CY1111105T1 - Ενωσεις 5-(ετεροκυκλυλ)αλκυλ-ν-(αρυλσουλφονυλ)ινδολης και η χρηση τους ως προσδεματα του 5-ητ6 - Google Patents

Ενωσεις 5-(ετεροκυκλυλ)αλκυλ-ν-(αρυλσουλφονυλ)ινδολης και η χρηση τους ως προσδεματα του 5-ητ6

Info

Publication number
CY1111105T1
CY1111105T1 CY20111100042T CY111100042T CY1111105T1 CY 1111105 T1 CY1111105 T1 CY 1111105T1 CY 20111100042 T CY20111100042 T CY 20111100042T CY 111100042 T CY111100042 T CY 111100042T CY 1111105 T1 CY1111105 T1 CY 1111105T1
Authority
CY
Cyprus
Prior art keywords
compounds
disorders
pharmaceutically acceptable
arylsulfonyl
alkyl
Prior art date
Application number
CY20111100042T
Other languages
English (en)
Inventor
Nirogi Venkata Satya Ramakrishna
Rama Sastri Kambhampati
Jagadishbabu Konda
Prabhakar Kothmirkar
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Limited filed Critical Suven Life Sciences Limited
Publication of CY1111105T1 publication Critical patent/CY1111105T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέες ενώσεις 5-(ετεροκυκλυλ)αλκυλ-Ν-(αρυλσουλφονυλ)ινδόλης τύπου (I), στα παράγωγα τους, στα στερεοϊσομερή τους, στα φαρμακευτικά αποδεκτά άλατα τους και στις φαρμακευτικά αποδεκτές συνθέσεις που τις περιέχουν. Η παρούσα εφεύρεση αναφέρεται επίσης σε μία μέθοδο για την παρασκευή των προαναφερθέντων νέων ενώσεων, των παραγώγων τους, των στερεοϊσομερών τους, των φαρμακευτικά αποδεκτών αλάτων τους και των φαρμακευτικά αποδεκτών συνθέσεων που τις περιέχουν. Αυτές οι ενώσεις είναι χρήσιμες στην αγωγή ποικίλων διαταραχών που σχετίζονται με τις λειτουργίες του υποδοχέα 5-ΗΤ6. Ιδιαιτέρως, οι ενώσεις της παρούσας εφευρέσεως είναι επίσης χρήσιμες στην αγωγή διαφόρων διαταραχών του ΚΝΣ, αιματολογικών διαταραχών, διατροφικών διαταραχών, ασθενειών που σχετίζονται με το άλγος, αναπνευστικών ασθενειών, διαταραχών του ουρογεννητικού συστήματος, καρδιαγγειακών ασθενειών και καρκίνου.
CY20111100042T 2007-01-08 2011-01-13 Ενωσεις 5-(ετεροκυκλυλ)αλκυλ-ν-(αρυλσουλφονυλ)ινδολης και η χρηση τους ως προσδεματα του 5-ητ6 CY1111105T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN45CH2007 2007-01-08
EP07827525A EP2114878B1 (en) 2007-01-08 2007-07-26 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands

Publications (1)

Publication Number Publication Date
CY1111105T1 true CY1111105T1 (el) 2015-06-11

Family

ID=39495814

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100042T CY1111105T1 (el) 2007-01-08 2011-01-13 Ενωσεις 5-(ετεροκυκλυλ)αλκυλ-ν-(αρυλσουλφονυλ)ινδολης και η χρηση τους ως προσδεματα του 5-ητ6

Country Status (23)

Country Link
US (1) US8470830B2 (el)
EP (1) EP2114878B1 (el)
JP (1) JP2010515674A (el)
KR (1) KR101103023B1 (el)
CN (1) CN101553467B (el)
AT (1) ATE491685T1 (el)
AU (1) AU2007343063B2 (el)
BR (1) BRPI0718737A2 (el)
CA (1) CA2670717C (el)
CY (1) CY1111105T1 (el)
DE (1) DE602007011323D1 (el)
DK (1) DK2114878T3 (el)
EA (1) EA017007B1 (el)
ES (1) ES2357584T3 (el)
HK (1) HK1132273A1 (el)
IL (1) IL198821A (el)
MX (1) MX2009006077A (el)
NO (1) NO341713B1 (el)
NZ (1) NZ577769A (el)
PL (1) PL2114878T3 (el)
PT (1) PT2114878E (el)
WO (1) WO2008084492A1 (el)
ZA (1) ZA200903600B (el)

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US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
CN103304547A (zh) * 2012-03-13 2013-09-18 中国药科大学 一种抗抑郁药维拉唑酮的制备方法
CN105916841A (zh) * 2013-11-25 2016-08-31 诺沃根公司 作为抗癌药物的功能化的和取代的吲哚
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
US9974785B2 (en) 2014-07-08 2018-05-22 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
EP3169683A4 (en) * 2014-07-16 2017-11-22 Novogen Ltd. Functionalised and substituted indoles as anti-cancer agents
EP4175638A1 (en) * 2020-07-06 2023-05-10 Tactogen Inc. Advantageous benzothiophene compositions for mental disorders or enhancement

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Also Published As

Publication number Publication date
PT2114878E (pt) 2011-03-10
CN101553467A (zh) 2009-10-07
DE602007011323D1 (de) 2011-01-27
KR101103023B1 (ko) 2012-01-05
CN101553467B (zh) 2011-12-07
EA200970675A1 (ru) 2009-12-30
BRPI0718737A2 (pt) 2014-03-25
IL198821A (en) 2014-11-30
CA2670717A1 (en) 2008-07-17
ATE491685T1 (de) 2011-01-15
JP2010515674A (ja) 2010-05-13
PL2114878T3 (pl) 2011-05-31
EA017007B1 (ru) 2012-09-28
AU2007343063A1 (en) 2008-07-17
ZA200903600B (en) 2010-07-28
MX2009006077A (es) 2009-06-17
KR20090080544A (ko) 2009-07-24
CA2670717C (en) 2012-01-10
US20100041673A1 (en) 2010-02-18
ES2357584T3 (es) 2011-04-27
WO2008084492A1 (en) 2008-07-17
EP2114878B1 (en) 2010-12-15
NO20092067L (no) 2009-09-04
AU2007343063A8 (en) 2009-07-23
DK2114878T3 (da) 2011-03-14
NZ577769A (en) 2011-01-28
HK1132273A1 (el) 2010-02-19
US8470830B2 (en) 2013-06-25
IL198821A0 (en) 2010-02-17
NO341713B1 (no) 2018-01-08
EP2114878A1 (en) 2009-11-11
AU2007343063B2 (en) 2011-02-17

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