DK1368325T3 - Ny asymmetrisk fremgangsmåde til fremstilling af diarylmethylpiperazinderivater og hidtil ukendte asymmetriske diarylmethylaminer som mellemprodukter - Google Patents

Ny asymmetrisk fremgangsmåde til fremstilling af diarylmethylpiperazinderivater og hidtil ukendte asymmetriske diarylmethylaminer som mellemprodukter

Info

Publication number
DK1368325T3
DK1368325T3 DK02701852T DK02701852T DK1368325T3 DK 1368325 T3 DK1368325 T3 DK 1368325T3 DK 02701852 T DK02701852 T DK 02701852T DK 02701852 T DK02701852 T DK 02701852T DK 1368325 T3 DK1368325 T3 DK 1368325T3
Authority
DK
Denmark
Prior art keywords
asymmetric
preparation
diarylmethylamines
diarylmethylpiperazine
intermediates
Prior art date
Application number
DK02701852T
Other languages
Danish (da)
English (en)
Inventor
William Brown
Niklas Plobeck
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1368325T3 publication Critical patent/DK1368325T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK02701852T 2001-03-07 2002-03-05 Ny asymmetrisk fremgangsmåde til fremstilling af diarylmethylpiperazinderivater og hidtil ukendte asymmetriske diarylmethylaminer som mellemprodukter DK1368325T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100764A SE0100764D0 (sv) 2001-03-07 2001-03-07 New assymetric process
PCT/SE2002/000376 WO2002070492A1 (en) 2001-03-07 2002-03-05 New asymmetric process for the preparation of diarylmethylpiperazines derivatives and novel asymmetric diarylmetylamines as intermediates

Publications (1)

Publication Number Publication Date
DK1368325T3 true DK1368325T3 (da) 2008-11-24

Family

ID=20283236

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02701852T DK1368325T3 (da) 2001-03-07 2002-03-05 Ny asymmetrisk fremgangsmåde til fremstilling af diarylmethylpiperazinderivater og hidtil ukendte asymmetriske diarylmethylaminer som mellemprodukter

Country Status (21)

Country Link
US (2) US7045625B2 (zh)
EP (1) EP1368325B1 (zh)
JP (1) JP2004522793A (zh)
KR (1) KR100856996B1 (zh)
CN (2) CN1295217C (zh)
AT (1) ATE406354T1 (zh)
BR (1) BR0207817A (zh)
CA (1) CA2440104A1 (zh)
DE (1) DE60228548D1 (zh)
DK (1) DK1368325T3 (zh)
ES (1) ES2311050T3 (zh)
HK (1) HK1059436A1 (zh)
IL (1) IL157460A0 (zh)
MX (1) MXPA03007889A (zh)
NO (1) NO325156B1 (zh)
NZ (1) NZ527656A (zh)
PT (1) PT1368325E (zh)
SE (1) SE0100764D0 (zh)
SI (1) SI1368325T1 (zh)
WO (1) WO2002070492A1 (zh)
ZA (1) ZA200306448B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114560781A (zh) * 2022-03-01 2022-05-31 无锡捷化医药科技有限公司 一种n,n-二(2-氯乙基)-4-硝基苯基丙氨酸甲酯的制备方法
CN114702457A (zh) * 2022-03-30 2022-07-05 青岛科技大学 一种二芳基甲胺类化合物的绿色合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
MY111348A (en) * 1993-07-30 1999-11-30 Ardent Pharmaceuticals Inc Opioid diarylmethylpiperazines and piperidines
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds

Also Published As

Publication number Publication date
NZ527656A (en) 2005-04-29
KR100856996B1 (ko) 2008-09-04
WO2002070492A1 (en) 2002-09-12
US20040077861A1 (en) 2004-04-22
US20060074238A1 (en) 2006-04-06
NO20033944D0 (no) 2003-09-05
KR20030080075A (ko) 2003-10-10
NO325156B1 (no) 2008-02-11
SE0100764D0 (sv) 2001-03-07
EP1368325A1 (en) 2003-12-10
ZA200306448B (en) 2004-09-08
CN1494532A (zh) 2004-05-05
PT1368325E (pt) 2008-10-27
BR0207817A (pt) 2004-03-09
JP2004522793A (ja) 2004-07-29
CN1295217C (zh) 2007-01-17
MXPA03007889A (es) 2003-12-04
SI1368325T1 (sl) 2008-12-31
US7423154B2 (en) 2008-09-09
ATE406354T1 (de) 2008-09-15
CA2440104A1 (en) 2002-09-12
CN1244565C (zh) 2006-03-08
CN1721407A (zh) 2006-01-18
EP1368325B1 (en) 2008-08-27
US7045625B2 (en) 2006-05-16
ES2311050T3 (es) 2009-02-01
DE60228548D1 (de) 2008-10-09
IL157460A0 (en) 2004-03-28
HK1059436A1 (en) 2004-07-02
NO20033944L (no) 2003-10-31

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