DK1849762T3 - Substituerede biphenylcarboxylsyrer og derivater deraf - Google Patents

Substituerede biphenylcarboxylsyrer og derivater deraf

Info

Publication number
DK1849762T3
DK1849762T3 DK06112938T DK06112938T DK1849762T3 DK 1849762 T3 DK1849762 T3 DK 1849762T3 DK 06112938 T DK06112938 T DK 06112938T DK 06112938 T DK06112938 T DK 06112938T DK 1849762 T3 DK1849762 T3 DK 1849762T3
Authority
DK
Denmark
Prior art keywords
derivatives
biphenylcarboxylic acids
substituted biphenylcarboxylic
substituted
acids
Prior art date
Application number
DK06112938T
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernandez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Adeline Leformal
Andrew Cansfield
Svenja Burckhardt
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Application granted granted Critical
Publication of DK1849762T3 publication Critical patent/DK1849762T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK06112938T 2006-04-21 2006-04-21 Substituerede biphenylcarboxylsyrer og derivater deraf DK1849762T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
DK1849762T3 true DK1849762T3 (da) 2009-10-12

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06112938T DK1849762T3 (da) 2006-04-21 2006-04-21 Substituerede biphenylcarboxylsyrer og derivater deraf

Country Status (35)

Country Link
US (1) US7557244B2 (da)
EP (2) EP1849762B1 (da)
JP (1) JP5479088B2 (da)
KR (1) KR101542255B1 (da)
CN (1) CN101687758B (da)
AP (1) AP2008004656A0 (da)
AR (1) AR060568A1 (da)
AU (1) AU2007240335B2 (da)
BR (1) BRPI0710656A2 (da)
CA (1) CA2650006C (da)
CR (2) CR10375A (da)
CY (1) CY1109399T1 (da)
DE (1) DE602006007810D1 (da)
DK (1) DK1849762T3 (da)
EA (1) EA016129B9 (da)
ES (2) ES2328616T3 (da)
GE (1) GEP20115269B (da)
GT (1) GT200900120A (da)
IL (2) IL194852A0 (da)
MA (1) MA30475B1 (da)
MX (1) MX2008013445A (da)
MY (1) MY148953A (da)
NO (1) NO20084517L (da)
NZ (1) NZ573000A (da)
PE (1) PE20080364A1 (da)
PL (1) PL1849762T3 (da)
PT (1) PT1849762E (da)
SI (1) SI1849762T1 (da)
SM (1) SMP200800061B (da)
TN (1) TNSN08413A1 (da)
TW (1) TWI399362B (da)
UA (1) UA95952C2 (da)
UY (1) UY30301A1 (da)
WO (1) WO2007124394A1 (da)
ZA (1) ZA200809856B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903335A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
BRPI0818773A2 (pt) 2007-10-19 2015-04-14 Janssen Pharmaceutica Nv Moduladores de gama-secretase ligados a carbono
AU2008312362A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Gsm intermediates
CN101903347B (zh) 2007-10-19 2013-03-27 詹森药业有限公司 带哌啶基和哌嗪基的γ-分泌酶调节剂
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
WO2012119035A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
BR0311788A (pt) * 2002-06-27 2005-03-15 Fujisawa Pharmaceutical Co Composto derivado aminoalcoólico, processo para sua preparação, composição farmacêutica, compreendendo o mesmo, seu uso e método de tratamento
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
JPWO2006022237A1 (ja) * 2004-08-24 2008-05-08 キッセイ薬品工業株式会社 脂肪肝の予防または治療剤
EP1937632A1 (en) * 2005-10-06 2008-07-02 Astra Zeneca AB Novel compounds

Also Published As

Publication number Publication date
DE602006007810D1 (de) 2009-08-27
UY30301A1 (es) 2007-08-31
CA2650006C (en) 2016-08-23
TNSN08413A1 (en) 2010-04-14
WO2007124394A1 (en) 2007-11-01
EP2021314B1 (en) 2013-01-23
AR060568A1 (es) 2008-06-25
AU2007240335A1 (en) 2007-11-01
MY148953A (en) 2013-06-14
MX2008013445A (es) 2009-03-10
TWI399362B (zh) 2013-06-21
TW200815320A (en) 2008-04-01
CN101687758B (zh) 2014-05-14
GT200900120A (es) 2009-11-16
EA016129B9 (ru) 2012-06-29
ES2328616T3 (es) 2009-11-16
CN101687758A (zh) 2010-03-31
CA2650006A1 (en) 2007-11-01
MA30475B1 (fr) 2009-06-01
JP2009544573A (ja) 2009-12-17
IL194852A0 (en) 2009-08-03
PE20080364A1 (es) 2008-05-16
CR10451A (es) 2009-03-31
ZA200809856B (en) 2009-06-24
CR10375A (es) 2009-02-26
KR20090024679A (ko) 2009-03-09
EA016129B1 (ru) 2012-02-28
AP2008004656A0 (en) 2008-10-31
BRPI0710656A2 (pt) 2011-08-16
SMAP200800061A (it) 2008-11-19
CY1109399T1 (el) 2014-07-02
UA95952C2 (ru) 2011-09-26
IL194790A0 (en) 2009-08-03
SI1849762T1 (sl) 2009-12-31
ES2400530T3 (es) 2013-04-10
IL194790A (en) 2012-12-31
NZ573000A (en) 2011-11-25
SMP200800061B (it) 2009-07-14
JP5479088B2 (ja) 2014-04-23
PL1849762T3 (pl) 2009-12-31
US20070293567A1 (en) 2007-12-20
EP1849762B1 (en) 2009-07-15
EA200802172A1 (ru) 2009-06-30
AU2007240335B2 (en) 2013-05-02
KR101542255B1 (ko) 2015-08-06
PT1849762E (pt) 2009-09-16
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
EP1849762A1 (en) 2007-10-31
EP2021314A1 (en) 2009-02-11
GEP20115269B (en) 2011-08-25

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