DK161699C - Analogifremgangsmaade til fremstilling af 4-aryl-4-piperidincarbinoler eller farmaceutisk acceptable salte deraf - Google Patents
Analogifremgangsmaade til fremstilling af 4-aryl-4-piperidincarbinoler eller farmaceutisk acceptable salte derafInfo
- Publication number
- DK161699C DK161699C DK205083A DK205083A DK161699C DK 161699 C DK161699 C DK 161699C DK 205083 A DK205083 A DK 205083A DK 205083 A DK205083 A DK 205083A DK 161699 C DK161699 C DK 161699C
- Authority
- DK
- Denmark
- Prior art keywords
- analogue
- aryl
- preparation
- acceptable salts
- pharmaceutical acceptable
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37622982A | 1982-05-07 | 1982-05-07 | |
| US37622982 | 1982-05-07 | ||
| US06/468,040 US4485109A (en) | 1982-05-07 | 1983-02-25 | 4-Aryl-4-piperidinecarbinols |
| US46804083 | 1983-02-25 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK205083D0 DK205083D0 (da) | 1983-05-06 |
| DK205083A DK205083A (da) | 1983-11-08 |
| DK161699B DK161699B (da) | 1991-08-05 |
| DK161699C true DK161699C (da) | 1992-01-13 |
Family
ID=27007350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK205083A DK161699C (da) | 1982-05-07 | 1983-05-06 | Analogifremgangsmaade til fremstilling af 4-aryl-4-piperidincarbinoler eller farmaceutisk acceptable salte deraf |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4485109A (da) |
| EP (1) | EP0094018B1 (da) |
| AU (1) | AU560166B2 (da) |
| CA (1) | CA1252790A (da) |
| DE (1) | DE3375915D1 (da) |
| DK (1) | DK161699C (da) |
| ES (1) | ES8501750A1 (da) |
| FI (1) | FI78685C (da) |
| GR (1) | GR77502B (da) |
| HU (1) | HU188278B (da) |
| IE (1) | IE55994B1 (da) |
| IL (1) | IL68586A0 (da) |
| NO (1) | NO162817C (da) |
| NZ (1) | NZ204150A (da) |
| PH (1) | PH18380A (da) |
| PT (1) | PT76657B (da) |
| SU (1) | SU1187718A3 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019650A (en) * | 1988-03-28 | 1991-05-28 | E. I. Du Pont De Nemours And Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| CA1337418C (en) * | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5086063A (en) * | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| FR2639226B1 (fr) * | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
| CA2022886A1 (en) * | 1989-08-08 | 1991-02-09 | Raymond Baker | Substituted pyridines, their preparation, formulations and use in dementia |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| US6656953B2 (en) | 2000-12-06 | 2003-12-02 | Sepracor Inc. | 4,4-Disubstituted piperidines, and methods of use thereof |
| DE60213116T2 (de) * | 2001-10-16 | 2007-02-08 | Endo Pharmaceuticals Inc. | Verwendung von carbinolen zur behandlung von neuropathischer funktionsstörung |
| JP2006507363A (ja) * | 2002-11-01 | 2006-03-02 | ニューロサーチ、アクティーゼルスカブ | 新規ピペリジン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| CA2584831C (en) * | 2004-10-13 | 2013-09-17 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
| CN101068782A (zh) * | 2004-10-13 | 2007-11-07 | 神经研究瑞典公司 | 合成4－(3－磺酰基苯基)－哌啶类的方法 |
| EP2787997A4 (en) | 2011-12-08 | 2015-05-27 | Ivax Int Gmbh | HYDROBROMIDE SALT OF PRIDOPIDINE |
| MX2014011971A (es) | 2012-04-04 | 2015-01-16 | Ivax Int Gmbh | Composiciones farmaceuticas para terapia de combinacion. |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL88063C (da) * | 1950-12-05 | |||
| FR1049588A (fr) * | 1950-12-05 | 1953-12-30 | Schering Corp | Procédé ?? préparation de pipéridines substituées |
| US2832786A (en) * | 1956-02-27 | 1958-04-29 | Wm S Merrell Co | Phosphoramides |
| AT214445B (de) * | 1957-08-14 | 1961-04-10 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen, substituierten 1-(β-Oxyäthyl)-4-phenylpiperidinen |
| GB841120A (en) * | 1958-02-12 | 1960-07-13 | J F Macfarlan & Co Ltd | Improvements in or relating to piperidine compounds |
| GB888657A (en) * | 1958-07-14 | 1962-01-31 | J F Macfarlan & Co Ltd | Piperidine carbinols |
| US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
| US3108211A (en) * | 1960-08-08 | 1963-10-22 | Electro Sonic Ind Inc | Activation of ferroelectric elements |
| GB1243991A (en) * | 1968-06-10 | 1971-08-25 | Ici Ltd | Piperidine, morpholine and piperazine derivatives |
| US3824242A (en) * | 1973-01-26 | 1974-07-16 | Research Corp | Synthesis of meperidine |
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US3998832A (en) * | 1975-04-16 | 1976-12-21 | G. D. Searle & Co. | Anti-diarrheal compounds |
| AU509558B2 (en) * | 1976-10-18 | 1980-05-15 | G. D. Seale & Co | 1-(3, 3, 3-triarylalkyl1) 4-phenyl-piperidinemethanol ethers |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| FR2408602A2 (fr) * | 1977-11-15 | 1979-06-08 | Synthelabo | Nouveaux derives de piperidine et leur methode de preparation |
| US4228288A (en) * | 1978-11-29 | 1980-10-14 | Eli Lilly And Company | Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates |
| US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
| US4236009A (en) * | 1979-06-21 | 1980-11-25 | Eli Lilly And Company | Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines |
| US4277608A (en) * | 1979-06-21 | 1981-07-07 | Eli Lilly And Company | Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines |
-
1983
- 1983-02-25 US US06/468,040 patent/US4485109A/en not_active Expired - Lifetime
- 1983-05-04 DE DE8383104366T patent/DE3375915D1/de not_active Expired
- 1983-05-04 GR GR71306A patent/GR77502B/el unknown
- 1983-05-04 EP EP83104366A patent/EP0094018B1/en not_active Expired
- 1983-05-05 CA CA000427534A patent/CA1252790A/en not_active Expired
- 1983-05-05 IL IL68586A patent/IL68586A0/xx not_active IP Right Cessation
- 1983-05-05 ES ES522120A patent/ES8501750A1/es not_active Expired
- 1983-05-05 PH PH28859A patent/PH18380A/en unknown
- 1983-05-05 NO NO831588A patent/NO162817C/no unknown
- 1983-05-06 FI FI831567A patent/FI78685C/fi not_active IP Right Cessation
- 1983-05-06 AU AU14311/83A patent/AU560166B2/en not_active Ceased
- 1983-05-06 PT PT76657A patent/PT76657B/pt not_active IP Right Cessation
- 1983-05-06 IE IE1040/83A patent/IE55994B1/en not_active IP Right Cessation
- 1983-05-06 HU HU831582A patent/HU188278B/hu not_active IP Right Cessation
- 1983-05-06 SU SU833588607A patent/SU1187718A3/ru active
- 1983-05-06 NZ NZ204150A patent/NZ204150A/en unknown
- 1983-05-06 DK DK205083A patent/DK161699C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES522120A0 (es) | 1984-12-01 |
| IE55994B1 (en) | 1991-03-13 |
| DE3375915D1 (de) | 1988-04-14 |
| AU560166B2 (en) | 1987-04-02 |
| IE831040L (en) | 1983-11-07 |
| DK161699B (da) | 1991-08-05 |
| FI831567L (fi) | 1983-11-08 |
| DK205083A (da) | 1983-11-08 |
| EP0094018B1 (en) | 1988-03-09 |
| NO831588L (no) | 1983-11-08 |
| NO162817B (no) | 1989-11-13 |
| SU1187718A3 (ru) | 1985-10-23 |
| HU188278B (en) | 1986-03-28 |
| EP0094018A3 (en) | 1985-11-06 |
| CA1252790A (en) | 1989-04-18 |
| FI78685B (fi) | 1989-05-31 |
| IL68586A0 (en) | 1983-09-30 |
| PT76657B (en) | 1986-04-16 |
| DK205083D0 (da) | 1983-05-06 |
| NO162817C (no) | 1990-02-21 |
| NZ204150A (en) | 1985-05-31 |
| PH18380A (en) | 1985-06-19 |
| AU1431183A (en) | 1983-11-10 |
| EP0094018A2 (en) | 1983-11-16 |
| PT76657A (en) | 1983-06-01 |
| US4485109A (en) | 1984-11-27 |
| ES8501750A1 (es) | 1984-12-01 |
| FI78685C (fi) | 1989-09-11 |
| FI831567A0 (fi) | 1983-05-06 |
| GR77502B (da) | 1984-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK160940C (da) | Analogifremgangsmaade til fremstilling af benzoheterocycliske forbindelser eller farmaceutisk acceptable salte deraf | |
| DK152495C (da) | Analogifremgangsmaade til fremstilling af n2-arylsulfonyl-l-argininamider eller farmaceutisk tolerable salte deraf | |
| DK161770C (da) | Analogifremgangsmaade til fremstilling af cyklobutylaminderivater eller farmaceutisk acceptable salte deraf | |
| DK161968C (da) | Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf | |
| DK148537C (da) | Analogifremgangsmaade til fremstilling af 3-aminopyridazinforbindelser eller farmaceutisk acceptable salte deraf | |
| DK152114C (da) | Analogifremgangsmaade til fremstilling af propenylaminer eller farmaceutisk acceptable salte deraf | |
| DK552581A (da) | Fremgangsmaade til fremstilling af 3-pyridylaklyl-indol-forbindelser eller farmaceutisk acceptable salte deraf | |
| DK157862C (da) | Analogifremgangsmaade til fremstilling af imidazolylphenylamidiner eller farmaceutisk acceptable syreadditionssalte deraf | |
| DK162166C (da) | Analogifremgangsmaade til fremstilling af (2s)-isomere af 2-oe4-(2-hydroxycyclopentan-1-ylmethyl)phenylaapropionsyre eller farmaceutisk acceptable salte deraf | |
| DK161699C (da) | Analogifremgangsmaade til fremstilling af 4-aryl-4-piperidincarbinoler eller farmaceutisk acceptable salte deraf | |
| DK158306C (da) | Analogifremgangsmaade til fremstilling af substituerede pyridylallylforbindelser eller farmaceutisk acceptable salte deraf | |
| DK158658C (da) | Analogifremgangsmaade til fremstilling af 9-aminoalkylfluorener eller farmaceutisk acceptable salte deraf | |
| DK413883D0 (da) | Fremgangsmade til fremstilling af c-20-modificerede macrolid-derivater eller farmaceutisk acceptable salte deraf | |
| DK149269C (da) | Analogifremgangsmaade til fremstilling af beta-mono- eller -difluormethyl-beta-alanin-derivater eller farmaceutisk acceptable salte eller optiske isomere deraf | |
| DK145263C (da) | Analogifremgangsmaade til fremstilling af imidazothiaziner eller farmaceutisk acceptable salte deraf | |
| DK162102C (da) | Analogifremgangsmaade til fremstilling af 3-o-(beta-d-glucoronopyranosyl)-sojasapogenol b eller farmaceutisk acceptable salte deraf | |
| DK152491C (da) | Analogifremgangsmaade til fremstilling af esterholdige phenoxypropanolaminer eller farmaceutisk anvendelige salte deraf | |
| DK158227C (da) | Analogifremgangsmaade til fremstilling af substituerede imidazooe1,5-aaapyridiner eller 5,6,7,8-tetrahydroderivater deraf eller salte deraf | |
| DK157023C (da) | Analogifremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf | |
| DK148019C (da) | Analogifremgangsmaade til fremstilling af 2-pyridylaminobenzoesyrer eller farmaceutisk acceptable salte deraf | |
| DK150521C (da) | Analogifremgangsmaade til fremstilling af n2-arylsulfonyl-l-argininamider eller farmaceutisk acceptable salte deraf | |
| DK149823C (da) | Fremgangsmaade til fremstilling af kijanimicin eller farmaceutisk acceptable salte heraf | |
| DK151254C (da) | Analogifremgangsmaade til fremstilling af 2-hydroxymethyl-pyrazin-derivater eller farmaceutisk acceptable salte deraf | |
| DK164786C (da) | Analogifremgangsmaade til fremstilling af benzazolderivater eller salte deraf | |
| DK210183D0 (da) | Fremgangsmade til fremstillng af piperidinoquinazolin-forbindelser eller farmaceutisk acceptable salte deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |