CR10451A - Acidos bifenilocarbocilicos substituidos y sus derivados - Google Patents

Acidos bifenilocarbocilicos substituidos y sus derivados

Info

Publication number
CR10451A
CR10451A CR10451A CR10451A CR10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A
Authority
CR
Costa Rica
Prior art keywords
substituted
bifenylocarboyclic
derivatives
acids
group
Prior art date
Application number
CR10451A
Other languages
English (en)
Inventor
Wilson Francis
Reid Alison
Reader Valerie
John Harrison Richard
Sunose Mihiro
Hernandez-Perni Remedios
Mayor Jeremy
Boussard Cyrille
Smelt Kathryn
Taylor Jess
Leformal Adeline
Cansfield Andrew
Burckhardt Svenja
Yung Ho Chih
Zhang Yan
Original Assignee
Ortho Macneil Pharmaceutical Inc
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Macneil Pharmaceutical Inc, Cellzome Ltd filed Critical Ortho Macneil Pharmaceutical Inc
Publication of CR10451A publication Critical patent/CR10451A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

l o ester del mismo; mas aun, la invencion se relaciona con el uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y con su uso para la modulacion de la actividad y-secretasa, en donde A es O, NH, S; X es un enlace o grupo -CR5R6 Y es un grupo carboxi-C(O)OH o un grupo tetrazol sustituido o no sustituido.
CR10451A 2006-04-21 2008-11-21 Acidos bifenilocarbocilicos substituidos y sus derivados CR10451A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
CR10451A true CR10451A (es) 2009-03-31

Family

ID=36688012

Family Applications (2)

Application Number Title Priority Date Filing Date
CR10375A CR10375A (es) 2006-04-21 2008-10-17 Acidos bifenilcarboxilicos sustituidos y sus derivados
CR10451A CR10451A (es) 2006-04-21 2008-11-21 Acidos bifenilocarbocilicos substituidos y sus derivados

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR10375A CR10375A (es) 2006-04-21 2008-10-17 Acidos bifenilcarboxilicos sustituidos y sus derivados

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194852A0 (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903335A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
BRPI0818773A2 (pt) 2007-10-19 2015-04-14 Janssen Pharmaceutica Nv Moduladores de gama-secretase ligados a carbono
AU2008312362A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Gsm intermediates
CN101903347B (zh) 2007-10-19 2013-03-27 詹森药业有限公司 带哌啶基和哌嗪基的γ-分泌酶调节剂
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
WO2012119035A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
BR0311788A (pt) * 2002-06-27 2005-03-15 Fujisawa Pharmaceutical Co Composto derivado aminoalcoólico, processo para sua preparação, composição farmacêutica, compreendendo o mesmo, seu uso e método de tratamento
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
JPWO2006022237A1 (ja) * 2004-08-24 2008-05-08 キッセイ薬品工業株式会社 脂肪肝の予防または治療剤
EP1937632A1 (en) * 2005-10-06 2008-07-02 Astra Zeneca AB Novel compounds

Also Published As

Publication number Publication date
DE602006007810D1 (de) 2009-08-27
UY30301A1 (es) 2007-08-31
CA2650006C (en) 2016-08-23
TNSN08413A1 (en) 2010-04-14
WO2007124394A1 (en) 2007-11-01
EP2021314B1 (en) 2013-01-23
AR060568A1 (es) 2008-06-25
AU2007240335A1 (en) 2007-11-01
MY148953A (en) 2013-06-14
MX2008013445A (es) 2009-03-10
TWI399362B (zh) 2013-06-21
TW200815320A (en) 2008-04-01
CN101687758B (zh) 2014-05-14
GT200900120A (es) 2009-11-16
EA016129B9 (ru) 2012-06-29
ES2328616T3 (es) 2009-11-16
CN101687758A (zh) 2010-03-31
CA2650006A1 (en) 2007-11-01
MA30475B1 (fr) 2009-06-01
JP2009544573A (ja) 2009-12-17
IL194852A0 (en) 2009-08-03
PE20080364A1 (es) 2008-05-16
ZA200809856B (en) 2009-06-24
CR10375A (es) 2009-02-26
KR20090024679A (ko) 2009-03-09
EA016129B1 (ru) 2012-02-28
AP2008004656A0 (en) 2008-10-31
BRPI0710656A2 (pt) 2011-08-16
SMAP200800061A (it) 2008-11-19
CY1109399T1 (el) 2014-07-02
UA95952C2 (ru) 2011-09-26
IL194790A0 (en) 2009-08-03
SI1849762T1 (sl) 2009-12-31
ES2400530T3 (es) 2013-04-10
IL194790A (en) 2012-12-31
NZ573000A (en) 2011-11-25
SMP200800061B (it) 2009-07-14
JP5479088B2 (ja) 2014-04-23
PL1849762T3 (pl) 2009-12-31
US20070293567A1 (en) 2007-12-20
DK1849762T3 (da) 2009-10-12
EP1849762B1 (en) 2009-07-15
EA200802172A1 (ru) 2009-06-30
AU2007240335B2 (en) 2013-05-02
KR101542255B1 (ko) 2015-08-06
PT1849762E (pt) 2009-09-16
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
EP1849762A1 (en) 2007-10-31
EP2021314A1 (en) 2009-02-11
GEP20115269B (en) 2011-08-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)