DK171235B1 - Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren - Google Patents

Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren Download PDF

Info

Publication number
DK171235B1
DK171235B1 DK085490A DK85490A DK171235B1 DK 171235 B1 DK171235 B1 DK 171235B1 DK 085490 A DK085490 A DK 085490A DK 85490 A DK85490 A DK 85490A DK 171235 B1 DK171235 B1 DK 171235B1
Authority
DK
Denmark
Prior art keywords
acid
hydroxyethyl
penem
carbamoyloxymethyl
crystalline
Prior art date
Application number
DK085490A
Other languages
Danish (da)
English (en)
Other versions
DK85490A (da
DK85490D0 (da
Inventor
Carlo Battistini
Roberto Bianchini
Stefano Del Nero
Pierluigi Griggi
Sergio Vioglio
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK85490D0 publication Critical patent/DK85490D0/da
Publication of DK85490A publication Critical patent/DK85490A/da
Application granted granted Critical
Publication of DK171235B1 publication Critical patent/DK171235B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK085490A 1988-08-08 1990-04-05 Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren DK171235B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8818789 1988-08-08
GB888818789A GB8818789D0 (en) 1988-08-08 1988-08-08 Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation
EP8900924 1989-08-04
PCT/EP1989/000924 WO1990001484A1 (en) 1988-08-08 1989-08-04 Crystalline (5r,6s)-2-carbamoyloxymethyl-6-[(1r)-hydroxyethyl]-2-penem-carboxylic acid and its pharmaceutical formulation

Publications (3)

Publication Number Publication Date
DK85490D0 DK85490D0 (da) 1990-04-05
DK85490A DK85490A (da) 1990-06-07
DK171235B1 true DK171235B1 (da) 1996-08-05

Family

ID=10641768

Family Applications (1)

Application Number Title Priority Date Filing Date
DK085490A DK171235B1 (da) 1988-08-08 1990-04-05 Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren

Country Status (21)

Country Link
US (1) US5302588A (fi)
EP (1) EP0407478B1 (fi)
JP (1) JP2954956B2 (fi)
KR (1) KR900701799A (fi)
AT (1) ATE112777T1 (fi)
AU (1) AU626576B2 (fi)
CA (1) CA1339422C (fi)
DE (1) DE68918849T2 (fi)
DK (1) DK171235B1 (fi)
ES (1) ES2015770A6 (fi)
FI (1) FI95575C (fi)
GB (1) GB8818789D0 (fi)
GR (1) GR1002251B (fi)
HU (1) HU205934B (fi)
IE (1) IE68447B1 (fi)
IL (1) IL91216A (fi)
NZ (1) NZ230196A (fi)
PT (1) PT91383B (fi)
RU (1) RU2074858C1 (fi)
WO (1) WO1990001484A1 (fi)
ZA (1) ZA895966B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
US20090275746A1 (en) * 2006-07-28 2009-11-05 Hetero Drugs Limited Solid faropenem free acid
KR20160109904A (ko) * 2015-03-13 2016-09-21 주식회사 대웅제약 결정형 도리페넴의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
SU1389680A3 (ru) * 1981-12-11 1988-04-15 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени оптически активных пенемов или их солей с щелочными металлами
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
PT84767B (en) * 1986-04-29 1989-06-09 Ciba Geigy Ag Process for preparing a crystalline (5r.6s)-2-aminomethyl-6-](1r)-1-hydroxyethyl"-2-penem-3-carboxylic acid hydrate
GB8915392D0 (en) * 1989-07-05 1989-08-23 Erba Carlo Spa Process for penems

Also Published As

Publication number Publication date
FI901710A0 (fi) 1990-04-04
IE892528L (en) 1990-02-08
KR900701799A (ko) 1990-12-04
IL91216A (en) 1994-10-21
ES2015770A6 (es) 1990-09-01
GR1002251B (en) 1996-04-23
US5302588A (en) 1994-04-12
DK85490A (da) 1990-06-07
EP0407478B1 (en) 1994-10-12
DK85490D0 (da) 1990-04-05
ZA895966B (en) 1990-06-27
RU2074858C1 (ru) 1997-03-10
HUT56571A (en) 1991-09-30
NZ230196A (en) 1990-09-26
FI95575B (fi) 1995-11-15
PT91383A (pt) 1990-03-08
IL91216A0 (en) 1990-03-19
GB8818789D0 (en) 1988-09-07
GR890100493A (el) 1990-08-22
JPH03500781A (ja) 1991-02-21
PT91383B (pt) 1995-05-31
DE68918849T2 (de) 1995-02-23
FI95575C (fi) 1996-02-26
JP2954956B2 (ja) 1999-09-27
WO1990001484A1 (en) 1990-02-22
HU205934B (en) 1992-07-28
IE68447B1 (en) 1996-06-26
CA1339422C (en) 1997-09-02
ATE112777T1 (de) 1994-10-15
AU626576B2 (en) 1992-08-06
EP0407478A1 (en) 1991-01-16
DE68918849D1 (de) 1994-11-17
AU4049089A (en) 1990-03-05
HU894594D0 (en) 1991-07-29

Similar Documents

Publication Publication Date Title
AU679800B2 (en) Crystalline penicillin derivative, and its production and use
EP1535916B1 (en) Inclusion complexes of butylphthalide with cyclodextrin derivatives and processes for their preparation
DK171235B1 (da) Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren
JP4000397B2 (ja) モルヒネ−6−グルクロニドの新しい結晶形熊
JP7346485B2 (ja) 結晶性β-ラクタマーゼ阻害剤
US8871927B2 (en) Method for purifying Ceftizoxime sodium
US9452158B2 (en) R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1 acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial
JPS58103392A (ja) 3位においてチオメチルヘテロ環基により置換されたセフアロスポリンの新規な誘導体、これら化合物の製造方法およびこれらを含有する薬学的組成物
EP1264821B1 (en) Novel crystal of stilbene derivative and process for producing the same
KR930001830B1 (ko) 항균성 동결건조 제제
CN103570719A (zh) 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN109134256B (zh) 一种双醋瑞因晶体i及其制备方法与应用
MXPA06015112A (es) D-tartrato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il) piperazina.
CN1295234C (zh) 一种头孢呋辛酯非对映异构体的分离方法
JPH0673085A (ja) デカプラニン塩溶液および結晶デカプラニン塩ならびにそれらの調製方法
JPS643178B2 (fi)

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed