DK1546127T3 - Nye pyrimidinamidderivater og anvendelse deraf - Google Patents

Nye pyrimidinamidderivater og anvendelse deraf

Info

Publication number: DK1546127T3
Authority: DK; Denmark
Prior art keywords: derivatives; pyrimidinamide; disease; new; benzoylaminophenyl
Prior art date: 2002-09-27

Application number

DK03750639T

Other languages

English (en)

Inventor

Paul William Manley

Werner Breitenstein

Sandra Jacob

Pascal Furet

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-27

Filing date

2003-09-26

Publication date

2007-12-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944917&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1546127(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-26 Application filed by Novartis Ag filed Critical Novartis Ag

2007-12-10 Application granted granted Critical

2007-12-10 Publication of DK1546127T3 publication Critical patent/DK1546127T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

DK03750639T 2002-09-27 2003-09-26 Nye pyrimidinamidderivater og anvendelse deraf DK1546127T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0222514.2A GB0222514D0 (en)	2002-09-27	2002-09-27	Organic compounds
PCT/EP2003/010724 WO2004029038A1 (en)	2002-09-27	2003-09-26	Novel pyrimidineamide derivatives and the use thereof

Publications (1)

Publication Number	Publication Date
DK1546127T3 true DK1546127T3 (da)	2007-12-10

Family

ID=9944917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03750639T DK1546127T3 (da)	2002-09-27	2003-09-26	Nye pyrimidinamidderivater og anvendelse deraf

Country Status (24)

Country	Link
US (1)	US7655669B2 (da)
EP (1)	EP1546127B1 (da)
JP (2)	JP4463685B2 (da)
KR (2)	KR20070098940A (da)
CN (1)	CN100404528C (da)
AT (1)	ATE369355T1 (da)
AU (1)	AU2003270277B2 (da)
BR (1)	BR0314797A (da)
CA (1)	CA2499822C (da)
DE (1)	DE60315479T2 (da)
DK (1)	DK1546127T3 (da)
EC (1)	ECSP055701A (da)
ES (1)	ES2288615T3 (da)
GB (1)	GB0222514D0 (da)
HK (1)	HK1080459A1 (da)
MX (1)	MXPA05003253A (da)
NO (1)	NO20051966L (da)
NZ (1)	NZ538930A (da)
PL (1)	PL374443A1 (da)
PT (1)	PT1546127E (da)
RU (1)	RU2378267C2 (da)
SI (1)	SI1546127T1 (da)
WO (1)	WO2004029038A1 (da)
ZA (1)	ZA200502304B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0222514D0 (en) *	2002-09-27	2002-11-06	Novartis Ag	Organic compounds
US7232825B2 (en) *	2003-05-02	2007-06-19	Guoqing P Chen	Phenylaminopyrimidine derivatives and methods of use
GB0325031D0 (en) *	2003-10-27	2003-12-03	Novartis Ag	Organic compounds
DE10352979A1 (de)	2003-11-13	2005-06-09	Merck Patent Gmbh	Pyridopyrimidinone
TW200616974A (en) *	2004-07-01	2006-06-01	Astrazeneca Ab	Chemical compounds
CA2577275A1 (en)	2004-08-31	2006-03-09	Astrazeneca Ab	Quinazolinone derivatives and their use as b-raf inhibitors
US7939541B2 (en)	2004-09-09	2011-05-10	Natco Pharma Limited	Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
US8735415B2 (en)	2004-09-09	2014-05-27	Natco Pharma Limited	Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
MX2007002819A (es) *	2004-09-09	2007-08-14	Natco Pharma Ltd	Nuevos derivados de fenilaminopirimidina como inhibidores de bcl-abl cinasa.
CN1939910A (zh)	2004-12-31	2007-04-04	孙飘扬	氨基嘧啶类化合物及其盐和其制备方法与药物用途
PT1843771E (pt) *	2005-01-28	2011-12-02	Novartis Ag	Uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação da atividade da cinase tie-2
MY146795A (en) *	2005-06-09	2012-09-28	Novartis Ag	Process for the synthesis of organic compounds
WO2008020203A1 (en) *	2006-08-17	2008-02-21	Astrazeneca Ab	Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors
CA2662977A1 (en)	2006-09-22	2008-03-27	Novartis Ag	Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors
BRPI0718677A2 (pt) *	2006-11-03	2013-11-26	Irm Llc	Compostos e composições como inibidores de quinases proteicas
US7550591B2 (en) *	2007-05-02	2009-06-23	Chemagis Ltd.	Imatinib production process
WO2008137794A1 (en)	2007-05-04	2008-11-13	Irm Llc	Compounds and compositions as c-kit and pdgfr kinase inhibitors
ATE544761T1 (de) *	2007-05-04	2012-02-15	Irm Llc	Pyrimidinderivate und zusammensetzungen als c-kit-und pdgfr-kinasehemmer
TWI433677B (zh)	2007-06-04	2014-04-11	Avila Therapeutics Inc	雜環化合物及其用途
KR20120107538A (ko)	2007-08-22	2012-10-02	아이알엠 엘엘씨	키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
BRPI0815572A2 (pt)	2007-08-22	2015-02-18	Irm Llc	Compostos e composições como inibidores de quinases
US8067422B2 (en)	2008-03-04	2011-11-29	Natco Pharma Limited	Crystal form of phenylamino pyrimidine derivatives
EP2569288A2 (en) *	2010-05-11	2013-03-20	Krisani Biosciences (P) Ltd.	4,6-dibenzoylamino-2-methyl-pyrimidine derivatives and their use for the treatment of cancer
EP2822935B1 (en)	2011-11-17	2019-05-15	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG47583A1 (en)	1986-01-13	1998-04-17	American Cyanamid Co	4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines
US5215989A (en)	1989-12-08	1993-06-01	Merck & Co., Inc.	Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
TW225528B (da) *	1992-04-03	1994-06-21	Ciba Geigy Ag
US5516775A (en)	1992-08-31	1996-05-14	Ciba-Geigy Corporation	Further use of pyrimidine derivatives
US5543520A (en)	1993-10-01	1996-08-06	Ciba-Geigy Corporation	Pyrimidine derivatives
CA2148931A1 (en)	1993-10-01	1995-04-13	Jurg Zimmermann	Pyrimidineamine derivatives and processes for the preparation thereof
ITMI992711A1 (it)	1999-12-27	2001-06-27	Novartis Ag	Composti organici
US7087608B2 (en)	2000-03-03	2006-08-08	Robert Charles Atkins	Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
GB0022438D0 (en) *	2000-09-13	2000-11-01	Novartis Ag	Organic Compounds
GB0025820D0 (en)	2000-10-20	2000-12-06	Novartis Ag	Organic compounds
ATE331519T1 (de)	2001-05-16	2006-07-15	Gpc Biotech Ag	Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
GB0222514D0 (en) *	2002-09-27	2002-11-06	Novartis Ag	Organic compounds
WO2005064409A2 (en)	2003-12-23	2005-07-14	Koninklijke Philips Electronics N.V.	Removable pellicle for immersion lithography

2002
- 2002-09-27 GB GBGB0222514.2A patent/GB0222514D0/en not_active Ceased
2003
- 2003-09-26 AU AU2003270277A patent/AU2003270277B2/en not_active Ceased
- 2003-09-26 PT PT03750639T patent/PT1546127E/pt unknown
- 2003-09-26 US US10/528,913 patent/US7655669B2/en not_active Expired - Fee Related
- 2003-09-26 SI SI200331014T patent/SI1546127T1/sl unknown
- 2003-09-26 BR BR0314797-5A patent/BR0314797A/pt not_active IP Right Cessation
- 2003-09-26 KR KR1020077019251A patent/KR20070098940A/ko not_active Application Discontinuation
- 2003-09-26 EP EP03750639A patent/EP1546127B1/en not_active Expired - Lifetime
- 2003-09-26 MX MXPA05003253A patent/MXPA05003253A/es active IP Right Grant
- 2003-09-26 AT AT03750639T patent/ATE369355T1/de not_active IP Right Cessation
- 2003-09-26 WO PCT/EP2003/010724 patent/WO2004029038A1/en active IP Right Grant
- 2003-09-26 DK DK03750639T patent/DK1546127T3/da active
- 2003-09-26 CA CA2499822A patent/CA2499822C/en not_active Expired - Fee Related
- 2003-09-26 DE DE60315479T patent/DE60315479T2/de not_active Expired - Lifetime
- 2003-09-26 RU RU2005113153/04A patent/RU2378267C2/ru not_active IP Right Cessation
- 2003-09-26 KR KR1020057005204A patent/KR100876055B1/ko not_active IP Right Cessation
- 2003-09-26 JP JP2004539039A patent/JP4463685B2/ja not_active Expired - Fee Related
- 2003-09-26 CN CNB038232138A patent/CN100404528C/zh not_active Expired - Fee Related
- 2003-09-26 PL PL03374443A patent/PL374443A1/xx not_active Application Discontinuation
- 2003-09-26 NZ NZ538930A patent/NZ538930A/en unknown
- 2003-09-26 ES ES03750639T patent/ES2288615T3/es not_active Expired - Lifetime
2005
- 2005-03-18 ZA ZA200502304A patent/ZA200502304B/en unknown
- 2005-03-23 EC EC2005005701A patent/ECSP055701A/es unknown
- 2005-04-22 NO NO20051966A patent/NO20051966L/no not_active Application Discontinuation
- 2005-12-23 HK HK05111972A patent/HK1080459A1/xx not_active IP Right Cessation
2009
- 2009-10-09 JP JP2009235252A patent/JP5178681B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20050047128A (ko)	2005-05-19
JP2010043113A (ja)	2010-02-25
KR100876055B1 (ko)	2008-12-26
BR0314797A (pt)	2005-07-26
CA2499822C (en)	2012-04-10
ATE369355T1 (de)	2007-08-15
JP5178681B2 (ja)	2013-04-10
ECSP055701A (es)	2005-05-30
WO2004029038A1 (en)	2004-04-08
HK1080459A1 (en)	2006-04-28
NZ538930A (en)	2008-04-30
ES2288615T3 (es)	2008-01-16
PL374443A1 (en)	2005-10-17
AU2003270277B2 (en)	2007-08-23
US7655669B2 (en)	2010-02-02
RU2005113153A (ru)	2006-11-10
DE60315479D1 (de)	2007-09-20
CN1684951A (zh)	2005-10-19
EP1546127A1 (en)	2005-06-29
US20060142577A1 (en)	2006-06-29
CN100404528C (zh)	2008-07-23
EP1546127B1 (en)	2007-08-08
MXPA05003253A (es)	2005-06-08
NO20051966L (no)	2005-04-22
SI1546127T1 (sl)	2008-08-31
GB0222514D0 (en)	2002-11-06
KR20070098940A (ko)	2007-10-05
CA2499822A1 (en)	2004-04-08
ZA200502304B (en)	2006-04-26
AU2003270277A1 (en)	2004-04-19
DE60315479T2 (de)	2008-04-30
PT1546127E (pt)	2007-11-07
JP2006508064A (ja)	2006-03-09
JP4463685B2 (ja)	2010-05-19
RU2378267C2 (ru)	2010-01-10

Publication	Publication Date	Title
NO20051966L (no)	2005-04-22	Nye pyrimidinamidderivater og anvendelse derav
DE602004017194D1 (de)	2008-11-27	Pyridylpyrrol-derivate als wirksame kinase-hemmer
DK1636236T3 (da)	2013-12-09	Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
WO2004005281A8 (en)	2004-05-06	Inhibitors of tyrosine kinases
NO20055863L (no)	2001-09-12	W-karboksyarylsubstituerte difenylureaforbindelser som raf-kinaseinhibitorer
TW200615266A (en)	2006-05-16	Organic compounds
NO20062504L (no)	2006-07-21	Sammensetninger og doseringsformer for forbedret absorpsjon
CY1108932T1 (el)	2014-07-02	Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
MXPA06000302A (es)	2006-04-18	Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.
NO20040547L (no)	2004-03-03	Amino-ftalazinonderivater aktive som kinaseinhibitorer, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende disse.
ATE408601T1 (de)	2008-10-15	Fredericamycin-derivate
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
BRPI0413438A (pt)	2006-10-17	derivados de pirimidilpirrol ativos como inibidores de cinase
BR0312722A (pt)	2005-05-10	Derivados de pirazol heterobicìclico como inibidores de qinase
BR0316458A (pt)	2005-10-11	Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto
SE0002729D0 (sv)	2000-07-20	Novel compound form
TW200700075A (en)	2007-01-01	Roflumilast and integrin inhibitor combination and method of treatment
MXPA05014143A (es)	2006-02-24	Derivados de cumarina para el tratamiento de trastornos oftalmicos.
DE50312224D1 (de)	2010-01-21	Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel
NO20030021D0 (no)	2003-01-03	Heterosykliske forbindelser som er inhibitorer for enzymet DPP-IV
NO20034985L (no)	2003-11-10	Nye 5-tio-SS-D-xylopyranosid-derivater, fremgangsmåte for fremstilling derav, farmasöytiske blandinger inneholdende dem og den terapeutiskeanvendelse derav
DE60327249D1 (de)	2009-05-28	Anthranilsäureamide und ihre pharmazeutische verwendung
DE50304524D1 (de)	2006-09-14	Arzneimittel enthaltend substituierte 2,5-diaminomethyl-1h-pyrrole
ECSP12005525A (es)	2014-01-31	Inhibidores de cinasas de tirosina