ES2061845T3 - Un procedimiento para preparar un compuesto espiro. - Google Patents

Un procedimiento para preparar un compuesto espiro.

Info

Publication number
ES2061845T3
ES2061845T3 ES89116022T ES89116022T ES2061845T3 ES 2061845 T3 ES2061845 T3 ES 2061845T3 ES 89116022 T ES89116022 T ES 89116022T ES 89116022 T ES89116022 T ES 89116022T ES 2061845 T3 ES2061845 T3 ES 2061845T3
Authority
ES
Spain
Prior art keywords
preparing
procedure
integer equal
spiral compound
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89116022T
Other languages
English (en)
Inventor
Isao Hayakawa
Shohgo Atarashi
Masazumi Imamura
Youichi Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2061845T3 publication Critical patent/ES2061845T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Luminescent Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

UN COMPONENTE DE FORMULA (I) TIENE ACTIVIDAD ANTIBACTERIANA Y UNA COMPOSICION FARMACEUTICA QUE CONTIENE COMPONENTE DE FORMULA (I). EN DONDE A REPRESENTA UN ENTERO IGUAL DE 0 A 1; B REPRESENTA UN ENTERO IGUAL DE 2 A TRAVES DE 5, INCLUSIVE; C REPRESENTA UN ENTERO IGUAL DE 0 A 1; Y D REPRESENTA UN ENTERO IGUAL DE 0 A TRAVES DE 2 INCLUSIVE; Z REPRESENTA LA FORMULA (2) UN ATOMO DE HIDROGENO O UN ATOMO DE AZUFRE, EN DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO AMINO, UN GRUPO MONOALQUILAMINO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO DIALQUILAMINO QUE CONTIENE DE 1 A 6 ATOMOS DE CARBONO POR ALQUILO, UN GRUPO HIDROXILO, UN GRUPO ALCOXI DE 1 A 6 ATOMOS DE CARBONO O UN GRUPO HIDROXIALQUIL DE 1 A 6 ATOMOS DE CARBONO; R2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO HIDROXIALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO HALOALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO FORMIL O UN GRUPO ALQUILCARBONILO DE 2 A 7 ATOMOS DE CARBONO; Y R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO; Q REPRESENTA UNA ESTRUCTURA PARCIAL DE LA FORMULA (II). EN DONDE R4 REPRESENTA UN GRUPO ALQUILO DE 1 A 6 ATMOS DE CARBONO, UN GRUPO ALQUENILO DE 2 A 6 ATOMOS DE CARBONO, UN GRUPO HALOALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO CICLOALQUILO SUSTITUIDO O NO DE 3 A 6 ATOMOS DE CARBONO, UN GRUPO ARILO SUBSTITUIDO O NO, UN GRUPO HETEROALQUILO SUSTITUIDO O NO, UN GRUPO ALQUILAMINO DE 1 A 6 ATOMOS DE CARBONO; R5 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO; R6 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO AMINO SUSTITUIDO O NO UN GRUPO ALCOXI DE 1 A 6 ATOMOS DE CARBONO O UN ATOMO DE HALOGENO; A REPRESENTA UN ATOMO DE NITROGENO O FORMULA (3), EN DONDE R7 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN ATOMO DE HALOGENO, UN GRUPO ALCOXI DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO HALOALQUIL DE 1 A 6 ATOMOS DE CARBONO O UN GRUPO CIANO; R4 PUEDE UNIRSE CON R5 Y/O R7 FORMANDO UN ANILLO SUSTITUIDO O NO, EL CUAL PUEDE INCLUIR UN OXIGENO, NITROGENO O ATOMO DE AZUFRE, EN DONDE EL SUSTITUYENTE ES UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO, O UN GRUPO ALOALQUILO DE 1 A 6 ATOMOS DE CARBONO; X REPRESENTA UN ATOMO HALOGENO; Y REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE ALCOXIALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO FENILALQUILO QUE CONTIENE DE 1 A 6 ATOMOS DE CARBONO EN ESTE MOIETE ALQUILO, UN GRUPO DIHALOBORON, UN GRUPO FENIL, UN GRUPO ACETOXIMETLO, UN GRUPO PIVADOXIMETILO, UN GRUPO ETOXICARBONILOXI, UN GRUPO CHOLINO, UN GRUPO DIMETILAMINOETILO, UN GRUPO 5 - INDENILO, UN GRUPO FTALIDINIL, UN GRUPO 5 SUSTITUIDO - 2 - OXO - 1, 3 - DIOXAZOL - 4 - IMETIL O UN GRUPO 3 - ACETOXI - 2 - OXOBUTIL, O UNA SAL DEL MISMO.
ES89116022T 1988-08-31 1989-08-30 Un procedimiento para preparar un compuesto espiro. Expired - Lifetime ES2061845T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP21763888 1988-08-31
JP23131888 1988-09-14
JP29698588 1988-11-24
JP15631689 1989-06-19

Publications (1)

Publication Number Publication Date
ES2061845T3 true ES2061845T3 (es) 1994-12-16

Family

ID=27473404

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92117125T Expired - Lifetime ES2111029T3 (es) 1988-08-31 1989-08-30 Azaespiro(n,m)alcanos y diazaespiro(n,m)alcanos.
ES89116022T Expired - Lifetime ES2061845T3 (es) 1988-08-31 1989-08-30 Un procedimiento para preparar un compuesto espiro.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92117125T Expired - Lifetime ES2111029T3 (es) 1988-08-31 1989-08-30 Azaespiro(n,m)alcanos y diazaespiro(n,m)alcanos.

