DK1298124T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number: DK1298124T3
Authority: DK; Denmark
Prior art keywords: citalopram; preparation
Prior art date: 1999-10-25

Application number

DK02028326T

Other languages

Danish (da)

English (en)

Inventor

Michael Harold Rock

Hans Petersen

Peter Ellegaard

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-25

Filing date

1999-10-25

Publication date

2007-07-09

1999-10-25 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1999-10-25 Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en

2007-07-09 Application granted granted Critical

2007-07-09 Publication of DK1298124T3 publication Critical patent/DK1298124T3/da

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 1
229960001653 citalopram Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)

DK02028326T 1999-10-25 1999-10-25 Fremgangsmåde til fremstilling af citalopram DK1298124T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK1999/000581 WO2000012044A2 (en)	1999-10-25	1999-10-25	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
DK1298124T3 true DK1298124T3 (da)	2007-07-09

Family

ID=8157164

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99950511T DK1228056T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram
DK02028326T DK1298124T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK99950511T DK1228056T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram

Country Status (25)

Country	Link
US (1)	US6566540B2 (de)
EP (1)	EP1298124B1 (de)
KR (1)	KR100505820B1 (de)
AR (1)	AR024518A1 (de)
AT (2)	ATE355268T1 (de)
CA (1)	CA2291133C (de)
CY (1)	CY1107635T1 (de)
CZ (1)	CZ292894B6 (de)
DE (3)	DE19983836C1 (de)
DK (2)	DK1228056T3 (de)
EA (1)	EA002801B1 (de)
ES (1)	ES2282365T3 (de)
HK (1)	HK1043129B (de)
HR (1)	HRP20020344B1 (de)
HU (1)	HUP0200169A3 (de)
IL (3)	IL143875A0 (de)
IS (1)	IS2260B (de)
NO (1)	NO20071311L (de)
NZ (1)	NZ512406A (de)
PL (1)	PL201056B1 (de)
PT (2)	PT1228056E (de)
SI (2)	SI1298124T1 (de)
SK (1)	SK287140B6 (de)
TR (1)	TR200401456T1 (de)
UA (1)	UA72238C2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR034612A1 (es) *	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR040970A1 (es) *	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US20050137255A1 (en) *	2002-12-23	2005-06-23	H. Lundbeck A/S	Crystalline escitalopram hydrobromide and methods for preparing the same
DK1578738T3 (da) *	2002-12-23	2008-06-30	Lundbeck & Co As H	Escitalopram-hydrobromid og fremgangsmåde til fremstilling deraf
TR200504022T1 (tr) *	2003-03-24	2006-08-21	Hetero Drugs Limited	(S)-sitalopram oksalatın yeni sıvı kristal formları.
US20050196453A1 (en) *	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
KR20080080094A (ko) *	2005-10-14	2008-09-02	하. 룬트벡 아크티에 셀스카브	에스시탈로프람 및 부프로피온의 저용량 조합물을 이용한중추신경계 장애의 치료 방법
JP2009511607A (ja) *	2005-10-14	2009-03-19	ハー・ルンドベック・アクチエゼルスカベット	エスシタロプラムおよびブプロピオンを含有する安定な医薬製剤
EP2185155B1 (de) *	2007-08-03	2017-10-04	Richter Gedeon Nyrt.	Pharmazeutische zusammensetzungen mit dopamin-rezeptor-liganden und behandlungsverfahren mit dopamin-rezeptor-liganden

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143702A (de)	1965-03-18
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
DE3926765A1 (de)	1989-08-12	1991-02-14	Hoechst Ag	Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
ES2148120T3 (es) *	1997-07-08	2002-01-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
ES2149734T3 (es)	1997-11-11	2003-02-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
CN1129592C (zh)	1998-10-20	2003-12-03	H·隆德贝克有限公司	制备西酞普兰的方法
SI1140886T1 (en)	1998-12-23	2003-08-31	H. Lundbeck A/S	Method for the preparation of 5-cyanophthalide
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) *	1999-04-14	2003-05-15	Lundbeck & Co As H	Verfahren zur herstellung von citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
JP2003519121A (ja)	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法

1999
- 1999-10-25 DE DE19983836A patent/DE19983836C1/de not_active Expired - Fee Related
- 1999-10-25 EA EA200100593A patent/EA002801B1/ru not_active IP Right Cessation
- 1999-10-25 SK SK50008-2009A patent/SK287140B6/sk not_active IP Right Cessation
- 1999-10-25 TR TR2004/01456T patent/TR200401456T1/xx unknown
- 1999-10-25 PT PT99950511T patent/PT1228056E/pt unknown
- 1999-10-25 PT PT02028326T patent/PT1298124E/pt unknown
- 1999-10-25 EP EP02028326A patent/EP1298124B1/de not_active Expired - Lifetime
- 1999-10-25 AT AT02028326T patent/ATE355268T1/de active
- 1999-10-25 SI SI9930960T patent/SI1298124T1/sl unknown
- 1999-10-25 CA CA002291133A patent/CA2291133C/en not_active Expired - Fee Related
- 1999-10-25 KR KR10-2001-7008100A patent/KR100505820B1/ko not_active IP Right Cessation
- 1999-10-25 SI SI9930703T patent/SI1228056T1/xx unknown
- 1999-10-25 DE DE69920526T patent/DE69920526T2/de not_active Expired - Lifetime
- 1999-10-25 DK DK99950511T patent/DK1228056T3/da active
- 1999-10-25 AT AT99950511T patent/ATE277032T1/de active
- 1999-10-25 NZ NZ512406A patent/NZ512406A/xx not_active IP Right Cessation
- 1999-10-25 DK DK02028326T patent/DK1298124T3/da active
- 1999-10-25 PL PL349440A patent/PL201056B1/pl not_active IP Right Cessation
- 1999-10-25 UA UA2001075224A patent/UA72238C2/uk unknown
- 1999-10-25 IL IL14387599A patent/IL143875A0/xx active IP Right Grant
- 1999-10-25 HU HU0200169A patent/HUP0200169A3/hu unknown
- 1999-10-25 DE DE69935355T patent/DE69935355T2/de not_active Expired - Lifetime
- 1999-10-25 ES ES02028326T patent/ES2282365T3/es not_active Expired - Lifetime
- 1999-11-10 AR ARP990105703A patent/AR024518A1/es active IP Right Grant
2001
- 2001-06-15 IS IS5970A patent/IS2260B/is unknown
- 2001-06-20 IL IL143875A patent/IL143875A/en not_active IP Right Cessation
2002
- 2002-04-19 HR HR20020344A patent/HRP20020344B1/xx not_active IP Right Cessation
- 2002-05-03 US US10/138,811 patent/US6566540B2/en not_active Expired - Fee Related
- 2002-07-05 HK HK02105036.3A patent/HK1043129B/zh not_active IP Right Cessation
- 2002-08-29 CZ CZ20022925A patent/CZ292894B6/cs not_active IP Right Cessation
2006
- 2006-07-18 IL IL176943A patent/IL176943A0/en unknown
2007
- 2007-03-09 NO NO20071311A patent/NO20071311L/no unknown
- 2007-05-21 CY CY20071100690T patent/CY1107635T1/el unknown

Also Published As

Publication number	Publication date
KR100505820B1 (ko)	2005-08-03
DE19983836C1 (de)	2003-10-23
HK1043129B (zh)	2004-10-21
EP1298124A1 (de)	2003-04-02
HUP0200169A3 (en)	2002-11-28
SK287140B6 (sk)	2010-01-07
CA2291133C (en)	2003-06-17
NO20071311L (no)	2001-08-24
EA200100593A1 (ru)	2001-10-22
IS2260B (is)	2007-06-15
NZ512406A (en)	2004-01-30
CA2291133A1 (en)	2001-04-25
HRP20020344B1 (en)	2010-10-31
IL176943A0 (en)	2006-12-10
CY1107635T1 (el)	2013-04-18
AR024518A1 (es)	2002-10-16
PT1228056E (pt)	2005-02-28
PL201056B1 (pl)	2009-03-31
DE69935355T2 (de)	2007-11-08
HRP20020344A2 (en)	2004-02-29
DK1228056T3 (da)	2005-01-24
DE69920526T2 (de)	2006-02-23
US20020177722A1 (en)	2002-11-28
DE69920526D1 (de)	2004-10-28
IL143875A0 (en)	2002-04-21
EP1298124B1 (de)	2007-02-28
PT1298124E (pt)	2007-05-31
TR200401456T1 (tr)	2005-04-21
HK1043129A1 (en)	2002-09-06
HUP0200169A2 (en)	2002-06-29
SI1228056T1 (en)	2005-02-28
ATE277032T1 (de)	2004-10-15
SI1298124T1 (sl)	2007-08-31
IS5970A (is)	2001-06-15
UA72238C2 (en)	2005-02-15
IL143875A (en)	2008-03-20
PL349440A1 (en)	2002-07-29
US6566540B2 (en)	2003-05-20
DE69935355D1 (de)	2007-04-12
KR20010092799A (ko)	2001-10-27
CZ292894B6 (cs)	2003-12-17
EA002801B1 (ru)	2002-10-31
ES2282365T3 (es)	2007-10-16
ATE355268T1 (de)	2006-03-15

Publication	Publication Date	Title
DK1173431T3 (da)	2003-08-04	Fremgangsmåde til fremstilling af citalopram
DK1105382T3 (da)	2002-05-27	Fremgangsmåde til fremstilling af citalopram
DK1159274T3 (da)	2003-07-21	Fremgangsmåde til fremstilling af citalopram
DK1123284T3 (da)	2003-04-28	Fremgangsmåde til fremstilling af citalopram
DK1032566T5 (da)	2004-06-28	Fremgangsmåde til fremstilling af citalopram
DK1309581T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af citalopram
DK1150966T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af 5-cyanophthalid
DK1296935T3 (da)	2009-06-22	Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1181272T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af rent citalopram
DK1181713T3 (da)	2005-01-31	Fremgangsmåde til fremstilling af rent citalopram
DK1165576T3 (da)	2006-03-27	Fremgangsmåde til fremstilling af amin-platin-komplekser
DK1140886T3 (da)	2003-07-28	Fremgangsmåde til fremstilling af 5-cyanophtalid
DK1187833T3 (da)	2007-10-08	Fremgangsmåde til fremstilling af thiamethoxam
DK1296970T3 (da)	2008-07-14	Fremgangsmåde til fremstilling af citalopram
DK1228056T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af citalopram
DK0973769T3 (da)	2004-12-13	Fremgangsmåde til fremstilling af eprosartan
NO20021118D0 (no)	2002-03-06	Fremgangsmåte for fremstilling av citalopram
DK0970073T3 (da)	2005-02-21	Fremgangsmåde til fremstilling af eprosartan
DK1203000T3 (da)	2003-06-02	Fremgangsmåde til fremstilling af phosphonomethylglycin
DK1240173T3 (da)	2003-09-15	Fremgangsmåde til fremstilling af N-phosphonomethylglycin
DK1012152T3 (da)	2003-02-10	Fremgangsmåde til fremstilling af oxazaphosphorin-2-aminer
DK1029867T3 (da)	2004-08-16	Fremgangsmåde til fremstilling af organiske azider
DK0949246T3 (da)	2003-04-07	Fremgangsmåde til fremstilling af phenoxyphenylsulfonylhalogenider
DK1226125T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af mavesårsmidler
DK0949237T3 (da)	2004-06-14	Fremgangsmåde til fremstilling af dihydrocitral