistof.
8. Anvendelse ifølge krav 1 eller middel til anvendelse ifølge krav 2, hvor midlet er en opløselig form af en TWEAK-receptor.
9. Anvendelse ifølge krav 8 eller middel til anvendelse ifølge krav 8, hvor den opløselige form af TWEAK-receptoren er fusioneret med en antistof-Fc-regi-on.
10. Anvendelse ifølge krav 1 eller middel til anvendelse ifølge krav 2, hvor behandlingen omfatter indgivelse af midlet i en mængde eller i et tidsrum, der er tilstrækkeligt til at reducere omfanget af neural cellebeskadigelse i individet i forhold til et på lignende måde påvirket, men ikke-behandlet individ.
11. Anvendelse ifølge krav 1 eller middel til anvendelse ifølge krav 2, hvor behandlingen omfatter indgivelse af midlet i kombination med en anden behandling for Parkinsons sygdom.
12. Anvendelse ifølge krav 11 eller middel til anvendelse ifølge krav 12, hvor den anden behandling er udvalgt fra gruppen bestående af: levodopa, ropini-rol, pramipexol, pergolid og R(+)-N-propargyl-1-aminoindan.
DK12171177.4T 2005-02-17 2006-02-17 Behandling af neurologiske sygdomme DK2529619T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65381305P 2005-02-17 2005-02-17
EP10194040.1A EP2332408B1 (en) 2005-02-17 2006-02-17 Treating neurological disorders

Publications (1)

Publication Number Publication Date
DK2529619T3 true DK2529619T3 (da) 2016-01-11

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DK12171177.4T DK2529619T3 (da) 2005-02-17 2006-02-17 Behandling af neurologiske sygdomme
DK10194040.1T DK2332408T3 (da) 2005-02-17 2006-02-17 Behandling af neurologiske sygdomme

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Country Status (7)

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US (3) US20090124993A1 (da)
EP (3) EP1859277A4 (da)
AU (1) AU2006214179A1 (da)
CA (1) CA2597945C (da)
DK (2) DK2529619T3 (da)
HK (1) HK1157575A1 (da)
WO (1) WO2006089095A2 (da)

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