DK1140828T3 - 3-Azabicyclo[3.1.0]hexan-derivater som opiat-receptorligander - Google Patents
3-Azabicyclo[3.1.0]hexan-derivater som opiat-receptorliganderInfo
- Publication number
- DK1140828T3 DK1140828T3 DK99954290T DK99954290T DK1140828T3 DK 1140828 T3 DK1140828 T3 DK 1140828T3 DK 99954290 T DK99954290 T DK 99954290T DK 99954290 T DK99954290 T DK 99954290T DK 1140828 T3 DK1140828 T3 DK 1140828T3
- Authority
- DK
- Denmark
- Prior art keywords
- azabicyclo
- receptor ligands
- opiate receptor
- hexane derivatives
- hexane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9828485.4A GB9828485D0 (en) | 1998-12-23 | 1998-12-23 | Compounds useful in therapy |
GBGB9912425.7A GB9912425D0 (en) | 1999-05-27 | 1999-05-27 | Compounds useful in therapy |
US09/467,871 US6313312B1 (en) | 1998-12-23 | 1999-12-20 | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1140828T3 true DK1140828T3 (da) | 2006-12-11 |
Family
ID=27269601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99954290T DK1140828T3 (da) | 1998-12-23 | 1999-11-19 | 3-Azabicyclo[3.1.0]hexan-derivater som opiat-receptorligander |
Country Status (33)
Country | Link |
---|---|
US (3) | US6313312B1 (el) |
EP (1) | EP1140828B1 (el) |
JP (1) | JP3553886B2 (el) |
CN (1) | CN1192021C (el) |
AP (1) | AP1852A (el) |
AT (1) | ATE335725T1 (el) |
AU (1) | AU761574B2 (el) |
BG (1) | BG65402B1 (el) |
BR (1) | BR9916584A (el) |
CA (1) | CA2356300C (el) |
CY (1) | CY1106445T1 (el) |
CZ (1) | CZ20012299A3 (el) |
DE (1) | DE69932738T2 (el) |
DK (1) | DK1140828T3 (el) |
DZ (1) | DZ2962A1 (el) |
EA (1) | EA004672B1 (el) |
ES (1) | ES2274646T3 (el) |
HK (1) | HK1041698B (el) |
HR (1) | HRP20010477B1 (el) |
HU (1) | HUP0104816A3 (el) |
ID (1) | ID28981A (el) |
IL (1) | IL142697A0 (el) |
IS (1) | IS2467B (el) |
MA (1) | MA25035A1 (el) |
NO (1) | NO321658B1 (el) |
NZ (1) | NZ511234A (el) |
OA (1) | OA11727A (el) |
PL (1) | PL348453A1 (el) |
SI (1) | SI1140828T1 (el) |
SK (1) | SK8772001A3 (el) |
TW (1) | TWI244481B (el) |
UY (1) | UY25873A1 (el) |
WO (1) | WO2000039089A1 (el) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
DE60226161T2 (de) * | 2001-10-22 | 2009-07-02 | Pfizer Products Inc., Groton | 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren |
EP1546099B1 (en) | 2002-07-08 | 2008-12-31 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo 3.1.0 hexane derivatives useful as muscarinic receptor antagonists |
EP1546098B1 (en) * | 2002-07-31 | 2008-05-28 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
DE60231341D1 (de) * | 2002-08-23 | 2009-04-09 | Ranbaxy Lab Ltd | Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten |
US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
JP2006522791A (ja) * | 2003-04-09 | 2006-10-05 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗微生物性[3.1.0]ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体 |
WO2004089898A1 (en) * | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
BRPI0409302A (pt) * | 2003-04-11 | 2006-04-11 | Ranbaxy Lab Ltd | derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos |
BRPI0409307A (pt) * | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
BRPI0415459A (pt) * | 2003-10-16 | 2006-12-19 | Pfizer Prod Inc | preparação de derivados de 3-azabiciclo[3.1.0]hexano |
WO2006024955A1 (en) * | 2004-09-01 | 2006-03-09 | Pfizer Products Inc. | Azabicyclic amine histamine-3 receptor antagonists |
WO2006113458A1 (en) * | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
US20080319043A1 (en) * | 2005-05-03 | 2008-12-25 | Mohammad Salman | 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists |
EP1904843A2 (en) | 2005-07-08 | 2008-04-02 | Braincells, Inc. | Methods for identifying agents and conditions that modulate neurogenesis |
GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
GB0517193D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
WO2007022933A1 (en) * | 2005-08-22 | 2007-03-01 | Glaxo Group Limited | Triazole derivatives as modulators of dopamine d3 receptors |
GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
GB0716632D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
ES2390195T3 (es) * | 2007-08-27 | 2012-11-07 | Theravance, Inc. | Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu |
TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物 |
US7947710B2 (en) * | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
US7691878B2 (en) * | 2007-08-27 | 2010-04-06 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
WO2012042539A2 (en) | 2010-09-28 | 2012-04-05 | Panacea Biotec Ltd | Novel bicyclic compounds |
WO2013070659A1 (en) | 2011-11-07 | 2013-05-16 | Sunovion Pharmaceuticals Inc. | Modulators of opioid receptors and methods of use thereof |
US9663463B2 (en) | 2013-11-20 | 2017-05-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose |
CN106132406B (zh) | 2014-02-03 | 2020-03-27 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的γ-氨基酸和类似物 |
AU2015210638B2 (en) | 2014-02-03 | 2017-07-20 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
CN104177284B (zh) * | 2014-08-01 | 2016-08-24 | 常州大学 | 合成3-氮杂二环[3,1,0]己基-1-甲醛的方法 |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
RU2017144548A (ru) * | 2015-05-20 | 2019-06-20 | Санва Кагаку Кенкюсо Ко., Лтд. | Кристаллическая соль нового производного 3-азабицикло[3.1.0]гексана и ее применение в медицине |
AR105592A1 (es) | 2015-08-03 | 2017-10-18 | Quadriga Biosciences Inc | b-AMINOÁCIDOS b-SUSTITUIDOS Y ANÁLOGOS COMO AGENTES QUIMIOTERAPÉUTICOS Y USOS DE LOS MISMOS |
WO2017121692A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Substituierte sulfamide und ihre verwendung |
CA3054122A1 (en) | 2017-03-02 | 2018-09-07 | Sanwa Kagaku Kenkyusho Co., Ltd. | Therapeutic agent for alcohol use disorders |
CA3061787A1 (en) * | 2017-05-15 | 2018-11-22 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
CN107501272B (zh) * | 2017-09-05 | 2020-03-31 | 中国药科大学 | 咪唑并异吲哚类ido1抑制剂、其制备方法及应用 |
JP2021512952A (ja) | 2018-02-05 | 2021-05-20 | アルカームス・インコーポレイテッド | 疼痛の処置のための化合物 |
CN112939844B (zh) * | 2019-12-10 | 2023-02-03 | 华东师范大学 | 一种多取代四氢咔唑及其衍生物及其合成方法和应用 |
CN110938036A (zh) * | 2019-12-24 | 2020-03-31 | 中国药科大学 | 一种4-碘-1h-咪唑的制备方法 |
JP2023524547A (ja) | 2020-05-07 | 2023-06-12 | 小野薬品工業株式会社 | Kdm5阻害作用を有する3-アザビシクロ(3.1.0)ヘキサン誘導体およびその医薬用途 |
CN112300002A (zh) * | 2020-10-26 | 2021-02-02 | 安徽工业大学 | 一种5-硝基丹皮酚及5-硝基丹皮酚腙的制备方法 |
CN114057627B (zh) * | 2022-01-18 | 2022-04-01 | 南京桦冠生物技术有限公司 | 一种丙型肝炎及新冠药物中间体及其盐的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB872300A (en) * | 1956-10-26 | 1961-07-05 | Wellcome Found | Improvements in and relating to new derivatives of azabicyclohexane and the manufacture thereof |
US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
GB948730A (en) * | 1959-04-08 | 1964-02-05 | Wellcome Found | Substituted cyclopropanes and related compounds |
IL86061A (en) | 1987-04-16 | 1992-07-15 | Lilly Co Eli | Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them |
NZ242117A (en) * | 1991-03-29 | 1994-11-25 | Lilly Co Eli | 4-phenylpiperidine derivatives and medicaments containing them |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
DE4341403A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
-
1999
- 1999-11-16 TW TW088119947A patent/TWI244481B/zh not_active IP Right Cessation
- 1999-11-19 SK SK877-2001A patent/SK8772001A3/sk unknown
- 1999-11-19 HU HU0104816A patent/HUP0104816A3/hu unknown
- 1999-11-19 CZ CZ20012299A patent/CZ20012299A3/cs unknown
- 1999-11-19 AT AT99954290T patent/ATE335725T1/de not_active IP Right Cessation
- 1999-11-19 CN CNB998150436A patent/CN1192021C/zh not_active Expired - Fee Related
- 1999-11-19 EP EP99954290A patent/EP1140828B1/en not_active Expired - Lifetime
- 1999-11-19 SI SI9930926T patent/SI1140828T1/sl unknown
- 1999-11-19 PL PL99348453A patent/PL348453A1/xx not_active Application Discontinuation
- 1999-11-19 DK DK99954290T patent/DK1140828T3/da active
- 1999-11-19 AP APAP/P/2001/002185A patent/AP1852A/en active
- 1999-11-19 ES ES99954290T patent/ES2274646T3/es not_active Expired - Lifetime
- 1999-11-19 DE DE69932738T patent/DE69932738T2/de not_active Expired - Lifetime
- 1999-11-19 IL IL14269799A patent/IL142697A0/xx unknown
- 1999-11-19 WO PCT/IB1999/001852 patent/WO2000039089A1/en active IP Right Grant
- 1999-11-19 OA OA1200100149A patent/OA11727A/en unknown
- 1999-11-19 AU AU10698/00A patent/AU761574B2/en not_active Ceased
- 1999-11-19 EA EA200100417A patent/EA004672B1/ru not_active IP Right Cessation
- 1999-11-19 CA CA002356300A patent/CA2356300C/en not_active Expired - Fee Related
- 1999-11-19 ID IDW00200101352A patent/ID28981A/id unknown
- 1999-11-19 JP JP2000591001A patent/JP3553886B2/ja not_active Expired - Fee Related
- 1999-11-19 NZ NZ511234A patent/NZ511234A/en unknown
- 1999-11-19 BR BR9916584-8A patent/BR9916584A/pt not_active Application Discontinuation
- 1999-12-08 MA MA25862A patent/MA25035A1/fr unknown
- 1999-12-08 DZ DZ990262A patent/DZ2962A1/xx active
- 1999-12-20 US US09/467,871 patent/US6313312B1/en not_active Expired - Fee Related
- 1999-12-22 UY UY25873A patent/UY25873A1/es unknown
-
2001
- 2001-04-20 IS IS5922A patent/IS2467B/is unknown
- 2001-06-22 NO NO20013148A patent/NO321658B1/no not_active IP Right Cessation
- 2001-06-25 HR HR20010477A patent/HRP20010477B1/xx not_active IP Right Cessation
- 2001-07-16 BG BG105711A patent/BG65402B1/bg unknown
- 2001-10-30 US US10/016,745 patent/US20020072616A1/en not_active Abandoned
-
2002
- 2002-05-04 HK HK02103395.3A patent/HK1041698B/zh not_active IP Right Cessation
- 2002-08-07 US US10/214,658 patent/US7049444B2/en not_active Expired - Fee Related
-
2006
- 2006-11-08 CY CY20061101604T patent/CY1106445T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1140828T3 (da) | 3-Azabicyclo[3.1.0]hexan-derivater som opiat-receptorligander | |
AU4802500A (en) | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | |
ATE435861T1 (de) | 12,13-cyclopropan-epothilonderivate | |
ID26743A (id) | Turunan 1,2,4,5-tetrahidro-benzo [d] azepin | |
DE69928945D1 (de) | 4,4-biarylpiperidinederivate mit opioid-receptor-wirkung | |
AU2900499A (en) | Substituted aminomethylphosphines as ligands for catalysts | |
NO20015477L (no) | 4,5,6,7-tetrahydroindazolderivater som antitumormidler | |
DK1000048T3 (da) | Substituerede 1,2,3,4-tetrahydronapthalenderivater | |
AU1738900A (en) | Serotonin ligands as pro-erectile compounds | |
AP2004003007A0 (en) | 3-Azabicyclo (3.1.0) hexane derivatives as oploid receptor antagonists. | |
HK1037619A1 (en) | Indole derivatives. | |
IL153427A0 (en) | 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity | |
NO20003825D0 (no) | 1,3,4 - oxadiazolonderivater | |
DE60025958D1 (de) | 14,15-beta-methylen substituierte androgene | |
AU2001259051A1 (en) | Piperidyindoles as serotonin receptor ligands | |
AU3667699A (en) | Indolyl derivatives as serotonergic agents | |
AU3967099A (en) | Indolyl derivatives as serotonergic agents | |
ZA991893B (en) | 5-Heteroaryl substituted indoles. | |
NO983656D0 (no) | Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander | |
NO20015397D0 (no) | 1,5-Benzodiazepin-derivater | |
ZA200006596B (en) | Dihydrotriazolone derivatives as pesticides. | |
GB2350361B (en) | 3,4,5-tricyanophenyl derivatives | |
SI0885222T1 (en) | Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands | |
SI1073651T1 (en) | Indolyl derivatives as serotonergic agents |