ATE234294T1 - Verfahren zur herstellung von n-(4-cyan-3- trifluormethylphenyl)-3-(4-flurophenylsulfonyl) 2-hydroxy-2-methylpropionamid - Google Patents

Verfahren zur herstellung von n-(4-cyan-3- trifluormethylphenyl)-3-(4-flurophenylsulfonyl) 2-hydroxy-2-methylpropionamid

Info

Publication number: ATE234294T1
Authority: AT; Austria
Prior art keywords: methylpropionamide; hydroxy; flurophenylsulfonyl; trifluormethylphenyl; cyan
Prior art date: 1999-06-10

Application number

AT00937111T

Other languages

English (en)

Inventor

Bela Soeroes

Zoltan Tuba

Gyoergy Galik

Adam Bor

Adam Demeter

Ferenc Trischler

Janos Horvath

Janos Brlik

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-10

Filing date

2000-05-26

Publication date

2003-03-15

2000-05-26 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE234294T1 publication Critical patent/ATE234294T1/de

Links

DRYMMXUBDRJPDS-UHFFFAOYSA-N 2-hydroxy-2-methylpropanamide Chemical compound CC(C)(O)C(N)=O DRYMMXUBDRJPDS-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT00937111T 1999-06-10 2000-05-26 Verfahren zur herstellung von n-(4-cyan-3- trifluormethylphenyl)-3-(4-flurophenylsulfonyl) 2-hydroxy-2-methylpropionamid ATE234294T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9901937A HU223950B1 (hu)	1999-06-10	1999-06-10	Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
PCT/HU2000/000049 WO2001000608A1 (en)	1999-06-10	2000-05-26	Process for the synthesis of n-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide

Publications (1)

Publication Number	Publication Date
ATE234294T1 true ATE234294T1 (de)	2003-03-15

Family

ID=89998474

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00937111T ATE234294T1 (de)	1999-06-10	2000-05-26	Verfahren zur herstellung von n-(4-cyan-3- trifluormethylphenyl)-3-(4-flurophenylsulfonyl) 2-hydroxy-2-methylpropionamid

Country Status (8)

Country	Link
US (1)	US7199257B1 (de)
EP (1)	EP1189898B1 (de)
AT (1)	ATE234294T1 (de)
AU (1)	AU5239700A (de)
DE (1)	DE60001657T2 (de)
ES (1)	ES2188550T3 (de)
HU (1)	HU223950B1 (de)
WO (1)	WO2001000608A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002312431A1 (en)	2001-06-13	2002-12-23	Biogal Gyogyszergyar Rt.	Novel process for preparing rac-bicalutamide and its intermediates
US7102026B2 (en)	2001-06-13	2006-09-05	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Process for preparing and isolating rac-bicalutamide and its intermediates
AU2002354475B2 (en)	2001-12-13	2008-08-14	Sumitomo Chemical Company, Limited	Crystals of bicalutamide and process for their production
DE10222104A1 (de)	2002-05-17	2003-12-04	Helm Ag	Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
US20040063782A1 (en) *	2002-09-27	2004-04-01	Westheim Raymond J.H.	Bicalutamide forms
US6818766B2 (en) *	2002-10-02	2004-11-16	Synthon Bv	Process for making bicalutamide and intermediates thereof
WO2004074350A2 (en) *	2003-02-21	2004-09-02	Hetero Drugs Limited	Bicalutamide polymorphs
US20050008691A1 (en)	2003-05-14	2005-01-13	Arturo Siles Ortega	Bicalutamide compositions
CA2529232A1 (en) *	2003-06-25	2005-02-03	Teva Gyogyszergyar Reszvenytarsasag	Process for purifying and isolating rac-bicalutamide
JP4322621B2 (ja)	2003-10-16	2009-09-02	住友化学株式会社	４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
US20080177109A1 (en) *	2005-03-29	2008-07-24	Usv Limited	Novel Process for Preparation of Bicalutamide
WO2007013094A2 (en) *	2005-04-15	2007-02-01	Sun Pharmaceutical Industries Limited	A process for preparation of antiandrogen compound
CA2513356A1 (en) *	2005-07-26	2007-01-26	Apotex Pharmachem Inc.	Process for production of bicalutamide
WO2007074473A1 (en) *	2005-12-27	2007-07-05	Dabur Pharma Limited	An improved process for preparation of bicalutamide
CN101462988B (zh) *	2007-12-21	2014-01-01	中国医学科学院药物研究所	一种比卡鲁胺的合成工艺
WO2012042532A1 (en) *	2010-09-29	2012-04-05	Shilpa Medicare Limited	Process for preparing bicalutamide
CN102086167B (zh) *	2010-12-09	2013-05-08	济南大学	一种乙磺酰基乙腈的制备方法
CN102321000A (zh) *	2011-07-21	2012-01-18	宁波人健药业集团有限公司	氧化制备比卡鲁胺的方法
CN102351762A (zh) *	2011-07-21	2012-02-15	宁波人健药业集团有限公司	用n-(4-氰基-3-三氟甲基苯基)-3-(4-氟苯硫基)-2-甲基-2-羟基丙酰胺制备比卡鲁胺的方法
CN108069887B (zh) *	2016-11-17	2021-04-20	山西振东制药股份有限公司	一种(r)-比卡鲁胺中间体的制备方法
CN109336798B (zh) *	2018-11-19	2021-11-16	常州新星联生物科技有限公司	一种比卡鲁胺硫醚中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3372965D1 (en)	1982-07-23	1987-09-17	Ici Plc	Amide derivatives
JPH09508125A (ja)	1994-01-21	1997-08-19	セプラコー，インコーポレイテッド	光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成
AU7723198A (en)	1997-06-04	1998-12-21	University Of Tennessee Research Corporation, The	Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
AU2002354475B2 (en) *	2001-12-13	2008-08-14	Sumitomo Chemical Company, Limited	Crystals of bicalutamide and process for their production
US6818766B2 (en) *	2002-10-02	2004-11-16	Synthon Bv	Process for making bicalutamide and intermediates thereof

1999
- 1999-06-10 HU HU9901937A patent/HU223950B1/hu active IP Right Grant
2000
- 2000-05-26 ES ES00937111T patent/ES2188550T3/es not_active Expired - Lifetime
- 2000-05-26 DE DE60001657T patent/DE60001657T2/de not_active Expired - Lifetime
- 2000-05-26 US US10/030,665 patent/US7199257B1/en not_active Expired - Fee Related
- 2000-05-26 EP EP00937111A patent/EP1189898B1/de not_active Expired - Lifetime
- 2000-05-26 AT AT00937111T patent/ATE234294T1/de active
- 2000-05-26 WO PCT/HU2000/000049 patent/WO2001000608A1/en active IP Right Grant
- 2000-05-26 AU AU52397/00A patent/AU5239700A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001000608A1 (en)	2001-01-04
HU9901937D0 (en)	1999-08-30
AU5239700A (en)	2001-01-31
WO2001000608A8 (en)	2001-06-21
ES2188550T3 (es)	2003-07-01
EP1189898B1 (de)	2003-03-12
DE60001657D1 (de)	2003-04-17
US7199257B1 (en)	2007-04-03
HUP9901937A2 (hu)	2001-04-28
HU223950B1 (hu)	2005-03-29
EP1189898A1 (de)	2002-03-27
DE60001657T2 (de)	2003-12-04

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