DK2114878T3 - 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indolforbindelser og deres anvendelse som 5-HT6-ligander - Google Patents
5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indolforbindelser og deres anvendelse som 5-HT6-liganderInfo
- Publication number
- DK2114878T3 DK2114878T3 DK07827525.2T DK07827525T DK2114878T3 DK 2114878 T3 DK2114878 T3 DK 2114878T3 DK 07827525 T DK07827525 T DK 07827525T DK 2114878 T3 DK2114878 T3 DK 2114878T3
- Authority
- DK
- Denmark
- Prior art keywords
- disorders
- compounds
- pharmaceutically acceptable
- arylsulfonyl
- heterocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN45CH2007 | 2007-01-08 | ||
| PCT/IN2007/000312 WO2008084492A1 (en) | 2007-01-08 | 2007-07-26 | 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2114878T3 true DK2114878T3 (da) | 2011-03-14 |
Family
ID=39495814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07827525.2T DK2114878T3 (da) | 2007-01-08 | 2007-07-26 | 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indolforbindelser og deres anvendelse som 5-HT6-ligander |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8470830B2 (da) |
| EP (1) | EP2114878B1 (da) |
| JP (1) | JP2010515674A (da) |
| KR (1) | KR101103023B1 (da) |
| CN (1) | CN101553467B (da) |
| AT (1) | ATE491685T1 (da) |
| AU (1) | AU2007343063B2 (da) |
| BR (1) | BRPI0718737A2 (da) |
| CA (1) | CA2670717C (da) |
| CY (1) | CY1111105T1 (da) |
| DE (1) | DE602007011323D1 (da) |
| DK (1) | DK2114878T3 (da) |
| EA (1) | EA017007B1 (da) |
| ES (1) | ES2357584T3 (da) |
| HK (1) | HK1132273A1 (da) |
| IL (1) | IL198821A (da) |
| MX (1) | MX2009006077A (da) |
| NO (1) | NO341713B1 (da) |
| NZ (1) | NZ577769A (da) |
| PL (1) | PL2114878T3 (da) |
| PT (1) | PT2114878E (da) |
| WO (1) | WO2008084492A1 (da) |
| ZA (1) | ZA200903600B (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| CN103304547A (zh) * | 2012-03-13 | 2013-09-18 | 中国药科大学 | 一种抗抑郁药维拉唑酮的制备方法 |
| CA2931279A1 (en) * | 2013-11-25 | 2015-05-28 | Novogen ltd | Functionalised and substituted indoles as anti-cancer agents |
| US9663498B2 (en) | 2013-12-20 | 2017-05-30 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| JP6515175B2 (ja) * | 2014-07-08 | 2019-05-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族ヘテロ環誘導体及びその医薬的適用 |
| MX2017000613A (es) * | 2014-07-16 | 2017-04-27 | Novogen ltd | Indoles funcionalizados y sustituidos como agentes anticancer. |
| EP4175638A1 (en) * | 2020-07-06 | 2023-05-10 | Tactogen Inc. | Advantageous benzothiophene compositions for mental disorders or enhancement |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9026389D0 (en) * | 1990-12-05 | 1991-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| JP2002511097A (ja) | 1997-07-11 | 2002-04-09 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ▲下６▼レセプターアンタゴニストであるスルホンアミド誘導体およびその製造方法 |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| ATE375990T1 (de) | 1999-04-21 | 2007-11-15 | Nps Allelix Corp | Piperidin-indol derivate mit 5-ht6 affinität |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| BR0115102B1 (pt) * | 2000-11-02 | 2013-11-26 | Compostos 1-aril- ou 1-alquilsulfonil-heterociclilbenzazóis e composição compreendendo os mesmos | |
| DE60214990T2 (de) | 2001-01-30 | 2007-04-05 | Eli Lilly And Co., Indianapolis | Benzolsulfonsäureester-indol-5-yl als 5-ht6 rezeptor-antagonisten |
| BR0207302A (pt) | 2001-02-08 | 2004-02-10 | Memory Pharm Corp | Trifluorometilpurinas como inibidores da fosfodiesterase 4 |
| ES2280546T3 (es) | 2001-06-07 | 2007-09-16 | F. Hoffmann-La Roche Ag | Nuevos derivados de indol con afinidad por el receptor 5-ht6. |
| US20040242589A1 (en) * | 2001-08-07 | 2004-12-02 | Bromidge Steven Mark | 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
| AU2003238339A1 (en) | 2002-02-01 | 2003-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| AU2003244452A1 (en) | 2002-02-05 | 2003-09-02 | Glaxo Group Limited | Method of promoting neuronal growth |
| JP4455064B2 (ja) | 2002-03-27 | 2010-04-21 | グラクソ グループ リミテッド | キノリン誘導体および５−ｈｔ６リガンドとしてのその使用 |
| NZ540842A (en) | 2002-11-28 | 2008-05-30 | Suven Life Sciences Ltd | N-arylsulfonyl-3-aminoalkoxyindoles |
| AU2003292508A1 (en) | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| AU2003237599B2 (en) | 2002-11-28 | 2009-06-18 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| DK1581538T3 (da) | 2002-12-18 | 2007-06-25 | Suven Life Sciences Ltd | Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| EP1919896B1 (en) | 2005-08-12 | 2009-12-23 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands. |
| NZ573371A (en) * | 2006-07-03 | 2011-01-28 | Biovitrum Ab Publ | Indoles as 5-ht6 modulators |
-
2007
- 2007-07-26 CA CA2670717A patent/CA2670717C/en not_active Expired - Fee Related
- 2007-07-26 NZ NZ577769A patent/NZ577769A/en not_active IP Right Cessation
- 2007-07-26 EP EP07827525A patent/EP2114878B1/en active Active
- 2007-07-26 ES ES07827525T patent/ES2357584T3/es active Active
- 2007-07-26 AU AU2007343063A patent/AU2007343063B2/en not_active Ceased
- 2007-07-26 MX MX2009006077A patent/MX2009006077A/es active IP Right Grant
- 2007-07-26 PT PT07827525T patent/PT2114878E/pt unknown
- 2007-07-26 PL PL07827525T patent/PL2114878T3/pl unknown
- 2007-07-26 EA EA200970675A patent/EA017007B1/ru not_active IP Right Cessation
- 2007-07-26 KR KR1020097011686A patent/KR101103023B1/ko active IP Right Grant
- 2007-07-26 WO PCT/IN2007/000312 patent/WO2008084492A1/en active Application Filing
- 2007-07-26 BR BRPI0718737-8A2A patent/BRPI0718737A2/pt not_active Application Discontinuation
- 2007-07-26 DE DE602007011323T patent/DE602007011323D1/de active Active
- 2007-07-26 US US12/521,967 patent/US8470830B2/en not_active Expired - Fee Related
- 2007-07-26 CN CN2007800454515A patent/CN101553467B/zh not_active Expired - Fee Related
- 2007-07-26 JP JP2009544495A patent/JP2010515674A/ja active Pending
- 2007-07-26 AT AT07827525T patent/ATE491685T1/de active
- 2007-07-26 DK DK07827525.2T patent/DK2114878T3/da active
-
2009
- 2009-05-19 IL IL198821A patent/IL198821A/en active IP Right Grant
- 2009-05-25 ZA ZA200903600A patent/ZA200903600B/xx unknown
- 2009-05-27 NO NO20092067A patent/NO341713B1/no not_active IP Right Cessation
- 2009-12-29 HK HK09112256.5A patent/HK1132273A1/xx not_active IP Right Cessation
-
2011
- 2011-01-13 CY CY20111100042T patent/CY1111105T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL198821A0 (en) | 2010-02-17 |
| CN101553467B (zh) | 2011-12-07 |
| EA017007B1 (ru) | 2012-09-28 |
| JP2010515674A (ja) | 2010-05-13 |
| EA200970675A1 (ru) | 2009-12-30 |
| ZA200903600B (en) | 2010-07-28 |
| PL2114878T3 (pl) | 2011-05-31 |
| AU2007343063B2 (en) | 2011-02-17 |
| WO2008084492A1 (en) | 2008-07-17 |
| KR101103023B1 (ko) | 2012-01-05 |
| HK1132273A1 (da) | 2010-02-19 |
| EP2114878B1 (en) | 2010-12-15 |
| US8470830B2 (en) | 2013-06-25 |
| NZ577769A (en) | 2011-01-28 |
| KR20090080544A (ko) | 2009-07-24 |
| PT2114878E (pt) | 2011-03-10 |
| AU2007343063A1 (en) | 2008-07-17 |
| US20100041673A1 (en) | 2010-02-18 |
| AU2007343063A8 (en) | 2009-07-23 |
| CY1111105T1 (el) | 2015-06-11 |
| IL198821A (en) | 2014-11-30 |
| CA2670717C (en) | 2012-01-10 |
| CN101553467A (zh) | 2009-10-07 |
| EP2114878A1 (en) | 2009-11-11 |
| CA2670717A1 (en) | 2008-07-17 |
| ES2357584T3 (es) | 2011-04-27 |
| ATE491685T1 (de) | 2011-01-15 |
| NO20092067L (no) | 2009-09-04 |
| MX2009006077A (es) | 2009-06-17 |
| BRPI0718737A2 (pt) | 2014-03-25 |
| NO341713B1 (no) | 2018-01-08 |
| DE602007011323D1 (de) | 2011-01-27 |
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