DK2300799T3 - Fremgangsmåde til histokemisk forarbejdning og anvendelse af en sammensætning til histokemisk forarbejdning - Google Patents

Fremgangsmåde til histokemisk forarbejdning og anvendelse af en sammensætning til histokemisk forarbejdning Download PDF

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DK2300799T3
DK2300799T3 DK09759174.7T DK09759174T DK2300799T3 DK 2300799 T3 DK2300799 T3 DK 2300799T3 DK 09759174 T DK09759174 T DK 09759174T DK 2300799 T3 DK2300799 T3 DK 2300799T3
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composition
solution
cell
histochemical
edta
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DK09759174.7T
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Merrill Jackson
Michael Herman
Grace Hoben
Noemi Sebastiao
Scott Cockayne
Heather Ferrea
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Ventana Med Syst Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Claims (12)

1. Fremgangsmåde til forarbejdning af en biologisk prøve, omfattende: tilvejebringelse af en biologisk prøve; anvende en vandig histokemisk forarbejdningssammensætning til prøven, idet sammensætningen omfatter fra mere end nul til 25 dele pr. million af mindst én nanopartikel valgt fra aluminiumoxid (AI2O3), siliciumoxid (S1O2), titaniumoxid (T1O2), eller kombinationer deraf, i en mængde der er effektiv til at reducere gennemsnitsantallet af områder af reduceret farvningsintensitet pr. objektglas; farve den biologiske prøve, og udføre mindst ét yderligere histokemisk trin på prøven.
2. Fremgangsmåden ifølge krav 1, hvor udførelsen af en histokemisk forarbejdning omfatter udførelse af cellekonditionering på prøven under anvendelse af en cellekonditioneringssammensætning.
3. Fremgangsmåden ifølge krav 1, hvor den biologiske prøve og den histokemiske forarbejdningssammensætning opvarmes til en temperatur på fra 60°C til 101°C.
4. Fremgangsmåden ifølge krav 1, hvor sammensætningen har en nanopartikelkoncentration på fra 2 dele pr. million til 20 dele pr. million.
5. Fremgangsmåden ifølge krav 1 hvor sammensætningen har en nanopartikelkoncentration på fra 2,5 dele pr. million til 15 dele pr. million.
6. Anvendelse afen vandig sammensætning omfattende mere end nul og mindre end 25 dele pr. million af mindst én nanopartikel valgt fra aluminiumoxid (AI2O3), siliciumoxid (S1O2), titaniumoxid (T1O2), og kombinationer deraf, til at udføre en histokemisk forarbejdning omfattende et farvningstrin for at reducere gennemsnitsantallet af områder af reduceret farvningsintensitet pr. objektglas.
7. Anvendelse ifølge krav 6, hvor sammensætningen omfatter et cellekonditioneringsmiddel.
8. Anvendelse ifølge krav 7, hvor den histokemiske forarbejdning udføres på en biologisk prøve omfattende en nukleinsyre, og hvor den cellekonditionerende sammensætning omfatter en opløsning af EDTA, SSC, citronsyre, eller en kombination deraf.
9. Anvendelse ifølge krav 8, hvor nukleinsyren er DNA og den cellekonditionerende sammensætning omfatter EDTA.
10. Anvendelse ifølge krav 8, hvor nukleinsyren er RNA og den cellekonditionerende prøve omfatter SSC.
11. Anvendelse ifølge krav 7, hvor den histokemiske forarbejdning udføres på en biologisk prøve omfattende et protein og den cellekonditionerende sammensætning omfatter en phosphatbuffer, en borsyrebufferopløsning, urinstof, eller en kombination deraf.
12. Anvendelse ifølge krav 6, hvor sammensætningen omfatter Tris borat-ethylendiamin-tetraeddikesyre (EDTA)-buffer, ved en pH på ca. 8.
DK09759174.7T 2008-06-05 2009-06-01 Fremgangsmåde til histokemisk forarbejdning og anvendelse af en sammensætning til histokemisk forarbejdning DK2300799T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13120508P 2008-06-05 2008-06-05
PCT/US2009/045841 WO2009149013A2 (en) 2008-06-05 2009-06-01 Compositions comprising nanomaterials and method for using such compositions for histochemical processes

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DK15189792.3T DK2995925T3 (da) 2008-06-05 2009-06-01 Sammensætning til histokemisk processering
DK09759174.7T DK2300799T3 (da) 2008-06-05 2009-06-01 Fremgangsmåde til histokemisk forarbejdning og anvendelse af en sammensætning til histokemisk forarbejdning

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US (2) US8703490B2 (da)
EP (2) EP2995925B1 (da)
AU (1) AU2009256349B2 (da)
CA (2) CA2979353C (da)
DK (2) DK2995925T3 (da)
ES (2) ES2557594T3 (da)
WO (1) WO2009149013A2 (da)

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CN103834397B (zh) * 2014-03-11 2015-07-08 太原理工大学 一种水溶性荧光碳点的制备方法
US9145492B1 (en) * 2014-04-01 2015-09-29 King Fahd University Of Petroleum And Minerals Method to produce ultra-high molecular weight polyethylene
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US20110091897A1 (en) 2011-04-21
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