DK2450353T3 - Fremgangsmåde til fremstilling af en pyrimidinforbindelse - Google Patents
Fremgangsmåde til fremstilling af en pyrimidinforbindelse Download PDFInfo
- Publication number
- DK2450353T3 DK2450353T3 DK12000829.7T DK12000829T DK2450353T3 DK 2450353 T3 DK2450353 T3 DK 2450353T3 DK 12000829 T DK12000829 T DK 12000829T DK 2450353 T3 DK2450353 T3 DK 2450353T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- formula
- solvent
- added
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (2)
1. Fremgangsmåde, som omfatter at reagere forbindelsen med formlen (VI):
(hvor Y er alkyl, arylalkyl eller halogen, og p er et helt tal fra 0 til 3, forudsat at når p er mindst 2, kan flerheden af Y være den samme eller forskellig fra hinanden, og hver af R1 og R2 er methyl, methoxy eller ethoxy, og R1 og R2 kan være de samme eller forskellige fra hinanden), med en forbindelse repræsenteret af formlen (VII):
(hvor R3 er -CF3 eller -CON(R5)R6, R4 er halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkoxyalkyl, haloalkoxyalkyl eller -N(R7)R8, hver af R5 og R6 er et hydrogenatom, alkyl, haloalkyl, alkenyl, al-kynyl, alkoxy, haloalkoxy, alkoxyalkyl, haloalkoxyalkyl, cycloalkyl, halocy-cloalkyl, alkoxycarbonyl, haloalkoxycarbonyl, phenyl eller halophenyl, forudsat at når enten R5 eller R6 er et hydrogenatom, er det andet noget andet end et hydrogenatom, R5 og R6 kan danne en heterocyklisk ring sammen med det tilstødende nitrogenatom, og R5 og R6 kan være de samme eller forskellige fra hinanden, hver af R7 og R8 er et hydrogenatom eller alkyl, og R7 og R8 kan være de samme eller forskellige fra hinanden, n er et helt tal fra 0 til 2, forudsat at når n er 2, kan R4 være de samme eller forskellige fra hinanden, og m er 0 eller 1), i nærvær af kaliumcarbonat, for at fremstille en forbindelse repræsenteret af formlen (VIII):
(hvor R1, R2, R3, R4, n og m er som defineret ovenfor).
2. Fremgangsmåde ifølge krav 1, hvor kaliumcarbonatet anvendes som fint pulver.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008108898 | 2008-04-18 | ||
EP09732378.6A EP2264023B1 (en) | 2008-04-18 | 2009-04-16 | Method for producing pyrimidine compound |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2450353T3 true DK2450353T3 (da) | 2016-11-28 |
Family
ID=41199199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12000829.7T DK2450353T3 (da) | 2008-04-18 | 2009-04-16 | Fremgangsmåde til fremstilling af en pyrimidinforbindelse |
Country Status (11)
Country | Link |
---|---|
US (1) | US8440824B2 (da) |
EP (2) | EP2450353B1 (da) |
JP (1) | JP5468289B2 (da) |
KR (1) | KR101595140B1 (da) |
CN (2) | CN104151294B (da) |
BR (1) | BRPI0910595B1 (da) |
DK (1) | DK2450353T3 (da) |
ES (2) | ES2527045T3 (da) |
HU (1) | HUE031127T2 (da) |
PL (2) | PL2264023T3 (da) |
WO (1) | WO2009128512A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102993176A (zh) * | 2012-11-02 | 2013-03-27 | 安徽丰乐农化有限责任公司 | 一种烟嘧磺隆的合成新工艺 |
CN105377911B (zh) * | 2013-07-25 | 2017-05-24 | 昭和电工株式会社 | 组合物、固化性组合物、其制造方法及固化物 |
CN111116557A (zh) * | 2019-12-30 | 2020-05-08 | 大连九信精细化工有限公司 | 一种啶嘧磺隆晶型及其制备方法 |
CN111004217A (zh) * | 2019-12-30 | 2020-04-14 | 大连九信精细化工有限公司 | 一种啶嘧磺隆晶型及其制备方法 |
CN111423385B (zh) * | 2020-05-22 | 2022-02-18 | 北京英力精化技术发展有限公司 | 4,6-二甲氧基-2-((苯氧基羰基)氨基)-嘧啶的精制方法 |
CN114539165A (zh) * | 2022-02-21 | 2022-05-27 | 江苏瑞邦农化股份有限公司 | 一种甲基二磺隆的制备方法 |
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DE2703838A1 (de) | 1977-01-31 | 1978-08-10 | Basf Ag | Diurethane |
US4645531A (en) | 1980-03-07 | 1987-02-24 | Du Pont | Alkyl sulfones |
US4456469A (en) | 1980-03-07 | 1984-06-26 | E. I. Du Pont De Nemours And Company | Pyridyl sulfone herbicides |
CA1189073A (en) | 1980-03-07 | 1985-06-18 | John B. Adams, Jr. | Pyridyl sulfone herbicides |
US4605432A (en) | 1980-03-07 | 1986-08-12 | E. I. Du Pont De Nemours And Company | Pyridyl sulfone herbicides |
US4547509A (en) | 1983-01-03 | 1985-10-15 | Usv Pharmaceutical Corp. | 5,6,7-Quinoline carbanilates and method of treating ischemic heart disease therewith |
US4744814A (en) * | 1984-12-06 | 1988-05-17 | Ishihara Sangyo Kaisha | N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-trifluoromethylpyridine-2-sulfonamide or salts thereof, herbicidal composition containing the same |
IN164880B (da) | 1986-01-30 | 1989-06-24 | Ishihara Sangyo Kaisha | |
CN1016661B (zh) * | 1986-01-30 | 1992-05-20 | 石原产业株式会社 | 含吡啶磺酰胺的除草组合物 |
US4935529A (en) * | 1986-01-31 | 1990-06-19 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Cytoxic substances from the marine cyanophyte hormothamnion enteromorphoides grunow |
JPH0688997B2 (ja) * | 1986-02-07 | 1994-11-09 | 石原産業株式会社 | スルホンアミド系化合物及びその塩、それらを含有する除草組成物並びにそれらの製造方法 |
US4790869A (en) * | 1986-02-07 | 1988-12-13 | Ishihara Sangyo Kaisha Ltd. | Sulfonamide compounds and salts thereof, herbicidal compositions containing them |
US4789393A (en) * | 1986-03-07 | 1988-12-06 | E. I. Du Pont De Nemours And Company | Herbicidal pyridine sulfonamides |
PH25866A (en) | 1986-03-20 | 1991-12-02 | Takeda Chemical Industries Ltd | Sulfonylurea compounds and their herbicides |
JPS6438091A (en) | 1986-03-20 | 1989-02-08 | Takeda Chemical Industries Ltd | Condensed heterocyclic sulfonylurea |
JPS62178588A (ja) * | 1987-01-19 | 1987-08-05 | Ishihara Sangyo Kaisha Ltd | 置換ピリジンスルホンアミド系化合物及びそれらを含有する除草剤 |
JP2526067B2 (ja) * | 1987-07-10 | 1996-08-21 | 石原産業株式会社 | 置換ピリジン系化合物及びその製造方法 |
US5529976A (en) * | 1990-01-10 | 1996-06-25 | Hoechst Aktiengesellschaft | Pyridyl sulphonyl ureas as herbicides and plant growth regulators |
JPH04235971A (ja) * | 1991-01-16 | 1992-08-25 | Nissan Chem Ind Ltd | 置換アミノスルホンアミド及び除草剤 |
PL327397A1 (en) * | 1995-12-14 | 1998-12-07 | Merck & Co Inc | Antagonists of a gonadothropin liberating hormone |
US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
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DE10232971A1 (de) * | 2001-07-23 | 2003-02-13 | Syngenta Participations Ag | Neue Herbizide |
CN1235873C (zh) * | 2002-08-13 | 2006-01-11 | 浙江工业大学 | 异氰酸异丙酯的化学合成方法 |
WO2006103555A1 (en) * | 2005-03-28 | 2006-10-05 | Pharmacia & Upjohn Company Llc | 4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
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-
2009
- 2009-04-13 JP JP2009097513A patent/JP5468289B2/ja active Active
- 2009-04-16 EP EP12000829.7A patent/EP2450353B1/en active Active
- 2009-04-16 CN CN201410400178.5A patent/CN104151294B/zh active Active
- 2009-04-16 BR BRPI0910595-6A patent/BRPI0910595B1/pt active IP Right Grant
- 2009-04-16 PL PL09732378T patent/PL2264023T3/pl unknown
- 2009-04-16 HU HUE12000829A patent/HUE031127T2/en unknown
- 2009-04-16 PL PL12000829T patent/PL2450353T3/pl unknown
- 2009-04-16 WO PCT/JP2009/057674 patent/WO2009128512A1/ja active Application Filing
- 2009-04-16 KR KR1020107023061A patent/KR101595140B1/ko active IP Right Grant
- 2009-04-16 ES ES09732378.6T patent/ES2527045T3/es active Active
- 2009-04-16 CN CN200980113753.0A patent/CN102007119B/zh active Active
- 2009-04-16 EP EP09732378.6A patent/EP2264023B1/en active Active
- 2009-04-16 ES ES12000829.7T patent/ES2592281T3/es active Active
- 2009-04-16 US US12/933,980 patent/US8440824B2/en active Active
- 2009-04-16 DK DK12000829.7T patent/DK2450353T3/da active
Also Published As
Publication number | Publication date |
---|---|
CN102007119B (zh) | 2014-10-15 |
KR20110003339A (ko) | 2011-01-11 |
CN102007119A (zh) | 2011-04-06 |
PL2450353T3 (pl) | 2017-02-28 |
KR101595140B1 (ko) | 2016-02-17 |
EP2450353B1 (en) | 2016-09-07 |
EP2450353A1 (en) | 2012-05-09 |
PL2264023T3 (pl) | 2015-05-29 |
WO2009128512A1 (ja) | 2009-10-22 |
CN104151294A (zh) | 2014-11-19 |
ES2592281T3 (es) | 2016-11-29 |
US20110021774A1 (en) | 2011-01-27 |
JP2009275038A (ja) | 2009-11-26 |
US8440824B2 (en) | 2013-05-14 |
HUE031127T2 (en) | 2017-07-28 |
ES2527045T3 (es) | 2015-01-19 |
CN104151294B (zh) | 2016-08-24 |
EP2264023A1 (en) | 2010-12-22 |
EP2264023B1 (en) | 2014-12-17 |
EP2264023A4 (en) | 2011-08-24 |
JP5468289B2 (ja) | 2014-04-09 |
BRPI0910595B1 (pt) | 2020-08-18 |
BRPI0910595A2 (pt) | 2016-10-04 |
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