DK175853B1 - Sekretoriske ledersekvenser - Google Patents
Sekretoriske ledersekvenser Download PDFInfo
- Publication number
- DK175853B1 DK175853B1 DK199000729A DK72990A DK175853B1 DK 175853 B1 DK175853 B1 DK 175853B1 DK 199000729 A DK199000729 A DK 199000729A DK 72990 A DK72990 A DK 72990A DK 175853 B1 DK175853 B1 DK 175853B1
- Authority
- DK
- Denmark
- Prior art keywords
- leu
- ser
- phe
- ile
- lys
- Prior art date
Links
- UYDYIIZGDLDBCF-GVHYBUMESA-N C[C@H](CC1)CC1C=C Chemical compound C[C@H](CC1)CC1C=C UYDYIIZGDLDBCF-GVHYBUMESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888817598A GB8817598D0 (en) | 1988-07-23 | 1988-07-23 | Dna & peptide sequences |
| GB898906920A GB8906920D0 (en) | 1989-03-28 | 1989-03-28 | Peptide and dna sequences |
| PCT/GB1989/000816 WO1990001063A1 (en) | 1988-07-23 | 1989-07-14 | New secretory leader sequences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK72990A DK72990A (da) | 1990-03-21 |
| DK72990D0 DK72990D0 (da) | 1990-03-21 |
| DK175853B1 true DK175853B1 (da) | 2005-04-04 |
Family
ID=26294196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199000729A DK175853B1 (da) | 1988-07-23 | 1990-03-21 | Sekretoriske ledersekvenser |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5302697A (da) |
| EP (1) | EP0387319B1 (da) |
| JP (1) | JP3092811B2 (da) |
| KR (1) | KR100195632B1 (da) |
| AT (1) | ATE135045T1 (da) |
| AU (1) | AU633020B2 (da) |
| CA (1) | CA1340547C (da) |
| DE (1) | DE68925893T2 (da) |
| DK (1) | DK175853B1 (da) |
| FI (1) | FI104564B (da) |
| GB (1) | GB2230268B (da) |
| HU (1) | HU213571B (da) |
| IE (1) | IE62266B1 (da) |
| IL (1) | IL91024A (da) |
| WO (1) | WO1990001063A1 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| US5759802A (en) * | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| FR2650598B1 (fr) * | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
| US5919654A (en) * | 1995-02-03 | 1999-07-06 | Asahi Glass Company Ltd. | Secretion signal gene and expression vector containing it |
| US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| ES2178854T3 (es) * | 1997-11-07 | 2003-01-01 | Conjuchem Inc | Bibliotecas de marcadores de afinidad para albumina de suero humano. |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2405563A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050244931A1 (en) * | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20060084794A1 (en) * | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| AU2002332041A1 (en) * | 2001-10-05 | 2003-04-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| ES2500918T3 (es) | 2001-12-21 | 2014-10-01 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina e interferón beta |
| AU2002364587A1 (en) * | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CN1646154B (zh) | 2002-02-07 | 2010-12-01 | 诺维信生物制药英国有限公司 | 与白蛋白融合的抗-血管生成肽 |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
| JP5236189B2 (ja) | 2003-12-05 | 2013-07-17 | チルドレンズ ホスピタル メディカル センター | オリゴ糖組成物および感染症の治療における該組成物の使用 |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| EP1831375B1 (en) | 2004-12-23 | 2014-07-16 | Novozymes Biopharma DK A/S | Gene expression technique |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| AU2007278994B2 (en) | 2006-07-24 | 2013-08-15 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
| EP2054437A2 (en) | 2006-08-07 | 2009-05-06 | Teva Biopharmaceuticals USA, Inc. | Albumin-insulin fusion proteins |
| US20090252703A1 (en) * | 2006-10-19 | 2009-10-08 | Gegg Jr Colin V | Use of alcohol co-solvents to improve pegylation reaction yields |
| PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| AU2008262490B2 (en) * | 2007-05-22 | 2011-11-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| EP2594583A1 (en) | 2007-08-08 | 2013-05-22 | Novozymes Biopharma DK A/S | Transferrin variants and conugates |
| US20110294988A1 (en) | 2009-02-06 | 2011-12-01 | Novozymes Bio Pharma DK A/S | Purification Process |
| CN106986933A (zh) | 2009-02-11 | 2017-07-28 | 阿尔布梅迪克斯医疗公司 | 白蛋白变体和缀合物 |
| MX347291B (es) | 2009-03-20 | 2017-04-17 | Amgen Inc | Inmunoglobulinas portadoras y usos de las mismas. |
| CA2781532A1 (en) | 2009-11-20 | 2011-05-26 | Amgen Inc. | Anti-orai1 antigen binding protein that binds the second extracellular loop of orai1 |
| EP2603794A1 (en) | 2010-08-10 | 2013-06-19 | Amgen Inc. | Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies |
| WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| SG191993A1 (en) | 2011-01-18 | 2013-08-30 | Amgen Inc | Nav1.7 knockout mice and uses thereof |
| AU2012222833B2 (en) | 2011-03-03 | 2017-03-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| CN103930437A (zh) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Nav1.3和Nav1.7的强效及选择性抑制剂 |
| CA2864702A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
| JP6498601B2 (ja) | 2012-07-13 | 2019-04-10 | ザイムワークス，インコーポレイテッド | 多価ヘテロ多量体足場設計および構築物 |
| EP2970408B1 (en) | 2013-03-12 | 2018-01-10 | Amgen Inc. | Potent and selective inhibitors of nav1.7 |
| AU2014262566A1 (en) | 2013-05-08 | 2015-11-12 | Zymeworks Inc. | Bispecific HER2 and HER3 antigen binding constructs |
| EP3039129B1 (en) | 2013-08-30 | 2018-06-27 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
| EP3206707B1 (en) | 2014-10-13 | 2020-12-02 | University of Maryland, Baltimore | Fc-ela-32 and its use in the treatment of cardiac conditions |
| MX2017004769A (es) | 2014-10-15 | 2017-10-16 | Amgen Inc | Elementos promotores y reguladores para mejorar la expresion de genes heterologos en celulas hospederas. |
| CA2874083C (en) | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| CA3005953A1 (en) | 2015-12-22 | 2017-06-29 | Albumedix Ltd | Improved protein expression strains |
| ES2823173T3 (es) | 2016-01-27 | 2021-05-06 | Just Biotherapeutics Inc | Promotor híbrido y usos del mismo |
| US11135266B2 (en) | 2016-11-21 | 2021-10-05 | Just-Evotec Biologics, Inc. | Aflibercept formulations and uses thereof |
| ES2906997T3 (es) | 2017-06-20 | 2022-04-21 | Albumedix Ltd | Cepas de expresión de proteínas mejoradas |
| WO2019036626A1 (en) | 2017-08-17 | 2019-02-21 | Just Biotherapeutics, Inc. | PROCESS FOR PURIFYING GLYCOSYLATED PROTEIN FROM GALECTINES AND OTHER HOST CELL CONTAMINANTS |
| WO2019099965A1 (en) | 2017-11-20 | 2019-05-23 | Just Biotherapeutics, Inc. | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
| KR20210127947A (ko) | 2019-02-15 | 2021-10-25 | 저스트-에보텍 바이오로직스, 아이엔씨. | 자동화된 바이오 제조 시스템, 설비 및 공정 |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| WO2023287707A1 (en) | 2021-07-15 | 2023-01-19 | Just-Evotec Biologics, Inc. | Bidirectional tangential flow filtration (tff) perfusion system |
| WO2023154305A2 (en) | 2022-02-10 | 2023-08-17 | Amgen Inc. | Antibody protein product expression constructs for high throughput sequencing |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| NZ207925A (en) * | 1983-04-25 | 1988-05-30 | Genentech Inc | Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture |
| US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
| FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
| AU5912586A (en) * | 1985-06-20 | 1986-12-24 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Alpha-factor leader peptide-facilitated secretion from transformed s cerevisiae |
| RU2091490C1 (ru) * | 1985-10-25 | 1997-09-27 | Зимодженетикс, Инк. | Способ получения гетерологичного полипептида в эукариотических микроорганизмов |
| EP0243465A1 (en) * | 1985-10-25 | 1987-11-04 | Vivian L. Mackay | Method of using bar1 for secreting foreign proteins |
| GB8613388D0 (en) * | 1986-06-03 | 1986-07-09 | Delta Biotechnology Ltd | Induction of galactose regulated gene expression in yeast |
| IT1196484B (it) * | 1986-07-11 | 1988-11-16 | Sclavo Spa | Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe |
| JP2507874B2 (ja) * | 1986-11-27 | 1996-06-19 | 工業技術院長 | 分泌シグナルペプチドをコ−ドするｄｎａ配列 |
-
1989
- 1989-07-14 EP EP89909015A patent/EP0387319B1/en not_active Expired - Lifetime
- 1989-07-14 DE DE68925893T patent/DE68925893T2/de not_active Expired - Lifetime
- 1989-07-14 WO PCT/GB1989/000816 patent/WO1990001063A1/en active IP Right Grant
- 1989-07-14 AU AU40427/89A patent/AU633020B2/en not_active Expired
- 1989-07-14 KR KR1019900700595A patent/KR100195632B1/ko not_active IP Right Cessation
- 1989-07-14 AT AT89909015T patent/ATE135045T1/de not_active IP Right Cessation
- 1989-07-14 HU HU894572A patent/HU213571B/hu unknown
- 1989-07-14 JP JP01508293A patent/JP3092811B2/ja not_active Expired - Lifetime
- 1989-07-17 CA CA000605832A patent/CA1340547C/en not_active Expired - Fee Related
- 1989-07-18 IL IL9102489A patent/IL91024A/en unknown
- 1989-07-20 IE IE236189A patent/IE62266B1/en not_active IP Right Cessation
- 1989-12-21 GB GB8928849A patent/GB2230268B/en not_active Expired
-
1990
- 1990-03-21 FI FI901428A patent/FI104564B/fi active IP Right Grant
- 1990-03-21 DK DK199000729A patent/DK175853B1/da not_active IP Right Cessation
-
1993
- 1993-05-21 US US08/067,243 patent/US5302697A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK72990A (da) | 1990-03-21 |
| IL91024A0 (en) | 1990-02-09 |
| HU894572D0 (en) | 1991-05-28 |
| GB2230268B (en) | 1992-01-29 |
| FI104564B (fi) | 2000-02-29 |
| IE892361L (en) | 1990-01-23 |
| HU213571B (en) | 1997-08-28 |
| FI901428A0 (fi) | 1990-03-21 |
| AU633020B2 (en) | 1993-01-21 |
| JP3092811B2 (ja) | 2000-09-25 |
| GB8928849D0 (en) | 1990-07-18 |
| DE68925893D1 (de) | 1996-04-11 |
| DE68925893T2 (de) | 1996-08-08 |
| IE62266B1 (en) | 1995-01-11 |
| HUT57829A (en) | 1991-12-30 |
| DK72990D0 (da) | 1990-03-21 |
| ATE135045T1 (de) | 1996-03-15 |
| KR100195632B1 (ko) | 1999-06-15 |
| GB2230268A (en) | 1990-10-17 |
| KR920700288A (ko) | 1992-02-19 |
| US5302697A (en) | 1994-04-12 |
| WO1990001063A1 (en) | 1990-02-08 |
| CA1340547C (en) | 1999-05-18 |
| EP0387319A1 (en) | 1990-09-19 |
| JPH03500370A (ja) | 1991-01-31 |
| EP0387319B1 (en) | 1996-03-06 |
| IL91024A (en) | 1995-08-31 |
| AU4042789A (en) | 1990-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |