DE3375915D1 - 4-aryl-4-piperidinecarbinols - Google Patents

4-aryl-4-piperidinecarbinols

Info

Publication number
DE3375915D1
DE3375915D1 DE8383104366T DE3375915T DE3375915D1 DE 3375915 D1 DE3375915 D1 DE 3375915D1 DE 8383104366 T DE8383104366 T DE 8383104366T DE 3375915 T DE3375915 T DE 3375915T DE 3375915 D1 DE3375915 D1 DE 3375915D1
Authority
DE
Germany
Prior art keywords
aryl
piperidine carbinols
carbinols
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383104366T
Other languages
English (en)
Inventor
Engelbert Ciganek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE3375915D1 publication Critical patent/DE3375915D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383104366T 1982-05-07 1983-05-04 4-aryl-4-piperidinecarbinols Expired DE3375915D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37622982A 1982-05-07 1982-05-07
US06/468,040 US4485109A (en) 1982-05-07 1983-02-25 4-Aryl-4-piperidinecarbinols

Publications (1)

Publication Number Publication Date
DE3375915D1 true DE3375915D1 (de) 1988-04-14

Family

ID=27007350

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383104366T Expired DE3375915D1 (de) 1982-05-07 1983-05-04 4-aryl-4-piperidinecarbinols

Country Status (17)

Country Link
US (1) US4485109A (de)
EP (1) EP0094018B1 (de)
AU (1) AU560166B2 (de)
CA (1) CA1252790A (de)
DE (1) DE3375915D1 (de)
DK (1) DK161699C (de)
ES (1) ES8501750A1 (de)
FI (1) FI78685C (de)
GR (1) GR77502B (de)
HU (1) HU188278B (de)
IE (1) IE55994B1 (de)
IL (1) IL68586A0 (de)
NO (1) NO162817C (de)
NZ (1) NZ204150A (de)
PH (1) PH18380A (de)
PT (1) PT76657B (de)
SU (1) SU1187718A3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019650A (en) * 1988-03-28 1991-05-28 E. I. Du Pont De Nemours And Company 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
CA1337418C (en) * 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5086063A (en) * 1988-03-28 1992-02-04 Du Pont Merck Pharmaceutical Company 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
CA2022886A1 (en) * 1989-08-08 1991-02-09 Raymond Baker Substituted pyridines, their preparation, formulations and use in dementia
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
US6656953B2 (en) 2000-12-06 2003-12-02 Sepracor Inc. 4,4-Disubstituted piperidines, and methods of use thereof
DE60213116T2 (de) * 2001-10-16 2007-02-08 Endo Pharmaceuticals Inc. Verwendung von carbinolen zur behandlung von neuropathischer funktionsstörung
JP2006507363A (ja) * 2002-11-01 2006-03-02 ニューロサーチ、アクティーゼルスカブ 新規ピペリジン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
CA2584831C (en) * 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
CN101068782A (zh) * 2004-10-13 2007-11-07 神经研究瑞典公司 合成4－(3－磺酰基苯基)－哌啶类的方法
EP2787997A4 (de) 2011-12-08 2015-05-27 Ivax Int Gmbh Hydrobromidsalz von pridopidin
MX2014011971A (es) 2012-04-04 2015-01-16 Ivax Int Gmbh Composiciones farmaceuticas para terapia de combinacion.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL88063C (de) * 1950-12-05
FR1049588A (fr) * 1950-12-05 1953-12-30 Schering Corp Procédé ?? préparation de pipéridines substituées
US2832786A (en) * 1956-02-27 1958-04-29 Wm S Merrell Co Phosphoramides
AT214445B (de) * 1957-08-14 1961-04-10 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen, substituierten 1-(β-Oxyäthyl)-4-phenylpiperidinen
GB841120A (en) * 1958-02-12 1960-07-13 J F Macfarlan & Co Ltd Improvements in or relating to piperidine compounds
GB888657A (en) * 1958-07-14 1962-01-31 J F Macfarlan & Co Ltd Piperidine carbinols
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
US3108211A (en) * 1960-08-08 1963-10-22 Electro Sonic Ind Inc Activation of ferroelectric elements
GB1243991A (en) * 1968-06-10 1971-08-25 Ici Ltd Piperidine, morpholine and piperazine derivatives
US3824242A (en) * 1973-01-26 1974-07-16 Research Corp Synthesis of meperidine
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
AU509558B2 (en) * 1976-10-18 1980-05-15 G. D. Seale & Co 1-(3, 3, 3-triarylalkyl1) 4-phenyl-piperidinemethanol ethers
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FR2408602A2 (fr) * 1977-11-15 1979-06-08 Synthelabo Nouveaux derives de piperidine et leur methode de preparation
US4228288A (en) * 1978-11-29 1980-10-14 Eli Lilly And Company Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates
US4284635A (en) * 1978-11-29 1981-08-18 Eli Lilly And Company Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines

Also Published As

Publication number Publication date
ES522120A0 (es) 1984-12-01
IE55994B1 (en) 1991-03-13
AU560166B2 (en) 1987-04-02
IE831040L (en) 1983-11-07
DK161699B (da) 1991-08-05
FI831567L (fi) 1983-11-08
DK205083A (da) 1983-11-08
EP0094018B1 (de) 1988-03-09
NO831588L (no) 1983-11-08
NO162817B (no) 1989-11-13
SU1187718A3 (ru) 1985-10-23
HU188278B (en) 1986-03-28
EP0094018A3 (en) 1985-11-06
CA1252790A (en) 1989-04-18
FI78685B (fi) 1989-05-31
IL68586A0 (en) 1983-09-30
PT76657B (en) 1986-04-16
DK161699C (da) 1992-01-13
DK205083D0 (da) 1983-05-06
NO162817C (no) 1990-02-21
NZ204150A (en) 1985-05-31
PH18380A (en) 1985-06-19
AU1431183A (en) 1983-11-10
EP0094018A2 (de) 1983-11-16
PT76657A (en) 1983-06-01
US4485109A (en) 1984-11-27
ES8501750A1 (es) 1984-12-01
FI78685C (fi) 1989-09-11
FI831567A0 (fi) 1983-05-06
GR77502B (de) 1984-09-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE DU PONT MERCK PHARMACEUTICAL CO., WILMINGTON,

8328 Change in the person/name/address of the agent

Free format text: VON KREISLER, A., DIPL.-CHEM. SELTING, G., DIPL.-ING. WERNER, H., DIPL.-CHEM. DR.RER.NAT. FUES, J., DIPL.-CHEM. DR.RER.NAT. BOECKMANN GEN. DALLMEYER, G., DIPL.-ING. HILLERINGMANN, J., DIPL.-ING. JOENSSON, H., DIPL.-CHEM. DR.RER.NAT. MEYERS, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 5000 KOELN

8339 Ceased/non-payment of the annual fee