DK149854C - Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen - Google Patents

Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen

Info

Publication number: DK149854C
Authority: DK; Denmark
Prior art keywords: preparation; oxadiazoline; intermediates; analogue; acid addition
Prior art date: 1979-10-11

Application number

DK429780A

Other languages

English (en)

Other versions

DK429780A (da

DK149854B (da

Inventor

Kalman Takacs

Ilona Kiss

Antal Simay

Nagy Peter Literati

Maria Hetyey

Marian Ecsery

Laszlo Szekeres

Gyula Papp

Sandor Viragh

Eva Udvardy

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-11

Filing date

1980-10-10

Publication date

1987-04-21

1980-10-10 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1981-04-12 Publication of DK429780A publication Critical patent/DK429780A/da

1986-10-13 Publication of DK149854B publication Critical patent/DK149854B/da

1987-04-21 Application granted granted Critical

1987-04-21 Publication of DK149854C publication Critical patent/DK149854C/da

Links

PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical compound O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK429780A 1979-10-11 1980-10-10 Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen DK149854C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HUCI001973		1979-10-11
HU79CI1973A HU179951B (en)	1979-10-11	1979-10-11	Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof

Publications (3)

Publication Number	Publication Date
DK429780A DK429780A (da)	1981-04-12
DK149854B DK149854B (da)	1986-10-13
DK149854C true DK149854C (da)	1987-04-21

Family

ID=10994764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK429780A DK149854C (da)	1979-10-11	1980-10-10	Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen

Country Status (23)

Country	Link
US (1)	US4365064A (da)
JP (1)	JPS5661375A (da)
AT (1)	AT375369B (da)
BE (1)	BE885633A (da)
CA (1)	CA1154019A (da)
CH (1)	CH649547A5 (da)
CS (1)	CS241032B2 (da)
DD (1)	DD153550A5 (da)
DE (1)	DE3037432A1 (da)
DK (1)	DK149854C (da)
ES (1)	ES495819A0 (da)
FI (2)	FI71318C (da)
FR (1)	FR2467203A1 (da)
GB (1)	GB2059967B (da)
HU (1)	HU179951B (da)
IL (1)	IL61175A (da)
IT (1)	IT1129305B (da)
NL (1)	NL8005586A (da)
NO (1)	NO154795C (da)
PL (3)	PL131375B1 (da)
SE (1)	SE452158B (da)
SU (1)	SU1087519A1 (da)
YU (1)	YU41738B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives
CZ20023110A3 (cs) *	2000-03-20	2003-02-12	N-Gene Research Laboratories Inc.	Deriváty amidoximu propenkarboxylové kyseliny, způsob jejich přípravy a farmaceutické přípravky je obsahující
US10118918B2 (en)	2012-12-21	2018-11-06	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
CA2899363A1 (en)	2012-12-21	2014-06-26	Epizyme, Inc.	Prmt5 inhibitors and uses thereof
WO2014100695A1 (en)	2012-12-21	2014-06-26	Epizyme, Inc.	Prmt5 inhibitors and uses thereof
CA2894130A1 (en)	2012-12-21	2014-06-26	Epizyme, Inc.	Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
PT2935222T (pt)	2012-12-21	2018-12-10	Epizyme Inc	Inibidores de prmt5 e seus usos
AU2015301196A1 (en)	2014-08-04	2017-01-12	Epizyme, Inc.	PRMT5 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1529700A (fr) *	1967-04-11	1968-06-21	Dausse Sa Lab	Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (da) *	1967-12-07	1969-07-25
US4038279A (en) *	1972-12-23	1977-07-26	Boehringer Ingelheim Gmbh	N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) *	1974-12-20	1976-11-30	Armour Pharmaceutical Company	Tetrahydroisoquinoline compounds
US4187220A (en) *	1977-08-30	1980-02-05	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives

1979
- 1979-10-11 HU HU79CI1973A patent/HU179951B/hu not_active IP Right Cessation
1980
- 1980-09-30 IL IL61175A patent/IL61175A/xx unknown
- 1980-10-03 DE DE19803037432 patent/DE3037432A1/de not_active Withdrawn
- 1980-10-06 CS CS806737A patent/CS241032B2/cs unknown
- 1980-10-07 SE SE8007025A patent/SE452158B/sv not_active IP Right Cessation
- 1980-10-09 FR FR8021624A patent/FR2467203A1/fr active Granted
- 1980-10-09 IT IT68555/80A patent/IT1129305B/it active
- 1980-10-09 AT AT0501380A patent/AT375369B/de not_active IP Right Cessation
- 1980-10-09 JP JP14066880A patent/JPS5661375A/ja active Pending
- 1980-10-09 NL NL8005586A patent/NL8005586A/nl not_active Application Discontinuation
- 1980-10-10 FI FI803219A patent/FI71318C/fi not_active IP Right Cessation
- 1980-10-10 SU SU802993201A patent/SU1087519A1/ru active
- 1980-10-10 GB GB8032828A patent/GB2059967B/en not_active Expired
- 1980-10-10 NO NO803044A patent/NO154795C/no unknown
- 1980-10-10 CH CH7599/80A patent/CH649547A5/de not_active IP Right Cessation
- 1980-10-10 BE BE0/202406A patent/BE885633A/fr not_active IP Right Cessation
- 1980-10-10 DK DK429780A patent/DK149854C/da not_active IP Right Cessation
- 1980-10-10 CA CA000362217A patent/CA1154019A/en not_active Expired
- 1980-10-10 DD DD80224478A patent/DD153550A5/de not_active IP Right Cessation
- 1980-10-10 YU YU2594/80A patent/YU41738B/xx unknown
- 1980-10-10 PL PL1980227209A patent/PL131375B1/pl unknown
- 1980-10-10 PL PL1980232293A patent/PL132131B1/pl unknown
- 1980-10-10 FI FI803220A patent/FI71932C/fi not_active IP Right Cessation
- 1980-10-10 ES ES495819A patent/ES495819A0/es active Granted
- 1980-10-10 PL PL1980232292A patent/PL131451B1/pl unknown
- 1980-10-14 US US06/196,583 patent/US4365064A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATA501380A (de)	1983-12-15
PL131451B1 (en)	1984-11-30
FI71932B (fi)	1986-11-28
SE452158B (sv)	1987-11-16
NO803044L (no)	1981-04-13
US4365064A (en)	1982-12-21
HU179951B (en)	1983-01-28
SE8007025L (sv)	1981-04-12
DK429780A (da)	1981-04-12
PL232293A1 (da)	1982-04-26
FR2467203B1 (da)	1985-03-22
IL61175A (en)	1984-08-31
PL131375B1 (en)	1984-11-30
PL232292A1 (da)	1982-04-26
IL61175A0 (en)	1980-11-30
YU259480A (en)	1984-02-29
NO154795C (no)	1986-12-29
NO154795B (no)	1986-09-15
IT1129305B (it)	1986-06-04
DK149854B (da)	1986-10-13
GB2059967A (en)	1981-04-29
DD153550A5 (de)	1982-01-13
FI803220L (fi)	1981-04-12
CA1154019A (en)	1983-09-20
FI71932C (fi)	1987-03-09
FI803219L (fi)	1981-04-12
CS673780A2 (en)	1985-06-13
PL227209A1 (da)	1981-12-11
YU41738B (en)	1987-12-31
JPS5661375A (en)	1981-05-26
BE885633A (fr)	1981-02-02
SU1087519A1 (ru)	1984-04-23
FI71318B (fi)	1986-09-09
ES8106725A1 (es)	1981-09-16
GB2059967B (en)	1983-06-02
FR2467203A1 (fr)	1981-04-17
CS241032B2 (en)	1986-03-13
AT375369B (de)	1984-07-25
PL132131B1 (en)	1985-02-28
DE3037432A1 (de)	1981-05-27
CH649547A5 (de)	1985-05-31
NL8005586A (nl)	1981-04-14
ES495819A0 (es)	1981-09-16
IT8068555A0 (it)	1980-10-09
FI71318C (fi)	1986-12-19

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Legal Events

Date	Code	Title	Description
1994-06-20	PBP	Patent lapsed