DK174689B1 - Azaspirocycloalkylsubstituerede oxoquinolin- eller oxonaphthyridinforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeholdende sådanne forbindelser - Google Patents

Azaspirocycloalkylsubstituerede oxoquinolin- eller oxonaphthyridinforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeholdende sådanne forbindelser Download PDF

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Publication number
DK174689B1
DK174689B1 DK198904262A DK426289A DK174689B1 DK 174689 B1 DK174689 B1 DK 174689B1 DK 198904262 A DK198904262 A DK 198904262A DK 426289 A DK426289 A DK 426289A DK 174689 B1 DK174689 B1 DK 174689B1
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DK
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Prior art keywords
group
compound
carboxylic acid
atoms
dihydro
Prior art date
Application number
DK198904262A
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Danish (da)
English (en)
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DK426289A (da
DK426289D0 (da
Inventor
Isao Hayakawa
Shohgo Atarashi
Masazumi Imamura
Youichi Kimura
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of DK426289D0 publication Critical patent/DK426289D0/da
Publication of DK426289A publication Critical patent/DK426289A/da
Application granted granted Critical
Publication of DK174689B1 publication Critical patent/DK174689B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Luminescent Compositions (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK198904262A 1988-08-31 1989-08-30 Azaspirocycloalkylsubstituerede oxoquinolin- eller oxonaphthyridinforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeholdende sådanne forbindelser DK174689B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP21763888 1988-08-31
JP21763888 1988-08-31
JP23131888 1988-09-14
JP23131888 1988-09-14
JP29698588 1988-11-24
JP29698588 1988-11-24
JP15631689 1989-06-19
JP15631689 1989-06-19

Publications (3)

Publication Number Publication Date
DK426289D0 DK426289D0 (da) 1989-08-30
DK426289A DK426289A (da) 1990-03-01
DK174689B1 true DK174689B1 (da) 2003-09-15

Family

ID=27473404

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198904262A DK174689B1 (da) 1988-08-31 1989-08-30 Azaspirocycloalkylsubstituerede oxoquinolin- eller oxonaphthyridinforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeholdende sådanne forbindelser

Country Status (20)

Country Link
US (1) US5508428A (fr)
EP (2) EP0529688B1 (fr)
KR (2) KR0148688B1 (fr)
CN (1) CN1036193C (fr)
AT (1) ATE160141T1 (fr)
AU (1) AU619891B2 (fr)
CA (1) CA1336090C (fr)
DE (2) DE68928447T2 (fr)
DK (1) DK174689B1 (fr)
ES (2) ES2061845T3 (fr)
FI (1) FI92703C (fr)
HK (1) HK1003000A1 (fr)
IE (2) IE63492B1 (fr)
IL (1) IL91474A (fr)
IN (1) IN170262B (fr)
MY (1) MY104652A (fr)
NO (1) NO177638C (fr)
NZ (1) NZ230484A (fr)
PH (1) PH31278A (fr)
PT (1) PT91602B (fr)