Country Status (20)

Country Link
US (1) US5508428A (es)
EP (2) EP0529688B1 (es)
KR (2) KR0148688B1 (es)
CN (1) CN1036193C (es)
AT (1) ATE160141T1 (es)
AU (1) AU619891B2 (es)
CA (1) CA1336090C (es)
DE (2) DE68928447T2 (es)
DK (1) DK174689B1 (es)
ES (2) ES2111029T3 (es)
FI (1) FI92703C (es)
HK (1) HK1003000A1 (es)
IE (2) IE82128B1 (es)
IL (1) IL91474A (es)
IN (1) IN170262B (es)
MY (1) MY104652A (es)
NO (1) NO177638C (es)
NZ (1) NZ230484A (es)
PH (1) PH31278A (es)
PT (1) PT91602B (es)

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US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
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KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
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NZ286951A (en) * 1995-07-13 1998-02-26 Anormed Inc Substituted Under N-n-diethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
AU7940598A (en) 1997-06-26 1999-01-19 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
AU2001232238B2 (en) 2000-02-09 2005-03-24 Daiichi Pharmaceutical Co., Ltd. Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
EP1310487B1 (en) * 2000-08-08 2007-01-03 Daiichi Pharmaceutical Co., Ltd. Processes for preparation of bicyclic compounds and intermediates therefor
JP4108311B2 (ja) * 2001-10-02 2008-06-25 ダイセル化学工業株式会社 １−アシル−１−シクロプロパンカルボン酸エステル誘導体の製造法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
EP2249828A1 (en) * 2008-01-07 2010-11-17 Janssen Pharmaceutica, N.V. Preparation of sulfamide derivatives
CN103562208B (zh) 2011-03-15 2016-08-31 默沙东公司 三环促旋酶抑制剂
WO2012150221A2 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Neue halogenierte benzylalkoholester der cyclopropancarbonsäure als schädlingsbekämpfungsmittel
WO2012150208A1 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Verwendung von substituierten benzylalkoholestern der cyclopropancarbonsäure zur bekämpfung von insektizid-resistenten insekten
CN103073481A (zh) * 2013-02-06 2013-05-01 上海药明康德新药开发有限公司 一种4-氮杂螺[2.4]庚烷盐酸盐的制备方法
US20200369611A1 (en) * 2017-08-01 2020-11-26 Boehringer Ingelheim International Gmbh Intermediate compounds and methods

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Also Published As

Publication number Publication date
ES2111029T3 (es) 1998-03-01
ATE160141T1 (de) 1997-11-15
DK426289A (da) 1990-03-01
FI92703B (fi) 1994-09-15
EP0529688B1 (en) 1997-11-12
CN1100095A (zh) 1995-03-15
PT91602B (pt) 1995-05-31
CA1336090C (en) 1995-06-27
NO177638C (no) 1995-10-25
FI894045A0 (fi) 1989-08-29
IL91474A (en) 1994-05-30
CN1036193C (zh) 1997-10-22
IE892785L (en) 1990-02-28
PT91602A (pt) 1990-03-08
DE68928447D1 (de) 1997-12-18
US5508428A (en) 1996-04-16
IL91474A0 (en) 1990-04-29
EP0529688A3 (en) 1993-03-10
KR0148719B1 (en) 1998-08-17
DK174689B1 (da) 2003-09-15
DK426289D0 (da) 1989-08-30
EP0357047B1 (en) 1993-11-03
FI894045A (fi) 1990-03-01
KR900003152A (ko) 1990-03-23
AU619891B2 (en) 1992-02-06
IE930570L (en) 1990-02-28
IN170262B (es) 1992-03-07
NZ230484A (en) 1991-06-25
NO893453D0 (no) 1989-08-29
AU4100689A (en) 1990-03-08
DE68928447T2 (de) 1998-06-18
IE63492B1 (en) 1995-05-03
EP0357047A1 (en) 1990-03-07
HK1003000A1 (en) 1998-09-30
NO893453L (no) 1990-03-01
MY104652A (en) 1994-05-31
PH31278A (en) 1998-07-06
FI92703C (fi) 1994-12-27
NO177638B (no) 1995-07-17
DE68910441D1 (de) 1993-12-09
IE82128B1 (en) 2002-02-20
EP0529688A2 (en) 1993-03-03
KR0148688B1 (ko) 1998-08-17
DE68910441T2 (de) 1994-03-03

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