DK1297338T3 - Mikroopstillinger til udförelse af proteomikanalyser - Google Patents
Mikroopstillinger til udförelse af proteomikanalyserInfo
- Publication number
- DK1297338T3 DK1297338T3 DK01946078T DK01946078T DK1297338T3 DK 1297338 T3 DK1297338 T3 DK 1297338T3 DK 01946078 T DK01946078 T DK 01946078T DK 01946078 T DK01946078 T DK 01946078T DK 1297338 T3 DK1297338 T3 DK 1297338T3
- Authority
- DK
- Denmark
- Prior art keywords
- array
- protein
- peptidomimetic
- binding
- microarrays
- Prior art date
Links
- 238000002493 microarray Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000816 peptidomimetic Substances 0.000 abstract 3
- 239000007787 solid Substances 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003491 array Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 238000012916 structural analysis Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20971100P | 2000-06-05 | 2000-06-05 | |
PCT/US2001/018066 WO2001094946A2 (en) | 2000-06-05 | 2001-06-04 | Microarrays for performing proteomic analyses |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1297338T3 true DK1297338T3 (da) | 2007-06-11 |
Family
ID=22779937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01946078T DK1297338T3 (da) | 2000-06-05 | 2001-06-04 | Mikroopstillinger til udförelse af proteomikanalyser |
Country Status (10)
Country | Link |
---|---|
US (1) | US20020055125A1 (da) |
EP (1) | EP1297338B1 (da) |
JP (1) | JP2003536073A (da) |
AT (1) | ATE360207T1 (da) |
AU (1) | AU2001268173A1 (da) |
DE (1) | DE60127958D1 (da) |
DK (1) | DK1297338T3 (da) |
ES (1) | ES2281424T3 (da) |
PT (1) | PT1297338E (da) |
WO (1) | WO2001094946A2 (da) |
Families Citing this family (65)
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US7148058B2 (en) | 2000-06-05 | 2006-12-12 | Chiron Corporation | Protein microarrays on mirrored surfaces for performing proteomic analyses |
US7153682B2 (en) | 2000-06-05 | 2006-12-26 | Chiron Corporation | Microarrays on mirrored substrates for performing proteomic analyses |
AU2001277245A1 (en) * | 2000-08-03 | 2002-02-18 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
US20020102617A1 (en) * | 2000-08-03 | 2002-08-01 | Macbeath Gavin | Protein microarrays |
US7727713B2 (en) * | 2001-06-20 | 2010-06-01 | Nuevolution A/S | Templated molecules and methods for using such molecules |
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CA2477563A1 (en) * | 2001-12-21 | 2003-07-03 | Sense Proteomic Limited | Probe for mass spectrometry |
GB0205910D0 (en) * | 2002-03-13 | 2002-04-24 | Sense Proteomic Ltd | Arrays and methods |
GB2386372A (en) * | 2002-03-13 | 2003-09-17 | Amersham Biosciences Uk Ltd | The use of organic solvents in the preparation of arrays |
DE60324778D1 (de) | 2002-03-15 | 2009-01-02 | Nuevolution As | Eine verbesserte methode zur synthese von matritzenabhängigen molekülen |
US6791690B2 (en) * | 2002-04-30 | 2004-09-14 | Agilent Technologies, Inc. | Reading dry chemical arrays |
DE60332115D1 (de) * | 2002-07-11 | 2010-05-27 | American Nat Red Cross | Verfahren zur identifizierung einzelner aktiver einheiten aus komplexen gemischen |
DE10233303A1 (de) * | 2002-07-22 | 2004-02-12 | Micronas Holding Gmbh | Sensoroberfläche mit verbessertem Signal/Rausch-Verhältnis |
EP1539980B1 (en) * | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
EP1545762A2 (en) * | 2002-09-27 | 2005-06-29 | Carlsberg A/S | Spatially encoded polymer matrix |
EP1406089A1 (en) * | 2002-10-02 | 2004-04-07 | Taiwan Unison Biotechnology Co. Ltd. | A method for selectively staining water soluble protein using reactive dye |
CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
EP2175019A3 (en) | 2002-12-19 | 2011-04-06 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
EP1597395A2 (en) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Method for producing second-generation library |
US20060216775A1 (en) * | 2003-06-17 | 2006-09-28 | The Regents Of The University Of Califoenia | Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes |
ATE447626T1 (de) * | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
KR100518953B1 (ko) * | 2003-09-19 | 2005-10-12 | 주식회사 제노포커스 | 포자 외막단백질을 이용한 목적단백질의 표면발현 방법 |
US7019288B2 (en) * | 2003-09-30 | 2006-03-28 | Sequenom, Inc. | Methods of making substrates for mass spectrometry analysis and related devices |
WO2005040163A1 (en) | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd | Heterocyclic compounds that block the effects of advanced glycation end products (age) |
EP1723255B1 (en) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
JP4736439B2 (ja) * | 2005-01-25 | 2011-07-27 | 東レ株式会社 | 核酸固定化担体 |
WO2006124644A2 (en) * | 2005-05-12 | 2006-11-23 | Board Of Regents, The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
WO2006138647A2 (en) * | 2005-06-16 | 2006-12-28 | Gtc Biotherapeutics, Inc. | Method of making recombinant human antibodies for use in biosensor technology |
AU2006295515A1 (en) * | 2005-09-27 | 2007-04-05 | Polybatics Limited | Polymer particles and uses thereof |
PT3305900T (pt) | 2005-12-01 | 2021-10-27 | Nuevolution As | Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes |
WO2008136058A1 (ja) * | 2007-04-25 | 2008-11-13 | Shimadzu Corporation | レーザ脱離イオン化用サンプルプレート及び該サンプルプレートを用いた質量分析装置 |
CN104830812B (zh) | 2009-03-16 | 2017-09-05 | 盘古生物制药有限公司 | 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法 |
WO2010120509A2 (en) | 2009-03-31 | 2010-10-21 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
US20100303835A1 (en) * | 2009-05-29 | 2010-12-02 | The Board Of Regents Of The University Of Texas System | Peptoid ligands for isolation and treatment of autoimmune t-cells |
CA2764153C (en) * | 2009-06-02 | 2021-07-27 | The Board Of Regents Of The University Of Texas System | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
EP2488543A1 (en) * | 2009-10-16 | 2012-08-22 | The Board of Regents of The University of Texas System | Compositions and methods for producing cyclic peptoid libraries |
WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
AU2011248614B2 (en) | 2010-04-27 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
US9598734B2 (en) | 2010-04-29 | 2017-03-21 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
EP2563383B1 (en) | 2010-04-29 | 2017-03-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
WO2011139986A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
CA2797977C (en) | 2010-05-03 | 2019-08-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
JP6008841B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | メチオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
CA2799197C (en) | 2010-05-14 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
CA2799480C (en) | 2010-05-17 | 2020-12-15 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
EP2608801B1 (en) | 2010-08-25 | 2019-08-21 | aTyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
CN103930563B (zh) | 2011-06-01 | 2016-11-09 | 医学预后研究所 | 用于预测癌症复发的方法和装置 |
ES2652136T3 (es) | 2012-02-16 | 2018-01-31 | Atyr Pharma, Inc. | Histidil-tRNA sintetasas para tratar enfermedades autoinmunitarias e inflamatorias |
JP6301311B2 (ja) * | 2012-04-10 | 2018-03-28 | ザ トラスティーズ オブ プリンストン ユニバーシティThe Trustees Of Princeton University | 超高感度センサ |
CA2892822C (en) | 2012-11-27 | 2023-08-08 | Pontificia Universidad Catolica De Chile | Compositions and methods for diagnosing thyroid tumors |
CN105229467A (zh) * | 2013-03-15 | 2016-01-06 | 普林斯顿大学理事会 | 快速且灵敏的分析物测量测定法 |
US10392667B2 (en) | 2013-06-07 | 2019-08-27 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients |
CN104345153B (zh) * | 2013-07-30 | 2017-05-10 | 香港中文大学 | 微阵列基底、微阵列、微流体***及其制备方法 |
JP6336984B2 (ja) * | 2013-08-07 | 2018-06-06 | シチズンファインデバイス株式会社 | 試料積載プレート |
WO2015047958A1 (en) * | 2013-09-24 | 2015-04-02 | Entopsis | Detectable arrays, systems for diagnosis, and methods of making and using the same |
US11214836B2 (en) | 2014-07-15 | 2022-01-04 | Ontario Institute For Cancer Research | Methods and devices for predicting anthracycline treatment efficacy |
WO2017066454A2 (en) | 2015-10-14 | 2017-04-20 | X-Therma, Inc. | Compositions and methods for reducing ice crystal formation |
US20200141904A1 (en) * | 2017-07-07 | 2020-05-07 | Aviana Molecular Technologies, Llc | Bioactive coating for surface acoustic wave sensor |
CN112868086A (zh) * | 2018-10-18 | 2021-05-28 | Dh科技发展私人贸易有限公司 | 使与质谱***一起应用的取样元件官能化的方法 |
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US3864085A (en) * | 1973-10-31 | 1975-02-04 | Princenton Biomedix Inc | Glutathione reagent and test method |
US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5965695A (en) * | 1990-05-15 | 1999-10-12 | Chiron Corporation | Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such |
IE911670A1 (en) * | 1990-05-17 | 1991-11-20 | Adeza Biomedical Corp | Highly reflective biogratings and method |
DE4039677A1 (de) * | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | Universalbindefilm |
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US6306584B1 (en) * | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
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DE19741716A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung |
US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
EP1066295A2 (en) * | 1998-03-23 | 2001-01-10 | President And Fellows Of Harvard College | Synthesis of compounds and libraries of compounds |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
WO2001001142A2 (en) * | 1999-06-29 | 2001-01-04 | Chiron Corporation | Arrays of biopolymeric agents and method for their production and use |
US7153682B2 (en) * | 2000-06-05 | 2006-12-26 | Chiron Corporation | Microarrays on mirrored substrates for performing proteomic analyses |
US7148058B2 (en) * | 2000-06-05 | 2006-12-12 | Chiron Corporation | Protein microarrays on mirrored surfaces for performing proteomic analyses |
-
2001
- 2001-06-04 JP JP2002502444A patent/JP2003536073A/ja not_active Withdrawn
- 2001-06-04 DE DE60127958T patent/DE60127958D1/de not_active Expired - Lifetime
- 2001-06-04 PT PT01946078T patent/PT1297338E/pt unknown
- 2001-06-04 AT AT01946078T patent/ATE360207T1/de not_active IP Right Cessation
- 2001-06-04 WO PCT/US2001/018066 patent/WO2001094946A2/en active IP Right Grant
- 2001-06-04 ES ES01946078T patent/ES2281424T3/es not_active Expired - Lifetime
- 2001-06-04 DK DK01946078T patent/DK1297338T3/da active
- 2001-06-04 EP EP01946078A patent/EP1297338B1/en not_active Expired - Lifetime
- 2001-06-04 AU AU2001268173A patent/AU2001268173A1/en not_active Abandoned
- 2001-06-04 US US09/874,091 patent/US20020055125A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1297338A2 (en) | 2003-04-02 |
PT1297338E (pt) | 2007-05-31 |
WO2001094946A9 (en) | 2002-04-11 |
AU2001268173A1 (en) | 2001-12-17 |
EP1297338B1 (en) | 2007-04-18 |
WO2001094946A3 (en) | 2003-01-30 |
US20020055125A1 (en) | 2002-05-09 |
ES2281424T3 (es) | 2007-10-01 |
ATE360207T1 (de) | 2007-05-15 |
JP2003536073A (ja) | 2003-12-02 |
WO2001094946A2 (en) | 2001-12-13 |
DE60127958D1 (de) | 2007-05-31 |
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