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MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
ATE184603T1 (de) * 1991-06-19 1999-10-15 Pfizer Azaspirochinolone als antibakterielle wirkstoffe
US5276041A (en) * 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
EP0550016A1 (fr) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Dérivés de l'acide quinolone carboxylique et procédés pour leur préparation
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
EP0688772B1 (fr) * 1994-06-16 1999-05-06 LG Chemical Limited Dérivés de l'acide quinolinecarboxylique ayant des substituants 7-(4-amino-méthyl-3-oxime)-pyrrolidine et procédé pour leur préparation
EP0829473B1 (fr) 1995-05-26 2002-08-07 Daiichi Pharmaceutical Co., Ltd. Procedes de preparation de composes cycliques
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
JP3280388B2 (ja) 1997-06-26 2002-05-13 ドング ホワ ファーマシューチカル インダストリアル カンパニー，リミテッド キノロンカルボン酸誘導体
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
EP1262477B1 (fr) * 2000-02-09 2008-09-03 Daiichi Sankyo Company, Limited Agents antibacteriens acidoresistants renfermant des acides pyridonecarboxyliques comme principe actif
AU2001276750A1 (en) * 2000-08-08 2002-02-25 Daiichi Pharmaceutical Co., Ltd. Processes for preparation of bicyclic compounds and intermediates therefor
JP4108311B2 (ja) * 2001-10-02 2008-06-25 ダイセル化学工業株式会社 １−アシル−１−シクロプロパンカルボン酸エステル誘導体の製造法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
WO2005026145A2 (fr) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Agents antibacteriens a base de quinolone
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
WO2009089235A1 (fr) * 2008-01-07 2009-07-16 Janssen Pharmaceutica N.V. Préparation de dérivés de sulfamide
CN103562208B (zh) 2011-03-15 2016-08-31 默沙东公司 三环促旋酶抑制剂
WO2012150208A1 (fr) 2011-05-04 2012-11-08 Bayer Cropscience Ag Utilisation d'esters d'alcools benzyliques substitués de l'acide cyclopropane carboxylique pour lutter contre des insectes résistants aux insecticides
WO2012150221A2 (fr) 2011-05-04 2012-11-08 Bayer Cropscience Ag Nouveaux esters d'alcools benzyliques halogénés de l'acide cyclopropancarboxique utilisés comme pesticides
CN103073481A (zh) * 2013-02-06 2013-05-01 上海药明康德新药开发有限公司 一种4-氮杂螺[2.4]庚烷盐酸盐的制备方法
WO2019027860A1 (fr) * 2017-08-01 2019-02-07 Boehringer Ingelheim International Gmbh Composés intermédiaires et procédés

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US2814622A (en) * 1955-07-18 1957-11-26 Upjohn Co Organic compounds
GB984119A (en) * 1960-06-20 1965-02-24 Aspro Nicholas Ltd Substituted piperidines and methods for their preparation
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US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3721745A1 (de) * 1986-07-04 1988-01-14 Lentia Gmbh Bicyclisch substituierte chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ZA877471B (en) * 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
WO1989000158A1 (fr) * 1987-07-02 1989-01-12 Pfizer Inc. Acides et esters carboxyliques de quinolone de diazabicycloalkyle shunte
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤

Also Published As

Publication number Publication date
KR900003152A (ko) 1990-03-23
AU619891B2 (en) 1992-02-06
KR0148719B1 (en) 1998-08-17
MY104652A (en) 1994-05-31
IE892785L (en) 1990-02-28
NO177638C (no) 1995-10-25
DK426289A (da) 1990-03-01
CN1036193C (zh) 1997-10-22
CN1100095A (zh) 1995-03-15
PT91602A (pt) 1990-03-08
EP0529688A3 (fr) 1993-03-10
FI92703B (fi) 1994-09-15
NO177638B (no) 1995-07-17
FI894045A0 (fi) 1989-08-29
PT91602B (pt) 1995-05-31
EP0529688B1 (fr) 1997-11-12
NZ230484A (en) 1991-06-25
DE68910441D1 (de) 1993-12-09
DK426289D0 (da) 1989-08-30
HK1003000A1 (en) 1998-09-30
NO893453L (no) 1990-03-01
IL91474A0 (en) 1990-04-29
DE68928447T2 (de) 1998-06-18
DE68910441T2 (de) 1994-03-03
FI894045A (fi) 1990-03-01
ES2061845T3 (es) 1994-12-16
CA1336090C (fr) 1995-06-27
IE930570L (en) 1990-02-28
DE68928447D1 (de) 1997-12-18
EP0529688A2 (fr) 1993-03-03
ES2111029T3 (es) 1998-03-01
NO893453D0 (no) 1989-08-29
US5508428A (en) 1996-04-16
IE82128B1 (en) 2002-02-20
FI92703C (fi) 1994-12-27
AU4100689A (en) 1990-03-08
IN170262B (fr) 1992-03-07
PH31278A (en) 1998-07-06
IL91474A (en) 1994-05-30
ATE160141T1 (de) 1997-11-15
KR0148688B1 (ko) 1998-08-17
EP0357047B1 (fr) 1993-11-03
EP0357047A1 (fr) 1990-03-07
IE63492B1 (en) 1995-05-03

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