DK1272468T3 - Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne - Google Patents

Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne

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Publication number
DK1272468T3
DK1272468T3 DK01919610T DK01919610T DK1272468T3 DK 1272468 T3 DK1272468 T3 DK 1272468T3 DK 01919610 T DK01919610 T DK 01919610T DK 01919610 T DK01919610 T DK 01919610T DK 1272468 T3 DK1272468 T3 DK 1272468T3
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DK
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Prior art keywords
indolin
ligands
derivatives
oxytocin receptors
oxytocin
Prior art date
Application number
DK01919610T
Other languages
English (en)
Inventor
Georges Garcia
Gal Claudine Serradeil-Le
Gerard Valette
Loic Foulon
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
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Publication of DK1272468T3 publication Critical patent/DK1272468T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DK01919610T 2000-04-03 2001-04-02 Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne DK1272468T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004193A FR2807038B1 (fr) 2000-04-03 2000-04-03 Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2001/000980 WO2001074775A1 (fr) 2000-04-03 2001-04-02 Derives d'indolin-2-one et leur utilisation en tant que ligands des recepteurs de l'ocytocine

Publications (1)

Publication Number Publication Date
DK1272468T3 true DK1272468T3 (da) 2005-03-29

Family

ID=8848777

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DK01919610T DK1272468T3 (da) 2000-04-03 2001-04-02 Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne

Country Status (35)

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US (2) US20040059132A1 (da)
EP (1) EP1272468B1 (da)
JP (1) JP2003529586A (da)
KR (1) KR100765028B1 (da)
CN (1) CN1224614C (da)
AR (1) AR034547A1 (da)
AT (1) ATE282593T1 (da)
AU (2) AU2001246671B2 (da)
BR (1) BR0109814A (da)
CA (1) CA2404592A1 (da)
CZ (1) CZ20023297A3 (da)
DE (1) DE60107221T2 (da)
DK (1) DK1272468T3 (da)
EA (1) EA005093B1 (da)
EE (1) EE05002B1 (da)
ES (1) ES2232610T3 (da)
FR (1) FR2807038B1 (da)
HK (1) HK1050004A1 (da)
HU (1) HUP0303109A3 (da)
IL (1) IL152085A0 (da)
IS (1) IS2458B (da)
ME (1) MEP24308A (da)
MX (1) MXPA02009773A (da)
NO (1) NO324314B1 (da)
NZ (1) NZ521617A (da)
PL (1) PL358222A1 (da)
PT (1) PT1272468E (da)
SI (1) SI1272468T1 (da)
SK (1) SK14272002A3 (da)
TR (1) TR200202288T2 (da)
TW (1) TWI225860B (da)
UA (1) UA73163C2 (da)
WO (1) WO2001074775A1 (da)
YU (1) YU80902A (da)
ZA (1) ZA200207802B (da)

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EP1556068B1 (en) * 2002-10-03 2010-08-18 Neuropharmacology Services, LLC Oxytocin for use in the treatment of Autism and Asperger's disorder
TWI289141B (en) 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
FR2875499B1 (fr) * 2004-09-20 2006-10-27 Sanofi Aventis Sa Nouveaux derives pyridiniques d'indolin-2-one, leur preparation et leur application en therapeutique
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR056317A1 (es) * 2005-04-20 2007-10-03 Xenon Pharmaceuticals Inc Compuestos de oxindol y composicion farmaceutica
ES2366130T3 (es) * 2005-05-10 2011-10-17 Ferring B.V. Uso de antagonistas de oxitocina y/o vasopresina en reproducción asistida.
CN101336239A (zh) * 2005-12-02 2008-12-31 艾博特股份有限两合公司 经取代的羟吲哚衍生物，含有该衍生物的药物及其用途
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
WO2007120102A1 (en) * 2006-04-19 2007-10-25 Astrazeneca Ab New substituted oxindole derivatives
WO2008046083A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of oxindole compounds as therapeutic agents
ATE545416T1 (de) 2006-10-12 2012-03-15 Xenon Pharmaceuticals Inc Verwendung von spiro-oxindol-verbindungen als therapeutika
FR2909668B1 (fr) * 2006-12-12 2009-01-23 Sanofi Aventis Sa Derives de 5-alkyloxy-indolin-2-one,leur preparation et leurs applications en therapeutique
CA2741024A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CA2741029A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
NZ712378A (en) 2009-10-14 2017-05-26 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
EP2538919B1 (en) 2010-02-26 2017-07-12 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
CN103623268B (zh) * 2013-12-04 2015-07-15 张国显 神经康复再造丸及其制备方法
CN103830666B (zh) * 2014-02-14 2016-02-10 孔祥英 一种治疗高血压的中药足浴组合物
CN104402886B (zh) * 2014-09-18 2017-01-25 陕西科技大学 一种具有抗肿瘤活性的7‑氮杂靛红类双螺环化合物及其合成方法
CN104230786B (zh) * 2014-09-26 2017-03-22 陕西科技大学 一种具有抗肿瘤活性的含吲哚结构的化合物及其合成方法
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
MA43159B1 (fr) 2015-11-06 2020-08-31 Hoffmann La Roche Dérivés d'indoline-2-one
CN108698991B (zh) 2016-01-20 2022-08-23 凯莫森特里克斯股份有限公司 2-氧代吲哚化合物
CN109232290A (zh) * 2018-11-07 2019-01-18 陕西科技大学 一种含氟酰胺及其制备方法
CN109678781B (zh) * 2018-12-20 2022-03-29 苏州麦迪耐斯医药科技有限公司 一种刺猬通路抑制剂
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders

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DK0429685T3 (da) * 1989-07-25 1997-12-15 Taiho Pharmaceutical Co Ltd Oxoindolderivat
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
JPH10338672A (ja) * 1996-07-16 1998-12-22 Takeda Chem Ind Ltd 排尿調節剤および２環性化合物

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CA2404592A1 (fr) 2001-10-11
PT1272468E (pt) 2005-03-31
AU4667101A (en) 2001-10-15
NO20024749L (no) 2002-12-03
FR2807038B1 (fr) 2002-08-16
KR100765028B1 (ko) 2007-10-09
TWI225860B (en) 2005-01-01
UA73163C2 (en) 2005-06-15
PL358222A1 (en) 2004-08-09
CN1224614C (zh) 2005-10-26
US20040059132A1 (en) 2004-03-25
EP1272468A1 (fr) 2003-01-08
WO2001074775A1 (fr) 2001-10-11
ATE282593T1 (de) 2004-12-15
SK14272002A3 (sk) 2003-05-02
EP1272468B1 (fr) 2004-11-17
KR20020089427A (ko) 2002-11-29
EA200200912A1 (ru) 2003-06-26
ES2232610T3 (es) 2005-06-01
SI1272468T1 (en) 2005-04-30
CN1427825A (zh) 2003-07-02
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MXPA02009773A (es) 2003-06-17
HUP0303109A2 (hu) 2004-01-28
DE60107221D1 (de) 2004-12-23
IS6566A (is) 2002-09-24
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EE05002B1 (et) 2008-04-15
HK1050004A1 (en) 2003-06-06
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MEP24308A (en) 2010-06-10
AU2001246671B2 (en) 2006-03-16
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ZA200207802B (en) 2003-09-29
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US20070203184A1 (en) 2007-08-30
BR0109814A (pt) 2003-01-21
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EA005093B1 (ru) 2004-10-28
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JP2003529586A (ja) 2003-10-07
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HUP0303109A3 (en) 2010-04-28
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YU80902A (sh) 2005-11-28
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