DE60228548D1 - Neues asymmetrisches verfahren zur herstellung von diarylmethylpiperazinderivaten und neue asymmetrische diarylmethylamine als zwischenprodukte - Google Patents

Neues asymmetrisches verfahren zur herstellung von diarylmethylpiperazinderivaten und neue asymmetrische diarylmethylamine als zwischenprodukte

Info

Publication number
DE60228548D1
DE60228548D1 DE60228548T DE60228548T DE60228548D1 DE 60228548 D1 DE60228548 D1 DE 60228548D1 DE 60228548 T DE60228548 T DE 60228548T DE 60228548 T DE60228548 T DE 60228548T DE 60228548 D1 DE60228548 D1 DE 60228548D1
Authority
DE
Germany
Prior art keywords
new asymmetric
preparation
diarylmethylamines
diarylmethylpiperazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60228548T
Other languages
English (en)
Inventor
William Brown
Niklas Plobeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60228548D1 publication Critical patent/DE60228548D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60228548T 2001-03-07 2002-03-05 Neues asymmetrisches verfahren zur herstellung von diarylmethylpiperazinderivaten und neue asymmetrische diarylmethylamine als zwischenprodukte Expired - Fee Related DE60228548D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100764A SE0100764D0 (sv) 2001-03-07 2001-03-07 New assymetric process
PCT/SE2002/000376 WO2002070492A1 (en) 2001-03-07 2002-03-05 New asymmetric process for the preparation of diarylmethylpiperazines derivatives and novel asymmetric diarylmetylamines as intermediates

Publications (1)

Publication Number Publication Date
DE60228548D1 true DE60228548D1 (de) 2008-10-09

Family

ID=20283236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228548T Expired - Fee Related DE60228548D1 (de) 2001-03-07 2002-03-05 Neues asymmetrisches verfahren zur herstellung von diarylmethylpiperazinderivaten und neue asymmetrische diarylmethylamine als zwischenprodukte

Country Status (21)

Country Link
US (2) US7045625B2 (de)
EP (1) EP1368325B1 (de)
JP (1) JP2004522793A (de)
KR (1) KR100856996B1 (de)
CN (2) CN1295217C (de)
AT (1) ATE406354T1 (de)
BR (1) BR0207817A (de)
CA (1) CA2440104A1 (de)
DE (1) DE60228548D1 (de)
DK (1) DK1368325T3 (de)
ES (1) ES2311050T3 (de)
HK (1) HK1059436A1 (de)
IL (1) IL157460A0 (de)
MX (1) MXPA03007889A (de)
NO (1) NO325156B1 (de)
NZ (1) NZ527656A (de)
PT (1) PT1368325E (de)
SE (1) SE0100764D0 (de)
SI (1) SI1368325T1 (de)
WO (1) WO2002070492A1 (de)
ZA (1) ZA200306448B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114560781A (zh) * 2022-03-01 2022-05-31 无锡捷化医药科技有限公司 一种n,n-二(2-氯乙基)-4-硝基苯基丙氨酸甲酯的制备方法
CN114702457A (zh) * 2022-03-30 2022-07-05 青岛科技大学 一种二芳基甲胺类化合物的绿色合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
MY111348A (en) * 1993-07-30 1999-11-30 Ardent Pharmaceuticals Inc Opioid diarylmethylpiperazines and piperidines
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds

Also Published As

Publication number Publication date
NZ527656A (en) 2005-04-29
KR100856996B1 (ko) 2008-09-04
WO2002070492A1 (en) 2002-09-12
US20040077861A1 (en) 2004-04-22
US20060074238A1 (en) 2006-04-06
NO20033944D0 (no) 2003-09-05
KR20030080075A (ko) 2003-10-10
NO325156B1 (no) 2008-02-11
SE0100764D0 (sv) 2001-03-07
EP1368325A1 (de) 2003-12-10
ZA200306448B (en) 2004-09-08
CN1494532A (zh) 2004-05-05
PT1368325E (pt) 2008-10-27
BR0207817A (pt) 2004-03-09
JP2004522793A (ja) 2004-07-29
DK1368325T3 (da) 2008-11-24
CN1295217C (zh) 2007-01-17
MXPA03007889A (es) 2003-12-04
SI1368325T1 (sl) 2008-12-31
US7423154B2 (en) 2008-09-09
ATE406354T1 (de) 2008-09-15
CA2440104A1 (en) 2002-09-12
CN1244565C (zh) 2006-03-08
CN1721407A (zh) 2006-01-18
EP1368325B1 (de) 2008-08-27
US7045625B2 (en) 2006-05-16
ES2311050T3 (es) 2009-02-01
IL157460A0 (en) 2004-03-28
HK1059436A1 (en) 2004-07-02
NO20033944L (no) 2003-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee